Rattus norvegicus

29 known processes

F2

coagulation factor II (thrombin)

F2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
plasminogen activationGO:003163920.412
regulation of programmed cell deathGO:00430673410.275
regulation of serine type peptidase activityGO:190257110.275
positive regulation of blood coagulationGO:003019440.211
Human Rat
negative regulation of macromolecule metabolic processGO:00106052600.172
Human
regulation of apoptotic processGO:00429813350.167
blood circulationGO:00080151830.167
inflammatory responseGO:00069541500.166
fibrinolysisGO:004273020.166
Human
programmed cell deathGO:00125013920.157
alpha amino acid metabolic processGO:1901605710.153
oxoacid metabolic processGO:00434362900.148
apoptotic processGO:00069153810.147
negative regulation of serine type endopeptidase activityGO:190000410.137
negative regulation of metabolic processGO:00098923310.135
Human
response to inorganic substanceGO:00100353770.131
organic acid metabolic processGO:00060822920.131
response to nutrient levelsGO:00316673700.122
Rat
extracellular matrix constituent secretionGO:007027840.122
response to corticosteroidGO:00319602350.121
response to extracellular stimulusGO:00099913800.120
Rat
negative regulation of serine type peptidase activityGO:190257210.119
regulation of protein maturationGO:1903317500.119
Human
negative regulation of cellular metabolic processGO:00313242810.117
Human
response to acid chemicalGO:00011012220.112
cellular amino acid metabolic processGO:00065201070.109
regulation of cell proliferationGO:00421273590.105
Mouse
regulation of cellular localizationGO:00603412630.103
Human
response to woundingGO:00096112540.099
regulation of fibrinolysisGO:005191720.094
metal ion homeostasisGO:00550651860.092
Human
negative regulation of proteolysisGO:0045861410.090
Human
circulatory system processGO:00030131830.089
regulation of serine type endopeptidase activityGO:190000310.089
positive regulation of extracellular matrix constituent secretionGO:000333120.089
positive regulation of extracellular matrix organizationGO:190305540.088
negative regulation of multicellular organismal processGO:00512412030.086
Human
response to glucocorticoidGO:00513842230.085
response to nutrientGO:00075842480.085
Rat
hepatocyte proliferationGO:007257430.084
positive regulation of nitrogen compound metabolic processGO:00511733340.082
positive regulation of biosynthetic processGO:00098913190.081
Human
regulation of protein processingGO:0070613500.080
Human
tissue developmentGO:00098882520.080
response to peptide hormoneGO:00434342780.080
Rat
regulation of extracellular matrix constituent secretionGO:000333020.079
response to campGO:0051591910.078
carboxylic acid metabolic processGO:00197522890.075
negative regulation of programmed cell deathGO:00430691830.073
negative regulation of molecular functionGO:00440921330.072
homeostatic processGO:00425923310.069
Human
metal ion transportGO:00300012890.068
Human
response to vitaminGO:00332731310.067
Rat
muscle system processGO:00030121150.065
regulation of system processGO:00440572080.063
positive regulation of multicellular organismal processGO:00512403870.061
Human Rat
cellular chemical homeostasisGO:00550822470.060
Human
response to muscle activity involved in regulation of muscle adaptationGO:001487320.060
growthGO:00400071650.059
Mouse
response to metal ionGO:00100382530.059
negative regulation of protein metabolic processGO:00512481140.058
Human
macromolecule localizationGO:00330362520.058
response to vitamin b6GO:003451610.058
regulation of cellular amine metabolic processGO:003323880.057
protein maturationGO:0051604680.057
Human
negative regulation of protein maturationGO:1903318470.057
Human
vasculature developmentGO:0001944700.057
response to biotic stimulusGO:00096072260.057
negative regulation of peptidase activityGO:0010466380.056
immune system processGO:00023762040.056
macromolecular complex subunit organizationGO:00439333390.055
regulation of growthGO:00400081050.055
Mouse
cellular response to glucocorticoid stimulusGO:0071385680.055
urea metabolic processGO:001962750.054
macromolecular complex assemblyGO:00650032730.054
negative regulation of endopeptidase activityGO:0010951360.054
positive regulation of response to stimulusGO:00485842850.053
Human Mouse Rat
divalent metal ion transportGO:00708381320.052
Human
negative regulation of cell proliferationGO:00082851190.052
proteolysisGO:00065081750.052
negative regulation of gene expressionGO:00106291990.051
Human
organic acid biosynthetic processGO:0016053830.051
negative regulation of response to stimulusGO:00485851550.051
Human
cytolysisGO:001983540.049
regulation of cellular component organizationGO:00511283680.049
Mouse
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.049
protein complex subunit organizationGO:00718223020.049
renin angiotensin regulation of aldosterone productionGO:000201830.048
positive regulation of cell proliferationGO:00082842490.048
Mouse
positive regulation of secretion by cellGO:19035321280.048
cell cell signalingGO:00072673350.047
regulation of neuronal synaptic plasticityGO:0048168310.047
carboxylic acid biosynthetic processGO:0046394830.047
regulation of hydrolase activityGO:00513361430.046
response to peptideGO:19016522920.045
Rat
defense responseGO:00069521940.045
regulation of synaptic transmissionGO:00508041410.044
regulation of response to external stimulusGO:00321011060.044
Human Rat
organ regenerationGO:00311001010.043
Rat
coagulationGO:0050817280.043
regulation of transcription dna templatedGO:00063553740.043
cellular response to cytokine stimulusGO:00713451270.042
positive regulation of coagulationGO:005082050.042
Human Rat
response to external biotic stimulusGO:00432072210.042
response to triglycerideGO:003401430.041
cellular homeostasisGO:00197252520.041
Human
blood vessel morphogenesisGO:0048514580.041
regulation of secretion by cellGO:19035302080.041
protein processingGO:0016485680.040
Human
cellular ketone metabolic processGO:0042180510.040
tonic smooth muscle contractionGO:001482040.040
anatomical structure morphogenesisGO:00096532980.039
Mouse
response to mechanical stimulusGO:00096121340.039
amine metabolic processGO:0009308380.038
nuclear transportGO:0051169490.038
response to insulinGO:00328681330.038
cellular response to oxygen containing compoundGO:19017013860.038
response to glucoseGO:00097491360.038
cell growthGO:00160491040.038
Mouse
regulation of inflammatory responseGO:0050727480.038
reproductionGO:00000032450.037
regulation of plasminogen activationGO:001075520.037
protein complex assemblyGO:00064612630.037
protein oligomerizationGO:00512591910.036
positive regulation of cellular biosynthetic processGO:00313282950.036
regenerationGO:00310991630.036
Rat
regulation of cell growthGO:0001558850.036
Mouse
cation transportGO:00068123820.035
Human
response to decreased oxygen levelsGO:00362932370.035
response to organophosphorusGO:00466831020.035
nitrogen compound transportGO:00717052290.035
regulation of cellular amino acid metabolic processGO:000652120.035
negative regulation of apoptotic processGO:00430661810.035
regulation of immune system processGO:00026821230.035
response to estrogenGO:00436272320.034
Rat
vascular process in circulatory systemGO:0003018960.034
response to hypoxiaGO:00016662310.034
response to chromateGO:004668730.034
extracellular matrix organizationGO:0030198130.034
calcium ion transportGO:00068161310.034
Human
regulation of phosphorylationGO:00423252480.034
Human
regulation of signal transductionGO:00099663180.034
Human Mouse
negative regulation of protein processingGO:0010955470.034
Human
transcription dna templatedGO:00063513770.033
immune responseGO:00069551040.033
positive regulation of immune system processGO:0002684900.033
catenin import into nucleusGO:003541110.033
negative regulation of cell deathGO:00605482290.032
cellular amine metabolic processGO:0044106380.032
neurological system processGO:00508772190.032
aromatic amino acid family catabolic processGO:000907470.031
regulation of cellular ketone metabolic processGO:0010565270.031
cellular sodium ion homeostasisGO:000688340.031
negative regulation of response to external stimulusGO:0032102370.031
Human
negative regulation of fibrinolysisGO:005191820.031
response to ketoneGO:19016541820.031
Rat
developmental growthGO:00485891000.031
regulation of homeostatic processGO:00328441010.030
Human
ion homeostasisGO:00508012120.030
Human
regulation of response to woundingGO:1903034690.030
Human Rat
regulation of reactive oxygen species metabolic processGO:2000377260.030
Human
cell activationGO:0001775970.030
Human Mouse
smooth muscle cell proliferationGO:0048659770.030
positive regulation of rna biosynthetic processGO:19026801970.030
regulation of secretionGO:00510462240.030
nitrogen cycle metabolic processGO:007194150.030
feeding behaviorGO:0007631530.029
intracellular signal transductionGO:00355563140.029
Mouse
wound healingGO:00420601220.029
reactive nitrogen species metabolic processGO:200105710.029
cellular component biogenesisGO:00440853680.029
glucose homeostasisGO:0042593750.029
cellular metal ion homeostasisGO:00068751720.029
Human
regulation of multicellular organismal developmentGO:20000263760.029
Human
cardiovascular system developmentGO:00723581340.028
regulation of synaptic plasticityGO:0048167700.028
regulation of blood pressureGO:0008217830.028
cellular cation homeostasisGO:00300031800.028
Human
response to oxygen levelsGO:00704822650.028
intracellular transportGO:00469071850.028
Human
transmission of nerve impulseGO:0019226420.027
protein localizationGO:00081041910.027
single organism reproductive processGO:00447022970.027
negative regulation of endothelial cell proliferationGO:000193750.027
positive regulation of nucleobase containing compound metabolic processGO:00459353190.027
mesoderm developmentGO:000749820.027
response to hexoseGO:00097461440.027
protein complex biogenesisGO:00702712630.027
regulation of rna biosynthetic processGO:20011413810.026
chemical homeostasisGO:00488782920.026
Human
cation homeostasisGO:00550801950.026
Human
response to bacteriumGO:00096172000.026
regulation of body fluid levelsGO:0050878900.025
dicarboxylic acid metabolic processGO:0043648420.025
multi organism reproductive processGO:00447032620.025
renal system processGO:0003014400.025
nucleobase containing small molecule metabolic processGO:00550863160.025
negative regulation of epithelial cell proliferationGO:0050680160.025
positive regulation of phosphorus metabolic processGO:00105622620.024
Human
brain renin angiotensin systemGO:000203530.024
behaviorGO:00076102050.024
negative regulation of catalytic activityGO:00430861030.024
regulation of protein metabolic processGO:00512462890.024
Human
sexual reproductionGO:00199531480.024
response to other organismGO:00517072200.024
positive regulation of signalingGO:00230562700.024
Human Mouse
cellular response to nitrogen compoundGO:19016992100.023
regulation of cellular protein metabolic processGO:00322682670.023
Human
ion transmembrane transportGO:00342203650.023
regulation of rna metabolic processGO:00512523910.023
nucleic acid templated transcriptionGO:00976593790.023
urea cycleGO:000005050.023
regulation of catalytic activityGO:00507903040.023
multi multicellular organism processGO:00447061380.022
cellular response to stressGO:00335542690.022
regulation of hormone levelsGO:00108171870.022
negative regulation of cellular protein metabolic processGO:00322691060.022
Human
cellular component assemblyGO:00226073600.022
negative regulation of cell communicationGO:00106481580.022
positive regulation of nucleic acid templated transcriptionGO:19035081970.022
regulation of renal sodium excretionGO:0035813200.022
positive regulation of cellular amino acid metabolic processGO:004576410.022
angiotensin mediated drinking behaviorGO:000305120.022
response to cytokineGO:00340972150.021
small molecule biosynthetic processGO:00442831240.021
regulation of vesicle mediated transportGO:0060627810.021
agingGO:00075682410.021
circulatory system developmentGO:00723591340.021
regulation of ion homeostasisGO:2000021630.021
Human
mapk cascadeGO:00001651400.020
positive regulation of neuron differentiationGO:00456661260.020
organonitrogen compound biosynthetic processGO:19015661670.020
circadian rhythmGO:0007623880.020
Rat
multicellular organism reproductionGO:00325042330.020
protein transportGO:00150311320.020
alpha amino acid catabolic processGO:1901606200.020
sterol homeostasisGO:005509230.020
localization of cellGO:00516742020.020
organophosphate biosynthetic processGO:00904071430.020
complement activationGO:0006956110.020
locomotionGO:00400112370.020
regulation of cell differentiationGO:00455953200.019
Human
regulation of tube sizeGO:0035150890.019
alpha amino acid biosynthetic processGO:1901607230.019
rna metabolic processGO:00160704060.019
regulation of molecular functionGO:00650093980.019
cellular component movementGO:00069282480.019
regulation of peptidase activityGO:0052547550.019
response to methanolGO:003398610.019
cellular amino acid catabolic processGO:0009063210.019
transmembrane transportGO:00550854120.019
response to molecule of bacterial originGO:00022371940.018
single organism biosynthetic processGO:00447113420.018
Human
response to purine containing compoundGO:00140741260.018
regulation of proteolysisGO:0030162660.018
Human
regulation of anatomical structure sizeGO:00900661350.018
negative regulation of nitrogen compound metabolic processGO:00511721610.018
liver developmentGO:0001889900.018
response to mineralocorticoidGO:0051385490.018
multicellular organismal reproductive processGO:00486092330.018
positive regulation of immunoglobulin productionGO:000263940.018
regulation of calcium ion transportGO:0051924770.018
Human
intracellular protein transportGO:0006886790.018
nucleoside phosphate biosynthetic processGO:19012931020.018
positive regulation of hemostasisGO:190004840.018
Human Rat
protein homooligomerizationGO:0051260910.018
neuron differentiationGO:00301823680.018
camera type eye developmentGO:0043010480.018
liver morphogenesisGO:007257630.017
hemostasisGO:0007599260.017
response to transition metal nanoparticleGO:19902671220.017
cellular response to organic cyclic compoundGO:00714072020.017
positive regulation of apoptotic processGO:00430651540.017
positive regulation of developmental processGO:00510942830.017
organic substance catabolic processGO:19015753160.017
indolalkylamine metabolic processGO:000658650.017
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.017
single organism behaviorGO:00447081300.017
carbohydrate homeostasisGO:0033500750.017
gamete generationGO:00072761240.017
lipid transportGO:0006869610.017
reproductive processGO:00224143720.017
rna biosynthetic processGO:00327743800.017
cellular modified amino acid metabolic processGO:0006575610.017
organophosphate metabolic processGO:00196373700.016
regulation of immune responseGO:0050776550.016
blood vessel developmentGO:0001568690.016
regulation of blood circulationGO:19035221100.016
positive regulation of neuron projection developmentGO:0010976990.016
endocrine processGO:0050886320.016
regulation of reactive oxygen species biosynthetic processGO:190342650.016
regulation of defense responseGO:0031347680.016
positive regulation of programmed cell deathGO:00430681570.016
cardiac cell developmentGO:0055006160.016
positive regulation of rna metabolic processGO:00512542030.016
positive regulation of heterotypic cell cell adhesionGO:003411610.016
negative regulation of hydrolase activityGO:0051346520.016
cell projection organizationGO:00300303020.016
tissue regenerationGO:0042246360.016
epithelial cell proliferationGO:0050673540.016
establishment of protein localizationGO:00451841410.016
cholesterol homeostasisGO:004263230.016
innate immune responseGO:0045087350.015
cellular response to campGO:0071320260.015
organelle organizationGO:00069962660.015
cellular response to endogenous stimulusGO:00714953770.015
response to monosaccharideGO:00342841590.015
organic acid catabolic processGO:0016054490.015
regulation of blood vessel sizeGO:0050880890.015
positive regulation of reactive oxygen species metabolic processGO:2000379160.015
Human
cellular response to mechanical stimulusGO:0071260480.015
artery smooth muscle contractionGO:001482440.015
reactive oxygen species metabolic processGO:0072593370.015
Human
rhythmic processGO:00485111560.015
Rat
negative regulation of immune system processGO:0002683390.015
regulation of phosphate metabolic processGO:00192203490.015
Human
negative regulation of phosphorus metabolic processGO:0010563800.015
regulation of phosphorus metabolic processGO:00511743490.015
Human
positive regulation of cellular amine metabolic processGO:003324030.015
cellular response to steroid hormone stimulusGO:0071383930.015
protein targetingGO:0006605610.015
positive regulation of blood pressureGO:0045777310.015
aromatic amino acid family metabolic processGO:000907290.014
positive regulation of protein metabolic processGO:00512471780.014
Human
response to activityGO:0014823730.014
vesicle mediated transportGO:00161921810.014
cellular response to hormone stimulusGO:00328702470.014
sodium ion homeostasisGO:0055078230.014
positive regulation of immunoglobulin mediated immune responseGO:000289120.014
purine containing compound metabolic processGO:00725212530.014
coenzyme metabolic processGO:0006732860.014
secretion by cellGO:00329402480.014
multicellular organismal signalingGO:0035637440.014
regulation of muscle system processGO:0090257790.014
response to growth factorGO:00708481890.014
anion transportGO:00068201780.014
regulation of systemic arterial blood pressureGO:0003073300.014
cellular response to corticosteroid stimulusGO:0071384690.013
cellular response to interferon gammaGO:0071346140.013
response to carbohydrateGO:00097431830.013
regulation of endothelial cell apoptotic processGO:200035130.013
carbohydrate derivative metabolic processGO:19011353460.013
regulation of vasculature developmentGO:1901342440.013
spermatogenesisGO:0007283990.013
positive regulation of transcription dna templatedGO:00458931970.013
transcription from rna polymerase ii promoterGO:00063662520.013
negative regulation of growthGO:0045926370.013
coenzyme biosynthetic processGO:0009108220.013
positive regulation of peptide hormone secretionGO:0090277500.013
negative regulation of cellular amide metabolic processGO:003424910.013
neuron projection developmentGO:00311752730.013
cellular response to external stimulusGO:00714961180.013
regulation of nucleic acid templated transcriptionGO:19035063800.013
protein targeting to nucleusGO:0044744350.013
reactive oxygen species biosynthetic processGO:190340980.013
positive regulation of homeostatic processGO:0032846490.013
Human
lipid localizationGO:0010876620.013
sulfur compound metabolic processGO:0006790700.013
regulation of excretionGO:0044062210.012
negative regulation of signalingGO:00230571570.012
regulation of ion transportGO:00432692450.012
Human
catabolic processGO:00090563510.012
response to estradiolGO:00323551640.012
erk1 and erk2 cascadeGO:0070371480.012
g protein coupled receptor signaling pathwayGO:00071862420.012
Human
secretionGO:00469033070.012
negative regulation of developmental processGO:00510931250.012
Human
regulation of protein localizationGO:0032880810.012
positive regulation of macromolecule biosynthetic processGO:00105572470.012
Human
defense response to gram negative bacteriumGO:005082930.012
regulation of immunoglobulin mediated immune responseGO:000288920.012
nucleotide biosynthetic processGO:0009165980.012
carboxylic acid transportGO:00469421150.012
angiogenesisGO:0001525530.012
regulation of response to stressGO:00801341260.012
Human Rat
cellular macromolecule localizationGO:00707271220.012
response to toxic substanceGO:00096361330.012
positive regulation of triglyceride metabolic processGO:009020840.012
response to lead ionGO:0010288330.012
epithelial cell proliferation involved in liver morphogenesisGO:007257530.012
cellular response to hexose stimulusGO:0071331650.012
protein activation cascadeGO:0072376120.012
cofactor biosynthetic processGO:0051188280.012
negative regulation of natural killer cell mediated cytotoxicityGO:004595340.012
cellular response to peptide hormone stimulusGO:00713751200.012
negative regulation of cellular biosynthetic processGO:00313271610.012
muscle cell proliferationGO:0033002840.011
vasoconstrictionGO:0042310540.011
blood coagulationGO:0007596260.011
extracellular structure organizationGO:0043062130.011
positive regulation of gene expressionGO:00106282440.011
negative regulation of tissue remodelingGO:003410460.011
carbohydrate derivative biosynthetic processGO:19011371240.011
regulation of peptide hormone secretionGO:0090276800.011
regulation of neurogenesisGO:00507672470.011
Human
regulation of wound healingGO:0061041140.011
Human Rat
cellular macromolecular complex assemblyGO:0034622580.011
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.011
acute inflammatory responseGO:0002526580.011
regulation of endopeptidase activityGO:0052548510.011
divalent inorganic cation transportGO:00725111340.011
Human
cellular response to insulin stimulusGO:0032869810.011
positive regulation of cellular component organizationGO:00511302000.011
signal releaseGO:00230611450.011
signal transduction by phosphorylationGO:00230141440.011
cardiac muscle cell developmentGO:0055013160.011
heterotypic cell cell adhesionGO:003411320.011
amide transportGO:00428861050.010
cardiac muscle tissue growthGO:0055017200.010
monocarboxylic acid transportGO:0015718520.010
positive regulation of transportGO:00510502450.010
Human
positive regulation of hormone secretionGO:0046887650.010
nucleocytoplasmic transportGO:0006913480.010
male gamete generationGO:0048232990.010
neuron developmentGO:00486662860.010
regulation of locomotionGO:00400121480.010
regulation of peptide secretionGO:0002791820.010
actin crosslink formationGO:005176430.010
hormone transportGO:00099141210.010
muscle cell differentiationGO:0042692520.010
nicotinamide nucleotide biosynthetic processGO:001935920.010
regulation of cell projection organizationGO:00313441750.010
protein phosphorylationGO:00064683450.010
Human
establishment of tissue polarityGO:000716420.010
monoamine transportGO:0015844430.010

F2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.026
disease of anatomical entityDOID:700.022
Human
musculoskeletal system diseaseDOID:1700.022
muscle tissue diseaseDOID:6600.019
cardiovascular system diseaseDOID:128700.019
Human
cardiomyopathyDOID:005070000.019
heart diseaseDOID:11400.019
muscular diseaseDOID:008000000.019
myopathyDOID:42300.019
hematopoietic system diseaseDOID:7400.016
Human
immune system diseaseDOID:291400.016
Human
inherited blood coagulation diseaseDOID:221400.015
blood coagulation diseaseDOID:124700.015
Human
inherited metabolic disorderDOID:65500.014