Rattus norvegicus

69 known processes

Furin

furin (paired basic amino acid cleaving enzyme)

(Aliases: Pace,Pcsk3)

Furin biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to oxygen containing compoundGO:19017013860.139
programmed cell deathGO:00125013920.128
reproductive processGO:00224143720.121
neuron differentiationGO:00301823680.111
Fly
response to peptideGO:19016522920.097
Rat
organelle organizationGO:00069962660.092
apoptotic processGO:00069153810.090
response to inorganic substanceGO:00100353770.087
Rat
response to nutrient levelsGO:00316673700.086
Rat
intracellular signal transductionGO:00355563140.085
positive regulation of phosphorus metabolic processGO:00105622620.084
cellular response to peptide hormone stimulusGO:00713751200.083
positive regulation of multicellular organismal processGO:00512403870.075
localization of cellGO:00516742020.075
catabolic processGO:00090563510.069
Human
regulation of cell differentiationGO:00455953200.068
gland developmentGO:00487321550.068
Rat
positive regulation of phosphate metabolic processGO:00459372620.067
regulation of phosphate metabolic processGO:00192203490.067
regulation of phosphorus metabolic processGO:00511743490.067
membrane organizationGO:0061024940.065
regulation of signal transductionGO:00099663180.065
organophosphate metabolic processGO:00196373700.065
cellular response to organonitrogen compoundGO:00714171970.064
regulation of cellular component organizationGO:00511283680.064
nucleotide metabolic processGO:00091172790.063
regulation of transcription dna templatedGO:00063553740.063
positive regulation of cell communicationGO:00106472710.062
positive regulation of biosynthetic processGO:00098913190.062
regulation of cell developmentGO:00602842630.059
response to metal ionGO:00100382530.059
Rat
regulation of neuron differentiationGO:00456642080.058
regulation of response to stressGO:00801341260.058
cellular response to hormone stimulusGO:00328702470.057
nucleobase containing small molecule metabolic processGO:00550863160.057
regulation of multicellular organismal developmentGO:20000263760.055
multi organism reproductive processGO:00447032620.055
response to acid chemicalGO:00011012220.054
Rat
negative regulation of developmental processGO:00510931250.053
regulation of nervous system developmentGO:00519602640.053
anion transportGO:00068201780.053
cellular catabolic processGO:00442482950.053
Human
negative regulation of cellular metabolic processGO:00313242810.053
Human
positive regulation of nitrogen compound metabolic processGO:00511733340.053
single organism intracellular transportGO:19025821660.052
positive regulation of response to stimulusGO:00485842850.052
neuron projection developmentGO:00311752730.051
cation transportGO:00068123820.050
response to peptide hormoneGO:00434342780.050
Rat
positive regulation of developmental processGO:00510942830.048
positive regulation of signalingGO:00230562700.047
regulation of neurogenesisGO:00507672470.047
negative regulation of macromolecule metabolic processGO:00106052600.047
Human
regulation of phosphorylationGO:00423252480.046
immune responseGO:00069551040.046
regulation of apoptotic processGO:00429813350.046
neuron developmentGO:00486662860.046
Fly
negative regulation of metabolic processGO:00098923310.045
Human
macromolecule localizationGO:00330362520.045
Rat
cell part morphogenesisGO:00329901230.043
rna biosynthetic processGO:00327743800.043
response to extracellular stimulusGO:00099913800.041
Rat
cellular response to nitrogen compoundGO:19016992100.041
purine containing compound metabolic processGO:00725212530.040
regulation of intracellular signal transductionGO:19025312180.040
cellular response to insulin stimulusGO:0032869810.039
central nervous system developmentGO:00074173110.039
Rat
response to carbohydrateGO:00097431830.038
Rat
single organism cellular localizationGO:19025801020.038
cellular response to peptideGO:19016531330.038
small gtpase mediated signal transductionGO:0007264360.038
positive regulation of nucleobase containing compound metabolic processGO:00459353190.038
single organism reproductive processGO:00447022970.037
single organism organelle organizationGO:19025891800.037
negative regulation of cell differentiationGO:0045596990.037
anatomical structure morphogenesisGO:00096532980.037
chemical homeostasisGO:00488782920.037
cellular response to external stimulusGO:00714961180.036
positive regulation of transportGO:00510502450.036
Rat
cellular component assemblyGO:00226073600.036
ribonucleotide metabolic processGO:00092592310.035
purine ribonucleotide metabolic processGO:00091502270.035
protein phosphorylationGO:00064683450.034
ion transmembrane transportGO:00342203650.034
regulation of programmed cell deathGO:00430673410.034
cellular response to endogenous stimulusGO:00714953770.034
macromolecular complex subunit organizationGO:00439333390.034
regulation of nucleic acid templated transcriptionGO:19035063800.033
positive regulation of cellular biosynthetic processGO:00313282950.033
organophosphate biosynthetic processGO:00904071430.033
response to insulinGO:00328681330.033
regulation of protein metabolic processGO:00512462890.033
Human
macromolecular complex assemblyGO:00650032730.033
regenerationGO:00310991630.033
organic anion transportGO:00157111320.032
purine nucleotide metabolic processGO:00061632290.032
tissue developmentGO:00098882520.032
nucleoside phosphate metabolic processGO:00067532830.032
agingGO:00075682410.032
ribose phosphate metabolic processGO:00196932350.031
response to other organismGO:00517072200.031
Rat
liver developmentGO:0001889900.031
multicellular organismal signalingGO:0035637440.030
cell motilityGO:00488702020.030
reproductionGO:00000032450.030
regulation of cellular protein metabolic processGO:00322682670.030
Human
positive regulation of ion transportGO:0043270940.029
positive regulation of cell differentiationGO:00455972170.029
immune system processGO:00023762040.029
cellular response to stressGO:00335542690.029
aromatic compound catabolic processGO:00194391680.028
regulation of membrane potentialGO:00423911100.028
response to growth factorGO:00708481890.028
transmembrane transportGO:00550854120.027
positive regulation of cell deathGO:00109421840.027
carbohydrate derivative metabolic processGO:19011353460.027
response to estrogenGO:00436272320.027
cellular component biogenesisGO:00440853680.027
cell projection organizationGO:00300303020.027
positive regulation of gene expressionGO:00106282440.027
negative regulation of apoptotic processGO:00430661810.027
regulation of cell proliferationGO:00421273590.026
positive regulation of molecular functionGO:00440932300.026
response to cytokineGO:00340972150.026
Rat
single organism catabolic processGO:00447122830.026
response to starvationGO:0042594590.026
regulation of cell projection organizationGO:00313441750.026
response to oxygen levelsGO:00704822650.026
regulation of locomotionGO:00400121480.025
negative regulation of response to stimulusGO:00485851550.025
cellular response to lipidGO:00713962010.025
response to external biotic stimulusGO:00432072210.025
Rat
locomotionGO:00400112370.025
brain developmentGO:00074202470.025
Rat
regulation of purine nucleotide metabolic processGO:19005421150.025
secretionGO:00469033070.024
Human Rat
regulation of mapk cascadeGO:00434081160.024
rna metabolic processGO:00160704060.024
positive regulation of camp biosynthetic processGO:0030819280.024
hepaticobiliary system developmentGO:0061008900.024
positive regulation of cell proliferationGO:00082842490.024
nucleic acid templated transcriptionGO:00976593790.024
cell type specific apoptotic processGO:00972851340.024
regulation of molecular functionGO:00650093980.024
Human
response to monosaccharideGO:00342841590.024
Rat
negative regulation of multicellular organismal processGO:00512412030.024
Human
positive regulation of phosphorylationGO:00423271770.024
cardiac conductionGO:006133720.023
regulation of nucleotide metabolic processGO:00061401170.023
carboxylic acid metabolic processGO:00197522890.023
response to woundingGO:00096112540.023
Rat
regulation of cellular localizationGO:00603412630.023
Rat
response to decreased oxygen levelsGO:00362932370.023
regulation of protein phosphorylationGO:00019321830.023
positive regulation of nucleotide metabolic processGO:0045981910.023
regulation of rna biosynthetic processGO:20011413810.023
cellular component movementGO:00069282480.023
head developmentGO:00603222470.022
Rat
ion homeostasisGO:00508012120.022
positive regulation of intracellular signal transductionGO:19025331380.022
response to glucoseGO:00097491360.022
Rat
positive regulation of immune system processGO:0002684900.022
cell communication involved in cardiac conductionGO:008606520.021
homeostatic processGO:00425923310.021
transcription dna templatedGO:00063513770.021
cellular homeostasisGO:00197252520.021
vesicle mediated transportGO:00161921810.021
sexual reproductionGO:00199531480.021
regulation of catabolic processGO:00098941130.021
Human
regulation of anatomical structure morphogenesisGO:00226031410.021
positive regulation of cell developmentGO:00107201760.021
regulation of catalytic activityGO:00507903040.021
Human
regulation of cell migrationGO:00303341280.020
ras protein signal transductionGO:0007265290.020
response to ketoneGO:19016541820.020
endocytosisGO:0006897840.020
neuron apoptotic processGO:0051402880.020
response to oxidative stressGO:00069791860.020
organic substance catabolic processGO:19015753160.020
Human
cell activationGO:0001775970.020
g protein coupled receptor signaling pathwayGO:00071862420.020
purine containing compound catabolic processGO:00725231380.020
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.020
signal transduction by phosphorylationGO:00230141440.020
metal ion transportGO:00300012890.020
enzyme linked receptor protein signaling pathwayGO:00071671160.020
regulation of hormone levelsGO:00108171870.019
Human Rat
mapk cascadeGO:00001651400.019
cellular chemical homeostasisGO:00550822470.019
regulation of response to external stimulusGO:00321011060.019
positive regulation of signal transductionGO:00099671750.019
sensory organ developmentGO:0007423740.019
developmental process involved in reproductionGO:00030061590.019
organic acid transportGO:00158491160.019
response to glucocorticoidGO:00513842230.019
Rat
nucleoside phosphate biosynthetic processGO:19012931020.019
negative regulation of nitrogen compound metabolic processGO:00511721610.019
reproductive system developmentGO:00614581280.019
response to hexoseGO:00097461440.019
Rat
carboxylic acid transportGO:00469421150.019
intracellular transportGO:00469071850.019
cell projection morphogenesisGO:00488581230.018
positive regulation of locomotionGO:00400171020.018
positive regulation of cellular catabolic processGO:0031331710.018
positive regulation of apoptotic processGO:00430651540.018
monovalent inorganic cation transportGO:00156721720.018
purine ribonucleoside catabolic processGO:00461301240.018
single organism membrane organizationGO:0044802740.018
camp biosynthetic processGO:0006171470.018
lipid metabolic processGO:00066292830.018
response to corticosteroidGO:00319602350.018
Rat
positive regulation of programmed cell deathGO:00430681570.018
organophosphate catabolic processGO:00464341480.018
regulation of transcription from rna polymerase ii promoterGO:00063572340.018
purine ribonucleoside metabolic processGO:00461281680.018
multicellular organismal reproductive processGO:00486092330.018
gamete generationGO:00072761240.018
ribonucleotide catabolic processGO:00092611360.018
regulation of neuron projection developmentGO:00109751610.018
gap junction assemblyGO:001626420.018
organic cyclic compound catabolic processGO:19013611750.017
epithelial cell differentiationGO:0030855710.017
embryonic pattern specificationGO:000988010.017
response to mechanical stimulusGO:00096121340.017
regulation of rna metabolic processGO:00512523910.017
olfactory learningGO:000835510.017
cellular response to acid chemicalGO:0071229750.017
negative regulation of programmed cell deathGO:00430691830.017
organ regenerationGO:00311001010.017
regulation of protein modification processGO:00313991940.017
purine nucleotide catabolic processGO:00061951360.017
positive regulation of neuron differentiationGO:00456661260.017
multicellular organism reproductionGO:00325042330.017
neuron projection morphogenesisGO:00488121220.017
anterior posterior pattern specificationGO:000995210.017
female pregnancyGO:00075651220.017
epithelium developmentGO:0060429960.016
single organism biosynthetic processGO:00447113420.016
chemosensory behaviorGO:000763520.016
ribose phosphate biosynthetic processGO:0046390870.016
heterocycle catabolic processGO:00467001670.016
inorganic ion transmembrane transportGO:00986602290.016
dephosphorylationGO:0016311980.016
negative regulation of macromolecule biosynthetic processGO:00105581480.016
blood circulationGO:00080151830.016
negative regulation of nucleic acid templated transcriptionGO:19035071170.016
wound healingGO:00420601220.016
positive regulation of nervous system developmentGO:00519621780.016
multi multicellular organism processGO:00447061380.016
positive regulation of neurogenesisGO:00507691650.016
purine ribonucleoside triphosphate catabolic processGO:00092071220.016
action potentialGO:0001508540.016
secretion by cellGO:00329402480.015
Human Rat
ribonucleoside triphosphate catabolic processGO:00092031220.015
nucleoside metabolic processGO:00091161790.015
ribonucleoside metabolic processGO:00091191740.015
cellular nitrogen compound catabolic processGO:00442701630.015
cell growthGO:00160491040.015
regulation of hydrolase activityGO:00513361430.015
Human
cell migrationGO:00164771970.015
transmission of nerve impulseGO:0019226420.015
ribonucleoside triphosphate metabolic processGO:00091991410.015
leukocyte activationGO:0045321760.015
regulation of ion transportGO:00432692450.015
regulation of cellular catabolic processGO:00313291010.015
Human
cellular ketone metabolic processGO:0042180510.015
defense responseGO:00069521940.015
positive regulation of camp metabolic processGO:0030816310.015
cell morphogenesisGO:00009021420.015
growthGO:00400071650.015
multicellular organism growthGO:003526410.015
regulation of growthGO:00400081050.015
response to campGO:0051591910.015
cytoskeleton organizationGO:00070101110.015
negative regulation of cell proliferationGO:00082851190.015
response to hypoxiaGO:00016662310.015
positive regulation of rna biosynthetic processGO:19026801970.015
regulation of cellular ketone metabolic processGO:0010565270.015
gonad developmentGO:00084061040.014
carbohydrate homeostasisGO:0033500750.014
regulation of anatomical structure sizeGO:00900661350.014
negative regulation of transcription dna templatedGO:00458921160.014
lipid transportGO:0006869610.014
axis specificationGO:000979840.014
negative regulation of catalytic activityGO:00430861030.014
Human
negative regulation of cellular component organizationGO:0051129830.014
regulation of cell motilityGO:20001451310.014
protein localization to membraneGO:0072657360.014
negative regulation of gene expressionGO:00106291990.014
Human
purine ribonucleoside triphosphate metabolic processGO:00092051400.014
regulation of cell growthGO:0001558850.014
cellular amine metabolic processGO:0044106380.014
positive regulation of secretion by cellGO:19035321280.014
Rat
anion transmembrane transportGO:0098656770.014
ribonucleotide biosynthetic processGO:0009260850.014
defense response to gram negative bacteriumGO:005082930.014
cellular response to growth factor stimulusGO:00713631620.014
positive regulation of nucleotide biosynthetic processGO:0030810360.014
purine nucleoside triphosphate metabolic processGO:00091441410.014
negative regulation of cell deathGO:00605482290.013
regulation of cellular amino acid metabolic processGO:000652120.013
negative regulation of cell communicationGO:00106481580.013
negative regulation of phosphorus metabolic processGO:0010563800.013
negative regulation of cell developmentGO:0010721820.013
metal ion homeostasisGO:00550651860.013
positive regulation of macromolecule biosynthetic processGO:00105572470.013
regulation of secretionGO:00510462240.013
Rat
jak stat cascadeGO:0007259260.013
regulation of immune responseGO:0050776550.013
alcohol metabolic processGO:0006066770.013
protein complex subunit organizationGO:00718223020.013
purine ribonucleotide biosynthetic processGO:0009152810.013
chromosome segregationGO:000705920.013
ribonucleoside catabolic processGO:00424541260.013
cell cycleGO:00070491010.013
negative regulation of neurogenesisGO:0050768780.013
cell adhesionGO:00071551100.013
heart morphogenesisGO:000300730.013
carbohydrate metabolic processGO:00059751300.013
negative regulation of signalingGO:00230571570.013
b cell differentiationGO:003018320.013
positive regulation of mapk cascadeGO:0043410920.013
nucleotide biosynthetic processGO:0009165980.013
negative regulation of protein metabolic processGO:00512481140.013
Human
transcription from rna polymerase ii promoterGO:00063662520.013
bmp signaling pathwayGO:003050940.013
carbohydrate derivative catabolic processGO:19011361470.013
purine ribonucleotide catabolic processGO:00091541360.013
cellular component morphogenesisGO:00329891550.013
regulation of fc receptor mediated stimulatory signaling pathwayGO:006036830.013
endochondral bone growthGO:000341630.013
adult locomotory behaviorGO:000834440.012
organ morphogenesisGO:0009887750.012
regulation of response to woundingGO:1903034690.012
protein maturationGO:0051604680.012
protein autophosphorylationGO:0046777660.012
regulation of cellular amine metabolic processGO:003323880.012
skeletal system developmentGO:0001501410.012
nucleotide catabolic processGO:00091661390.012
establishment of tissue polarityGO:000716420.012
positive regulation of cell projection organizationGO:00313461110.012
positive regulation of immune responseGO:0050778420.012
cell morphogenesis involved in differentiationGO:00009041190.012
response to fatty acidGO:0070542650.012
Rat
negative regulation of biosynthetic processGO:00098901680.012
response to hydrogen peroxideGO:0042542890.012
positive regulation of cellular amine metabolic processGO:003324030.012
oxoacid metabolic processGO:00434362900.012
cell cell signalingGO:00072673350.012
positive regulation of cellular component organizationGO:00511302000.012
forebrain developmentGO:0030900980.012
Rat
signal releaseGO:00230611450.012
response to calcium ionGO:0051592590.012
Rat
muscle system processGO:00030121150.012
cell differentiation involved in kidney developmentGO:006100540.012
muscle structure developmentGO:0061061870.012
nucleobase containing compound catabolic processGO:00346551520.012
positive regulation of protein metabolic processGO:00512471780.012
inner ear morphogenesisGO:004247210.011
positive regulation of protein phosphorylationGO:00019341350.011
positive regulation of cellular amino acid metabolic processGO:004576410.011
response to reactive oxygen speciesGO:00003021200.011
motor neuron axon guidanceGO:000804510.011
innate immune responseGO:0045087350.011
cellular response to reactive oxygen speciesGO:0034614550.011
muscle tissue developmentGO:0060537580.011
cellular amino acid metabolic processGO:00065201070.011
circulatory system processGO:00030131830.011
regulation of cellular response to stressGO:0080135490.011
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.011
cell morphogenesis involved in neuron differentiationGO:00486671060.011
striated muscle tissue developmentGO:0014706580.011
purine containing compound biosynthetic processGO:0072522850.011
endomembrane system organizationGO:0010256480.011
positive regulation of cellular component movementGO:00512721020.011
response to nutrientGO:00075842480.011
neuronal action potentialGO:0019228350.011
gliogenesisGO:0042063930.011
embryo developmentGO:0009790490.011
organic hydroxy compound metabolic processGO:19016151150.011
response to bacteriumGO:00096172000.011
Rat
positive regulation of catabolic processGO:0009896780.011
glycosyl compound catabolic processGO:19016581260.011
cellular response to starvationGO:0009267270.011
olfactory behaviorGO:004204820.011
development of primary sexual characteristicsGO:00451371070.011
positive regulation of rna metabolic processGO:00512542030.011
protein transportGO:00150311320.011
Rat
positive regulation of neuron projection developmentGO:0010976990.011
cellular response to nutrient levelsGO:0031669600.011
cellular response to cytokine stimulusGO:00713451270.011
sex differentiationGO:00075481130.011
response to organophosphorusGO:00466831020.011
regulation of system processGO:00440572080.010
regulation of synaptic transmissionGO:00508041410.010
cellular component maintenanceGO:004395440.010
cellular response to organic cyclic compoundGO:00714072020.010
immune system developmentGO:0002520410.010
regulation of sodium ion transportGO:0002028210.010
cytoplasmic transportGO:00164821150.010
positive regulation of hydrolase activityGO:0051345860.010
regulation of kinase activityGO:00435491170.010
behaviorGO:00076102050.010
monosaccharide metabolic processGO:0005996610.010
regulation of cyclic nucleotide biosynthetic processGO:0030802450.010
synaptic transmissionGO:00072682350.010
divalent inorganic cation transportGO:00725111340.010
monocarboxylic acid metabolic processGO:00327871520.010
negative regulation of innate immune responseGO:004582440.010
purine nucleoside metabolic processGO:00422781690.010
negative regulation of rna biosynthetic processGO:19026791180.010

Furin disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.027
nervous system diseaseDOID:86300.027
cardiovascular system diseaseDOID:128700.018
central nervous system diseaseDOID:33100.014
hypertensionDOID:1076300.012
artery diseaseDOID:005082800.012
vascular diseaseDOID:17800.012