| protein modification by small protein conjugation or removal | GO:0070647 | 35 | 0.304 | |
| cellular response to stress | GO:0033554 | 269 | 0.238 | |
| response to uv c | GO:0010225 | 2 | 0.157 | |
| sulfur compound metabolic process | GO:0006790 | 70 | 0.146 | |
| positive regulation of intracellular protein transport | GO:0090316 | 20 | 0.144 | |
| regulation of catalytic activity | GO:0050790 | 304 | 0.142 | |
| regulation of p38mapk cascade | GO:1900744 | 1 | 0.137 | |
| response to oxidative stress | GO:0006979 | 186 | 0.134 | |
| positive regulation of locomotion | GO:0040017 | 102 | 0.133 | |
| regulation of protein metabolic process | GO:0051246 | 289 | 0.117 | |
| protein dephosphorylation | GO:0006470 | 38 | 0.113 | |
| regulation of cellular response to stress | GO:0080135 | 49 | 0.111 | |
| regulation of phosphorus metabolic process | GO:0051174 | 349 | 0.088 | |
| oxoacid metabolic process | GO:0043436 | 290 | 0.083 | |
| cell motility | GO:0048870 | 202 | 0.083 | |
| cellular response to oxidative stress | GO:0034599 | 76 | 0.082 | |
| regulation of intracellular signal transduction | GO:1902531 | 218 | 0.074 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 4 | 0.072 | |
| regulation of molecular function | GO:0065009 | 398 | 0.070 | |
| positive regulation of protein transport | GO:0051222 | 41 | 0.069 | |
| regulation of phosphate metabolic process | GO:0019220 | 349 | 0.068 | |
| protein phosphorylation | GO:0006468 | 345 | 0.068 | |
| dephosphorylation | GO:0016311 | 98 | 0.068 | |
| regulation of small gtpase mediated signal transduction | GO:0051056 | 48 | 0.066 | |
| regulation of signal transduction | GO:0009966 | 318 | 0.065 | |
| intracellular signal transduction | GO:0035556 | 314 | 0.064 | |
| gtp catabolic process | GO:0006184 | 71 | 0.063 | |
| regulation of intracellular protein transport | GO:0033157 | 34 | 0.063 | |
| cellular catabolic process | GO:0044248 | 295 | 0.063 | |
| positive regulation of phosphorus metabolic process | GO:0010562 | 262 | 0.060 | |
| programmed cell death | GO:0012501 | 392 | 0.058 | |
| catabolic process | GO:0009056 | 351 | 0.054 | |
| regulation of cell motility | GO:2000145 | 131 | 0.054 | |
| localization of cell | GO:0051674 | 202 | 0.052 | |
| neuron death | GO:0070997 | 127 | 0.051 | |
| single organism catabolic process | GO:0044712 | 283 | 0.050 | |
| organic substance catabolic process | GO:1901575 | 316 | 0.050 | |
| regulation of phosphorylation | GO:0042325 | 248 | 0.049 | |
| cellular component biogenesis | GO:0044085 | 368 | 0.047 | |
| nucleocytoplasmic transport | GO:0006913 | 48 | 0.046 | |
| protein catabolic process | GO:0030163 | 30 | 0.045 | |
| apoptotic process | GO:0006915 | 381 | 0.045 | |
| positive regulation of intracellular signal transduction | GO:1902533 | 138 | 0.045 | |
| regulation of locomotion | GO:0040012 | 148 | 0.045 | |
| response to oxygen levels | GO:0070482 | 265 | 0.044 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 80 | 0.044 | |
| small gtpase mediated signal transduction | GO:0007264 | 36 | 0.043 | |
| positive regulation of signal transduction | GO:0009967 | 175 | 0.042 | |
| negative regulation of cellular component organization | GO:0051129 | 83 | 0.041 | |
| mast cell migration | GO:0097531 | 4 | 0.039 | |
| cellular response to oxygen containing compound | GO:1901701 | 386 | 0.038 | |
| positive regulation of biosynthetic process | GO:0009891 | 319 | 0.038 | |
| proteolysis | GO:0006508 | 175 | 0.036 | |
| response to wounding | GO:0009611 | 254 | 0.036 | |
| regulation of protein modification process | GO:0031399 | 194 | 0.035 | |
| negative regulation of protein metabolic process | GO:0051248 | 114 | 0.034 | |
| enzyme linked receptor protein signaling pathway | GO:0007167 | 116 | 0.034 | |
| macromolecular complex assembly | GO:0065003 | 273 | 0.033 | |
| regulation of stress activated protein kinase signaling cascade | GO:0070302 | 23 | 0.033 | |
| aging | GO:0007568 | 241 | 0.033 | |
| positive regulation of molecular function | GO:0044093 | 230 | 0.033 | |
| peptide biosynthetic process | GO:0043043 | 3 | 0.032 | |
| regulation of neurogenesis | GO:0050767 | 247 | 0.032 | |
| organelle organization | GO:0006996 | 266 | 0.031 | |
| ubiquitin dependent protein catabolic process | GO:0006511 | 14 | 0.031 | |
| homeostatic process | GO:0042592 | 331 | 0.031 | |
| regulation of cellular protein metabolic process | GO:0032268 | 267 | 0.031 | |
| ras protein signal transduction | GO:0007265 | 29 | 0.031 | |
| meiosis i | GO:0007127 | 2 | 0.030 | |
| response to nutrient | GO:0007584 | 248 | 0.030 | |
| stress activated protein kinase signaling cascade | GO:0031098 | 37 | 0.030 | |
| regulation of ubiquitin protein transferase activity | GO:0051438 | 1 | 0.030 | |
| regulation of cellular catabolic process | GO:0031329 | 101 | 0.030 | |
| positive regulation of cell motility | GO:2000147 | 97 | 0.030 | |
| organophosphate catabolic process | GO:0046434 | 148 | 0.030 | |
| p38mapk cascade | GO:0038066 | 1 | 0.030 | |
| macromolecule catabolic process | GO:0009057 | 58 | 0.029 | |
| response to carbohydrate | GO:0009743 | 183 | 0.029 | |
| regulation of catabolic process | GO:0009894 | 113 | 0.029 | |
| single organism organelle organization | GO:1902589 | 180 | 0.029 | |
| regulation of protein phosphorylation | GO:0001932 | 183 | 0.029 | |
| regulation of protein kinase activity | GO:0045859 | 105 | 0.029 | |
| carbohydrate metabolic process | GO:0005975 | 130 | 0.028 | |
| regulation of jnk cascade | GO:0046328 | 19 | 0.027 | |
| negative regulation of phosphorylation | GO:0042326 | 57 | 0.027 | |
| cellular response to endogenous stimulus | GO:0071495 | 377 | 0.027 | |
| nuclear transport | GO:0051169 | 49 | 0.027 | |
| positive regulation of neurogenesis | GO:0050769 | 165 | 0.027 | |
| response to reactive oxygen species | GO:0000302 | 120 | 0.027 | |
| intracellular protein transport | GO:0006886 | 79 | 0.026 | |
| cell migration | GO:0016477 | 197 | 0.026 | |
| regulation of neuron death | GO:1901214 | 115 | 0.026 | |
| carboxylic acid metabolic process | GO:0019752 | 289 | 0.026 | |
| cellular response to reactive oxygen species | GO:0034614 | 55 | 0.025 | |
| regulation of hydrolase activity | GO:0051336 | 143 | 0.025 | |
| cellular amino acid metabolic process | GO:0006520 | 107 | 0.025 | |
| organophosphate metabolic process | GO:0019637 | 370 | 0.025 | |
| guanosine containing compound catabolic process | GO:1901069 | 71 | 0.025 | |
| positive regulation of cellular biosynthetic process | GO:0031328 | 295 | 0.025 | |
| protein ubiquitination | GO:0016567 | 28 | 0.025 | |
| regulation of protein transport | GO:0051223 | 68 | 0.025 | |
| cellular ketone metabolic process | GO:0042180 | 51 | 0.025 | |
| regulation of anatomical structure morphogenesis | GO:0022603 | 141 | 0.025 | |
| regulation of protein localization | GO:0032880 | 81 | 0.024 | |
| acetyl coa metabolic process | GO:0006084 | 17 | 0.024 | |
| alpha amino acid metabolic process | GO:1901605 | 71 | 0.024 | |
| regulation of stress activated mapk cascade | GO:0032872 | 23 | 0.024 | |
| regulation of arp2 3 complex mediated actin nucleation | GO:0034315 | 2 | 0.024 | |
| ribose phosphate metabolic process | GO:0019693 | 235 | 0.024 | |
| ribonucleotide metabolic process | GO:0009259 | 231 | 0.024 | |
| negative regulation of metabolic process | GO:0009892 | 331 | 0.024 | |
| modification dependent protein catabolic process | GO:0019941 | 14 | 0.024 | |
| coenzyme metabolic process | GO:0006732 | 86 | 0.024 | |
| response to ethanol | GO:0045471 | 162 | 0.023 | |
| response to transition metal nanoparticle | GO:1990267 | 122 | 0.023 | |
| positive regulation of phosphorylation | GO:0042327 | 177 | 0.023 | |
| salivary gland development | GO:0007431 | 3 | 0.023 | |
| positive regulation of phosphate metabolic process | GO:0045937 | 262 | 0.023 | |
| positive regulation of photoreceptor cell differentiation | GO:0046534 | 2 | 0.023 | |
| cellular response to cytokine stimulus | GO:0071345 | 127 | 0.023 | |
| positive regulation of transport | GO:0051050 | 245 | 0.023 | |
| establishment of protein localization | GO:0045184 | 141 | 0.023 | |
| stress activated mapk cascade | GO:0051403 | 35 | 0.023 | |
| negative regulation of cell communication | GO:0010648 | 158 | 0.022 | |
| negative regulation of protein phosphorylation | GO:0001933 | 44 | 0.022 | |
| protein complex subunit organization | GO:0071822 | 302 | 0.022 | |
| nucleic acid templated transcription | GO:0097659 | 379 | 0.022 | |
| single organism nuclear import | GO:1902593 | 35 | 0.022 | |
| response to estrogen | GO:0043627 | 232 | 0.022 | |
| dna metabolic process | GO:0006259 | 96 | 0.022 | |
| response to extracellular stimulus | GO:0009991 | 380 | 0.022 | |
| positive regulation of signaling | GO:0023056 | 270 | 0.022 | |
| lipid metabolic process | GO:0006629 | 283 | 0.022 | |
| regulation of kinase activity | GO:0043549 | 117 | 0.022 | |
| organic acid metabolic process | GO:0006082 | 292 | 0.021 | |
| positive regulation of cellular component movement | GO:0051272 | 102 | 0.021 | |
| negative regulation of cellular metabolic process | GO:0031324 | 281 | 0.021 | |
| regulation of transferase activity | GO:0051338 | 123 | 0.021 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 14 | 0.021 | |
| glycosyl compound catabolic process | GO:1901658 | 126 | 0.021 | |
| regulation of neuron apoptotic process | GO:0043523 | 83 | 0.021 | |
| negative regulation of stress activated protein kinase signaling cascade | GO:0070303 | 4 | 0.020 | |
| regulation of transcription dna templated | GO:0006355 | 374 | 0.020 | |
| protein import | GO:0017038 | 37 | 0.020 | |
| regulation of intracellular transport | GO:0032386 | 65 | 0.020 | |
| regulation of neuron projection development | GO:0010975 | 161 | 0.020 | |
| response to growth factor | GO:0070848 | 189 | 0.020 | |
| response to nutrient levels | GO:0031667 | 370 | 0.020 | |
| carbohydrate derivative metabolic process | GO:1901135 | 346 | 0.020 | |
| positive regulation of mapk cascade | GO:0043410 | 92 | 0.020 | |
| purine containing compound metabolic process | GO:0072521 | 253 | 0.019 | |
| cofactor metabolic process | GO:0051186 | 95 | 0.019 | |
| positive regulation of cell migration | GO:0030335 | 96 | 0.019 | |
| regulation of stem cell differentiation | GO:2000736 | 2 | 0.019 | |
| negative regulation of molecular function | GO:0044092 | 133 | 0.019 | |
| negative regulation of neurogenesis | GO:0050768 | 78 | 0.019 | |
| gtp metabolic process | GO:0046039 | 72 | 0.019 | |
| nucleotide metabolic process | GO:0009117 | 279 | 0.019 | |
| response to inorganic substance | GO:0010035 | 377 | 0.019 | |
| positive regulation of ligase activity | GO:0051351 | 1 | 0.019 | |
| sensory perception of pain | GO:0019233 | 73 | 0.018 | |
| amp metabolic process | GO:0046033 | 8 | 0.018 | |
| cellular modified amino acid metabolic process | GO:0006575 | 61 | 0.018 | |
| positive regulation of neuron differentiation | GO:0045666 | 126 | 0.018 | |
| regulation of protein serine threonine kinase activity | GO:0071900 | 64 | 0.018 | |
| positive regulation of cellular protein metabolic process | GO:0032270 | 167 | 0.018 | |
| regulation of nucleocytoplasmic transport | GO:0046822 | 28 | 0.018 | |
| nuclear import | GO:0051170 | 35 | 0.018 | |
| guanosine containing compound metabolic process | GO:1901068 | 74 | 0.018 | |
| transcription dna templated | GO:0006351 | 377 | 0.018 | |
| cellular response to hormone stimulus | GO:0032870 | 247 | 0.018 | |
| actin filament branching | GO:0090135 | 1 | 0.017 | |
| regulation of mapk cascade | GO:0043408 | 116 | 0.017 | |
| negative regulation of macromolecule metabolic process | GO:0010605 | 260 | 0.017 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 38 | 0.017 | |
| organic cyclic compound catabolic process | GO:1901361 | 175 | 0.017 | |
| cation transport | GO:0006812 | 382 | 0.017 | |
| regulation of neuron differentiation | GO:0045664 | 208 | 0.017 | |
| reproductive process | GO:0022414 | 372 | 0.017 | |
| cellular amide metabolic process | GO:0043603 | 44 | 0.017 | |
| negative regulation of nervous system development | GO:0051961 | 79 | 0.017 | |
| gastrulation | GO:0007369 | 2 | 0.017 | |
| positive regulation of focal adhesion assembly | GO:0051894 | 2 | 0.017 | |
| gland development | GO:0048732 | 155 | 0.017 | |
| regulation of dendrite development | GO:0050773 | 59 | 0.017 | |
| muscle tissue morphogenesis | GO:0060415 | 1 | 0.016 | |
| protein monoubiquitination | GO:0006513 | 3 | 0.016 | |
| regulation of response to stress | GO:0080134 | 126 | 0.016 | |
| nucleotide catabolic process | GO:0009166 | 139 | 0.016 | |
| response to toxic substance | GO:0009636 | 133 | 0.016 | |
| positive regulation of protein modification process | GO:0031401 | 142 | 0.016 | |
| regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032434 | 3 | 0.016 | |
| secretion | GO:0046903 | 307 | 0.016 | |
| regulation of apoptotic process | GO:0042981 | 335 | 0.016 | |
| response to luteinizing hormone | GO:0034699 | 5 | 0.016 | |
| actin cytoskeleton organization | GO:0030036 | 73 | 0.015 | |
| purine containing compound catabolic process | GO:0072523 | 138 | 0.015 | |
| negative regulation of catalytic activity | GO:0043086 | 103 | 0.015 | |
| response to peptide | GO:1901652 | 292 | 0.015 | |
| positive regulation of developmental process | GO:0051094 | 283 | 0.015 | |
| response to hypoxia | GO:0001666 | 231 | 0.015 | |
| positive regulation of catalytic activity | GO:0043085 | 184 | 0.015 | |
| neurological system process | GO:0050877 | 219 | 0.015 | |
| defense response | GO:0006952 | 194 | 0.015 | |
| regulation of anatomical structure size | GO:0090066 | 135 | 0.015 | |
| macromolecular complex subunit organization | GO:0043933 | 339 | 0.015 | |
| cytoplasmic transport | GO:0016482 | 115 | 0.015 | |
| regulation of cellular component movement | GO:0051270 | 150 | 0.014 | |
| bmp signaling pathway | GO:0030509 | 4 | 0.014 | |
| purine ribonucleotide metabolic process | GO:0009150 | 227 | 0.014 | |
| cellular response to ethanol | GO:0071361 | 13 | 0.014 | |
| positive regulation of cell death | GO:0010942 | 184 | 0.014 | |
| negative regulation of neuron death | GO:1901215 | 69 | 0.014 | |
| heterocycle catabolic process | GO:0046700 | 167 | 0.014 | |
| protein oligomerization | GO:0051259 | 191 | 0.014 | |
| peptide metabolic process | GO:0006518 | 32 | 0.014 | |
| cellular amine metabolic process | GO:0044106 | 38 | 0.014 | |
| rna biosynthetic process | GO:0032774 | 380 | 0.014 | |
| response to decreased oxygen levels | GO:0036293 | 237 | 0.014 | |
| behavioral response to ethanol | GO:0048149 | 1 | 0.014 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 37 | 0.014 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 1 | 0.014 | |
| regulation of cellular amine metabolic process | GO:0033238 | 8 | 0.014 | |
| positive regulation of secretion by cell | GO:1903532 | 128 | 0.014 | |
| cellular response to peptide | GO:1901653 | 133 | 0.014 | |
| regulation of cell morphogenesis | GO:0022604 | 77 | 0.014 | |
| response to magnesium ion | GO:0032026 | 20 | 0.014 | |
| mast cell chemotaxis | GO:0002551 | 4 | 0.013 | |
| regulation of rna metabolic process | GO:0051252 | 391 | 0.013 | |
| cellular component assembly | GO:0022607 | 360 | 0.013 | |
| regulation of protein export from nucleus | GO:0046825 | 4 | 0.013 | |
| positive regulation of programmed cell death | GO:0043068 | 157 | 0.013 | |
| response to heat | GO:0009408 | 60 | 0.013 | |
| positive regulation of cell communication | GO:0010647 | 271 | 0.013 | |
| glutathione biosynthetic process | GO:0006750 | 3 | 0.013 | |
| nucleobase containing compound catabolic process | GO:0034655 | 152 | 0.013 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 19 | 0.013 | |
| nonribosomal peptide biosynthetic process | GO:0019184 | 3 | 0.013 | |
| regulation of establishment of protein localization | GO:0070201 | 69 | 0.013 | |
| cellular response to nitrogen compound | GO:1901699 | 210 | 0.013 | |
| purine ribonucleoside catabolic process | GO:0046130 | 124 | 0.013 | |
| phospholipid metabolic process | GO:0006644 | 61 | 0.013 | |
| purine ribonucleotide catabolic process | GO:0009154 | 136 | 0.013 | |
| male gamete generation | GO:0048232 | 99 | 0.013 | |
| regulation of nervous system development | GO:0051960 | 264 | 0.012 | |
| actin filament based process | GO:0030029 | 86 | 0.012 | |
| maintenance of location | GO:0051235 | 17 | 0.012 | |
| rna metabolic process | GO:0016070 | 406 | 0.012 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 141 | 0.012 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 316 | 0.012 | |
| rho protein signal transduction | GO:0007266 | 11 | 0.012 | |
| purine nucleotide metabolic process | GO:0006163 | 229 | 0.012 | |
| negative regulation of cell projection organization | GO:0031345 | 50 | 0.012 | |
| smad protein complex assembly | GO:0007183 | 1 | 0.012 | |
| negative regulation of apoptotic process | GO:0043066 | 181 | 0.012 | |
| neural precursor cell proliferation | GO:0061351 | 23 | 0.012 | |
| regulation of ligase activity | GO:0051340 | 3 | 0.012 | |
| negative regulation of cell development | GO:0010721 | 82 | 0.012 | |
| spermatogenesis | GO:0007283 | 99 | 0.012 | |
| cell cycle | GO:0007049 | 101 | 0.012 | |
| response to metal ion | GO:0010038 | 253 | 0.012 | |
| positive regulation of gene expression | GO:0010628 | 244 | 0.012 | |
| aromatic compound catabolic process | GO:0019439 | 168 | 0.012 | |
| regulation of axon extension | GO:0030516 | 24 | 0.012 | |
| positive regulation of apoptotic process | GO:0043065 | 154 | 0.012 | |
| purine nucleotide catabolic process | GO:0006195 | 136 | 0.012 | |
| metal ion transport | GO:0030001 | 289 | 0.012 | |
| regulation of nucleotide catabolic process | GO:0030811 | 65 | 0.012 | |
| ribonucleoside catabolic process | GO:0042454 | 126 | 0.012 | |
| cellular macromolecular complex assembly | GO:0034622 | 58 | 0.012 | |
| response to temperature stimulus | GO:0009266 | 94 | 0.012 | |
| regulation of programmed cell death | GO:0043067 | 341 | 0.012 | |
| protein transport | GO:0015031 | 132 | 0.012 | |
| neuron differentiation | GO:0030182 | 368 | 0.012 | |
| response to cytokine | GO:0034097 | 215 | 0.011 | |
| negative regulation of programmed cell death | GO:0043069 | 183 | 0.011 | |
| negative regulation of neuron differentiation | GO:0045665 | 62 | 0.011 | |
| t cell receptor signaling pathway | GO:0050852 | 1 | 0.011 | |
| cell junction maintenance | GO:0034331 | 1 | 0.011 | |
| cellular response to organonitrogen compound | GO:0071417 | 197 | 0.011 | |
| regulation of gtpase activity | GO:0043087 | 57 | 0.011 | |
| response to biotic stimulus | GO:0009607 | 226 | 0.011 | |
| cell part morphogenesis | GO:0032990 | 123 | 0.011 | |
| response to activity | GO:0014823 | 73 | 0.011 | |
| cellular protein catabolic process | GO:0044257 | 19 | 0.011 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 2 | 0.011 | |
| regulation of cell cycle | GO:0051726 | 73 | 0.011 | |
| locomotion | GO:0040011 | 237 | 0.011 | |
| nucleoside phosphate catabolic process | GO:1901292 | 140 | 0.011 | |
| salivary gland morphogenesis | GO:0007435 | 1 | 0.011 | |
| cell cell junction organization | GO:0045216 | 20 | 0.011 | |
| ribonucleoside metabolic process | GO:0009119 | 174 | 0.011 | |
| nucleoside metabolic process | GO:0009116 | 179 | 0.011 | |
| motor neuron axon guidance | GO:0008045 | 1 | 0.011 | |
| nuclear division | GO:0000280 | 22 | 0.011 | |
| negative regulation of kinase activity | GO:0033673 | 27 | 0.010 | |
| single organism reproductive process | GO:0044702 | 297 | 0.010 | |
| positive regulation of intracellular transport | GO:0032388 | 39 | 0.010 | |
| muscle cell proliferation | GO:0033002 | 84 | 0.010 | |
| ribonucleotide catabolic process | GO:0009261 | 136 | 0.010 | |
| cellular lipid metabolic process | GO:0044255 | 208 | 0.010 | |
| positive regulation of protein export from nucleus | GO:0046827 | 3 | 0.010 | |
| adherens junction maintenance | GO:0034334 | 1 | 0.010 | |