Rattus norvegicus

15 known processes

Akr1c1

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

(Aliases: Akr1c6,MGC125057,Hsd17b5)

Akr1c1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to nutrient levelsGO:00316673700.477
Human
carboxylic acid metabolic processGO:00197522890.287
Human
response to corticosteroidGO:00319602350.267
Human
cellular component biogenesisGO:00440853680.211
Human
response to glucocorticoidGO:00513842230.173
cellular response to endogenous stimulusGO:00714953770.166
Human Rat
response to external biotic stimulusGO:00432072210.162
regulation of protein metabolic processGO:00512462890.149
reproductive processGO:00224143720.136
Human Rat
positive regulation of nitrogen compound metabolic processGO:00511733340.134
response to nutrientGO:00075842480.132
Human
response to other organismGO:00517072200.122
response to cytokineGO:00340972150.115
intracellular signal transductionGO:00355563140.112
Human Rat
positive regulation of response to stimulusGO:00485842850.110
Human Rat
regulation of rna metabolic processGO:00512523910.104
Mouse
organic acid metabolic processGO:00060822920.098
Human
positive regulation of nucleobase containing compound metabolic processGO:00459353190.095
positive regulation of multicellular organismal processGO:00512403870.094
lipid metabolic processGO:00066292830.093
Human Mouse Rat
positive regulation of macromolecule biosynthetic processGO:00105572470.092
multi organism reproductive processGO:00447032620.091
Rat
cellular amino acid metabolic processGO:00065201070.090
nucleic acid templated transcriptionGO:00976593790.089
immune system processGO:00023762040.088
macromolecular complex subunit organizationGO:00439333390.088
Human
regulation of hormone levelsGO:00108171870.081
Human Rat
organonitrogen compound catabolic processGO:19015651790.079
neuron developmentGO:00486662860.077
apoptotic processGO:00069153810.077
Human
single organism biosynthetic processGO:00447113420.076
Human Mouse Rat
regulation of protein modification processGO:00313991940.076
head developmentGO:00603222470.076
Rat
positive regulation of cellular protein metabolic processGO:00322701670.075
rna metabolic processGO:00160704060.075
Mouse
macromolecular complex assemblyGO:00650032730.073
Human
regulation of nucleic acid templated transcriptionGO:19035063800.073
cellular component assemblyGO:00226073600.070
Human
organic acid transportGO:00158491160.070
organic hydroxy compound metabolic processGO:19016151150.069
Human Rat
response to organophosphorusGO:00466831020.069
Human
positive regulation of biosynthetic processGO:00098913190.068
negative regulation of biosynthetic processGO:00098901680.068
Human
chemotaxisGO:0006935660.068
positive regulation of signalingGO:00230562700.067
Human Rat
regulation of phosphate metabolic processGO:00192203490.066
regulation of phosphorus metabolic processGO:00511743490.066
negative regulation of metabolic processGO:00098923310.066
Human Mouse
rna biosynthetic processGO:00327743800.065
response to extracellular stimulusGO:00099913800.064
Human
protein complex subunit organizationGO:00718223020.064
Human
regulation of multicellular organismal developmentGO:20000263760.064
carboxylic acid transportGO:00469421150.061
regulation of protein phosphorylationGO:00019321830.058
positive regulation of gene expressionGO:00106282440.056
brain developmentGO:00074202470.056
Rat
transcription dna templatedGO:00063513770.056
positive regulation of cell communicationGO:00106472710.056
Human Rat
positive regulation of phosphorus metabolic processGO:00105622620.055
regulation of cell differentiationGO:00455953200.055
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.055
locomotionGO:00400112370.054
positive regulation of cellular biosynthetic processGO:00313282950.054
protein complex assemblyGO:00064612630.054
Human
response to inorganic substanceGO:00100353770.054
Human Rat
cellular response to organic cyclic compoundGO:00714072020.053
Human
regulation of rna biosynthetic processGO:20011413810.053
cardiovascular system developmentGO:00723581340.052
response to biotic stimulusGO:00096072260.052
response to oxygen levelsGO:00704822650.051
anion transportGO:00068201780.051
protein phosphorylationGO:00064683450.050
defense responseGO:00069521940.050
fatty acid derivative metabolic processGO:1901568380.049
Human
regulation of transcription from rna polymerase ii promoterGO:00063572340.048
response to molecule of bacterial originGO:00022371940.048
positive regulation of signal transductionGO:00099671750.048
Human Rat
regulation of cellular component organizationGO:00511283680.046
neuron differentiationGO:00301823680.046
regulation of molecular functionGO:00650093980.046
positive regulation of protein metabolic processGO:00512471780.045
cellular response to alcoholGO:0097306870.045
small molecule biosynthetic processGO:00442831240.043
Human Rat
cell projection organizationGO:00300303020.043
neuron projection developmentGO:00311752730.042
organic substance catabolic processGO:19015753160.042
Human
response to peptide hormoneGO:00434342780.041
regulation of nervous system developmentGO:00519602640.041
regulation of transcription dna templatedGO:00063553740.040
monocarboxylic acid metabolic processGO:00327871520.040
Human
regulation of neuron projection developmentGO:00109751610.040
amine metabolic processGO:0009308380.040
regulation of signal transductionGO:00099663180.040
Human Rat
cellular response to lipidGO:00713962010.039
Human
positive regulation of cell developmentGO:00107201760.039
regulation of programmed cell deathGO:00430673410.039
Human
cell migrationGO:00164771970.039
response to reactive oxygen speciesGO:00003021200.038
Human Rat
protein complex biogenesisGO:00702712630.038
Human
negative regulation of macromolecule metabolic processGO:00106052600.037
Mouse
cellular response to nitrogen compoundGO:19016992100.037
Rat
regulation of cellular protein metabolic processGO:00322682670.037
response to metal ionGO:00100382530.037
Human
cellular response to stressGO:00335542690.036
Human Rat
negative regulation of cellular metabolic processGO:00313242810.036
Human Mouse
cellular ketone metabolic processGO:0042180510.036
Human
cellular homeostasisGO:00197252520.036
regulation of catalytic activityGO:00507903040.036
response to vitaminGO:00332731310.035
cellular response to growth factor stimulusGO:00713631620.035
positive regulation of neuron differentiationGO:00456661260.035
response to lipopolysaccharideGO:00324961910.035
positive regulation of neuron projection developmentGO:0010976990.035
cellular response to oxygen containing compoundGO:19017013860.034
Human Rat
positive regulation of molecular functionGO:00440932300.033
oxoacid metabolic processGO:00434362900.033
Human
regulation of intracellular signal transductionGO:19025312180.032
Human Rat
positive regulation of transportGO:00510502450.032
regulation of phosphorylationGO:00423252480.032
catabolic processGO:00090563510.032
Human
regulation of cell developmentGO:00602842630.032
response to ketoneGO:19016541820.032
Rat
inflammatory responseGO:00069541500.032
cell part morphogenesisGO:00329901230.031
regulation of cell proliferationGO:00421273590.031
Human Rat
cellular modified amino acid metabolic processGO:0006575610.031
negative regulation of multicellular organismal processGO:00512412030.031
regulation of cellular ketone metabolic processGO:0010565270.031
Human
signal transduction by phosphorylationGO:00230141440.031
negative regulation of nitrogen compound metabolic processGO:00511721610.030
Mouse
agingGO:00075682410.030
oxidation reduction processGO:00551143040.030
response to growth factorGO:00708481890.030
negative regulation of molecular functionGO:00440921330.030
response to oxidative stressGO:00069791860.030
Human Rat
cell morphogenesisGO:00009021420.030
immune system developmentGO:0002520410.030
regulation of cell projection organizationGO:00313441750.029
regulation of kinase activityGO:00435491170.029
positive regulation of catalytic activityGO:00430851840.029
hormone metabolic processGO:0042445690.029
Human Rat
positive regulation of rna biosynthetic processGO:19026801970.028
cellular hormone metabolic processGO:0034754490.028
Human Rat
leukocyte differentiationGO:0002521300.028
positive regulation of cell proliferationGO:00082842490.028
Human Rat
cation transportGO:00068123820.028
urogenital system developmentGO:0001655780.028
Rat
positive regulation of intracellular signal transductionGO:19025331380.028
Human Rat
cellular response to hormone stimulusGO:00328702470.028
Human
immune responseGO:00069551040.027
nucleoside phosphate metabolic processGO:00067532830.027
reproductionGO:00000032450.027
Rat
response to bacteriumGO:00096172000.027
cellular catabolic processGO:00442482950.026
Human
inflammatory response to antigenic stimulusGO:0002437180.026
gland developmentGO:00487321550.026
positive regulation of cellular component movementGO:00512721020.025
exogenous drug catabolic processGO:004273810.025
cell motilityGO:00488702020.025
kidney developmentGO:0001822670.025
Rat
aromatic amino acid family catabolic processGO:000907470.025
positive regulation of developmental processGO:00510942830.025
localization of cellGO:00516742020.025
regulation of cellular amino acid metabolic processGO:000652120.024
negative regulation of gene expressionGO:00106291990.024
Mouse
response to insecticideGO:0017085210.024
developmental process involved in reproductionGO:00030061590.024
Human
cellular amine metabolic processGO:0044106380.024
cellular response to external stimulusGO:00714961180.024
Human
response to hexoseGO:00097461440.024
regulation of apoptotic processGO:00429813350.024
Human
positive regulation of cytosolic calcium ion concentrationGO:00072041220.024
regulation of myeloid cell differentiationGO:0045637120.024
renal system developmentGO:0072001670.024
Rat
response to alkaloidGO:00432791320.023
circulatory system developmentGO:00723591340.023
negative regulation of natural killer cell mediated immunityGO:000271640.023
positive regulation of phosphorylationGO:00423271770.023
single organism catabolic processGO:00447122830.023
Human
glycerolipid metabolic processGO:0046486670.023
negative regulation of response to stimulusGO:00485851550.023
regulation of hydrolase activityGO:00513361430.023
erk1 and erk2 cascadeGO:0070371480.022
ribose phosphate metabolic processGO:00196932350.022
cytokine productionGO:0001816610.022
guanosine containing compound metabolic processGO:1901068740.022
mapk cascadeGO:00001651400.022
glycosyl compound metabolic processGO:19016571820.022
Human
positive regulation of rna metabolic processGO:00512542030.022
positive regulation of cell differentiationGO:00455972170.022
monosaccharide metabolic processGO:0005996610.021
Rat
response to peptideGO:19016522920.021
Rat
cellular component movementGO:00069282480.021
response to cesium ionGO:001016420.021
sulfur compound metabolic processGO:0006790700.021
regulation of protein kinase activityGO:00458591050.021
positive regulation of protein phosphorylationGO:00019341350.021
cellular ion homeostasisGO:00068731840.020
negative regulation of transcription dna templatedGO:00458921160.020
myeloid leukocyte differentiationGO:0002573200.020
regulation of neuron differentiationGO:00456642080.020
single organism organelle organizationGO:19025891800.020
organ regenerationGO:00311001010.020
multicellular organism reproductionGO:00325042330.020
Rat
positive regulation of phosphate metabolic processGO:00459372620.020
regulation of anatomical structure sizeGO:00900661350.020
cellular response to cytokine stimulusGO:00713451270.020
anatomical structure morphogenesisGO:00096532980.020
positive regulation of nucleic acid templated transcriptionGO:19035081970.020
organic cyclic compound catabolic processGO:19013611750.020
negative regulation of nucleic acid templated transcriptionGO:19035071170.020
positive regulation of cell projection organizationGO:00313461110.020
organelle organizationGO:00069962660.019
negative regulation of rna biosynthetic processGO:19026791180.019
lipid localizationGO:0010876620.019
cellular response to organonitrogen compoundGO:00714171970.019
Rat
divalent inorganic cation homeostasisGO:00725071650.019
jak stat cascadeGO:0007259260.019
Rat
regulation of cellular amine metabolic processGO:003323880.019
positive regulation of protein modification processGO:00314011420.019
organic acid catabolic processGO:0016054490.019
cell cell signalingGO:00072673350.019
alcohol metabolic processGO:0006066770.019
Human Rat
regulation of anatomical structure morphogenesisGO:00226031410.019
cellular response to extracellular stimulusGO:0031668730.019
Human
organic hydroxy compound biosynthetic processGO:1901617510.019
Human Rat
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.019
central nervous system developmentGO:00074173110.018
Rat
tissue developmentGO:00098882520.018
Human
drug metabolic processGO:0017144110.018
steroid metabolic processGO:0008202730.018
Human Mouse
lipid transportGO:0006869610.018
cellular response to transforming growth factor beta stimulusGO:0071560410.018
regulation of hormone secretionGO:00468831060.018
cellular nitrogen compound catabolic processGO:00442701630.018
positive regulation of cellular component organizationGO:00511302000.018
negative regulation of innate immune responseGO:004582440.018
lipid biosynthetic processGO:00086101280.018
Human Mouse
naphthalene containing compound metabolic processGO:009042020.018
Rat
response to hypoxiaGO:00016662310.018
positive regulation of cell deathGO:00109421840.018
Human
negative regulation of nucleobase containing compound metabolic processGO:00459341530.018
Mouse
insecticide metabolic processGO:001714340.018
positive regulation of nervous system developmentGO:00519621780.018
taxisGO:0042330670.017
response to carbohydrateGO:00097431830.017
ribonucleotide metabolic processGO:00092592310.017
male sex differentiationGO:0046661640.017
Human
sexual reproductionGO:00199531480.017
alkaloid metabolic processGO:000982030.017
cation homeostasisGO:00550801950.017
negative regulation of natural killer cell mediated cytotoxicityGO:004595340.017
regulation of neurogenesisGO:00507672470.017
regulation of cellular localizationGO:00603412630.017
response to monosaccharideGO:00342841590.017
nucleobase containing compound catabolic processGO:00346551520.017
nucleobase containing small molecule metabolic processGO:00550863160.016
regulation of reactive oxygen species biosynthetic processGO:190342650.016
cellular protein complex assemblyGO:0043623440.016
multicellular organismal reproductive processGO:00486092330.016
Rat
myeloid cell differentiationGO:0030099220.016
response to campGO:0051591910.016
forebrain developmentGO:0030900980.016
Rat
response to glucoseGO:00097491360.016
transcription from rna polymerase ii promoterGO:00063662520.016
divalent inorganic cation transportGO:00725111340.016
synaptic growth at neuromuscular junctionGO:005112410.016
regulation of mapk cascadeGO:00434081160.016
single organism reproductive processGO:00447022970.016
Human Rat
response to purine containing compoundGO:00140741260.016
response to estradiolGO:00323551640.016
maternal process involved in female pregnancyGO:0060135380.016
Rat
regulation of cytoskeleton organizationGO:0051493490.016
female pregnancyGO:00075651220.015
Rat
regulation of metal ion transportGO:00109591180.015
amino acid transportGO:0006865700.015
positive regulation of transferase activityGO:0051347810.015
locomotor rhythmGO:004547510.015
negative regulation of developmental processGO:00510931250.015
cell morphogenesis involved in differentiationGO:00009041190.015
cellular component morphogenesisGO:00329891550.015
chemical homeostasisGO:00488782920.015
calcitriol biosynthetic process from calciolGO:003637820.015
drug catabolic processGO:004273710.015
fatty acid metabolic processGO:0006631990.015
Human
oligopeptide transportGO:000685740.015
gonad developmentGO:00084061040.015
Human
positive regulation of cellular amine metabolic processGO:003324030.015
acute inflammatory responseGO:0002526580.015
response to transition metal nanoparticleGO:19902671220.015
cellular lipid metabolic processGO:00442552080.014
Human Rat
carbohydrate derivative metabolic processGO:19011353460.014
Human
calcium ion transportGO:00068161310.014
cellular response to interleukin 1GO:0071347370.014
cellular chemical homeostasisGO:00550822470.014
tube developmentGO:0035295890.014
Rat
liver developmentGO:0001889900.014
innate immune responseGO:0045087350.014
organophosphate metabolic processGO:00196373700.014
gamete generationGO:00072761240.014
response to toxic substanceGO:00096361330.014
positive regulation of neurogenesisGO:00507691650.014
positive regulation of transcription dna templatedGO:00458931970.014
purine nucleoside metabolic processGO:00422781690.014
aromatic compound catabolic processGO:00194391680.014
trichloroethylene metabolic processGO:001897910.014
reactive oxygen species biosynthetic processGO:190340980.014
regulation of cell morphogenesisGO:0022604770.014
positive regulation of hydrolase activityGO:0051345860.013
transmission of nerve impulseGO:0019226420.013
regulation of ion transportGO:00432692450.013
transmembrane transportGO:00550854120.013
chlorinated hydrocarbon metabolic processGO:004219640.013
response to amineGO:0014075460.013
hormone transportGO:00099141210.013
cellular response to glucocorticoid stimulusGO:0071385680.013
negative regulation of programmed cell deathGO:00430691830.013
programmed cell deathGO:00125013920.013
Human
developmental growthGO:00485891000.013
hemopoiesisGO:0030097340.013
response to gonadotropinGO:0034698340.013
naphthalene metabolic processGO:001893120.013
Rat
negative regulation of catalytic activityGO:00430861030.013
unsaturated fatty acid metabolic processGO:0033559390.013
Human
hematopoietic or lymphoid organ developmentGO:0048534360.013
positive regulation of immune system processGO:0002684900.012
positive regulation of apoptotic processGO:00430651540.012
Human
lauric acid metabolic processGO:004825240.012
toxin catabolic processGO:000940710.012
response to activityGO:0014823730.012
male gamete generationGO:0048232990.012
cellular response to glucose stimulusGO:0071333650.012
response to estrogenGO:00436272320.012
positive regulation of erk1 and erk2 cascadeGO:0070374290.012
defense response to gram negative bacteriumGO:005082930.012
glycerophospholipid metabolic processGO:0006650470.012
actin cytoskeleton organizationGO:0030036730.012
carbohydrate derivative catabolic processGO:19011361470.012
behaviorGO:00076102050.012
positive regulation of cellular amino acid metabolic processGO:004576410.012
cellular macromolecular complex assemblyGO:0034622580.012
halogenated hydrocarbon metabolic processGO:004219740.012
homeostatic processGO:00425923310.012
Rat
negative regulation of immune system processGO:0002683390.012
purine ribonucleotide metabolic processGO:00091502270.012
positive regulation of programmed cell deathGO:00430681570.012
Human
negative regulation of protein metabolic processGO:00512481140.012
cellular response to hexose stimulusGO:0071331650.012
response to woundingGO:00096112540.012
cellular metal ion homeostasisGO:00068751720.012
nicotine metabolic processGO:001893310.012
ras protein signal transductionGO:0007265290.011
negative regulation of cellular biosynthetic processGO:00313271610.011
Human
gtp metabolic processGO:0046039720.011
regulation of proteolysisGO:0030162660.011
arachidonic acid metabolic processGO:0019369200.011
protein oligomerizationGO:00512591910.011
Human
cellular response to inorganic substanceGO:0071241650.011
Human
regulation of calcium ion transportGO:0051924770.011
ribonucleoside metabolic processGO:00091191740.011
positive regulation of protein kinase activityGO:0045860730.011
coenzyme metabolic processGO:0006732860.011
circadian rhythmGO:0007623880.011
organic hydroxy compound transportGO:0015850770.011
cellular response to follicle stimulating hormone stimulusGO:0071372130.011
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.011
secretionGO:00469033070.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
gtp catabolic processGO:0006184710.011
cellular response to corticosteroid stimulusGO:0071384690.011
Human
g protein coupled receptor signaling pathwayGO:00071862420.011
Human
reactive nitrogen species metabolic processGO:200105710.011
male gonad developmentGO:0008584590.011
Human
secondary metabolic processGO:0019748150.011
Human
nucleoside metabolic processGO:00091161790.011
steroid biosynthetic processGO:0006694480.011
Human Mouse
regulation of cell migrationGO:00303341280.011
alpha amino acid metabolic processGO:1901605710.011
response to ddtGO:004668010.011
activation of protein kinase activityGO:0032147470.011
regulation of phosphatidylinositol dephosphorylationGO:006030410.011
multi multicellular organism processGO:00447061380.011
Rat
monocarboxylic acid transportGO:0015718520.011
polyol metabolic processGO:0019751200.011
Rat
macromolecule localizationGO:00330362520.011
Human
xenobiotic metabolic processGO:0006805190.011
negative regulation of rna metabolic processGO:00512531230.010
Mouse
endoplasmic reticulum organizationGO:000702910.010
cellular response to steroid hormone stimulusGO:0071383930.010
Human
blood circulationGO:00080151830.010
metal ion transportGO:00300012890.010
response to mercury ionGO:0046689150.010
hematopoietic progenitor cell differentiationGO:000224420.010
small gtpase mediated signal transductionGO:0007264360.010

Akr1c1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
artery diseaseDOID:005082800.028
disease of anatomical entityDOID:700.028
essential hypertensionDOID:1082500.028
cardiovascular system diseaseDOID:128700.028
vascular diseaseDOID:17800.028
hypertensionDOID:1076300.028
musculoskeletal system diseaseDOID:1700.013
nervous system diseaseDOID:86300.011
connective tissue diseaseDOID:6500.011