Rattus norvegicus

12 known processes

Pdia4

protein disulfide isomerase family A, member 4

(Aliases: ERp-72,Erp70,Erp72)

Pdia4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to endogenous stimulusGO:00714953770.525
response to ketoneGO:19016541820.496
regulation of programmed cell deathGO:00430673410.456
retinoic acid receptor signaling pathwayGO:004838470.416
cerebellar purkinje cell layer developmentGO:002168020.416
er associated ubiquitin dependent protein catabolic processGO:003043310.394
neurological system processGO:00508772190.390
negative regulation of apoptotic processGO:00430661810.373
cellular response to topologically incorrect proteinGO:003596730.347
response to other organismGO:00517072200.341
cellular response to transforming growth factor beta stimulusGO:0071560410.339
response to estradiolGO:00323551640.317
regulation of signal transductionGO:00099663180.305
regulation of apoptotic processGO:00429813350.296
catabolic processGO:00090563510.282
immune system processGO:00023762040.280
cellular catabolic processGO:00442482950.272
antigen processing and presentation of peptide antigen via mhc class iGO:000247410.268
programmed cell deathGO:00125013920.260
apoptotic processGO:00069153810.254
response to testosteroneGO:0033574550.246
organic substance catabolic processGO:19015753160.220
cellular response to organonitrogen compoundGO:00714171970.219
response to inorganic substanceGO:00100353770.205
response to oxygen levelsGO:00704822650.201
response to nutrient levelsGO:00316673700.200
response to biotic stimulusGO:00096072260.198
positive regulation of locomotionGO:00400171020.195
cell migrationGO:00164771970.185
positive regulation of response to external stimulusGO:0032103510.182
proteolysisGO:00065081750.182
response to decreased oxygen levelsGO:00362932370.179
positive regulation of cellular component movementGO:00512721020.178
negative regulation of transforming growth factor beta receptor signaling pathwayGO:003051220.175
response to cytokineGO:00340972150.172
startle responseGO:000196420.170
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.168
positive regulation of cell differentiationGO:00455972170.166
negative regulation of cell deathGO:00605482290.161
response to extracellular stimulusGO:00099913800.159
establishment of protein localizationGO:00451841410.159
regulation of cell migrationGO:00303341280.156
cellular response to oxygen containing compoundGO:19017013860.155
cellular response to atpGO:007131850.153
positive regulation of nitrogen compound metabolic processGO:00511733340.150
cellular component movementGO:00069282480.149
cell chemotaxisGO:0060326310.146
response to purine containing compoundGO:00140741260.144
cellular response to growth factor stimulusGO:00713631620.142
centrosome organizationGO:005129710.142
multicellular organism reproductionGO:00325042330.138
cellular response to nitrogen compoundGO:19016992100.138
central nervous system developmentGO:00074173110.137
enzyme linked receptor protein signaling pathwayGO:00071671160.137
response to external biotic stimulusGO:00432072210.135
regulation of cellular protein metabolic processGO:00322682670.130
response to hypoxiaGO:00016662310.125
proteolysis involved in cellular protein catabolic processGO:0051603190.122
chaperone mediated protein foldingGO:006107760.117
monocarboxylic acid metabolic processGO:00327871520.114
regulation of protein metabolic processGO:00512462890.113
negative regulation of signalingGO:00230571570.111
neuromuscular processGO:005090520.109
regulation of molecular functionGO:00650093980.106
transcription from rna polymerase ii promoterGO:00063662520.103
response to toxic substanceGO:00096361330.102
response to growth factorGO:00708481890.100
positive regulation of transportGO:00510502450.099
negative regulation of cell communicationGO:00106481580.098
regulation of phosphorus metabolic processGO:00511743490.098
taxisGO:0042330670.097
regulation of behaviorGO:0050795610.096
organic acid metabolic processGO:00060822920.096
regulation of cell motilityGO:20001451310.096
negative regulation of programmed cell deathGO:00430691830.095
single organism biosynthetic processGO:00447113420.093
negative regulation of gene expressionGO:00106291990.092
anatomical structure morphogenesisGO:00096532980.091
carboxylic acid metabolic processGO:00197522890.090
lipid metabolic processGO:00066292830.089
behaviorGO:00076102050.087
single organism organelle organizationGO:19025891800.086
positive regulation of gene expressionGO:00106282440.086
dephosphorylationGO:0016311980.085
macromolecule catabolic processGO:0009057580.084
localization of cellGO:00516742020.082
nucleic acid templated transcriptionGO:00976593790.082
reproductionGO:00000032450.081
modification dependent protein catabolic processGO:0019941140.081
organ morphogenesisGO:0009887750.079
response to estrogenGO:00436272320.077
cellular response to unfolded proteinGO:003462020.077
positive regulation of cell motilityGO:2000147970.076
negative regulation of response to stimulusGO:00485851550.076
regulation of cell differentiationGO:00455953200.076
response to antibioticGO:0046677390.075
cellular response to external stimulusGO:00714961180.074
response to organophosphorusGO:00466831020.074
apoptotic signaling pathwayGO:0097190270.072
regulation of secretionGO:00510462240.071
head developmentGO:00603222470.071
cellular lipid metabolic processGO:00442552080.069
regulation of locomotionGO:00400121480.069
cellular macromolecule catabolic processGO:0044265290.068
modification dependent macromolecule catabolic processGO:0043632140.068
neuron differentiationGO:00301823680.068
regulation of phagocytosisGO:0050764130.067
chemosensory behaviorGO:000763520.066
response to lipopolysaccharideGO:00324961910.066
regulation of anatomical structure morphogenesisGO:00226031410.065
positive regulation of cellular biosynthetic processGO:00313282950.064
regulation of cell developmentGO:00602842630.064
cell motilityGO:00488702020.063
oxoacid metabolic processGO:00434362900.061
regulation of catalytic activityGO:00507903040.058
cellular response to cytokine stimulusGO:00713451270.057
positive regulation of cell developmentGO:00107201760.056
regulation of cellular component movementGO:00512701500.056
response to insulinGO:00328681330.055
cellular response to biotic stimulusGO:0071216590.053
endoplasmic reticulum unfolded protein responseGO:003096820.053
positive regulation of triglyceride metabolic processGO:009020840.053
positive regulation of cellular protein metabolic processGO:00322701670.052
positive regulation of response to stimulusGO:00485842850.052
negative regulation of metabolic processGO:00098923310.051
multicellular organismal reproductive processGO:00486092330.051
regulation of phosphate metabolic processGO:00192203490.050
cellular response to organic cyclic compoundGO:00714072020.050
proteasomal protein catabolic processGO:001049880.050
positive regulation of cell deathGO:00109421840.048
cation transportGO:00068123820.048
response to bacteriumGO:00096172000.048
cellular component assemblyGO:00226073600.048
response to endoplasmic reticulum stressGO:0034976100.047
organelle organizationGO:00069962660.046
posttranscriptional regulation of gene expressionGO:0010608370.046
response to nutrientGO:00075842480.046
defense responseGO:00069521940.045
positive regulation of multicellular organismal processGO:00512403870.045
cytoskeleton organizationGO:00070101110.045
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.044
cellular amino acid metabolic processGO:00065201070.044
positive regulation of biosynthetic processGO:00098913190.044
sensory organ developmentGO:0007423740.043
positive regulation of developmental processGO:00510942830.042
protein catabolic processGO:0030163300.042
brain developmentGO:00074202470.042
transmembrane transportGO:00550854120.042
response to transforming growth factor betaGO:0071559460.042
locomotionGO:00400112370.042
positive regulation of molecular functionGO:00440932300.040
reproductive processGO:00224143720.040
proteasome mediated ubiquitin dependent protein catabolic processGO:004316170.040
positive regulation of apoptotic processGO:00430651540.040
cellular response to stressGO:00335542690.040
cellular response to peptide hormone stimulusGO:00713751200.039
regulation of phosphorylationGO:00423252480.039
cell adhesionGO:00071551100.039
cellular ion homeostasisGO:00068731840.039
response to atpGO:0033198130.039
single organism catabolic processGO:00447122830.039
protein modification by small protein conjugation or removalGO:0070647350.039
negative regulation of macromolecule metabolic processGO:00106052600.038
response to ethanolGO:00454711620.038
macromolecular complex subunit organizationGO:00439333390.038
positive regulation of chemotaxisGO:0050921230.038
regulation of immune system processGO:00026821230.038
positive regulation of cell proliferationGO:00082842490.038
positive regulation of phosphorus metabolic processGO:00105622620.037
regulation of systemic arterial blood pressureGO:0003073300.037
transcription dna templatedGO:00063513770.037
vascular process in circulatory systemGO:0003018960.037
single organism carbohydrate metabolic processGO:00447231180.037
positive regulation of macromolecule biosynthetic processGO:00105572470.036
cellular protein localizationGO:00346131220.036
cellular protein catabolic processGO:0044257190.036
regulation of chemotaxisGO:0050920290.036
regulation of transforming growth factor beta receptor signaling pathwayGO:001701550.036
nucleoside phosphate metabolic processGO:00067532830.035
cardiovascular system developmentGO:00723581340.035
agingGO:00075682410.035
tissue developmentGO:00098882520.035
response to anoxiaGO:003405940.034
positive regulation of protein metabolic processGO:00512471780.034
regulation of interleukin 1 beta secretionGO:005070630.034
rna biosynthetic processGO:00327743800.034
gamete generationGO:00072761240.034
regulation of protein modification processGO:00313991940.033
neuronal action potentialGO:0019228350.033
response to molecule of bacterial originGO:00022371940.033
transmission of nerve impulseGO:0019226420.033
multi organism reproductive processGO:00447032620.032
regulation of blood pressureGO:0008217830.032
response to interferon gammaGO:0034341200.032
positive regulation of dna metabolic processGO:0051054390.032
positive regulation of cell migrationGO:0030335960.032
response to woundingGO:00096112540.032
interleukin 1 beta secretionGO:005070230.032
sleepGO:0030431300.031
cytokine productionGO:0001816610.031
regulation of hormone levelsGO:00108171870.031
regulation of leukocyte migrationGO:0002685240.031
antigen processing and presentationGO:001988220.031
antigen processing and presentation of peptide antigenGO:004800220.031
response to acid chemicalGO:00011012220.030
negative regulation of protein metabolic processGO:00512481140.029
positive regulation of protein kinase activityGO:0045860730.029
intracellular transportGO:00469071850.029
single organism cell adhesionGO:0098602460.029
olfactory behaviorGO:004204820.029
regulation of rna biosynthetic processGO:20011413810.029
metal ion homeostasisGO:00550651860.029
cellular response to metal ionGO:0071248550.029
regenerationGO:00310991630.029
b cell differentiationGO:003018320.028
negative regulation of signal transductionGO:0009968830.028
regulation of dna metabolic processGO:0051052600.028
actin cytoskeleton organizationGO:0030036730.027
organic acid transportGO:00158491160.027
negative regulation of nucleobase containing compound metabolic processGO:00459341530.027
negative regulation of cellular metabolic processGO:00313242810.027
actin filament based processGO:0030029860.027
myelinationGO:0042552390.027
organic hydroxy compound metabolic processGO:19016151150.027
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.027
protein phosphorylationGO:00064683450.026
chemical homeostasisGO:00488782920.026
cellular response to extracellular stimulusGO:0031668730.026
homeostatic processGO:00425923310.026
ubiquitin dependent protein catabolic processGO:0006511140.026
gland developmentGO:00487321550.026
positive regulation of interleukin 1 beta secretionGO:005071830.026
regulation of neurogenesisGO:00507672470.026
regulation of hydrolase activityGO:00513361430.025
translationGO:0006412350.025
circulatory system processGO:00030131830.025
negative regulation of transcription dna templatedGO:00458921160.025
cellular response to peptideGO:19016531330.025
cellular amine metabolic processGO:0044106380.025
reproductive structure developmentGO:00486081280.025
positive regulation of secretionGO:00510471400.024
interleukin 1 secretionGO:005070130.024
regulation of tube sizeGO:0035150890.024
leukocyte migrationGO:0050900380.024
cardiocyte differentiationGO:0035051220.024
regulation of response to external stimulusGO:00321011060.024
cell cell signalingGO:00072673350.024
organophosphate metabolic processGO:00196373700.024
muscle contractionGO:0006936880.024
negative regulation of neuron deathGO:1901215690.024
rna metabolic processGO:00160704060.023
positive regulation of behaviorGO:0048520380.023
regulation of blood vessel sizeGO:0050880890.023
positive regulation of cell communicationGO:00106472710.023
eye developmentGO:0001654500.023
positive regulation of programmed cell deathGO:00430681570.023
cellular ketone metabolic processGO:0042180510.022
ensheathment of neuronsGO:0007272400.022
negative regulation of cellular protein metabolic processGO:00322691060.022
transforming growth factor beta receptor signaling pathwayGO:0007179180.022
response to vitaminGO:00332731310.022
positive regulation of protein modification processGO:00314011420.022
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.022
positive regulation of hydrolase activityGO:0051345860.022
positive regulation of nucleic acid templated transcriptionGO:19035081970.022
positive regulation of cell adhesionGO:0045785300.022
multicellular organism growthGO:003526410.022
response to campGO:0051591910.021
negative regulation of biosynthetic processGO:00098901680.021
eye morphogenesisGO:004859240.021
cellular response to hormone stimulusGO:00328702470.021
arp2 3 complex mediated actin nucleationGO:003431420.021
response to transition metal nanoparticleGO:19902671220.021
protein oligomerizationGO:00512591910.021
macromolecule localizationGO:00330362520.021
regulation of transcription from rna polymerase ii promoterGO:00063572340.021
positive regulation of catalytic activityGO:00430851840.021
regulation of cellular ketone metabolic processGO:0010565270.021
leukocyte activationGO:0045321760.021
signal releaseGO:00230611450.021
regulation of apoptotic signaling pathwayGO:2001233130.021
centrosome cycleGO:000709810.021
positive regulation of apoptotic signaling pathwayGO:200123560.020
cell activationGO:0001775970.020
action potentialGO:0001508540.020
cellular response to nutrient levelsGO:0031669600.020
positive regulation of lipid catabolic processGO:005099640.020
nucleotide catabolic processGO:00091661390.020
inner ear developmentGO:0048839210.020
nitrogen compound transportGO:00717052290.020
cellular divalent inorganic cation homeostasisGO:00725031620.020
regulation of cytokine productionGO:0001817560.020
sex differentiationGO:00075481130.020
synaptic transmissionGO:00072682350.020
calcium ion transportGO:00068161310.019
carbohydrate metabolic processGO:00059751300.019
single organism reproductive processGO:00447022970.019
glycerolipid metabolic processGO:0046486670.019
regulation of endocytosisGO:0030100420.019
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.019
protein foldingGO:0006457120.019
response to oxidative stressGO:00069791860.019
blood vessel developmentGO:0001568690.019
endocytosisGO:0006897840.019
camera type eye developmentGO:0043010480.019
reproductive system developmentGO:00614581280.019
negative regulation of rna metabolic processGO:00512531230.019
regulation of peptide transportGO:0090087870.019
regulation of rna metabolic processGO:00512523910.019
positive regulation of immune system processGO:0002684900.019
protein transportGO:00150311320.018
cell cycleGO:00070491010.018
cellular component morphogenesisGO:00329891550.018
positive regulation of protein phosphorylationGO:00019341350.018
regulation of nervous system developmentGO:00519602640.018
developmental process involved in reproductionGO:00030061590.018
hormone metabolic processGO:0042445690.018
single organism intracellular transportGO:19025821660.018
positive regulation of cytokine productionGO:0001819420.018
multicellular organismal signalingGO:0035637440.018
positive regulation of immunoglobulin productionGO:000263940.018
cellular macromolecular complex assemblyGO:0034622580.018
regulation of cell adhesionGO:0030155520.018
cellular response to starvationGO:0009267270.018
response to peptideGO:19016522920.018
neutral lipid metabolic processGO:0006638210.018
regulation of multicellular organismal developmentGO:20000263760.018
immune responseGO:00069551040.018
activation of cysteine type endopeptidase activityGO:009720240.018
positive regulation of leukocyte migrationGO:0002687210.018
anion transportGO:00068201780.018
vasoconstrictionGO:0042310540.018
leukocyte chemotaxisGO:0030595220.017
response to glucocorticoidGO:00513842230.017
nuclear transportGO:0051169490.017
muscle tissue developmentGO:0060537580.017
negative regulation of cellular biosynthetic processGO:00313271610.017
cellular response to molecule of bacterial originGO:0071219560.017
ribonucleoside triphosphate catabolic processGO:00092031220.017
axon ensheathmentGO:0008366400.017
positive regulation of rna biosynthetic processGO:19026801970.017
muscle cell differentiationGO:0042692520.017
regulation of protein phosphorylationGO:00019321830.017
response to corticosteroidGO:00319602350.017
chemotaxisGO:0006935660.017
carboxylic acid catabolic processGO:0046395490.017
development of primary female sexual characteristicsGO:0046545560.017
response to fungusGO:000962080.017
digestive system developmentGO:0055123410.017
single organism behaviorGO:00447081300.017
protein complex subunit organizationGO:00718223020.016
cellular metal ion homeostasisGO:00068751720.016
response to glucoseGO:00097491360.016
carbohydrate derivative metabolic processGO:19011353460.016
regulation of extrinsic apoptotic signaling pathwayGO:200123670.016
positive regulation of kinase activityGO:0033674770.016
intracellular signal transductionGO:00355563140.016
cellular modified amino acid metabolic processGO:0006575610.016
ion homeostasisGO:00508012120.016
positive regulation of cell morphogenesis involved in differentiationGO:0010770410.016
cytosolic calcium ion homeostasisGO:00514801400.016
macromolecular complex assemblyGO:00650032730.016
regulation of secretion by cellGO:19035302080.016
negative regulation of nitrogen compound metabolic processGO:00511721610.016
positive regulation of cellular component organizationGO:00511302000.015
heart morphogenesisGO:000300730.015
female gonad developmentGO:0008585530.015
peptide transportGO:0015833970.015
peptidyl amino acid modificationGO:00181931260.015
response to fatty acidGO:0070542650.015
negative regulation of canonical wnt signaling pathwayGO:009009040.015
retina morphogenesis in camera type eyeGO:006004210.015
coenzyme metabolic processGO:0006732860.015
regulation of membrane potentialGO:00423911100.015
regulation of growthGO:00400081050.015
positive regulation of transferase activityGO:0051347810.015
positive regulation of nucleobase containing compound metabolic processGO:00459353190.015
fatty acid metabolic processGO:0006631990.015
positive regulation of phosphorylationGO:00423271770.015
regulation of translationGO:0006417270.015
cofactor metabolic processGO:0051186950.015
protein ubiquitinationGO:0016567280.014
small molecule biosynthetic processGO:00442831240.014
regulation of interleukin 1 secretionGO:005070430.014
peptidyl glutamic acid modificationGO:001820010.014
positive regulation of neurogenesisGO:00507691650.014
regulation of cell substrate adhesionGO:0010810180.014
regulation of neuron deathGO:19012141150.014
regulation of ion homeostasisGO:2000021630.014
bone developmentGO:0060348250.014
atp metabolic processGO:0046034720.014
sexual reproductionGO:00199531480.014
development of primary sexual characteristicsGO:00451371070.014
cerebellum morphogenesisGO:002158720.013
amine metabolic processGO:0009308380.013
regulation of response to stressGO:00801341260.013
circulatory system developmentGO:00723591340.013
regulation of vasculature developmentGO:1901342440.013
positive regulation of phagocytosisGO:005076690.013
regulation of meiotic cell cycleGO:005144530.013
spermatogenesisGO:0007283990.013
protein homooligomerizationGO:0051260910.013
regulation of cell cycleGO:0051726730.013
multi multicellular organism processGO:00447061380.013
striated muscle tissue developmentGO:0014706580.013
organ regenerationGO:00311001010.013
male gamete generationGO:0048232990.013
cellular cation homeostasisGO:00300031800.013
mesenchymal cell proliferationGO:001046340.013
renal system developmentGO:0072001670.013
respiratory system developmentGO:0060541450.013
cell cycle processGO:0022402570.013
carboxylic acid transportGO:00469421150.013
regulation of transcription dna templatedGO:00063553740.013
regulation of body fluid levelsGO:0050878900.013
ovulation cycleGO:0042698670.013
inner ear morphogenesisGO:004247210.012
cellular response to inorganic substanceGO:0071241650.012
regulation of kinase activityGO:00435491170.012
protein complex biogenesisGO:00702712630.012
jak stat cascadeGO:0007259260.012
nucleoside triphosphate catabolic processGO:00091431230.012
negative regulation of multicellular organismal processGO:00512412030.012
gonad developmentGO:00084061040.012
negative regulation of macromolecule biosynthetic processGO:00105581480.012
organic anion transportGO:00157111320.012
ovulation cycle processGO:0022602500.012
response to peptide hormoneGO:00434342780.012
maintenance of locationGO:0051235170.012
heterocycle catabolic processGO:00467001670.012
regulation of anatomical structure sizeGO:00900661350.012
urogenital system developmentGO:0001655780.012
salivary gland developmentGO:000743130.012
regulation of circadian sleep wake cycle sleepGO:0045187180.012
motor neuron axon guidanceGO:000804510.012
positive regulation of cellular component biogenesisGO:0044089550.012
secretionGO:00469033070.012
skeletal system developmentGO:0001501410.012
negative regulation of innate immune responseGO:004582440.012
er nucleus signaling pathwayGO:000698430.012
small molecule catabolic processGO:0044282590.012
response to carbohydrateGO:00097431830.012
positive regulation of fatty acid beta oxidationGO:003200040.011
leydig cell differentiationGO:003332780.011
male sex differentiationGO:0046661640.011
regulation of cellular amino acid metabolic processGO:000652120.011
hair cell differentiationGO:003531520.011
camera type eye morphogenesisGO:004859320.011
erythrocyte differentiationGO:003021810.011
secretion by cellGO:00329402480.011
cellular response to insulin stimulusGO:0032869810.011
dna metabolic processGO:0006259960.011
response to radiationGO:00093141370.011
regulation of response to woundingGO:1903034690.011
positive regulation of cellular amine metabolic processGO:003324030.011
positive regulation of cytosolic calcium ion concentrationGO:00072041220.011
lung developmentGO:0030324430.011
inflammatory responseGO:00069541500.011
peptide metabolic processGO:0006518320.011
regulation of peptide secretionGO:0002791820.011
negative regulation of developmental processGO:00510931250.011
regulation of lipid metabolic processGO:0019216680.011
cellular response to ketoneGO:1901655510.011
cellular protein complex assemblyGO:0043623440.011
response to hydrogen peroxideGO:0042542890.011
dna integrity checkpointGO:003157020.011
carbohydrate derivative biosynthetic processGO:19011371240.011
cellular carbohydrate metabolic processGO:0044262720.011
regulation of proteolysisGO:0030162660.011
negative regulation of phosphate metabolic processGO:0045936800.011
cellular calcium ion homeostasisGO:00068741600.010
muscle structure developmentGO:0061061870.010
steroid metabolic processGO:0008202730.010
dna replicationGO:0006260370.010
male gonad developmentGO:0008584590.010
respiratory tube developmentGO:0030323430.010
response to starvationGO:0042594590.010
cell morphogenesis involved in differentiationGO:00009041190.010
erythrocyte homeostasisGO:003410120.010
lipid biosynthetic processGO:00086101280.010
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281310.010
microtubule organizing center organizationGO:003102310.010
synaptic vesicle endocytosisGO:004848840.010
regulation of blood circulationGO:19035221100.010

Pdia4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:005068600.081
cancerDOID:16200.081
disease of cellular proliferationDOID:1456600.081
sensory system diseaseDOID:005015500.034
disease of anatomical entityDOID:700.034
eye and adnexa diseaseDOID:149200.034
nervous system diseaseDOID:86300.034
eye diseaseDOID:561400.034
musculoskeletal system diseaseDOID:1700.027
connective tissue diseaseDOID:6500.026
bone diseaseDOID:008000100.026
bone development diseaseDOID:008000600.026
gastrointestinal system cancerDOID:311900.013