IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

March5

membrane-associated ring finger (C3HC4) 5

(Aliases: Rnf153)

Ensembl: ENSRNOG00000017396
Entrez: 294079
RGD: 1305617
UniProtKB: B0BNF6

Process Predictions
Disease Predictions

March5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
protein modification by small protein conjugation or removal	GO:0070647	35	0.304
cellular response to stress	GO:0033554	269	0.238
response to uv c	GO:0010225	2	0.157
sulfur compound metabolic process	GO:0006790	70	0.146
positive regulation of intracellular protein transport	GO:0090316	20	0.144
regulation of catalytic activity	GO:0050790	304	0.142
regulation of p38mapk cascade	GO:1900744	1	0.137
response to oxidative stress	GO:0006979	186	0.134
positive regulation of locomotion	GO:0040017	102	0.133
regulation of protein metabolic process	GO:0051246	289	0.117
protein dephosphorylation	GO:0006470	38	0.113
regulation of cellular response to stress	GO:0080135	49	0.111
regulation of phosphorus metabolic process	GO:0051174	349	0.088
oxoacid metabolic process	GO:0043436	290	0.083
cell motility	GO:0048870	202	0.083
cellular response to oxidative stress	GO:0034599	76	0.082
regulation of intracellular signal transduction	GO:1902531	218	0.074
regulation of proteasomal protein catabolic process	GO:0061136	4	0.072
regulation of molecular function	GO:0065009	398	0.070
positive regulation of protein transport	GO:0051222	41	0.069
regulation of phosphate metabolic process	GO:0019220	349	0.068
protein phosphorylation	GO:0006468	345	0.068
dephosphorylation	GO:0016311	98	0.068
regulation of small gtpase mediated signal transduction	GO:0051056	48	0.066
regulation of signal transduction	GO:0009966	318	0.065
intracellular signal transduction	GO:0035556	314	0.064
gtp catabolic process	GO:0006184	71	0.063
regulation of intracellular protein transport	GO:0033157	34	0.063
cellular catabolic process	GO:0044248	295	0.063
positive regulation of phosphorus metabolic process	GO:0010562	262	0.060
programmed cell death	GO:0012501	392	0.058
catabolic process	GO:0009056	351	0.054
regulation of cell motility	GO:2000145	131	0.054
localization of cell	GO:0051674	202	0.052
neuron death	GO:0070997	127	0.051
single organism catabolic process	GO:0044712	283	0.050
organic substance catabolic process	GO:1901575	316	0.050
regulation of phosphorylation	GO:0042325	248	0.049
cellular component biogenesis	GO:0044085	368	0.047
nucleocytoplasmic transport	GO:0006913	48	0.046
protein catabolic process	GO:0030163	30	0.045
apoptotic process	GO:0006915	381	0.045
positive regulation of intracellular signal transduction	GO:1902533	138	0.045
regulation of locomotion	GO:0040012	148	0.045
response to oxygen levels	GO:0070482	265	0.044
negative regulation of phosphorus metabolic process	GO:0010563	80	0.044
small gtpase mediated signal transduction	GO:0007264	36	0.043
positive regulation of signal transduction	GO:0009967	175	0.042
negative regulation of cellular component organization	GO:0051129	83	0.041
mast cell migration	GO:0097531	4	0.039
cellular response to oxygen containing compound	GO:1901701	386	0.038
positive regulation of biosynthetic process	GO:0009891	319	0.038
proteolysis	GO:0006508	175	0.036
response to wounding	GO:0009611	254	0.036
regulation of protein modification process	GO:0031399	194	0.035
negative regulation of protein metabolic process	GO:0051248	114	0.034
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.034
macromolecular complex assembly	GO:0065003	273	0.033
regulation of stress activated protein kinase signaling cascade	GO:0070302	23	0.033
aging	GO:0007568	241	0.033
positive regulation of molecular function	GO:0044093	230	0.033
peptide biosynthetic process	GO:0043043	3	0.032
regulation of neurogenesis	GO:0050767	247	0.032
organelle organization	GO:0006996	266	0.031
ubiquitin dependent protein catabolic process	GO:0006511	14	0.031
homeostatic process	GO:0042592	331	0.031
regulation of cellular protein metabolic process	GO:0032268	267	0.031
ras protein signal transduction	GO:0007265	29	0.031
meiosis i	GO:0007127	2	0.030
response to nutrient	GO:0007584	248	0.030
stress activated protein kinase signaling cascade	GO:0031098	37	0.030
regulation of ubiquitin protein transferase activity	GO:0051438	1	0.030
regulation of cellular catabolic process	GO:0031329	101	0.030
positive regulation of cell motility	GO:2000147	97	0.030
organophosphate catabolic process	GO:0046434	148	0.030
p38mapk cascade	GO:0038066	1	0.030
macromolecule catabolic process	GO:0009057	58	0.029
response to carbohydrate	GO:0009743	183	0.029
regulation of catabolic process	GO:0009894	113	0.029
single organism organelle organization	GO:1902589	180	0.029
regulation of protein phosphorylation	GO:0001932	183	0.029
regulation of protein kinase activity	GO:0045859	105	0.029
carbohydrate metabolic process	GO:0005975	130	0.028
regulation of jnk cascade	GO:0046328	19	0.027
negative regulation of phosphorylation	GO:0042326	57	0.027
cellular response to endogenous stimulus	GO:0071495	377	0.027
nuclear transport	GO:0051169	49	0.027
positive regulation of neurogenesis	GO:0050769	165	0.027
response to reactive oxygen species	GO:0000302	120	0.027
intracellular protein transport	GO:0006886	79	0.026
cell migration	GO:0016477	197	0.026
regulation of neuron death	GO:1901214	115	0.026
carboxylic acid metabolic process	GO:0019752	289	0.026
cellular response to reactive oxygen species	GO:0034614	55	0.025
regulation of hydrolase activity	GO:0051336	143	0.025
cellular amino acid metabolic process	GO:0006520	107	0.025
organophosphate metabolic process	GO:0019637	370	0.025
guanosine containing compound catabolic process	GO:1901069	71	0.025
positive regulation of cellular biosynthetic process	GO:0031328	295	0.025
protein ubiquitination	GO:0016567	28	0.025
regulation of protein transport	GO:0051223	68	0.025
cellular ketone metabolic process	GO:0042180	51	0.025
regulation of anatomical structure morphogenesis	GO:0022603	141	0.025
regulation of protein localization	GO:0032880	81	0.024
acetyl coa metabolic process	GO:0006084	17	0.024
alpha amino acid metabolic process	GO:1901605	71	0.024
regulation of stress activated mapk cascade	GO:0032872	23	0.024
regulation of arp2 3 complex mediated actin nucleation	GO:0034315	2	0.024
ribose phosphate metabolic process	GO:0019693	235	0.024
ribonucleotide metabolic process	GO:0009259	231	0.024
negative regulation of metabolic process	GO:0009892	331	0.024
modification dependent protein catabolic process	GO:0019941	14	0.024
coenzyme metabolic process	GO:0006732	86	0.024
response to ethanol	GO:0045471	162	0.023
response to transition metal nanoparticle	GO:1990267	122	0.023
positive regulation of phosphorylation	GO:0042327	177	0.023
salivary gland development	GO:0007431	3	0.023
positive regulation of phosphate metabolic process	GO:0045937	262	0.023
positive regulation of photoreceptor cell differentiation	GO:0046534	2	0.023
cellular response to cytokine stimulus	GO:0071345	127	0.023
positive regulation of transport	GO:0051050	245	0.023
establishment of protein localization	GO:0045184	141	0.023
stress activated mapk cascade	GO:0051403	35	0.023
negative regulation of cell communication	GO:0010648	158	0.022
negative regulation of protein phosphorylation	GO:0001933	44	0.022
protein complex subunit organization	GO:0071822	302	0.022
nucleic acid templated transcription	GO:0097659	379	0.022
single organism nuclear import	GO:1902593	35	0.022
response to estrogen	GO:0043627	232	0.022
dna metabolic process	GO:0006259	96	0.022
response to extracellular stimulus	GO:0009991	380	0.022
positive regulation of signaling	GO:0023056	270	0.022
lipid metabolic process	GO:0006629	283	0.022
regulation of kinase activity	GO:0043549	117	0.022
organic acid metabolic process	GO:0006082	292	0.021
positive regulation of cellular component movement	GO:0051272	102	0.021
negative regulation of cellular metabolic process	GO:0031324	281	0.021
regulation of transferase activity	GO:0051338	123	0.021
modification dependent macromolecule catabolic process	GO:0043632	14	0.021
glycosyl compound catabolic process	GO:1901658	126	0.021
regulation of neuron apoptotic process	GO:0043523	83	0.021
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	4	0.020
regulation of transcription dna templated	GO:0006355	374	0.020
protein import	GO:0017038	37	0.020
regulation of intracellular transport	GO:0032386	65	0.020
regulation of neuron projection development	GO:0010975	161	0.020
response to growth factor	GO:0070848	189	0.020
response to nutrient levels	GO:0031667	370	0.020
carbohydrate derivative metabolic process	GO:1901135	346	0.020
positive regulation of mapk cascade	GO:0043410	92	0.020
purine containing compound metabolic process	GO:0072521	253	0.019
cofactor metabolic process	GO:0051186	95	0.019
positive regulation of cell migration	GO:0030335	96	0.019
regulation of stem cell differentiation	GO:2000736	2	0.019
negative regulation of molecular function	GO:0044092	133	0.019
negative regulation of neurogenesis	GO:0050768	78	0.019
gtp metabolic process	GO:0046039	72	0.019
nucleotide metabolic process	GO:0009117	279	0.019
response to inorganic substance	GO:0010035	377	0.019
positive regulation of ligase activity	GO:0051351	1	0.019
sensory perception of pain	GO:0019233	73	0.018
amp metabolic process	GO:0046033	8	0.018
cellular modified amino acid metabolic process	GO:0006575	61	0.018
positive regulation of neuron differentiation	GO:0045666	126	0.018
regulation of protein serine threonine kinase activity	GO:0071900	64	0.018
positive regulation of cellular protein metabolic process	GO:0032270	167	0.018
regulation of nucleocytoplasmic transport	GO:0046822	28	0.018
nuclear import	GO:0051170	35	0.018
guanosine containing compound metabolic process	GO:1901068	74	0.018
transcription dna templated	GO:0006351	377	0.018
cellular response to hormone stimulus	GO:0032870	247	0.018
actin filament branching	GO:0090135	1	0.017
regulation of mapk cascade	GO:0043408	116	0.017
negative regulation of macromolecule metabolic process	GO:0010605	260	0.017
negative regulation of intracellular signal transduction	GO:1902532	38	0.017
organic cyclic compound catabolic process	GO:1901361	175	0.017
cation transport	GO:0006812	382	0.017
regulation of neuron differentiation	GO:0045664	208	0.017
reproductive process	GO:0022414	372	0.017
cellular amide metabolic process	GO:0043603	44	0.017
negative regulation of nervous system development	GO:0051961	79	0.017
gastrulation	GO:0007369	2	0.017
positive regulation of focal adhesion assembly	GO:0051894	2	0.017
gland development	GO:0048732	155	0.017
regulation of dendrite development	GO:0050773	59	0.017
muscle tissue morphogenesis	GO:0060415	1	0.016
protein monoubiquitination	GO:0006513	3	0.016
regulation of response to stress	GO:0080134	126	0.016
nucleotide catabolic process	GO:0009166	139	0.016
response to toxic substance	GO:0009636	133	0.016
positive regulation of protein modification process	GO:0031401	142	0.016
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	3	0.016
secretion	GO:0046903	307	0.016
regulation of apoptotic process	GO:0042981	335	0.016
response to luteinizing hormone	GO:0034699	5	0.016
actin cytoskeleton organization	GO:0030036	73	0.015
purine containing compound catabolic process	GO:0072523	138	0.015
negative regulation of catalytic activity	GO:0043086	103	0.015
response to peptide	GO:1901652	292	0.015
positive regulation of developmental process	GO:0051094	283	0.015
response to hypoxia	GO:0001666	231	0.015
positive regulation of catalytic activity	GO:0043085	184	0.015
neurological system process	GO:0050877	219	0.015
defense response	GO:0006952	194	0.015
regulation of anatomical structure size	GO:0090066	135	0.015
macromolecular complex subunit organization	GO:0043933	339	0.015
cytoplasmic transport	GO:0016482	115	0.015
regulation of cellular component movement	GO:0051270	150	0.014
bmp signaling pathway	GO:0030509	4	0.014
purine ribonucleotide metabolic process	GO:0009150	227	0.014
cellular response to ethanol	GO:0071361	13	0.014
positive regulation of cell death	GO:0010942	184	0.014
negative regulation of neuron death	GO:1901215	69	0.014
heterocycle catabolic process	GO:0046700	167	0.014
protein oligomerization	GO:0051259	191	0.014
peptide metabolic process	GO:0006518	32	0.014
cellular amine metabolic process	GO:0044106	38	0.014
rna biosynthetic process	GO:0032774	380	0.014
response to decreased oxygen levels	GO:0036293	237	0.014
behavioral response to ethanol	GO:0048149	1	0.014
posttranscriptional regulation of gene expression	GO:0010608	37	0.014
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.014
regulation of cellular amine metabolic process	GO:0033238	8	0.014
positive regulation of secretion by cell	GO:1903532	128	0.014
cellular response to peptide	GO:1901653	133	0.014
regulation of cell morphogenesis	GO:0022604	77	0.014
response to magnesium ion	GO:0032026	20	0.014
mast cell chemotaxis	GO:0002551	4	0.013
regulation of rna metabolic process	GO:0051252	391	0.013
cellular component assembly	GO:0022607	360	0.013
regulation of protein export from nucleus	GO:0046825	4	0.013
positive regulation of programmed cell death	GO:0043068	157	0.013
response to heat	GO:0009408	60	0.013
positive regulation of cell communication	GO:0010647	271	0.013
glutathione biosynthetic process	GO:0006750	3	0.013
nucleobase containing compound catabolic process	GO:0034655	152	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.013
nonribosomal peptide biosynthetic process	GO:0019184	3	0.013
regulation of establishment of protein localization	GO:0070201	69	0.013
cellular response to nitrogen compound	GO:1901699	210	0.013
purine ribonucleoside catabolic process	GO:0046130	124	0.013
phospholipid metabolic process	GO:0006644	61	0.013
purine ribonucleotide catabolic process	GO:0009154	136	0.013
male gamete generation	GO:0048232	99	0.013
regulation of nervous system development	GO:0051960	264	0.012
actin filament based process	GO:0030029	86	0.012
maintenance of location	GO:0051235	17	0.012
rna metabolic process	GO:0016070	406	0.012
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.012
nucleobase containing small molecule metabolic process	GO:0055086	316	0.012
rho protein signal transduction	GO:0007266	11	0.012
purine nucleotide metabolic process	GO:0006163	229	0.012
negative regulation of cell projection organization	GO:0031345	50	0.012
smad protein complex assembly	GO:0007183	1	0.012
negative regulation of apoptotic process	GO:0043066	181	0.012
neural precursor cell proliferation	GO:0061351	23	0.012
regulation of ligase activity	GO:0051340	3	0.012
negative regulation of cell development	GO:0010721	82	0.012
spermatogenesis	GO:0007283	99	0.012
cell cycle	GO:0007049	101	0.012
response to metal ion	GO:0010038	253	0.012
positive regulation of gene expression	GO:0010628	244	0.012
aromatic compound catabolic process	GO:0019439	168	0.012
regulation of axon extension	GO:0030516	24	0.012
positive regulation of apoptotic process	GO:0043065	154	0.012
purine nucleotide catabolic process	GO:0006195	136	0.012
metal ion transport	GO:0030001	289	0.012
regulation of nucleotide catabolic process	GO:0030811	65	0.012
ribonucleoside catabolic process	GO:0042454	126	0.012
cellular macromolecular complex assembly	GO:0034622	58	0.012
response to temperature stimulus	GO:0009266	94	0.012
regulation of programmed cell death	GO:0043067	341	0.012
protein transport	GO:0015031	132	0.012
neuron differentiation	GO:0030182	368	0.012
response to cytokine	GO:0034097	215	0.011
negative regulation of programmed cell death	GO:0043069	183	0.011
negative regulation of neuron differentiation	GO:0045665	62	0.011
t cell receptor signaling pathway	GO:0050852	1	0.011
cell junction maintenance	GO:0034331	1	0.011
cellular response to organonitrogen compound	GO:0071417	197	0.011
regulation of gtpase activity	GO:0043087	57	0.011
response to biotic stimulus	GO:0009607	226	0.011
cell part morphogenesis	GO:0032990	123	0.011
response to activity	GO:0014823	73	0.011
cellular protein catabolic process	GO:0044257	19	0.011
regulation of cellular amino acid metabolic process	GO:0006521	2	0.011
regulation of cell cycle	GO:0051726	73	0.011
locomotion	GO:0040011	237	0.011
nucleoside phosphate catabolic process	GO:1901292	140	0.011
salivary gland morphogenesis	GO:0007435	1	0.011
cell cell junction organization	GO:0045216	20	0.011
ribonucleoside metabolic process	GO:0009119	174	0.011
nucleoside metabolic process	GO:0009116	179	0.011
motor neuron axon guidance	GO:0008045	1	0.011
nuclear division	GO:0000280	22	0.011
negative regulation of kinase activity	GO:0033673	27	0.010
single organism reproductive process	GO:0044702	297	0.010
positive regulation of intracellular transport	GO:0032388	39	0.010
muscle cell proliferation	GO:0033002	84	0.010
ribonucleotide catabolic process	GO:0009261	136	0.010
cellular lipid metabolic process	GO:0044255	208	0.010
positive regulation of protein export from nucleus	GO:0046827	3	0.010
adherens junction maintenance	GO:0034334	1	0.010

March5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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