IMP: Integrative Multi-species Prediction

Rattus norvegicus

31 known processes

Hba-a2

hemoglobin alpha, adult chain 2

(Aliases: Hba1,Hba-a1,HBAM)

Entrez: 25632
RGD: 2782
Ensembl: ENSRNOG00000029886
UniProtKB: B1H216

Process Predictions
Disease Predictions

Hba-a2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hydrogen peroxide metabolic process	GO:0042743	13	0.998	Human
glutathione metabolic process	GO:0006749	15	0.996
oxygen transport	GO:0015671	2	0.993
peptide metabolic process	GO:0006518	32	0.958
translational initiation	GO:0006413	8	0.886
cellular modified amino acid metabolic process	GO:0006575	61	0.878
cellular amide metabolic process	GO:0043603	44	0.839
protein heterooligomerization	GO:0051291	89	0.797
cellular component assembly	GO:0022607	360	0.771
homeostasis of number of cells	GO:0048872	10	0.708	Mouse
regulation of translation in response to stress	GO:0043555	5	0.614
gas transport	GO:0015669	4	0.611
regulation of translational initiation in response to stress	GO:0043558	4	0.530
oxoacid metabolic process	GO:0043436	290	0.517
cellular response to oxidative stress	GO:0034599	76	0.453	Human
organic acid metabolic process	GO:0006082	292	0.408
macromolecular complex subunit organization	GO:0043933	339	0.386
sulfur compound metabolic process	GO:0006790	70	0.382
carboxylic acid metabolic process	GO:0019752	289	0.345
cellular amino acid metabolic process	GO:0006520	107	0.334
protein complex subunit organization	GO:0071822	302	0.331
protein complex assembly	GO:0006461	263	0.312
macromolecular complex assembly	GO:0065003	273	0.297
protein complex biogenesis	GO:0070271	263	0.293
cellular response to stress	GO:0033554	269	0.252	Human
protein oligomerization	GO:0051259	191	0.248
myeloid cell development	GO:0061515	1	0.229	Mouse
cellular component biogenesis	GO:0044085	368	0.187
regulation of blood pressure	GO:0008217	83	0.174
hematopoietic or lymphoid organ development	GO:0048534	36	0.131	Mouse
regulation of sensory perception of pain	GO:0051930	29	0.107
neutrophil chemotaxis	GO:0030593	11	0.102
myeloid cell homeostasis	GO:0002262	6	0.100	Mouse
response to oxidative stress	GO:0006979	186	0.094	Human
regulation of sensory perception	GO:0051931	29	0.087
granulocyte chemotaxis	GO:0071621	15	0.084
cellular response to hydrogen peroxide	GO:0070301	42	0.079	Human
cellular component movement	GO:0006928	248	0.071
response to inorganic substance	GO:0010035	377	0.058	Human
hepoxilin biosynthetic process	GO:0051122	5	0.057
reactive oxygen species metabolic process	GO:0072593	37	0.052	Human
regulation of translational initiation	GO:0006446	6	0.049
regulation of translation	GO:0006417	27	0.046
positive regulation of developmental process	GO:0051094	283	0.043
inorganic cation transmembrane transport	GO:0098662	202	0.041
protein phosphorylation	GO:0006468	345	0.040
response to nutrient levels	GO:0031667	370	0.037
cellular response to oxygen containing compound	GO:1901701	386	0.035	Human
response to lead ion	GO:0010288	33	0.033
regulation of cellular protein metabolic process	GO:0032268	267	0.031
transcription from rna polymerase ii promoter	GO:0006366	252	0.031
secretion	GO:0046903	307	0.029
metal ion homeostasis	GO:0055065	186	0.028
regulation of protein metabolic process	GO:0051246	289	0.028
positive regulation of leukocyte migration	GO:0002687	21	0.027
cell chemotaxis	GO:0060326	31	0.026
cellular metal ion homeostasis	GO:0006875	172	0.026
response to extracellular stimulus	GO:0009991	380	0.025
positive regulation of phosphorus metabolic process	GO:0010562	262	0.024
cellular response to lipid	GO:0071396	201	0.024
single organism catabolic process	GO:0044712	283	0.024	Human
response to reactive oxygen species	GO:0000302	120	0.023	Human
regulation of rna metabolic process	GO:0051252	391	0.023
carbohydrate derivative metabolic process	GO:1901135	346	0.023
single organism cell adhesion	GO:0098602	46	0.022
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.022
response to nutrient	GO:0007584	248	0.022
reproductive process	GO:0022414	372	0.022
regulation of nervous system development	GO:0051960	264	0.022
response to molecule of bacterial origin	GO:0002237	194	0.021
regulation of synaptic plasticity	GO:0048167	70	0.021
erythrocyte homeostasis	GO:0034101	2	0.020	Mouse
cell motility	GO:0048870	202	0.020
ribose phosphate metabolic process	GO:0019693	235	0.020
negative regulation of programmed cell death	GO:0043069	183	0.020
response to biotic stimulus	GO:0009607	226	0.019
regeneration	GO:0031099	163	0.019
response to estradiol	GO:0032355	164	0.019
regulation of protein modification process	GO:0031399	194	0.019
regulation of protein phosphorylation	GO:0001932	183	0.019
response to oxygen levels	GO:0070482	265	0.019
regulation of molecular function	GO:0065009	398	0.019
cellular amine metabolic process	GO:0044106	38	0.018
positive regulation of catalytic activity	GO:0043085	184	0.018
regulation of cellular component organization	GO:0051128	368	0.018
rna biosynthetic process	GO:0032774	380	0.018
head development	GO:0060322	247	0.018
nucleotide metabolic process	GO:0009117	279	0.018
response to hydrogen peroxide	GO:0042542	89	0.018	Human
actin filament based process	GO:0030029	86	0.018
cellular response to reactive oxygen species	GO:0034614	55	0.018	Human
immune system development	GO:0002520	41	0.017	Mouse
aging	GO:0007568	241	0.017
regulation of catalytic activity	GO:0050790	304	0.017
regulation of cell projection organization	GO:0031344	175	0.017
apoptotic process	GO:0006915	381	0.017
synaptic transmission	GO:0007268	235	0.017
purine nucleotide metabolic process	GO:0006163	229	0.016
neuron differentiation	GO:0030182	368	0.016
regulation of cellular amino acid metabolic process	GO:0006521	2	0.016
single organism organelle organization	GO:1902589	180	0.016
regulation of neurogenesis	GO:0050767	247	0.016
regulation of cell differentiation	GO:0045595	320	0.016
response to corticosteroid	GO:0031960	235	0.016
transcription dna templated	GO:0006351	377	0.015
amine metabolic process	GO:0009308	38	0.015
multi multicellular organism process	GO:0044706	138	0.015
regulation of transcription dna templated	GO:0006355	374	0.015
chemical homeostasis	GO:0048878	292	0.015
regulation of hydrolase activity	GO:0051336	143	0.015
purine containing compound metabolic process	GO:0072521	253	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.015
regulation of system process	GO:0044057	208	0.015
second messenger mediated signaling	GO:0019932	51	0.015
homeostatic process	GO:0042592	331	0.014	Mouse
response to cytokine	GO:0034097	215	0.014
positive regulation of leukocyte differentiation	GO:1902107	13	0.014
oxidation reduction process	GO:0055114	304	0.014	Human
blood circulation	GO:0008015	183	0.014
response to hypoxia	GO:0001666	231	0.014
ribonucleotide metabolic process	GO:0009259	231	0.014
multi organism reproductive process	GO:0044703	262	0.014
regulation of multicellular organismal development	GO:2000026	376	0.014
cellular lipid metabolic process	GO:0044255	208	0.013
positive regulation of gene expression	GO:0010628	244	0.013
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.013
positive regulation of cellular amine metabolic process	GO:0033240	3	0.013
regulation of phosphorylation	GO:0042325	248	0.013
positive regulation of cell proliferation	GO:0008284	249	0.013
nitrogen compound transport	GO:0071705	229	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.013
g protein coupled receptor signaling pathway	GO:0007186	242	0.013
single organism reproductive process	GO:0044702	297	0.013
smooth muscle cell proliferation	GO:0048659	77	0.013
rna metabolic process	GO:0016070	406	0.013
erythrocyte differentiation	GO:0030218	1	0.013	Mouse
gland development	GO:0048732	155	0.013
regulation of membrane potential	GO:0042391	110	0.013
negative regulation of developmental process	GO:0051093	125	0.013
neuronal action potential	GO:0019228	35	0.013
response to estrogen	GO:0043627	232	0.013
positive regulation of biosynthetic process	GO:0009891	319	0.013
negative regulation of biosynthetic process	GO:0009890	168	0.013
hemopoiesis	GO:0030097	34	0.012	Mouse
regulation of cellular amine metabolic process	GO:0033238	8	0.012
organ regeneration	GO:0031100	101	0.012
circulatory system process	GO:0003013	183	0.012
regulation of rna biosynthetic process	GO:2001141	381	0.012
regulation of neuron projection development	GO:0010975	161	0.012
regulation of response to stress	GO:0080134	126	0.012
gonad development	GO:0008406	104	0.012
intracellular transport	GO:0046907	185	0.012
posttranscriptional regulation of gene expression	GO:0010608	37	0.012
protein localization	GO:0008104	191	0.012
carbohydrate derivative catabolic process	GO:1901136	147	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.012
positive regulation of phosphorylation	GO:0042327	177	0.012
response to metal ion	GO:0010038	253	0.011
multicellular organismal signaling	GO:0035637	44	0.011
glycerophospholipid biosynthetic process	GO:0046474	22	0.011
regulation of cell proliferation	GO:0042127	359	0.011
positive regulation of intracellular signal transduction	GO:1902533	138	0.011
nucleobase containing compound catabolic process	GO:0034655	152	0.011
response to vitamin	GO:0033273	131	0.011
regulation of camp metabolic process	GO:0030814	43	0.011
cell growth	GO:0016049	104	0.011
cellular response to organonitrogen compound	GO:0071417	197	0.011
negative regulation of response to stimulus	GO:0048585	155	0.011
sexual reproduction	GO:0019953	148	0.011
response to ionizing radiation	GO:0010212	59	0.011
ion transmembrane transport	GO:0034220	365	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
regulation of cellular response to stress	GO:0080135	49	0.011
negative regulation of metabolic process	GO:0009892	331	0.011
cellular response to endogenous stimulus	GO:0071495	377	0.011
proteolysis	GO:0006508	175	0.011
positive regulation of rna biosynthetic process	GO:1902680	197	0.011
brain development	GO:0007420	247	0.011
regulation of cell development	GO:0060284	263	0.011
regulation of phosphate metabolic process	GO:0019220	349	0.011
response to wounding	GO:0009611	254	0.010
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.010
sensory perception	GO:0007600	101	0.010
neuron projection development	GO:0031175	273	0.010
sensory perception of pain	GO:0019233	73	0.010
nucleobase containing small molecule metabolic process	GO:0055086	316	0.010
gamete generation	GO:0007276	124	0.010
cation transport	GO:0006812	382	0.010
response to external biotic stimulus	GO:0043207	221	0.010
secretion by cell	GO:0032940	248	0.010

Hba-a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.030
nervous system disease	DOID:863	0.030
inherited metabolic disorder	DOID:655	0.018
disease of metabolism	DOID:0014667	0.018
sensory system disease	DOID:0050155	0.011
cardiovascular system disease	DOID:1287	0.011
eye and adnexa disease	DOID:1492	0.010

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