Rattus norvegicus

45 known processes

Ctla4

cytotoxic T-lymphocyte-associated protein 4

(Aliases: Cd152,CTLA-4,sCTLA4)

Ctla4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cell proliferationGO:00421273590.299
response to nutrient levelsGO:00316673700.225
cytokine mediated signaling pathwayGO:0019221430.197
homeostatic processGO:00425923310.162
response to foodGO:0032094270.146
cellular response to oxygen containing compoundGO:19017013860.133
immune responseGO:00069551040.129
response to cytokineGO:00340972150.114
cation transportGO:00068123820.108
regulation of programmed cell deathGO:00430673410.107
Human
response to other organismGO:00517072200.106
negative regulation of response to external stimulusGO:0032102370.100
response to decreased oxygen levelsGO:00362932370.099
response to carbohydrateGO:00097431830.096
regulation of cellular localizationGO:00603412630.095
response to corticosteroidGO:00319602350.095
negative regulation of multicellular organismal processGO:00512412030.092
Human
cardiovascular system developmentGO:00723581340.092
gland developmentGO:00487321550.092
kidney developmentGO:0001822670.086
response to reactive oxygen speciesGO:00003021200.082
response to oxygen levelsGO:00704822650.082
regulation of protein transportGO:0051223680.080
g protein coupled receptor signaling pathwayGO:00071862420.079
negative regulation of response to stimulusGO:00485851550.077
response to toxic substanceGO:00096361330.077
inflammatory responseGO:00069541500.075
secretionGO:00469033070.075
organic substance catabolic processGO:19015753160.075
negative regulation of chronic inflammatory responseGO:000267720.074
regulation of secretionGO:00510462240.073
regulation of vasculature developmentGO:1901342440.073
chemical homeostasisGO:00488782920.072
regulation of immune system processGO:00026821230.070
response to biotic stimulusGO:00096072260.066
macromolecule localizationGO:00330362520.064
response to purine containing compoundGO:00140741260.064
negative regulation of cellular metabolic processGO:00313242810.063
nucleobase containing small molecule metabolic processGO:00550863160.062
cellular response to lipidGO:00713962010.060
metal ion transportGO:00300012890.058
cellular response to cytokine stimulusGO:00713451270.057
oxoacid metabolic processGO:00434362900.057
secretion by cellGO:00329402480.056
regulation of cytokine productionGO:0001817560.055
proteolysisGO:00065081750.055
monovalent inorganic cation transportGO:00156721720.054
feeding behaviorGO:0007631530.054
apoptotic processGO:00069153810.053
Human
divalent metal ion transportGO:00708381320.052
regulation of signal transductionGO:00099663180.052
macromolecular complex assemblyGO:00650032730.050
positive regulation of biosynthetic processGO:00098913190.050
cellular metal ion homeostasisGO:00068751720.050
blood circulationGO:00080151830.049
cellular homeostasisGO:00197252520.049
dna metabolic processGO:0006259960.047
intracellular transportGO:00469071850.047
organic acid metabolic processGO:00060822920.045
regulation of system processGO:00440572080.044
cellular calcium ion homeostasisGO:00068741600.044
protein complex assemblyGO:00064612630.043
intracellular signal transductionGO:00355563140.043
positive regulation of cytosolic calcium ion concentrationGO:00072041220.043
response to extracellular stimulusGO:00099913800.041
lipid metabolic processGO:00066292830.041
response to inorganic substanceGO:00100353770.041
protein localizationGO:00081041910.041
response to glucoseGO:00097491360.041
response to hexoseGO:00097461440.041
vascular process in circulatory systemGO:0003018960.040
cellular response to stressGO:00335542690.039
Human
response to antibioticGO:0046677390.038
protein transportGO:00150311320.038
divalent inorganic cation homeostasisGO:00725071650.037
muscle contractionGO:0006936880.037
regulation of locomotionGO:00400121480.037
regulation of phosphate metabolic processGO:00192203490.037
potassium ion transportGO:0006813970.037
positive regulation of cell deathGO:00109421840.037
Human
muscle system processGO:00030121150.037
cellular chemical homeostasisGO:00550822470.036
protein processingGO:0016485680.035
reproductive processGO:00224143720.035
response to glucocorticoidGO:00513842230.035
programmed cell deathGO:00125013920.034
Human
cation homeostasisGO:00550801950.034
regulation of apoptotic processGO:00429813350.033
Human
establishment of protein localizationGO:00451841410.033
negative regulation of metabolic processGO:00098923310.033
response to oxidative stressGO:00069791860.033
positive regulation of nucleobase containing compound metabolic processGO:00459353190.033
response to ethanolGO:00454711620.033
inflammatory response to antigenic stimulusGO:0002437180.032
nucleic acid templated transcriptionGO:00976593790.032
purine ribonucleoside metabolic processGO:00461281680.032
positive regulation of nitrogen compound metabolic processGO:00511733340.032
protein maturationGO:0051604680.032
rhythmic processGO:00485111560.031
multi organism reproductive processGO:00447032620.031
ribonucleoside metabolic processGO:00091191740.031
circulatory system processGO:00030131830.031
purine nucleotide biosynthetic processGO:0006164830.031
circulatory system developmentGO:00723591340.031
response to ionizing radiationGO:0010212590.031
regulation of mononuclear cell proliferationGO:0032944260.031
carbohydrate derivative metabolic processGO:19011353460.030
circadian sleep wake cycleGO:0042745230.030
regulation of homeostatic processGO:00328441010.030
nucleoside phosphate biosynthetic processGO:19012931020.030
regulation of ion transportGO:00432692450.029
positive regulation of transportGO:00510502450.029
negative regulation of immune system processGO:0002683390.029
glycosyl compound metabolic processGO:19016571820.029
protein complex biogenesisGO:00702712630.029
neuron differentiationGO:00301823680.029
circadian rhythmGO:0007623880.029
positive regulation of cell proliferationGO:00082842490.029
sensory organ developmentGO:0007423740.029
positive regulation of signal transductionGO:00099671750.029
positive regulation of transcription factor import into nucleusGO:004299340.028
regulation of anatomical structure sizeGO:00900661350.028
sexual reproductionGO:00199531480.028
response to external biotic stimulusGO:00432072210.027
cellular response to abiotic stimulusGO:0071214850.027
cellular protein localizationGO:00346131220.027
positive regulation of cellular biosynthetic processGO:00313282950.026
ribonucleotide biosynthetic processGO:0009260850.025
central nervous system developmentGO:00074173110.025
purine ribonucleoside catabolic processGO:00461301240.025
ion transmembrane transportGO:00342203650.025
metal ion homeostasisGO:00550651860.025
calcium ion homeostasisGO:00550741620.025
cellular response to hexose stimulusGO:0071331650.025
cellular response to nitrogen compoundGO:19016992100.025
nucleoside metabolic processGO:00091161790.025
immune system processGO:00023762040.025
negative regulation of cell proliferationGO:00082851190.025
hormone metabolic processGO:0042445690.024
cellular lipid metabolic processGO:00442552080.024
regulation of protein localizationGO:0032880810.024
response to organophosphorusGO:00466831020.024
regulation of dna metabolic processGO:0051052600.024
cytoplasmic transportGO:00164821150.024
cognitionGO:0050890920.024
regulation of neurological system processGO:0031644430.023
ribose phosphate metabolic processGO:00196932350.023
nucleoside catabolic processGO:00091641260.023
positive regulation of nervous system developmentGO:00519621780.023
protein phosphorylationGO:00064683450.023
cellular response to growth factor stimulusGO:00713631620.023
carbohydrate homeostasisGO:0033500750.023
salivary gland developmentGO:000743130.023
organic acid transportGO:00158491160.023
carboxylic acid metabolic processGO:00197522890.022
negative regulation of macromolecule biosynthetic processGO:00105581480.022
regulation of response to external stimulusGO:00321011060.022
response to campGO:0051591910.022
protein secretionGO:0009306340.022
response to starvationGO:0042594590.022
rna biosynthetic processGO:00327743800.022
response to acid chemicalGO:00011012220.022
negative regulation of cell communicationGO:00106481580.022
response to hypoxiaGO:00016662310.022
male sex differentiationGO:0046661640.022
response to growth factorGO:00708481890.022
regulation of protein metabolic processGO:00512462890.022
response to radiationGO:00093141370.021
regulation of phosphorus metabolic processGO:00511743490.021
cell migrationGO:00164771970.021
negative regulation of cell deathGO:00605482290.021
cellular cation homeostasisGO:00300031800.021
neurological system processGO:00508772190.021
negative regulation of macromolecule metabolic processGO:00106052600.021
regulation of multicellular organismal developmentGO:20000263760.021
Human
cellular response to acid chemicalGO:0071229750.021
ion homeostasisGO:00508012120.021
leukocyte activationGO:0045321760.021
regulation of anatomical structure morphogenesisGO:00226031410.021
regulation of establishment of protein localizationGO:0070201690.021
locomotionGO:00400112370.020
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124030.020
response to woundingGO:00096112540.020
divalent inorganic cation transportGO:00725111340.020
positive regulation of programmed cell deathGO:00430681570.020
Human
heterocycle catabolic processGO:00467001670.020
positive regulation of molecular functionGO:00440932300.020
transmembrane transportGO:00550854120.020
positive regulation of catalytic activityGO:00430851840.020
catabolic processGO:00090563510.020
regulation of neurogenesisGO:00507672470.020
tolerance induction dependent upon immune responseGO:000246120.020
negative regulation of long term synaptic potentiationGO:190027210.020
acute inflammatory responseGO:0002526580.020
nucleoside phosphate metabolic processGO:00067532830.019
regulation of mapk cascadeGO:00434081160.019
negative regulation of phosphorus metabolic processGO:0010563800.019
male mating behaviorGO:006017930.019
calcium ion transportGO:00068161310.019
response to hydrogen peroxideGO:0042542890.019
positive regulation of cyclic nucleotide biosynthetic processGO:0030804340.019
regulation of cellular extravasationGO:000269120.019
response to estrogenGO:00436272320.019
response to mineralocorticoidGO:0051385490.019
aromatic compound catabolic processGO:00194391680.019
cellular response to molecule of bacterial originGO:0071219560.019
protein oligomerizationGO:00512591910.018
reactive oxygen species biosynthetic processGO:190340980.018
cellular divalent inorganic cation homeostasisGO:00725031620.018
purine containing compound metabolic processGO:00725212530.018
developmental process involved in reproductionGO:00030061590.018
response to nutrientGO:00075842480.018
regulation of membrane potentialGO:00423911100.018
cellular component movementGO:00069282480.018
regulation of neuron projection developmentGO:00109751610.018
cellular amino acid metabolic processGO:00065201070.018
cell motilityGO:00488702020.018
negative regulation of phosphate metabolic processGO:0045936800.018
learning or memoryGO:0007611900.018
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.018
camera type eye developmentGO:0043010480.018
male gonad developmentGO:0008584590.018
regulation of nervous system developmentGO:00519602640.018
regulation of phosphorylationGO:00423252480.018
macromolecular complex subunit organizationGO:00439333390.018
purine nucleotide metabolic processGO:00061632290.018
cellular ketone metabolic processGO:0042180510.018
regulation of immunoglobulin secretionGO:005102310.018
localization of cellGO:00516742020.018
positive regulation of response to stimulusGO:00485842850.018
Human
startle responseGO:000196420.018
regulation of cellular ketone metabolic processGO:0010565270.017
organonitrogen compound catabolic processGO:19015651790.017
regulation of t cell activationGO:0050863230.017
cellular response to organic cyclic compoundGO:00714072020.017
regulation of intracellular signal transductionGO:19025312180.017
negative regulation of nitrogen compound metabolic processGO:00511721610.017
negative regulation of nucleobase containing compound metabolic processGO:00459341530.017
ribonucleotide metabolic processGO:00092592310.017
tissue remodelingGO:0048771400.017
regulation of neutrophil apoptotic processGO:003302940.017
regulation of molecular functionGO:00650093980.017
response to transition metal nanoparticleGO:19902671220.017
multicellular organism growthGO:003526410.017
urogenital system developmentGO:0001655780.017
protein homooligomerizationGO:0051260910.017
negative regulation of gene expressionGO:00106291990.017
regulation of reactive oxygen species biosynthetic processGO:190342650.017
regulation of cellular protein metabolic processGO:00322682670.017
single organism biosynthetic processGO:00447113420.017
response to monosaccharideGO:00342841590.017
positive regulation of macromolecule biosynthetic processGO:00105572470.016
negative regulation of signalingGO:00230571570.016
regulation of protein secretionGO:0050708280.016
sequestering of calcium ionGO:005120880.016
regulation of rna biosynthetic processGO:20011413810.016
cellular response to organonitrogen compoundGO:00714171970.016
eye developmentGO:0001654500.016
tissue developmentGO:00098882520.016
anion transportGO:00068201780.016
response to dexamethasoneGO:0071548490.016
fertilizationGO:000956630.016
leukocyte differentiationGO:0002521300.016
Human
regulation of cell projection organizationGO:00313441750.016
prepulse inhibitionGO:006013410.016
response to interleukin 1GO:0070555550.016
response to peptideGO:19016522920.016
purine nucleoside triphosphate catabolic processGO:00091461220.016
purine nucleoside metabolic processGO:00422781690.016
reactive nitrogen species metabolic processGO:200105710.016
regulation of hormone levelsGO:00108171870.015
cellular response to carbohydrate stimulusGO:0071322720.015
purine ribonucleotide metabolic processGO:00091502270.015
response to molecule of bacterial originGO:00022371940.015
angioblast cell migrationGO:003547610.015
telencephalon developmentGO:0021537620.015
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.015
regulation of cellular component movementGO:00512701500.015
anatomical structure morphogenesisGO:00096532980.015
regulation of blood pressureGO:0008217830.015
organic cyclic compound catabolic processGO:19013611750.015
protein complex subunit organizationGO:00718223020.015
cellular response to external stimulusGO:00714961180.015
negative regulation of programmed cell deathGO:00430691830.015
regulation of calcium ion transportGO:0051924770.015
regulation of peptide transportGO:0090087870.015
nucleotide metabolic processGO:00091172790.015
positive regulation of neurogenesisGO:00507691650.015
intracellular protein transportGO:0006886790.015
cellular response to biotic stimulusGO:0071216590.015
regulation of cell migrationGO:00303341280.015
gastrulationGO:000736920.015
camp metabolic processGO:0046058630.015
defense responseGO:00069521940.014
positive regulation of developmental processGO:00510942830.014
glucose homeostasisGO:0042593750.014
single organism cellular localizationGO:19025801020.014
lymphocyte activationGO:0046649430.014
rna metabolic processGO:00160704060.014
cytokine productionGO:0001816610.014
sequestering of metal ionGO:005123890.014
cellular response to reactive oxygen speciesGO:0034614550.014
regulation of protein modification processGO:00313991940.014
response to estradiolGO:00323551640.014
blood vessel developmentGO:0001568690.014
reproductionGO:00000032450.014
agingGO:00075682410.014
dna replicationGO:0006260370.014
liver developmentGO:0001889900.014
response to vitaminGO:00332731310.014
carbohydrate derivative biosynthetic processGO:19011371240.014
cellular catabolic processGO:00442482950.014
rhythmic behaviorGO:0007622240.013
negative regulation of nucleic acid templated transcriptionGO:19035071170.013
sensory perceptionGO:00076001010.013
signal transduction by phosphorylationGO:00230141440.013
lipid localizationGO:0010876620.013
forebrain developmentGO:0030900980.013
regulation of cellular catabolic processGO:00313291010.013
single organism catabolic processGO:00447122830.013
regulation of cellular amino acid metabolic processGO:000652120.013
organonitrogen compound biosynthetic processGO:19015661670.013
myeloid leukocyte migrationGO:0097529200.013
oxidation reduction processGO:00551143040.013
adenohypophysis developmentGO:002198420.013
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.013
response to fatty acidGO:0070542650.013
organophosphate catabolic processGO:00464341480.013
steroid biosynthetic processGO:0006694480.013
macromolecule catabolic processGO:0009057580.013
negative regulation of fibrinolysisGO:005191820.013
regulation of nucleic acid templated transcriptionGO:19035063800.013
purine ribonucleoside triphosphate catabolic processGO:00092071220.013
organ formationGO:004864530.013
positive regulation of potassium ion transportGO:0043268130.013
sodium ion transportGO:0006814820.013
regulation of catalytic activityGO:00507903040.013
reactive oxygen species metabolic processGO:0072593370.012
neuronal action potentialGO:0019228350.012
synaptic transmissionGO:00072682350.012
neuron projection developmentGO:00311752730.012
positive regulation of apoptotic processGO:00430651540.012
Human
purine containing compound catabolic processGO:00725231380.012
positive regulation of cyclic nucleotide metabolic processGO:0030801370.012
epithelial cell differentiationGO:0030855710.012
organophosphate metabolic processGO:00196373700.012
single organism intracellular transportGO:19025821660.012
behaviorGO:00076102050.012
cellular response to endogenous stimulusGO:00714953770.012
memoryGO:0007613540.012
cardiac muscle contractionGO:0060048270.012
positive regulation of nucleotide metabolic processGO:0045981910.012
single organism reproductive processGO:00447022970.012
reproductive structure developmentGO:00486081280.012
calcium ion importGO:0070509220.012
single organism behaviorGO:00447081300.012
multicellular organismal reproductive processGO:00486092330.012
cellular response to transforming growth factor beta stimulusGO:0071560410.012
cellular nitrogen compound catabolic processGO:00442701630.012
regulation of reactive oxygen species metabolic processGO:2000377260.012
cellular ion homeostasisGO:00068731840.012
brain developmentGO:00074202470.012
response to peptide hormoneGO:00434342780.012
positive regulation of long term synaptic potentiationGO:190027340.012
mapk cascadeGO:00001651400.012
negative regulation of protein metabolic processGO:00512481140.012
positive regulation of ion transportGO:0043270940.012
isoprenoid metabolic processGO:0006720450.012
cellular response to peptideGO:19016531330.012
organic anion transportGO:00157111320.011
protein targetingGO:0006605610.011
insulin secretionGO:0030073690.011
carboxylic acid transportGO:00469421150.011
neuromuscular processGO:005090520.011
positive regulation of rna metabolic processGO:00512542030.011
metanephric tubule morphogenesisGO:007217320.011
regulation of cell developmentGO:00602842630.011
striated muscle contractionGO:0006941440.011
cellular response to dexamethasone stimulusGO:0071549360.011
neutrophil apoptotic processGO:000178140.011
regulation of immune effector processGO:0002697320.011
negative regulation of protein phosphorylationGO:0001933440.011
cellular response to monosaccharide stimulusGO:0071326670.011
positive regulation of purine nucleotide metabolic processGO:1900544910.011
regulation of protein processingGO:0070613500.011
sleepGO:0030431300.011
response to metal ionGO:00100382530.011
negative regulation of transportGO:00510511360.011
purine ribonucleotide catabolic processGO:00091541360.011
response to phGO:0009268270.011
regulation of lipid biosynthetic processGO:0046890380.011
cellular glucose homeostasisGO:0001678660.011
regulation of chronic inflammatory responseGO:000267630.011
c21 steroid hormone metabolic processGO:0008207140.011
positive regulation of protein transportGO:0051222410.011
regulation of vascular smooth muscle contractionGO:000305630.011
regulation of protein phosphorylationGO:00019321830.011
regulation of hydrolase activityGO:00513361430.011
cellular amine metabolic processGO:0044106380.011
regulation of metal ion transportGO:00109591180.011
positive regulation of lymphocyte activationGO:0051251250.011
Rat
regulation of lymphocyte activationGO:0051249340.011
gamete generationGO:00072761240.011
eosinophil migrationGO:007267730.011
response to cgmpGO:007030530.011
cellular response to mechanical stimulusGO:0071260480.010
positive regulation of immune system processGO:0002684900.010
Human Rat
regulation of transmembrane transportGO:00347621220.010
negative regulation of circadian rhythmGO:004275450.010
defense response to gram negative bacteriumGO:005082930.010
n methyl d aspartate receptor clusteringGO:009711420.010
cellular response to starvationGO:0009267270.010
response to amineGO:0014075460.010
regulation of neuron differentiationGO:00456642080.010
cytosolic calcium ion homeostasisGO:00514801400.010
negative regulation of cellular biosynthetic processGO:00313271610.010
hepaticobiliary system developmentGO:0061008900.010
ras protein signal transductionGO:0007265290.010
regulation of intracellular transportGO:0032386650.010
metanephric tubule developmentGO:007217040.010
amine metabolic processGO:0009308380.010
activation of mapkk activityGO:0000186180.010
negative regulation of phosphorylationGO:0042326570.010
positive regulation of reactive oxygen species metabolic processGO:2000379160.010
response to ketoneGO:19016541820.010
transcription from rna polymerase ii promoterGO:00063662520.010
ribonucleoside triphosphate metabolic processGO:00091991410.010

Ctla4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.028
Human
nervous system diseaseDOID:86300.028
disease of metabolismDOID:001466700.014
sensory system diseaseDOID:005015500.012
eye diseaseDOID:561400.012
eye and adnexa diseaseDOID:149200.012
disease of cellular proliferationDOID:1456600.010