IMP: Integrative Multi-species Prediction

Rattus norvegicus

32 known processes

Fdxr

ferredoxin reductase

(Aliases: AR)

RGD: 621648
Entrez: 79122
Ensembl: ENSRNOG00000003387
UniProtKB: P56522

Process Predictions
Disease Predictions

Fdxr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
oxoacid metabolic process	GO:0043436	290	0.426
organic acid metabolic process	GO:0006082	292	0.263
response to inorganic substance	GO:0010035	377	0.242
carboxylic acid metabolic process	GO:0019752	289	0.211
arachidonic acid metabolic process	GO:0019369	20	0.208
cellular catabolic process	GO:0044248	295	0.201
response to metal ion	GO:0010038	253	0.173
fatty acid metabolic process	GO:0006631	99	0.168
gland development	GO:0048732	155	0.164
catabolic process	GO:0009056	351	0.140
cellular ketone metabolic process	GO:0042180	51	0.120
macromolecule localization	GO:0033036	252	0.111
carboxylic acid biosynthetic process	GO:0046394	83	0.099
liver development	GO:0001889	90	0.097
negative regulation of metabolic process	GO:0009892	331	0.097
cellular response to organonitrogen compound	GO:0071417	197	0.095
long chain fatty acid metabolic process	GO:0001676	32	0.086
fatty acid derivative metabolic process	GO:1901568	38	0.085
rna metabolic process	GO:0016070	406	0.082
cell morphogenesis involved in differentiation	GO:0000904	119	0.082
organic substance catabolic process	GO:1901575	316	0.077
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.072
negative regulation of pancreatic stellate cell proliferation	GO:2000230	1	0.072
unsaturated fatty acid metabolic process	GO:0033559	39	0.068
response to ionizing radiation	GO:0010212	59	0.067
purine ribonucleotide metabolic process	GO:0009150	227	0.066
negative regulation of cellular metabolic process	GO:0031324	281	0.066
regulation of molecular function	GO:0065009	398	0.065
response to oxidative stress	GO:0006979	186	0.064
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.061
regulation of cellular ketone metabolic process	GO:0010565	27	0.059
icosanoid metabolic process	GO:0006690	38	0.057
rna biosynthetic process	GO:0032774	380	0.056
response to estradiol	GO:0032355	164	0.054
regulation of rna metabolic process	GO:0051252	391	0.054
negative regulation of molecular function	GO:0044092	133	0.053
organic acid biosynthetic process	GO:0016053	83	0.052
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.051
cellular lipid metabolic process	GO:0044255	208	0.050
regulation of rna biosynthetic process	GO:2001141	381	0.050
cellular protein localization	GO:0034613	122	0.050
response to radiation	GO:0009314	137	0.048
carbohydrate derivative metabolic process	GO:1901135	346	0.048
regulation of cellular amino acid metabolic process	GO:0006521	2	0.047
transcription dna templated	GO:0006351	377	0.047
nucleoside phosphate metabolic process	GO:0006753	283	0.047
aging	GO:0007568	241	0.047
transcription from rna polymerase ii promoter	GO:0006366	252	0.047
regulation of transcription dna templated	GO:0006355	374	0.046
exogenous drug catabolic process	GO:0042738	1	0.046
alkaloid metabolic process	GO:0009820	3	0.046
linoleic acid metabolic process	GO:0043651	4	0.046
cellular amino acid metabolic process	GO:0006520	107	0.045
regulation of phosphorus metabolic process	GO:0051174	349	0.045
positive regulation of cellular biosynthetic process	GO:0031328	295	0.045
regulation of catalytic activity	GO:0050790	304	0.044
positive regulation of gene expression	GO:0010628	244	0.044
naphthalene containing compound metabolic process	GO:0090420	2	0.044
small molecule biosynthetic process	GO:0044283	124	0.044
negative regulation of macromolecule metabolic process	GO:0010605	260	0.044
cell communication involved in cardiac conduction	GO:0086065	2	0.042
cellular response to stress	GO:0033554	269	0.042
response to nutrient levels	GO:0031667	370	0.042
neuron development	GO:0048666	286	0.041
central nervous system development	GO:0007417	311	0.041
response to extracellular stimulus	GO:0009991	380	0.041
establishment of protein localization	GO:0045184	141	0.040
cell projection morphogenesis	GO:0048858	123	0.040
positive regulation of rna biosynthetic process	GO:1902680	197	0.040
response to insulin	GO:0032868	133	0.039
reproductive system development	GO:0061458	128	0.039
nucleoside metabolic process	GO:0009116	179	0.039
programmed cell death	GO:0012501	392	0.038
regulation of system process	GO:0044057	208	0.038
positive regulation of molecular function	GO:0044093	230	0.038
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.037
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.037
drug catabolic process	GO:0042737	1	0.036
regulation of protein metabolic process	GO:0051246	289	0.036
hepaticobiliary system development	GO:0061008	90	0.036
response to estrogen	GO:0043627	232	0.035
positive regulation of biosynthetic process	GO:0009891	319	0.035
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.035
nucleic acid templated transcription	GO:0097659	379	0.035
response to wounding	GO:0009611	254	0.035
response to peptide hormone	GO:0043434	278	0.034
fluorene metabolic process	GO:0018917	1	0.034
ribonucleotide metabolic process	GO:0009259	231	0.034
positive regulation of rna metabolic process	GO:0051254	203	0.033
naphthalene metabolic process	GO:0018931	2	0.033
response to acid chemical	GO:0001101	222	0.033
organophosphate metabolic process	GO:0019637	370	0.033
organonitrogen compound biosynthetic process	GO:1901566	167	0.033
nicotine metabolic process	GO:0018933	1	0.032
single organism intracellular transport	GO:1902582	166	0.032
positive regulation of catalytic activity	GO:0043085	184	0.032
regulation of phosphate metabolic process	GO:0019220	349	0.032
response to peptide	GO:1901652	292	0.031
cell projection organization	GO:0030030	302	0.031
nucleotide metabolic process	GO:0009117	279	0.030
positive regulation of programmed cell death	GO:0043068	157	0.030
regulation of cellular amine metabolic process	GO:0033238	8	0.030
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.030
trichloroethylene metabolic process	GO:0018979	1	0.029
amine metabolic process	GO:0009308	38	0.029
response to uv c	GO:0010225	2	0.029
lipid metabolic process	GO:0006629	283	0.029
purine containing compound metabolic process	GO:0072521	253	0.029
single organism catabolic process	GO:0044712	283	0.029
neuron projection morphogenesis	GO:0048812	122	0.029
reproductive structure development	GO:0048608	128	0.028
negative regulation of cellular biosynthetic process	GO:0031327	161	0.028
organonitrogen compound catabolic process	GO:1901565	179	0.027
response to hypoxia	GO:0001666	231	0.027
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.027
glial cell differentiation	GO:0010001	65	0.027
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.027
reproductive process	GO:0022414	372	0.027
single organism reproductive process	GO:0044702	297	0.027
response to vitamin	GO:0033273	131	0.027
positive regulation of cell death	GO:0010942	184	0.026
regulation of programmed cell death	GO:0043067	341	0.026
pyridine containing compound metabolic process	GO:0072524	32	0.026
positive regulation of hydrolase activity	GO:0051345	86	0.026
glycosyl compound metabolic process	GO:1901657	182	0.026
vitamin d receptor signaling pathway	GO:0070561	1	0.026
ribose phosphate metabolic process	GO:0019693	235	0.025
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.025
neuron projection development	GO:0031175	273	0.025
response to hydrogen peroxide	GO:0042542	89	0.025
single organism biosynthetic process	GO:0044711	342	0.025
intracellular signal transduction	GO:0035556	314	0.025
regulation of hydrolase activity	GO:0051336	143	0.024
drug metabolic process	GO:0017144	11	0.024
purine nucleotide metabolic process	GO:0006163	229	0.024
cardiac muscle cell action potential involved in contraction	GO:0086002	2	0.024
regulation of cellular component organization	GO:0051128	368	0.024
cellular amine metabolic process	GO:0044106	38	0.024
proteolysis	GO:0006508	175	0.023
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.023
regulation of telomerase activity	GO:0051972	2	0.023
cellular macromolecule localization	GO:0070727	122	0.023
cellular response to vitamin e	GO:0071306	3	0.023
negative regulation of biosynthetic process	GO:0009890	168	0.023
epoxygenase p450 pathway	GO:0019373	1	0.023
vesicle mediated transport	GO:0016192	181	0.023
atp metabolic process	GO:0046034	72	0.023
chemosensory behavior	GO:0007635	2	0.023
gap junction assembly	GO:0016264	2	0.022
negative regulation of gene expression	GO:0010629	199	0.022
protein phosphorylation	GO:0006468	345	0.022
regulation of cellular protein metabolic process	GO:0032268	267	0.022
intracellular protein transport	GO:0006886	79	0.022
positive regulation of multicellular organismal process	GO:0051240	387	0.022
intracellular transport	GO:0046907	185	0.022
protein localization	GO:0008104	191	0.022
cell cell signaling	GO:0007267	335	0.021
macromolecular complex subunit organization	GO:0043933	339	0.021
cell part morphogenesis	GO:0032990	123	0.021
regulation of cell differentiation	GO:0045595	320	0.021
multicellular organismal signaling	GO:0035637	44	0.021
regulation of phosphorylation	GO:0042325	248	0.021
cellular response to lipid	GO:0071396	201	0.021
monocarboxylic acid metabolic process	GO:0032787	152	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.021
regulation of cellular localization	GO:0060341	263	0.021
response to aluminum ion	GO:0010044	10	0.020
positive regulation of phosphorylation	GO:0042327	177	0.020
response to temperature stimulus	GO:0009266	94	0.020
nucleobase containing small molecule metabolic process	GO:0055086	316	0.020
nucleotide catabolic process	GO:0009166	139	0.020
cardiac conduction	GO:0061337	2	0.020
phenol containing compound metabolic process	GO:0018958	30	0.020
vitamin a metabolic process	GO:0006776	2	0.020
response to corticosteroid	GO:0031960	235	0.020
purine ribonucleoside monophosphate catabolic process	GO:0009169	55	0.019
cellular nitrogen compound catabolic process	GO:0044270	163	0.019
regulation of catabolic process	GO:0009894	113	0.019
response to toxic substance	GO:0009636	133	0.019
immune system process	GO:0002376	204	0.019
heterocycle catabolic process	GO:0046700	167	0.019
negative regulation of rna biosynthetic process	GO:1902679	118	0.019
negative regulation of developmental process	GO:0051093	125	0.019
divalent metal ion transport	GO:0070838	132	0.019
organic cyclic compound catabolic process	GO:1901361	175	0.019
response to starvation	GO:0042594	59	0.019
cellular response to extracellular stimulus	GO:0031668	73	0.019
purine nucleoside metabolic process	GO:0042278	169	0.019
reactive oxygen species biosynthetic process	GO:1903409	8	0.019
dna metabolic process	GO:0006259	96	0.018
response to organophosphorus	GO:0046683	102	0.018
single organism cellular localization	GO:1902580	102	0.018
cell morphogenesis	GO:0000902	142	0.018
negative regulation of catalytic activity	GO:0043086	103	0.018
regulation of response to stress	GO:0080134	126	0.018
response to cesium ion	GO:0010164	2	0.018
anatomical structure morphogenesis	GO:0009653	298	0.018
regulation of secretion by cell	GO:1903530	208	0.017
positive regulation of cellular amine metabolic process	GO:0033240	3	0.017
response to transition metal nanoparticle	GO:1990267	122	0.017
cellular component morphogenesis	GO:0032989	155	0.017
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.017
positive regulation of phosphate metabolic process	GO:0045937	262	0.017
regulation of protein modification process	GO:0031399	194	0.017
nucleoside triphosphate metabolic process	GO:0009141	144	0.017
negative regulation of cell communication	GO:0010648	158	0.017
response to oxygen levels	GO:0070482	265	0.017
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.017
negative regulation of follicle stimulating hormone secretion	GO:0046882	3	0.016
positive regulation of cellular protein metabolic process	GO:0032270	167	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.016
actin filament based process	GO:0030029	86	0.016
cellular response to oxygen containing compound	GO:1901701	386	0.016
establishment of protein localization to organelle	GO:0072594	44	0.016
cellular response to insulin stimulus	GO:0032869	81	0.016
cellular response to organic cyclic compound	GO:0071407	202	0.016
negative regulation of protein metabolic process	GO:0051248	114	0.016
regulation of transferase activity	GO:0051338	123	0.016
response to ketone	GO:1901654	182	0.016
negative regulation of cellular protein metabolic process	GO:0032269	106	0.016
aromatic compound catabolic process	GO:0019439	168	0.016
membrane organization	GO:0061024	94	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.016
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.015
regulation of protein catabolic process	GO:0042176	16	0.015
regulation of cellular catabolic process	GO:0031329	101	0.015
protein transport	GO:0015031	132	0.015
regulation of intracellular signal transduction	GO:1902531	218	0.015
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.015
purine nucleoside catabolic process	GO:0006152	124	0.015
response to nutrient	GO:0007584	248	0.015
cellular response to nutrient levels	GO:0031669	60	0.015
macromolecular complex assembly	GO:0065003	273	0.015
response to vitamin a	GO:0033189	36	0.015
transmission of nerve impulse	GO:0019226	42	0.015
positive regulation of cell communication	GO:0010647	271	0.015
neuron differentiation	GO:0030182	368	0.015
cell type specific apoptotic process	GO:0097285	134	0.015
catecholamine biosynthetic process	GO:0042423	9	0.015
cytoplasmic transport	GO:0016482	115	0.015
negative regulation of peptidase activity	GO:0010466	38	0.015
negative regulation of rna metabolic process	GO:0051253	123	0.015
ribonucleoside metabolic process	GO:0009119	174	0.014
response to sulfur dioxide	GO:0010477	3	0.014
regulation of apoptotic process	GO:0042981	335	0.014
response to other organism	GO:0051707	220	0.014
cellular component biogenesis	GO:0044085	368	0.014
developmental process involved in reproduction	GO:0003006	159	0.014
regulation of protein phosphorylation	GO:0001932	183	0.014
response to camp	GO:0051591	91	0.014
regulation of multicellular organismal development	GO:2000026	376	0.014
regulation of kinase activity	GO:0043549	117	0.014
dephosphorylation	GO:0016311	98	0.014
response to ethanol	GO:0045471	162	0.014
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	1	0.014
positive regulation of protein metabolic process	GO:0051247	178	0.014
defense response	GO:0006952	194	0.014
cellular response to ketone	GO:1901655	51	0.014
female pregnancy	GO:0007565	122	0.014
cofactor metabolic process	GO:0051186	95	0.013
transmembrane transport	GO:0055085	412	0.013
cellular macromolecule catabolic process	GO:0044265	29	0.013
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.013
regulation of cell projection organization	GO:0031344	175	0.013
growth	GO:0040007	165	0.013
oxidation reduction process	GO:0055114	304	0.013
purine ribonucleotide catabolic process	GO:0009154	136	0.013
positive regulation of protein modification process	GO:0031401	142	0.013
response to calcium ion	GO:0051592	59	0.013
hormone secretion	GO:0046879	115	0.013
lipid storage	GO:0019915	1	0.013
regulation of neurogenesis	GO:0050767	247	0.013
protein targeting	GO:0006605	61	0.013
regulation of protein maturation	GO:1903317	50	0.013
folic acid containing compound metabolic process	GO:0006760	10	0.013
nucleoside catabolic process	GO:0009164	126	0.013
response to hexose	GO:0009746	144	0.013
negative regulation of protein processing	GO:0010955	47	0.013
cellular response to endogenous stimulus	GO:0071495	377	0.013
negative regulation of cell differentiation	GO:0045596	99	0.013
positive regulation of developmental process	GO:0051094	283	0.013
organic hydroxy compound biosynthetic process	GO:1901617	51	0.012
mitotic spindle organization	GO:0007052	2	0.012
stress activated mapk cascade	GO:0051403	35	0.012
response to purine containing compound	GO:0014074	126	0.012
regulation of protein processing	GO:0070613	50	0.012
regulation of proteolysis	GO:0030162	66	0.012
organophosphate biosynthetic process	GO:0090407	143	0.012
centrosome organization	GO:0051297	1	0.012
gamete generation	GO:0007276	124	0.012
protein import	GO:0017038	37	0.012
negative regulation of transcription dna templated	GO:0045892	116	0.012
negative regulation of collagen metabolic process	GO:0010713	4	0.012
regulation of membrane repolarization	GO:0060306	1	0.012
regulation of insulin secretion	GO:0050796	65	0.012
chlorinated hydrocarbon metabolic process	GO:0042196	4	0.012
immune response	GO:0006955	104	0.012
protein localization to nucleus	GO:0034504	39	0.012
cellular response to lipopolysaccharide	GO:0071222	55	0.012
atp catabolic process	GO:0006200	54	0.012
organic hydroxy compound metabolic process	GO:1901615	115	0.012
regulation of membrane potential	GO:0042391	110	0.012
eye morphogenesis	GO:0048592	4	0.012
centrosome cycle	GO:0007098	1	0.012
axonogenesis	GO:0007409	71	0.012
negative regulation of secretion by cell	GO:1903531	72	0.012
regulation of calcium ion transport	GO:0051924	77	0.012
nucleobase containing compound catabolic process	GO:0034655	152	0.012
protein localization to organelle	GO:0033365	57	0.012
regulation of proteasomal protein catabolic process	GO:0061136	4	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.011
response to lipopolysaccharide	GO:0032496	191	0.011
olfactory behavior	GO:0042048	2	0.011
response to external biotic stimulus	GO:0043207	221	0.011
regeneration	GO:0031099	163	0.011
regulation of nucleic acid templated transcription	GO:1903506	380	0.011
regulation of peptidase activity	GO:0052547	55	0.011
response to amino acid	GO:0043200	75	0.011
steroid metabolic process	GO:0008202	73	0.011
protein complex biogenesis	GO:0070271	263	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
gastrulation	GO:0007369	2	0.011
hematopoietic progenitor cell differentiation	GO:0002244	2	0.011
purine ribonucleoside metabolic process	GO:0046128	168	0.011
negative regulation of calcium ion import	GO:0090281	2	0.011
male sex differentiation	GO:0046661	64	0.011
response to heat	GO:0009408	60	0.011
inorganic cation transmembrane transport	GO:0098662	202	0.011
stress activated protein kinase signaling cascade	GO:0031098	37	0.011
cyclic nucleotide metabolic process	GO:0009187	80	0.011
ribonucleoside catabolic process	GO:0042454	126	0.011
acylglycerol homeostasis	GO:0055090	2	0.011
cellular response to steroid hormone stimulus	GO:0071383	93	0.010
negative regulation of cell cycle phase transition	GO:1901988	4	0.010
protein oligomerization	GO:0051259	191	0.010
protein processing	GO:0016485	68	0.010
cellular response to nitrogen compound	GO:1901699	210	0.010
porphyrin containing compound metabolic process	GO:0006778	8	0.010
negative regulation of mitotic cell cycle phase transition	GO:1901991	3	0.010
response to glucocorticoid	GO:0051384	223	0.010
negative regulation of proteolysis	GO:0045861	41	0.010
cell cycle	GO:0007049	101	0.010
nucleoside triphosphate catabolic process	GO:0009143	123	0.010
regulation of cell cycle g2 m phase transition	GO:1902749	4	0.010
action potential	GO:0001508	54	0.010
protein complex subunit organization	GO:0071822	302	0.010
protein targeting to nucleus	GO:0044744	35	0.010
carbohydrate derivative catabolic process	GO:1901136	147	0.010
exploration behavior	GO:0035640	1	0.010
peptide transport	GO:0015833	97	0.010
hair cycle	GO:0042633	3	0.010
single organism nuclear import	GO:1902593	35	0.010
cellular response to alcohol	GO:0097306	87	0.010
inflammatory response	GO:0006954	150	0.010

Fdxr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.033
nervous system disease	DOID:863	0.033
cardiovascular system disease	DOID:1287	0.015
central nervous system disease	DOID:331	0.014

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