IMP: Integrative Multi-species Prediction

Rattus norvegicus

8 known processes

Dad1

defender against cell death 1

Ensembl: ENSRNOG00000009090
Entrez: 192275
RGD: 621028
UniProtKB: P61805

Process Predictions
Disease Predictions

Dad1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
pyrimidine nucleoside triphosphate biosynthetic process	GO:0009148	3	0.321
positive regulation of phosphate metabolic process	GO:0045937	262	0.182
rna biosynthetic process	GO:0032774	380	0.172
regulation of cellular component organization	GO:0051128	368	0.161
pyrimidine nucleotide biosynthetic process	GO:0006221	9	0.160
pyrimidine nucleotide metabolic process	GO:0006220	9	0.153
homeostatic process	GO:0042592	331	0.145
pyrimidine ribonucleoside triphosphate biosynthetic process	GO:0009209	2	0.136
neuron differentiation	GO:0030182	368	0.125
retinal metabolic process	GO:0042574	3	0.110
positive regulation of camp biosynthetic process	GO:0030819	28	0.103
regulation of rna metabolic process	GO:0051252	391	0.101
response to amine	GO:0014075	46	0.100
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.097
camp metabolic process	GO:0046058	63	0.094
regulation of purine nucleotide metabolic process	GO:1900542	115	0.094
tissue development	GO:0009888	252	0.093
regulation of neurogenesis	GO:0050767	247	0.089
protein oligomerization	GO:0051259	191	0.084
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.083
pyrimidine ribonucleotide metabolic process	GO:0009218	5	0.082
regulation of nucleotide metabolic process	GO:0006140	117	0.082
cell projection organization	GO:0030030	302	0.080
regulation of neuron differentiation	GO:0045664	208	0.079
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.078
regulation of signal transduction	GO:0009966	318	0.078
positive regulation of biosynthetic process	GO:0009891	319	0.077
regulation of camp biosynthetic process	GO:0030817	38	0.075
regulation of transcription dna templated	GO:0006355	374	0.075
reproduction	GO:0000003	245	0.074
response to purine containing compound	GO:0014074	126	0.074
positive regulation of multicellular organismal process	GO:0051240	387	0.073
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.071
pyrimidine nucleoside triphosphate metabolic process	GO:0009147	4	0.071
response to ketone	GO:1901654	182	0.070
hexitol biosynthetic process	GO:0019406	1	0.070
neuron projection development	GO:0031175	273	0.070
intracellular signal transduction	GO:0035556	314	0.069
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.069
ctp metabolic process	GO:0046036	1	0.068
ctp biosynthetic process	GO:0006241	1	0.065
aging	GO:0007568	241	0.065
programmed cell death	GO:0012501	392	0.064
regulation of cell projection organization	GO:0031344	175	0.064
transcription from rna polymerase ii promoter	GO:0006366	252	0.064
regulation of nucleotide biosynthetic process	GO:0030808	47	0.063
chemical homeostasis	GO:0048878	292	0.061
transcription dna templated	GO:0006351	377	0.058
cyclic nucleotide metabolic process	GO:0009187	80	0.058
cellular response to lipid	GO:0071396	201	0.057
rna metabolic process	GO:0016070	406	0.056
response to alkaloid	GO:0043279	132	0.056
regulation of cell development	GO:0060284	263	0.055
guanosine containing compound metabolic process	GO:1901068	74	0.054
purine ribonucleotide metabolic process	GO:0009150	227	0.054
oxoacid metabolic process	GO:0043436	290	0.053
cellular response to oxidative stress	GO:0034599	76	0.053
brain renin angiotensin system	GO:0002035	3	0.052
positive regulation of camp metabolic process	GO:0030816	31	0.050
positive regulation of cell proliferation	GO:0008284	249	0.049
second messenger mediated signaling	GO:0019932	51	0.048
neurological system process	GO:0050877	219	0.047
cellular homeostasis	GO:0019725	252	0.046
positive regulation of transcription dna templated	GO:0045893	197	0.046
positive regulation of developmental process	GO:0051094	283	0.046
positive regulation of nucleotide metabolic process	GO:0045981	91	0.045
cellular component biogenesis	GO:0044085	368	0.045
positive regulation of cellular biosynthetic process	GO:0031328	295	0.045
cyclic purine nucleotide metabolic process	GO:0052652	62	0.045
regulation of multicellular organismal development	GO:2000026	376	0.045
regulation of rna biosynthetic process	GO:2001141	381	0.045
positive regulation of cell differentiation	GO:0045597	217	0.044
regulation of immune system process	GO:0002682	123	0.044
positive regulation of cellular component organization	GO:0051130	200	0.043
secretion	GO:0046903	307	0.043
secretion by cell	GO:0032940	248	0.043
multicellular organism reproduction	GO:0032504	233	0.042
regulation of purine nucleotide biosynthetic process	GO:1900371	46	0.041
regulation of nervous system development	GO:0051960	264	0.041
immune system process	GO:0002376	204	0.041
positive regulation of secretion	GO:0051047	140	0.041
response to glucose	GO:0009749	136	0.041
negative regulation of metabolic process	GO:0009892	331	0.041
ribose phosphate metabolic process	GO:0019693	235	0.040
positive regulation of transport	GO:0051050	245	0.040
positive regulation of cell projection organization	GO:0031346	111	0.039
response to extracellular stimulus	GO:0009991	380	0.039
neuron development	GO:0048666	286	0.039
ion homeostasis	GO:0050801	212	0.038
positive regulation of gene expression	GO:0010628	244	0.038
cellular response to oxygen containing compound	GO:1901701	386	0.037
ribonucleoside metabolic process	GO:0009119	174	0.037
regulation of cyclic nucleotide biosynthetic process	GO:0030802	45	0.037
purine nucleotide metabolic process	GO:0006163	229	0.035
forebrain development	GO:0030900	98	0.035
response to peptide	GO:1901652	292	0.034
neuron death	GO:0070997	127	0.034
regulation of molecular function	GO:0065009	398	0.034
single organism intracellular transport	GO:1902582	166	0.034
response to camp	GO:0051591	91	0.034
golgi vesicle transport	GO:0048193	22	0.034
negative regulation of programmed cell death	GO:0043069	183	0.034
regulation of phosphate metabolic process	GO:0019220	349	0.034
regulation of nucleic acid templated transcription	GO:1903506	380	0.033
glycosyl compound metabolic process	GO:1901657	182	0.033
positive regulation of phosphorus metabolic process	GO:0010562	262	0.033
purine nucleoside metabolic process	GO:0042278	169	0.032
myeloid leukocyte differentiation	GO:0002573	20	0.032
purine ribonucleoside metabolic process	GO:0046128	168	0.032
regulation of apoptotic process	GO:0042981	335	0.032
protein phosphorylation	GO:0006468	345	0.032
regulation of neuron projection development	GO:0010975	161	0.032
cellular response to fatty acid	GO:0071398	29	0.032
regulation of intracellular signal transduction	GO:1902531	218	0.031
brain development	GO:0007420	247	0.031
regulation of cellular catabolic process	GO:0031329	101	0.030
protein complex assembly	GO:0006461	263	0.030
cellular ketone metabolic process	GO:0042180	51	0.029
regulation of catalytic activity	GO:0050790	304	0.029
response to glucocorticoid	GO:0051384	223	0.029
regulation of secretion by cell	GO:1903530	208	0.029
pyrimidine containing compound metabolic process	GO:0072527	20	0.029
positive regulation of rna biosynthetic process	GO:1902680	197	0.028
regulation of blood vessel size	GO:0050880	89	0.028
gland development	GO:0048732	155	0.028
central nervous system development	GO:0007417	311	0.028
blood circulation	GO:0008015	183	0.028
reproductive process	GO:0022414	372	0.028
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.028
cyclic nucleotide biosynthetic process	GO:0009190	63	0.028
nucleotide metabolic process	GO:0009117	279	0.028
regulation of phosphorus metabolic process	GO:0051174	349	0.027
nucleic acid templated transcription	GO:0097659	379	0.027
protein complex biogenesis	GO:0070271	263	0.027
wound healing	GO:0042060	122	0.027
response to oxidative stress	GO:0006979	186	0.027
regulation of camp metabolic process	GO:0030814	43	0.027
positive regulation of cell development	GO:0010720	176	0.027
metal ion homeostasis	GO:0055065	186	0.026
heart morphogenesis	GO:0003007	3	0.026
positive regulation of response to stimulus	GO:0048584	285	0.026
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.025
response to oxygen radical	GO:0000305	8	0.025
purine containing compound metabolic process	GO:0072521	253	0.024
multicellular organismal reproductive process	GO:0048609	233	0.024
carbohydrate metabolic process	GO:0005975	130	0.024
camp biosynthetic process	GO:0006171	47	0.024
single organism reproductive process	GO:0044702	297	0.024
regulation of anatomical structure size	GO:0090066	135	0.024
positive regulation of nervous system development	GO:0051962	178	0.024
response to peptide hormone	GO:0043434	278	0.023
limbic system development	GO:0021761	38	0.023
circulatory system process	GO:0003013	183	0.023
response to testosterone	GO:0033574	55	0.023
carbohydrate derivative metabolic process	GO:1901135	346	0.023
cellular cation homeostasis	GO:0030003	180	0.023
protein autophosphorylation	GO:0046777	66	0.022
cation transmembrane transport	GO:0098655	263	0.022
positive regulation of neuron differentiation	GO:0045666	126	0.022
regulation of catabolic process	GO:0009894	113	0.022
positive regulation of rna metabolic process	GO:0051254	203	0.022
cellular component assembly	GO:0022607	360	0.022
telencephalon development	GO:0021537	62	0.022
multi organism reproductive process	GO:0044703	262	0.022
gtp metabolic process	GO:0046039	72	0.022
hippocampus development	GO:0021766	30	0.022
nucleoside triphosphate metabolic process	GO:0009141	144	0.022
kidney development	GO:0001822	67	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.021
metal ion transport	GO:0030001	289	0.021
cellular amino acid metabolic process	GO:0006520	107	0.021
epithelium development	GO:0060429	96	0.021
positive regulation of cell communication	GO:0010647	271	0.021
protein complex subunit organization	GO:0071822	302	0.020
cell morphogenesis involved in differentiation	GO:0000904	119	0.020
response to acid chemical	GO:0001101	222	0.020
pyrimidine ribonucleotide biosynthetic process	GO:0009220	5	0.020
cellular chemical homeostasis	GO:0055082	247	0.020
response to estrogen	GO:0043627	232	0.020
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.020
negative regulation of developmental process	GO:0051093	125	0.019
cellular modified amino acid metabolic process	GO:0006575	61	0.019
intracellular transport	GO:0046907	185	0.019
positive regulation of purine nucleotide biosynthetic process	GO:1900373	36	0.019
organophosphate biosynthetic process	GO:0090407	143	0.019
head development	GO:0060322	247	0.019
vascular process in circulatory system	GO:0003018	96	0.019
cell motility	GO:0048870	202	0.019
response to monosaccharide	GO:0034284	159	0.018
organic acid metabolic process	GO:0006082	292	0.018
organ morphogenesis	GO:0009887	75	0.018
regulation of tube size	GO:0035150	89	0.018
ribonucleotide metabolic process	GO:0009259	231	0.018
negative regulation of multicellular organismal process	GO:0051241	203	0.017
response to bacterium	GO:0009617	200	0.017
protein ubiquitination	GO:0016567	28	0.017
regulation of secretion	GO:0051046	224	0.017
cellular amine metabolic process	GO:0044106	38	0.017
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.017
pyrimidine ribonucleoside biosynthetic process	GO:0046132	5	0.017
response to hexose	GO:0009746	144	0.017
positive regulation of signal transduction	GO:0009967	175	0.017
regulation of phosphorylation	GO:0042325	248	0.016
positive regulation of intracellular signal transduction	GO:1902533	138	0.016
nucleobase containing small molecule metabolic process	GO:0055086	316	0.016
regulation of hormone levels	GO:0010817	187	0.016
positive regulation of nucleotide biosynthetic process	GO:0030810	36	0.016
regulation of neuron death	GO:1901214	115	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.016
negative regulation of macromolecule metabolic process	GO:0010605	260	0.016
pallium development	GO:0021543	42	0.016
organophosphate metabolic process	GO:0019637	370	0.016
organophosphate catabolic process	GO:0046434	148	0.016
cellular response to stress	GO:0033554	269	0.016
regulation of blood pressure	GO:0008217	83	0.016
positive regulation of secretion by cell	GO:1903532	128	0.016
response to inorganic substance	GO:0010035	377	0.016
regulation of response to external stimulus	GO:0032101	106	0.015
regulation of body fluid levels	GO:0050878	90	0.015
cytokine mediated signaling pathway	GO:0019221	43	0.015
response to ethanol	GO:0045471	162	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.015
cellular component movement	GO:0006928	248	0.015
carboxylic acid metabolic process	GO:0019752	289	0.015
positive regulation of protein metabolic process	GO:0051247	178	0.015
positive regulation of hormone secretion	GO:0046887	65	0.015
regulation of ligase activity	GO:0051340	3	0.015
response to metal ion	GO:0010038	253	0.015
regulation of transmembrane transporter activity	GO:0022898	49	0.015
molting cycle process	GO:0022404	2	0.014
cellular ion homeostasis	GO:0006873	184	0.014
protein localization	GO:0008104	191	0.014
regulation of corticotropin secretion	GO:0051459	7	0.014
cellular metal ion homeostasis	GO:0006875	172	0.014
macromolecular complex assembly	GO:0065003	273	0.014
sleep	GO:0030431	30	0.014
catabolic process	GO:0009056	351	0.014
regulation of cellular protein metabolic process	GO:0032268	267	0.014
regulation of cell proliferation	GO:0042127	359	0.014
cellular calcium ion homeostasis	GO:0006874	160	0.014
gastrulation	GO:0007369	2	0.014
positive regulation of signaling	GO:0023056	270	0.013
anatomical structure morphogenesis	GO:0009653	298	0.013
regulation of cell differentiation	GO:0045595	320	0.013
positive regulation of peptide secretion	GO:0002793	52	0.013
extracellular matrix organization	GO:0030198	13	0.013
positive regulation of immune system process	GO:0002684	90	0.013
positive regulation of cellular amine metabolic process	GO:0033240	3	0.013
regulation of smoothened signaling pathway	GO:0008589	2	0.013
regulation of myeloid cell differentiation	GO:0045637	12	0.013
multicellular organism growth	GO:0035264	1	0.013
response to carbohydrate	GO:0009743	183	0.013
carbohydrate homeostasis	GO:0033500	75	0.013
sequestering of calcium ion	GO:0051208	8	0.013
cell cycle checkpoint	GO:0000075	2	0.013
sequestering of metal ion	GO:0051238	9	0.013
cellular response to acid chemical	GO:0071229	75	0.013
regulation of hormone secretion	GO:0046883	106	0.013
negative regulation of apoptotic process	GO:0043066	181	0.013
response to estradiol	GO:0032355	164	0.013
cellular response to organonitrogen compound	GO:0071417	197	0.013
regulation of neuron apoptotic process	GO:0043523	83	0.012
divalent inorganic cation homeostasis	GO:0072507	165	0.012
regulation of peptide hormone secretion	GO:0090276	80	0.012
response to wounding	GO:0009611	254	0.012
negative regulation of signaling	GO:0023057	157	0.012
negative regulation of catalytic activity	GO:0043086	103	0.012
response to lipopolysaccharide	GO:0032496	191	0.012
negative regulation of myeloid cell differentiation	GO:0045638	3	0.012
regulation of ryanodine sensitive calcium release channel activity	GO:0060314	5	0.012
pyrimidine nucleoside biosynthetic process	GO:0046134	5	0.012
protein localization to endoplasmic reticulum	GO:0070972	1	0.012
axon ensheathment	GO:0008366	40	0.012
negative regulation of cell death	GO:0060548	229	0.012
regulation of cellular amine metabolic process	GO:0033238	8	0.012
tube development	GO:0035295	89	0.012
signal release	GO:0023061	145	0.012
ovulation cycle process	GO:0022602	50	0.012
behavior	GO:0007610	205	0.011
cation homeostasis	GO:0055080	195	0.011
positive regulation of cellular catabolic process	GO:0031331	71	0.011
protein import	GO:0017038	37	0.011
negative regulation of cellular metabolic process	GO:0031324	281	0.011
apoptotic process	GO:0006915	381	0.011
cellular response to carbohydrate stimulus	GO:0071322	72	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.011
regulation of response to wounding	GO:1903034	69	0.011
myeloid cell differentiation	GO:0030099	22	0.011
peptidyl amino acid modification	GO:0018193	126	0.011
response to fatty acid	GO:0070542	65	0.011
positive regulation of locomotion	GO:0040017	102	0.011
negative regulation of protein modification by small protein conjugation or removal	GO:1903321	4	0.011
ensheathment of neurons	GO:0007272	40	0.011
regulation of homeostatic process	GO:0032844	101	0.011
cellular response to glucose stimulus	GO:0071333	65	0.011
gamete generation	GO:0007276	124	0.011
muscle cell migration	GO:0014812	36	0.011
regulation of membrane potential	GO:0042391	110	0.011
negative regulation of gene expression	GO:0010629	199	0.011
peptide hormone secretion	GO:0030072	84	0.010
male gamete generation	GO:0048232	99	0.010
hematopoietic or lymphoid organ development	GO:0048534	36	0.010
cardiac muscle tissue morphogenesis	GO:0055008	1	0.010
spermatogenesis	GO:0007283	99	0.010
peptide secretion	GO:0002790	86	0.010
regulation of cellular amino acid metabolic process	GO:0006521	2	0.010
endomembrane system organization	GO:0010256	48	0.010
regulation of cell migration	GO:0030334	128	0.010

Dad1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
connective tissue disease	DOID:65	0.021
bone development disease	DOID:0080006	0.021
bone disease	DOID:0080001	0.021
disease of anatomical entity	DOID:7	0.021
osteochondrodysplasia	DOID:2256	0.021
musculoskeletal system disease	DOID:17	0.021

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