Rattus norvegicus

52 known processes

Pah

phenylalanine hydroxylase

Pah biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
alpha amino acid metabolic processGO:1901605710.788
organic acid metabolic processGO:00060822920.451
aromatic amino acid family metabolic processGO:000907290.403
carboxylic acid metabolic processGO:00197522890.344
oxoacid metabolic processGO:00434362900.288
organic substance catabolic processGO:19015753160.277
Fly
alpha amino acid biosynthetic processGO:1901607230.267
cellular amino acid metabolic processGO:00065201070.240
aromatic amino acid family catabolic processGO:000907470.226
Fly
cellular amino acid biosynthetic processGO:0008652320.226
carboxylic acid catabolic processGO:0046395490.223
Fly
nitrogen cycle metabolic processGO:007194150.194
urea metabolic processGO:001962750.192
cellular amino acid catabolic processGO:0009063210.182
Fly
cellular catabolic processGO:00442482950.180
Fly
response to extracellular stimulusGO:00099913800.171
Rat
response to glucocorticoidGO:00513842230.166
Rat
response to nutrientGO:00075842480.166
organic acid biosynthetic processGO:0016053830.163
single organism biosynthetic processGO:00447113420.157
response to metal ionGO:00100382530.152
Rat
response to nutrient levelsGO:00316673700.148
Rat
single organism catabolic processGO:00447122830.141
Fly
small molecule catabolic processGO:0044282590.133
Fly
catabolic processGO:00090563510.127
Fly
response to corticosteroidGO:00319602350.124
Rat
response to hypoxiaGO:00016662310.117
Rat
cellular lipid metabolic processGO:00442552080.102
Rat
organonitrogen compound catabolic processGO:19015651790.100
Fly
coenzyme metabolic processGO:0006732860.097
response to peptide hormoneGO:00434342780.095
Rat
agingGO:00075682410.092
Rat
glutamine family amino acid metabolic processGO:0009064150.091
programmed cell deathGO:00125013920.088
sulfur compound metabolic processGO:0006790700.087
fatty acid metabolic processGO:0006631990.087
Rat
apoptotic processGO:00069153810.086
carboxylic acid biosynthetic processGO:0046394830.086
cellular response to oxygen containing compoundGO:19017013860.080
Rat
response to peptideGO:19016522920.080
Rat
macromolecular complex assemblyGO:00650032730.077
cellular amine metabolic processGO:0044106380.076
response to oxygen levelsGO:00704822650.070
Rat
regulation of secretionGO:00510462240.069
regulation of apoptotic processGO:00429813350.068
alpha amino acid catabolic processGO:1901606200.065
Fly
nitrogen compound transportGO:00717052290.062
Rat
cofactor metabolic processGO:0051186950.061
amine metabolic processGO:0009308380.060
response to campGO:0051591910.060
aromatic compound catabolic processGO:00194391680.058
Fly
response to organophosphorusGO:00466831020.058
response to acid chemicalGO:00011012220.056
Rat
regulation of programmed cell deathGO:00430673410.055
glycine metabolic processGO:000654470.053
secretionGO:00469033070.051
response to corticosteroneGO:0051412400.051
Rat
cellular response to lipidGO:00713962010.051
cellular response to organonitrogen compoundGO:00714171970.051
Rat
carbohydrate metabolic processGO:00059751300.050
cellular ketone metabolic processGO:0042180510.050
lipid catabolic processGO:0016042460.049
regulation of cellular ketone metabolic processGO:0010565270.048
cellular lipid catabolic processGO:0044242370.048
regulation of cellular amino acid metabolic processGO:000652120.048
cellular response to insulin stimulusGO:0032869810.047
response to inorganic substanceGO:00100353770.047
Rat
regulation of secretion by cellGO:19035302080.046
response to transition metal nanoparticleGO:19902671220.046
Rat
positive regulation of cell deathGO:00109421840.046
arginine metabolic processGO:000652560.045
positive regulation of programmed cell deathGO:00430681570.045
cellular modified amino acid metabolic processGO:0006575610.045
regulation of cell differentiationGO:00455953200.044
negative regulation of multicellular organismal processGO:00512412030.044
Rat
cation transportGO:00068123820.044
positive regulation of cellular biosynthetic processGO:00313282950.044
macromolecular complex subunit organizationGO:00439333390.044
thioester metabolic processGO:0035383280.043
response to estrogenGO:00436272320.043
Rat
cellular response to peptide hormone stimulusGO:00713751200.043
negative regulation of macromolecule metabolic processGO:00106052600.042
female pregnancyGO:00075651220.042
cellular component biogenesisGO:00440853680.042
cellular response to nitrogen compoundGO:19016992100.042
Rat
regulation of cellular component organizationGO:00511283680.042
cellular response to stressGO:00335542690.041
organic cyclic compound catabolic processGO:19013611750.041
Fly
positive regulation of cellular amine metabolic processGO:003324030.041
serine family amino acid metabolic processGO:0009069120.040
liver developmentGO:0001889900.040
response to growth factorGO:00708481890.039
Rat
sulfur amino acid metabolic processGO:000009690.039
catenin import into nucleusGO:003541110.039
response to insulinGO:00328681330.038
organic acid catabolic processGO:0016054490.038
Fly
regulation of reactive oxygen species metabolic processGO:2000377260.038
extracellular matrix constituent secretionGO:007027840.037
protein complex assemblyGO:00064612630.037
reactive nitrogen species metabolic processGO:200105710.037
cellular response to glucocorticoid stimulusGO:0071385680.037
regulation of ion transportGO:00432692450.036
small molecule biosynthetic processGO:00442831240.036
positive regulation of apoptotic processGO:00430651540.035
oxidation reduction processGO:00551143040.034
regulation of serine type peptidase activityGO:190257110.034
central nervous system developmentGO:00074173110.034
Rat
negative regulation of nitrogen compound metabolic processGO:00511721610.034
response to oxidative stressGO:00069791860.033
reproductionGO:00000032450.033
regulation of extracellular matrix constituent secretionGO:000333020.033
protein complex biogenesisGO:00702712630.033
indolalkylamine metabolic processGO:000658650.033
negative regulation of cell deathGO:00605482290.033
response to carbohydrateGO:00097431830.033
Rat
regulation of catalytic activityGO:00507903040.033
defense responseGO:00069521940.032
glycerolipid metabolic processGO:0046486670.032
monocarboxylic acid metabolic processGO:00327871520.032
Rat
reactive oxygen species biosynthetic processGO:190340980.032
regulation of cellular amine metabolic processGO:003323880.032
urea cycleGO:000005050.031
reactive oxygen species metabolic processGO:0072593370.031
negative regulation of gene expressionGO:00106291990.031
response to cytokineGO:00340972150.031
cellular response to organic cyclic compoundGO:00714072020.031
Rat
monovalent inorganic cation transportGO:00156721720.030
single organism reproductive processGO:00447022970.030
reproductive processGO:00224143720.030
response to molecule of bacterial originGO:00022371940.030
Rat
hepaticobiliary system developmentGO:0061008900.030
cellular response to external stimulusGO:00714961180.030
negative regulation of protein metabolic processGO:00512481140.030
response to methanolGO:003398610.029
response to ketoneGO:19016541820.029
Rat
secretion by cellGO:00329402480.029
cellular hormone metabolic processGO:0034754490.029
gland developmentGO:00487321550.028
multi organism reproductive processGO:00447032620.028
regulation of hormone levelsGO:00108171870.027
negative regulation of metabolic processGO:00098923310.027
regulation of protein metabolic processGO:00512462890.027
response to vitaminGO:00332731310.027
regulation of cellular localizationGO:00603412630.027
nucleobase containing small molecule metabolic processGO:00550863160.027
organonitrogen compound biosynthetic processGO:19015661670.027
cellular response to steroid hormone stimulusGO:0071383930.026
response to other organismGO:00517072200.026
Rat
positive regulation of cellular amino acid metabolic processGO:004576410.026
positive regulation of nitrogen compound metabolic processGO:00511733340.026
sulfur compound biosynthetic processGO:0044272190.026
cellular response to campGO:0071320260.026
anion transportGO:00068201780.026
cellular response to cytokine stimulusGO:00713451270.025
response to purine containing compoundGO:00140741260.025
organ regenerationGO:00311001010.025
response to fatty acidGO:0070542650.025
regulation of catabolic processGO:00098941130.025
monocarboxylic acid biosynthetic processGO:0072330480.025
cellular response to endogenous stimulusGO:00714953770.025
Rat
negative regulation of programmed cell deathGO:00430691830.025
multi multicellular organism processGO:00447061380.024
negative regulation of cellular metabolic processGO:00313242810.024
positive regulation of extracellular matrix constituent secretionGO:000333120.024
proteolysisGO:00065081750.024
brain developmentGO:00074202470.024
Rat
response to alkaloidGO:00432791320.024
Rat
organic anion transportGO:00157111320.023
regulation of reactive oxygen species biosynthetic processGO:190342650.023
cellular response to hormone stimulusGO:00328702470.023
regulation of phosphate metabolic processGO:00192203490.023
protein complex subunit organizationGO:00718223020.023
response to hexoseGO:00097461440.023
Rat
single organism carbohydrate metabolic processGO:00447231180.023
cell projection organizationGO:00300303020.022
response to toxic substanceGO:00096361330.022
Rat
regulation of cellular protein metabolic processGO:00322682670.022
cellular nitrogen compound catabolic processGO:00442701630.022
tube developmentGO:0035295890.022
negative regulation of cellular protein metabolic processGO:00322691060.022
regulation of cell developmentGO:00602842630.022
positive regulation of neuron differentiationGO:00456661260.022
response to ethanolGO:00454711620.022
Rat
dicarboxylic acid metabolic processGO:0043648420.021
Rat
behaviorGO:00076102050.021
Rat Fly
protein phosphorylationGO:00064683450.021
response to mercury ionGO:0046689150.021
vesicle mediated transportGO:00161921810.021
Rat Fly
hormone metabolic processGO:0042445690.021
response to amino acidGO:0043200750.021
anatomical structure morphogenesisGO:00096532980.021
protein homooligomerizationGO:0051260910.021
heterocycle catabolic processGO:00467001670.021
cellular component assemblyGO:00226073600.021
regulation of molecular functionGO:00650093980.021
macromolecule catabolic processGO:0009057580.021
positive regulation of catalytic activityGO:00430851840.021
innate immune responseGO:0045087350.020
response to monosaccharideGO:00342841590.020
Rat
ribonucleoside metabolic processGO:00091191740.020
negative regulation of serine type peptidase activityGO:190257210.020
kidney developmentGO:0001822670.020
serine family amino acid biosynthetic processGO:000907040.020
acyl coa metabolic processGO:0006637280.020
organic acid transportGO:00158491160.020
response to reactive oxygen speciesGO:00003021200.020
positive regulation of transcription dna templatedGO:00458931970.020
insulin secretionGO:0030073690.019
urogenital system developmentGO:0001655780.019
response to temperature stimulusGO:0009266940.019
positive regulation of phosphate metabolic processGO:00459372620.019
positive regulation of nucleic acid templated transcriptionGO:19035081970.019
indole containing compound metabolic processGO:0042430110.018
cellular response to metal ionGO:0071248550.018
Rat
benzene containing compound metabolic processGO:0042537220.018
Rat
negative regulation of cell communicationGO:00106481580.018
blood circulationGO:00080151830.018
response to triglycerideGO:003401430.018
response to decreased oxygen levelsGO:00362932370.018
Rat
negative regulation of catalytic activityGO:00430861030.018
regulation of rna biosynthetic processGO:20011413810.017
indolalkylamine catabolic processGO:004621850.017
positive regulation of extracellular matrix organizationGO:190305540.017
digestive system developmentGO:0055123410.017
response to mineralocorticoidGO:0051385490.017
Rat
carbohydrate derivative metabolic processGO:19011353460.017
Rat
protein localizationGO:00081041910.017
negative regulation of developmental processGO:00510931250.017
regenerationGO:00310991630.017
diterpenoid metabolic processGO:0016101330.017
regulation of blood vessel sizeGO:0050880890.017
skeletal system developmentGO:0001501410.017
positive regulation of immunoglobulin productionGO:000263940.017
positive regulation of secretionGO:00510471400.016
cellular biogenic amine catabolic processGO:004240290.016
regulation of neuron differentiationGO:00456642080.016
protein oligomerizationGO:00512591910.016
response to activityGO:0014823730.016
Rat
locomotionGO:00400112370.016
regulation of neurogenesisGO:00507672470.016
isoprenoid metabolic processGO:0006720450.016
Rat
regulation of neuron projection developmentGO:00109751610.016
positive regulation of molecular functionGO:00440932300.016
organic hydroxy compound metabolic processGO:19016151150.016
Rat
nucleoside metabolic processGO:00091161790.016
rna metabolic processGO:00160704060.016
cellular response to peptideGO:19016531330.016
regulation of transcription dna templatedGO:00063553740.016
ossificationGO:0001503700.016
Rat
negative regulation of molecular functionGO:00440921330.016
response to glucoseGO:00097491360.016
Rat
chemical homeostasisGO:00488782920.016
Rat
response to vitamin eGO:0033197240.015
glycosyl compound metabolic processGO:19016571820.015
Rat
positive regulation of biosynthetic processGO:00098913190.015
response to starvationGO:0042594590.015
regulation of immunoglobulin productionGO:000263740.015
g protein coupled receptor signaling pathwayGO:00071862420.015
cell cell signalingGO:00072673350.015
Rat
lipid metabolic processGO:00066292830.015
Rat
regulation of anatomical structure sizeGO:00900661350.015
cell adhesionGO:00071551100.015
response to vitamin b6GO:003451610.015
cellular response to alcoholGO:0097306870.015
cellular response to extracellular stimulusGO:0031668730.015
positive regulation of secretion by cellGO:19035321280.015
negative regulation of transportGO:00510511360.015
cellular macromolecule localizationGO:00707271220.015
acetyl coa metabolic processGO:0006084170.015
positive regulation of lipid catabolic processGO:005099640.015
regulation of multicellular organismal developmentGO:20000263760.015
positive regulation of cellular component organizationGO:00511302000.015
regulation of cell projection organizationGO:00313441750.015
negative regulation of serine type endopeptidase activityGO:190000410.015
intracellular signal transductionGO:00355563140.015
embryonic skeletal system developmentGO:004870630.015
organic hydroxy compound transportGO:0015850770.014
positive regulation of multicellular organismal processGO:00512403870.014
cellular response to interferon gammaGO:0071346140.014
cellular response to growth factor stimulusGO:00713631620.014
Rat
negative regulation of biosynthetic processGO:00098901680.014
organophosphate biosynthetic processGO:00904071430.014
positive regulation of reactive oxygen species metabolic processGO:2000379160.014
telencephalon developmentGO:0021537620.014
Rat
negative regulation of signalingGO:00230571570.014
response to interferon gammaGO:0034341200.014
peptide hormone secretionGO:0030072840.014
response to dexamethasoneGO:0071548490.014
response to muscle activity involved in regulation of muscle adaptationGO:001487320.014
glucose metabolic processGO:0006006520.014
multicellular organism growthGO:003526410.014
dna metabolic processGO:0006259960.014
axis specificationGO:000979840.014
heart morphogenesisGO:000300730.013
regulation of nervous system developmentGO:00519602640.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
regulation of serine type endopeptidase activityGO:190000310.013
response to platinum ionGO:007054140.013
response to vitamin aGO:0033189360.013
cellular response to corticosteroid stimulusGO:0071384690.013
divalent inorganic cation transportGO:00725111340.013
angiotensin mediated drinking behaviorGO:000305120.013
hormone secretionGO:00468791150.013
nucleoside phosphate metabolic processGO:00067532830.013
regulation of transferase activityGO:00513381230.013
regulation of hydrolase activityGO:00513361430.013
bile acid biosynthetic processGO:000669930.013
hormone transportGO:00099141210.013
cell growthGO:00160491040.013
response to external biotic stimulusGO:00432072210.013
Rat
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.013
positive regulation of macromolecule biosynthetic processGO:00105572470.013
amide biosynthetic processGO:0043604100.013
response to testosteroneGO:0033574550.013
neuron projection developmentGO:00311752730.013
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.013
amide transportGO:00428861050.013
positive regulation of hydrolase activityGO:0051345860.013
protein homotetramerizationGO:0051289250.013
cellular response to glucose stimulusGO:0071333650.013
Rat
regulation of phosphorus metabolic processGO:00511743490.013
insecticide metabolic processGO:001714340.013
cation transmembrane transportGO:00986552630.013
divalent metal ion transportGO:00708381320.013
response to estradiolGO:00323551640.013
Rat
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.013
negative regulation of response to stimulusGO:00485851550.012
nucleic acid templated transcriptionGO:00976593790.012
single organism intracellular transportGO:19025821660.012
positive regulation of rna metabolic processGO:00512542030.012
immunoglobulin mediated immune responseGO:001606440.012
triglyceride metabolic processGO:0006641210.012
rna biosynthetic processGO:00327743800.012
regulation of rna metabolic processGO:00512523910.012
organophosphate catabolic processGO:00464341480.012
positive regulation of nucleobase containing compound metabolic processGO:00459353190.012
regulation of cellular catabolic processGO:00313291010.012
protein transportGO:00150311320.012
positive regulation of rna biosynthetic processGO:19026801970.012
tryptophan metabolic processGO:000656850.012
cell migrationGO:00164771970.012
response to foodGO:0032094270.012
terpenoid metabolic processGO:0006721370.012
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.012
ion homeostasisGO:00508012120.012
cation homeostasisGO:00550801950.012
head developmentGO:00603222470.012
Rat
response to woundingGO:00096112540.012
purine ribonucleoside metabolic processGO:00461281680.012
response to lead ionGO:0010288330.012
monocarboxylic acid catabolic processGO:0072329280.012
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressureGO:000199910.012
regulation of insulin secretionGO:0050796650.012
response to bacteriumGO:00096172000.012
Rat
regulation of tube sizeGO:0035150890.012
intracellular protein transportGO:0006886790.012
ribonucleoside triphosphate catabolic processGO:00092031220.011
regulation of protein modification processGO:00313991940.011
nucleobase containing compound catabolic processGO:00346551520.011
macromolecule localizationGO:00330362520.011
rhythmic processGO:00485111560.011
Rat
fertilizationGO:000956630.011
protein localization to organelleGO:0033365570.011
multicellular organismal reproductive processGO:00486092330.011
carbohydrate derivative catabolic processGO:19011361470.011
regulation of cell growthGO:0001558850.011
cell type specific apoptotic processGO:00972851340.011
anterior posterior pattern specificationGO:000995210.011
small gtpase mediated signal transductionGO:0007264360.011
negative regulation of apoptotic processGO:00430661810.011
positive regulation of phosphorus metabolic processGO:00105622620.011
organophosphate metabolic processGO:00196373700.011
regulation of organelle organizationGO:0033043800.011
regulation of kinase activityGO:00435491170.011
transcription from rna polymerase ii promoterGO:00063662520.011
cellular response to acid chemicalGO:0071229750.011
gonad developmentGO:00084061040.011
vitamin transportGO:0051180140.011
positive regulation of immunoglobulin mediated immune responseGO:000289120.011
localization of cellGO:00516742020.011
purine nucleoside metabolic processGO:00422781690.011
response to chromateGO:004668730.011
sulfur amino acid biosynthetic processGO:000009750.011
lipid storageGO:001991510.011
negative regulation of cellular biosynthetic processGO:00313271610.011
negative regulation of cellular component organizationGO:0051129830.011
nucleoside triphosphate catabolic processGO:00091431230.011
cellular metal ion homeostasisGO:00068751720.011
lipid biosynthetic processGO:00086101280.011
amine catabolic processGO:000931090.011
metal ion transportGO:00300012890.011
positive regulation of catabolic processGO:0009896780.011
transmission of nerve impulseGO:0019226420.011
positive regulation of cell communicationGO:00106472710.011
jak stat cascadeGO:0007259260.011
regulation of mapk cascadeGO:00434081160.011
renal system developmentGO:0072001670.011
glutamate metabolic processGO:000653630.011
negative regulation of growthGO:0045926370.010
chromosome segregationGO:000705920.010
regulation of cell proliferationGO:00421273590.010
negative regulation of rna biosynthetic processGO:19026791180.010
establishment of protein localizationGO:00451841410.010
positive regulation of protein metabolic processGO:00512471780.010
regulation of intracellular signal transductionGO:19025312180.010
regulation of protein phosphorylationGO:00019321830.010
ras protein signal transductionGO:0007265290.010
negative regulation of rna metabolic processGO:00512531230.010
response to vitamin dGO:0033280340.010
renin angiotensin regulation of aldosterone productionGO:000201830.010
signal releaseGO:00230611450.010
carbohydrate homeostasisGO:0033500750.010
Rat
positive regulation of cellular catabolic processGO:0031331710.010
dicarboxylic acid transportGO:0006835340.010

Pah disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.025
Human
inherited metabolic disorderDOID:65500.025
Human
nervous system diseaseDOID:86300.011
disease of anatomical entityDOID:700.011
congenital adrenal hyperplasiaDOID:005081100.011
steroid inherited metabolic disorderDOID:170100.011
lipid metabolism disorderDOID:314600.011