Rattus norvegicus

0 known processes

Impg2

interphotoreceptor matrix proteoglycan 2

(Aliases: Pg10.2)

Impg2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
synaptic transmissionGO:00072682350.345
anion transportGO:00068201780.289
macromolecular complex subunit organizationGO:00439333390.273
protein complex biogenesisGO:00702712630.269
macromolecular complex assemblyGO:00650032730.260
cellular response to organic cyclic compoundGO:00714072020.258
response to glucocorticoidGO:00513842230.233
single organism behaviorGO:00447081300.229
ribonucleotide biosynthetic processGO:0009260850.228
organic acid transportGO:00158491160.222
cellular component biogenesisGO:00440853680.221
homeostatic processGO:00425923310.219
inorganic ion transmembrane transportGO:00986602290.211
regulation of secretionGO:00510462240.211
response to carbohydrateGO:00097431830.202
transcription from rna polymerase ii promoterGO:00063662520.199
response to light stimulusGO:0009416520.197
acid secretionGO:0046717480.194
carboxylic acid transportGO:00469421150.191
response to purine containing compoundGO:00140741260.191
response to corticosteroidGO:00319602350.182
cellular ion homeostasisGO:00068731840.179
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.177
camp biosynthetic processGO:0006171470.173
negative regulation of apoptotic processGO:00430661810.166
organic hydroxy compound metabolic processGO:19016151150.162
sensory perceptionGO:00076001010.156
cellular component assemblyGO:00226073600.156
cellular chemical homeostasisGO:00550822470.155
organic acid metabolic processGO:00060822920.155
carboxylic acid metabolic processGO:00197522890.153
neuron neuron synaptic transmissionGO:0007270600.153
positive regulation of nitrogen compound metabolic processGO:00511733340.151
small molecule biosynthetic processGO:00442831240.150
regulation of cellular localizationGO:00603412630.149
cyclic purine nucleotide metabolic processGO:0052652620.149
regulation of nucleic acid templated transcriptionGO:19035063800.145
negative regulation of cellular metabolic processGO:00313242810.141
cellular homeostasisGO:00197252520.140
nucleic acid templated transcriptionGO:00976593790.139
regulation of cyclic nucleotide metabolic processGO:0030799510.138
carbohydrate derivative metabolic processGO:19011353460.134
oxoacid metabolic processGO:00434362900.134
g protein coupled receptor signaling pathwayGO:00071862420.132
response to decreased oxygen levelsGO:00362932370.132
regulation of phosphate metabolic processGO:00192203490.130
neuron differentiationGO:00301823680.130
neurological system processGO:00508772190.130
nitrogen compound transportGO:00717052290.129
organic anion transportGO:00157111320.128
apoptotic processGO:00069153810.126
protein complex assemblyGO:00064612630.125
response to acid chemicalGO:00011012220.125
regulation of ion transportGO:00432692450.123
protein oligomerizationGO:00512591910.122
response to oxygen levelsGO:00704822650.118
cation homeostasisGO:00550801950.116
cellular divalent inorganic cation homeostasisGO:00725031620.116
ion homeostasisGO:00508012120.116
central nervous system developmentGO:00074173110.115
inorganic cation transmembrane transportGO:00986622020.114
rna metabolic processGO:00160704060.111
brain developmentGO:00074202470.111
programmed cell deathGO:00125013920.110
organophosphate biosynthetic processGO:00904071430.109
negative regulation of transportGO:00510511360.108
positive regulation of nucleobase containing compound metabolic processGO:00459353190.107
blood circulationGO:00080151830.107
glutamate secretionGO:0014047190.106
response to campGO:0051591910.106
divalent inorganic cation homeostasisGO:00725071650.105
purine nucleotide metabolic processGO:00061632290.105
regulation of intracellular signal transductionGO:19025312180.105
regulation of secretion by cellGO:19035302080.104
leukocyte activationGO:0045321760.104
nucleoside phosphate biosynthetic processGO:19012931020.103
metal ion homeostasisGO:00550651860.102
response to ammonium ionGO:0060359710.102
carboxylic acid biosynthetic processGO:0046394830.102
detection of stimulusGO:0051606240.101
response to alkaloidGO:00432791320.101
signal transduction by phosphorylationGO:00230141440.101
positive regulation of rna biosynthetic processGO:19026801970.100
response to peptide hormoneGO:00434342780.099
cation transmembrane transportGO:00986552630.099
rna biosynthetic processGO:00327743800.098
transmembrane transportGO:00550854120.097
circulatory system processGO:00030131830.096
camp metabolic processGO:0046058630.096
regulation of transcription from rna polymerase ii promoterGO:00063572340.095
receptor metabolic processGO:0043112180.095
cognitionGO:0050890920.095
phototransduction visible lightGO:000760320.094
cellular calcium ion homeostasisGO:00068741600.093
cyclic nucleotide metabolic processGO:0009187800.091
response to cytokineGO:00340972150.090
single organism biosynthetic processGO:00447113420.090
regulation of signal transductionGO:00099663180.089
positive regulation of cellular biosynthetic processGO:00313282950.089
head developmentGO:00603222470.089
calcium ion homeostasisGO:00550741620.088
negative regulation of signalingGO:00230571570.087
intracellular signal transductionGO:00355563140.085
negative regulation of cell deathGO:00605482290.084
cell projection organizationGO:00300303020.083
ion transmembrane transportGO:00342203650.083
response to cocaineGO:0042220390.083
rhythmic processGO:00485111560.082
purine ribonucleotide metabolic processGO:00091502270.082
regulation of nucleotide biosynthetic processGO:0030808470.082
regulation of nucleotide metabolic processGO:00061401170.082
sensory perception of painGO:0019233730.081
response to hypoxiaGO:00016662310.081
reproductive processGO:00224143720.081
defense responseGO:00069521940.080
regulation of phosphorus metabolic processGO:00511743490.080
agingGO:00075682410.079
positive regulation of nucleic acid templated transcriptionGO:19035081970.078
negative regulation of cell proliferationGO:00082851190.078
regulation of protein metabolic processGO:00512462890.078
regulation of rna metabolic processGO:00512523910.077
response to nicotineGO:0035094510.076
nucleoside phosphate metabolic processGO:00067532830.076
learningGO:0007612330.076
single organism reproductive processGO:00447022970.076
transcription dna templatedGO:00063513770.075
regulation of cellular component organizationGO:00511283680.075
organophosphate metabolic processGO:00196373700.074
synaptic transmission glutamatergicGO:0035249330.074
cellular metal ion homeostasisGO:00068751720.074
multi organism reproductive processGO:00447032620.074
cell cell signalingGO:00072673350.073
nucleobase containing small molecule metabolic processGO:00550863160.073
purine containing compound biosynthetic processGO:0072522850.073
response to mechanical stimulusGO:00096121340.072
response to estrogenGO:00436272320.072
positive regulation of macromolecule biosynthetic processGO:00105572470.071
regulation of immune system processGO:00026821230.071
amine metabolic processGO:0009308380.070
multicellular organism reproductionGO:00325042330.070
immune system processGO:00023762040.070
cytosolic calcium ion homeostasisGO:00514801400.069
regulation of cyclic nucleotide biosynthetic processGO:0030802450.069
negative regulation of metabolic processGO:00098923310.068
response to radiationGO:00093141370.068
response to organophosphorusGO:00466831020.067
cellular response to lipidGO:00713962010.067
regulation of phosphorylationGO:00423252480.067
excretionGO:0007588240.066
organonitrogen compound biosynthetic processGO:19015661670.066
positive regulation of biosynthetic processGO:00098913190.066
cyclic nucleotide biosynthetic processGO:0009190630.065
development of primary female sexual characteristicsGO:0046545560.064
amino acid transportGO:0006865700.064
positive regulation of phosphorus metabolic processGO:00105622620.063
positive regulation of transportGO:00510502450.063
positive regulation of cell proliferationGO:00082842490.063
negative regulation of programmed cell deathGO:00430691830.062
response to molecule of bacterial originGO:00022371940.061
ribose phosphate biosynthetic processGO:0046390870.060
peptide metabolic processGO:0006518320.060
regulation of organic acid transportGO:0032890350.060
nucleotide metabolic processGO:00091172790.059
multicellular organismal reproductive processGO:00486092330.059
regulation of transcription dna templatedGO:00063553740.059
monocarboxylic acid biosynthetic processGO:0072330480.058
protein phosphorylationGO:00064683450.058
positive regulation of phosphate metabolic processGO:00459372620.058
protein tetramerizationGO:0051262380.057
cellular response to cytokine stimulusGO:00713451270.057
amine transportGO:0015837570.055
learning or memoryGO:0007611900.055
cation transportGO:00068123820.055
chemical homeostasisGO:00488782920.055
regulation of transmembrane transportGO:00347621220.055
protein homooligomerizationGO:0051260910.055
regulation of heart contractionGO:0008016480.055
positive regulation of signalingGO:00230562700.055
cellular cation homeostasisGO:00300031800.054
protein complex subunit organizationGO:00718223020.054
cellular response to abiotic stimulusGO:0071214850.054
purine ribonucleotide biosynthetic processGO:0009152810.054
cellular lipid metabolic processGO:00442552080.053
vascular process in circulatory systemGO:0003018960.053
regulation of rna biosynthetic processGO:20011413810.053
limbic system developmentGO:0021761380.052
negative regulation of cell communicationGO:00106481580.051
regulation of hormone levelsGO:00108171870.051
regulation of system processGO:00440572080.051
regulation of amine transportGO:0051952540.050
purine nucleotide biosynthetic processGO:0006164830.050
sexual reproductionGO:00199531480.050
response to oxidative stressGO:00069791860.050
regulation of membrane potentialGO:00423911100.049
organic acid biosynthetic processGO:0016053830.049
reproductionGO:00000032450.049
regulation of programmed cell deathGO:00430673410.048
ribonucleotide metabolic processGO:00092592310.048
urogenital system developmentGO:0001655780.048
negative regulation of secretion by cellGO:1903531720.048
response to insulinGO:00328681330.046
negative regulation of macromolecule metabolic processGO:00106052600.046
potassium ion transmembrane transportGO:0071805710.046
protein heterooligomerizationGO:0051291890.046
purine containing compound metabolic processGO:00725212530.046
synaptic transmission glycinergicGO:006001220.045
response to toxic substanceGO:00096361330.045
carbohydrate derivative biosynthetic processGO:19011371240.045
regulation of hormone secretionGO:00468831060.044
desensitization of g protein coupled receptor protein signaling pathwayGO:0002029100.044
nucleotide biosynthetic processGO:0009165980.043
positive regulation of developmental processGO:00510942830.043
response to metal ionGO:00100382530.043
negative regulation of phosphorus metabolic processGO:0010563800.042
adaptation of signaling pathwayGO:0023058100.042
response to bacteriumGO:00096172000.042
regulation of anion transportGO:0044070430.042
response to electrical stimulusGO:0051602560.042
positive regulation of transcription dna templatedGO:00458931970.041
regulation of mapk cascadeGO:00434081160.041
regulation of leukocyte activationGO:0002694450.041
c21 steroid hormone biosynthetic processGO:0006700100.041
regulation of cell proliferationGO:00421273590.041
regulation of purine nucleotide biosynthetic processGO:1900371460.040
multi multicellular organism processGO:00447061380.040
oxidation reduction processGO:00551143040.040
regulation of locomotionGO:00400121480.040
peptide transportGO:0015833970.039
cellular component movementGO:00069282480.039
regulation of peptide hormone secretionGO:0090276800.039
regulation of peptide secretionGO:0002791820.038
response to inorganic substanceGO:00100353770.038
macromolecule localizationGO:00330362520.038
cellular amine metabolic processGO:0044106380.038
negative regulation of cell differentiationGO:0045596990.038
regulation of cellular protein metabolic processGO:00322682670.038
regulation of multicellular organismal developmentGO:20000263760.037
positive regulation of rna metabolic processGO:00512542030.037
monocarboxylic acid transportGO:0015718520.037
neuron developmentGO:00486662860.037
cellular response to nitrogen compoundGO:19016992100.037
fatty acid metabolic processGO:0006631990.037
positive regulation of amine transportGO:0051954260.036
regulation of cellular amine metabolic processGO:003323880.036
behaviorGO:00076102050.036
peptide hormone secretionGO:0030072840.036
heart processGO:0003015570.036
positive regulation of nucleotide metabolic processGO:0045981910.036
regulation of homeostatic processGO:00328441010.036
negative regulation of secretionGO:0051048820.036
proteolysisGO:00065081750.036
positive regulation of signal transductionGO:00099671750.036
negative regulation of nucleotide metabolic processGO:0045980230.035
positive regulation of multicellular organismal processGO:00512403870.035
memoryGO:0007613540.035
regulation of glutamate secretionGO:0014048170.035
cellular response to endogenous stimulusGO:00714953770.035
response to histamineGO:003477630.034
response to extracellular stimulusGO:00099913800.034
immune responseGO:00069551040.034
renal system processGO:0003014400.033
detection of visible lightGO:000958430.033
positive regulation of gene expressionGO:00106282440.033
positive regulation of molecular functionGO:00440932300.033
regulation of smooth muscle cell proliferationGO:0048660750.033
organelle organizationGO:00069962660.032
peristalsisGO:003043220.032
kidney developmentGO:0001822670.032
response to amineGO:0014075460.032
phasic smooth muscle contractionGO:001482130.032
regulation of apoptotic processGO:00429813350.032
regulation of camp biosynthetic processGO:0030817380.032
response to lipopolysaccharideGO:00324961910.032
secretionGO:00469033070.032
neuropeptide signaling pathwayGO:0007218290.032
cellular ketone metabolic processGO:0042180510.031
renal sodium excretionGO:0035812200.031
synaptic transmission cholinergicGO:0007271110.031
response to glucoseGO:00097491360.031
negative regulation of phosphate metabolic processGO:0045936800.031
cellular response to biotic stimulusGO:0071216590.030
positive regulation of protein phosphorylationGO:00019341350.030
multicellular organism growthGO:003526410.030
calcium ion transmembrane transportGO:0070588700.030
regulation of blood pressureGO:0008217830.030
regulation of calcium ion transportGO:0051924770.030
ovulation cycle processGO:0022602500.029
locomotionGO:00400112370.029
cellular amino acid metabolic processGO:00065201070.029
negative regulation of neurogenesisGO:0050768780.029
response to hexoseGO:00097461440.029
anatomical structure morphogenesisGO:00096532980.029
regulation of neuron differentiationGO:00456642080.029
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.029
negative adaptation of signaling pathwayGO:0022401100.028
cell motilityGO:00488702020.028
lymphocyte activationGO:0046649430.028
negative regulation of cell developmentGO:0010721820.028
negative regulation of gene expressionGO:00106291990.028
alcohol metabolic processGO:0006066770.028
female pregnancyGO:00075651220.028
lipid biosynthetic processGO:00086101280.028
positive regulation of immune system processGO:0002684900.028
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.028
secretion by cellGO:00329402480.028
phenol containing compound metabolic processGO:0018958300.027
insecticide metabolic processGO:001714340.027
regulation of g protein coupled receptor protein signaling pathwayGO:0008277280.027
regulation of neuron deathGO:19012141150.027
micturitionGO:006007340.027
fatty acid transportGO:0015908250.027
cellular response to oxygen containing compoundGO:19017013860.027
second messenger mediated signalingGO:0019932510.026
female gonad developmentGO:0008585530.026
carbohydrate homeostasisGO:0033500750.026
negative regulation of signal transductionGO:0009968830.026
cellular response to glucocorticoid stimulusGO:0071385680.026
positive regulation of cellular protein metabolic processGO:00322701670.026
regulation of neurotransmitter levelsGO:0001505420.026
cellular response to histamineGO:007142030.026
regulation of circadian sleep wake cycleGO:0042749180.026
regulation of insulin secretionGO:0050796650.025
cellular response to ammonium ionGO:0071242170.025
negative regulation of ion transportGO:0043271510.025
regulation of anatomical structure sizeGO:00900661350.025
sensory perception of light stimulusGO:005095330.025
response to estradiolGO:00323551640.025
forebrain developmentGO:0030900980.025
cellular potassium ion transportGO:0071804720.025
negative regulation of amine transportGO:0051953240.024
negative regulation of biosynthetic processGO:00098901680.024
positive regulation of protein metabolic processGO:00512471780.024
peptide secretionGO:0002790860.024
single organism organelle organizationGO:19025891800.024
potassium ion transportGO:0006813970.024
response to external biotic stimulusGO:00432072210.024
vesicle mediated transportGO:00161921810.024
neuron projection developmentGO:00311752730.024
regulation of metal ion transportGO:00109591180.024
ribose phosphate metabolic processGO:00196932350.024
eye developmentGO:0001654500.024
regulation of vesicle mediated transportGO:0060627810.024
cell type specific apoptotic processGO:00972851340.023
response to biotic stimulusGO:00096072260.023
regulation of nervous system developmentGO:00519602640.023
hormone transportGO:00099141210.023
cellular response to metal ionGO:0071248550.023
calcium ion transportGO:00068161310.023
cellular response to organonitrogen compoundGO:00714171970.023
cellular hormone metabolic processGO:0034754490.023
negative regulation of cellular component organizationGO:0051129830.023
positive regulation of response to stimulusGO:00485842850.023
monovalent inorganic cation transportGO:00156721720.023
leukocyte differentiationGO:0002521300.023
mapk cascadeGO:00001651400.023
regulation of peptide transportGO:0090087870.022
regulation of mononuclear cell proliferationGO:0032944260.022
regulation of catalytic activityGO:00507903040.022
regulation of amino acid transportGO:0051955250.022
positive regulation of purine nucleotide biosynthetic processGO:1900373360.022
response to monosaccharideGO:00342841590.022
regulation of cell activationGO:0050865500.022
regulation of hydrolase activityGO:00513361430.022
hippocampus developmentGO:0021766300.022
response to ketoneGO:19016541820.021
protein transportGO:00150311320.021
regulation of organelle organizationGO:0033043800.021
positive regulation of secretionGO:00510471400.021
positive regulation of cyclic nucleotide biosynthetic processGO:0030804340.021
cellular response to molecule of bacterial originGO:0071219560.021
regulation of transferase activityGO:00513381230.021
regulation of heart rateGO:0002027160.021
detection of abiotic stimulusGO:0009582130.021
cellular response to hormone stimulusGO:00328702470.021
regulation of cell developmentGO:00602842630.021
positive regulation of cell communicationGO:00106472710.021
protein maturationGO:0051604680.021
positive regulation of blood circulationGO:1903524650.021
cellular response to lipopolysaccharideGO:0071222550.021
positive regulation of catalytic activityGO:00430851840.020
regulation of protein phosphorylationGO:00019321830.020
negative regulation of nucleobase containing compound metabolic processGO:00459341530.020
visual perceptionGO:000760130.020
positive regulation of peptide hormone secretionGO:0090277500.020
response to woundingGO:00096112540.020
cellular amide metabolic processGO:0043603440.020
cellular response to corticosteroid stimulusGO:0071384690.020
positive regulation of cyclic nucleotide metabolic processGO:0030801370.020
negative regulation of cellular protein metabolic processGO:00322691060.020
regulation of leukocyte proliferationGO:0070663260.020
positive regulation of leukocyte activationGO:0002696300.019
calcium ion importGO:0070509220.019
cell migrationGO:00164771970.019
glucose homeostasisGO:0042593750.019
signal releaseGO:00230611450.019
neurotransmitter transportGO:0006836420.019
dicarboxylic acid transportGO:0006835340.019
ovulation cycleGO:0042698670.019
response to temperature stimulusGO:0009266940.019
reactive oxygen species metabolic processGO:0072593370.019
regulation of molecular functionGO:00650093980.019
muscle system processGO:00030121150.019
response to amphetamineGO:0001975250.018
sodium ion transmembrane transportGO:0035725670.018
telencephalon developmentGO:0021537620.018
negative regulation of nitrogen compound metabolic processGO:00511721610.018
positive regulation of phosphorylationGO:00423271770.018
response to reactive oxygen speciesGO:00003021200.018
regulation of saliva secretionGO:004687730.018
heart contractionGO:0060047570.018
gamete generationGO:00072761240.018
associative learningGO:0008306190.018
response to peptideGO:19016522920.018
negative regulation of g protein coupled receptor protein signaling pathwayGO:0045744150.018
receptor mediated endocytosisGO:0006898420.018
response to ethanolGO:00454711620.018
hemopoiesisGO:0030097340.018
catechol containing compound metabolic processGO:0009712190.018
positive regulation of protein modification processGO:00314011420.018
cellular catabolic processGO:00442482950.018
positive regulation of mononuclear cell proliferationGO:0032946200.017
spinal cord developmentGO:0021510270.017
protein localizationGO:00081041910.017
cellular response to stressGO:00335542690.017
response to heatGO:0009408600.017
positive regulation of long term synaptic potentiationGO:190027340.017
fatty acid biosynthetic processGO:0006633330.017
epithelium developmentGO:0060429960.017
positive regulation of cellular amine metabolic processGO:003324030.017
regulation of synaptic transmissionGO:00508041410.017
response to cgmpGO:007030530.017
circadian rhythmGO:0007623880.017
insulin secretionGO:0030073690.017
intracellular transportGO:00469071850.017
cgmp biosynthetic processGO:0006182150.017
negative regulation of neuron differentiationGO:0045665620.017
digestionGO:0007586260.016
organic substance catabolic processGO:19015753160.016
calcium mediated signalingGO:0019722230.016
catabolic processGO:00090563510.016
positive regulation of organic acid transportGO:0032892220.016
hormone secretionGO:00468791150.016
regulation of skeletal muscle tissue regenerationGO:004341620.016
response to nutrient levelsGO:00316673700.016
gamma aminobutyric acid transportGO:001581280.016
single organism cellular localizationGO:19025801020.016
regulation of cellular carbohydrate metabolic processGO:0010675390.016
cellular response to hexose stimulusGO:0071331650.016
positive regulation of nervous system developmentGO:00519621780.016
sex differentiationGO:00075481130.016
lipid metabolic processGO:00066292830.016
cellular response to carbohydrate stimulusGO:0071322720.016
negative regulation of purine nucleotide metabolic processGO:1900543230.016
phospholipid metabolic processGO:0006644610.015
regulation of ion homeostasisGO:2000021630.015
regulation of blood circulationGO:19035221100.015
positive regulation of cellular component organizationGO:00511302000.015
regulation of cellular amino acid metabolic processGO:000652120.015
response to other organismGO:00517072200.015
leukocyte cell cell adhesionGO:000715940.015
regulation of lymphocyte proliferationGO:0050670260.015
positive regulation of cellular amino acid metabolic processGO:004576410.015
dephosphorylationGO:0016311980.015
negative regulation of nervous system developmentGO:0051961790.015
response to nutrientGO:00075842480.015
negative regulation of protein processingGO:0010955470.015
regulation of purine nucleotide metabolic processGO:19005421150.015
response to cadmium ionGO:0046686350.015
regulation of excretionGO:0044062210.015
divalent metal ion transportGO:00708381320.015
positive regulation of apoptotic processGO:00430651540.015
positive regulation of hormone secretionGO:0046887650.015
transmission of nerve impulseGO:0019226420.015
male gamete generationGO:0048232990.015
negative regulation of peptidase activityGO:0010466380.015
cellular response to glucose stimulusGO:0071333650.015
positive regulation of cellular component biogenesisGO:0044089550.015
response to tumor necrosis factorGO:0034612560.014
response to dexamethasoneGO:0071548490.014
negative regulation of ion transmembrane transportGO:0034766160.014
biological adhesionGO:00226101100.014
positive regulation of lymphocyte proliferationGO:0050671200.014
smooth muscle contraction involved in micturitionGO:006008310.014
b cell differentiationGO:003018320.014
development of primary sexual characteristicsGO:00451371070.014
choline transportGO:001587140.014

Impg2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
retinal diseaseDOID:567900.202
Human
retinal degenerationDOID:846600.202
Human
sensory system diseaseDOID:005015500.202
Human
eye diseaseDOID:561400.202
Human
nervous system diseaseDOID:86300.202
Human
disease of anatomical entityDOID:700.202
Human
eye and adnexa diseaseDOID:149200.202
Human
retinitis pigmentosaDOID:1058400.202
Human
inherited metabolic disorderDOID:65500.025
disease of metabolismDOID:001466700.025
cardiovascular system diseaseDOID:128700.020