IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Fkbp10

FK506 binding protein 10

Ensembl: ENSRNOG00000015941
Entrez: 360627
RGD: 1549751
UniProtKB: Q5U2V1

Process Predictions
Disease Predictions

Fkbp10 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
rna metabolic process	GO:0016070	406	0.083
positive regulation of response to stimulus	GO:0048584	285	0.076
nucleic acid templated transcription	GO:0097659	379	0.064
cell motility	GO:0048870	202	0.063
response to wounding	GO:0009611	254	0.062
regulation of nucleic acid templated transcription	GO:1903506	380	0.060
inflammatory response	GO:0006954	150	0.058
rna biosynthetic process	GO:0032774	380	0.056
response to oxygen levels	GO:0070482	265	0.056
growth	GO:0040007	165	0.053
regulation of rna biosynthetic process	GO:2001141	381	0.050
cardiovascular system development	GO:0072358	134	0.049
regulation of rna metabolic process	GO:0051252	391	0.045
regulation of bmp signaling pathway	GO:0030510	2	0.044
vasculature development	GO:0001944	70	0.042
regulation of cell differentiation	GO:0045595	320	0.042
embryonic skeletal system morphogenesis	GO:0048704	3	0.041
wound healing	GO:0042060	122	0.037
immune system process	GO:0002376	204	0.037
regulation of multicellular organismal development	GO:2000026	376	0.035
appendage morphogenesis	GO:0035107	4	0.035
regulation of transcription dna templated	GO:0006355	374	0.034
tissue remodeling	GO:0048771	40	0.034
positive regulation of signaling	GO:0023056	270	0.033
multicellular organism reproduction	GO:0032504	233	0.033
protein oligomerization	GO:0051259	191	0.033
defense response	GO:0006952	194	0.032
negative regulation of macromolecule metabolic process	GO:0010605	260	0.032
transcription dna templated	GO:0006351	377	0.032
positive regulation of developmental process	GO:0051094	283	0.032
tissue development	GO:0009888	252	0.031
negative regulation of biosynthetic process	GO:0009890	168	0.031
response to increased oxygen levels	GO:0036296	45	0.031
intracellular signal transduction	GO:0035556	314	0.031
aging	GO:0007568	241	0.029
response to extracellular stimulus	GO:0009991	380	0.028
positive regulation of gene expression	GO:0010628	244	0.028
reproductive process	GO:0022414	372	0.027
regulation of cell proliferation	GO:0042127	359	0.027
positive regulation of rna metabolic process	GO:0051254	203	0.027
positive regulation of transcription dna templated	GO:0045893	197	0.027
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.026
reproduction	GO:0000003	245	0.026
positive regulation of cell communication	GO:0010647	271	0.025
regulation of signal transduction	GO:0009966	318	0.024
heart morphogenesis	GO:0003007	3	0.024
cellular response to oxygen containing compound	GO:1901701	386	0.023
gastrulation	GO:0007369	2	0.023
collagen metabolic process	GO:0032963	21	0.023
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.023
positive regulation of biosynthetic process	GO:0009891	319	0.023
rhythmic process	GO:0048511	156	0.023
collagen fibril organization	GO:0030199	1	0.022
protein complex assembly	GO:0006461	263	0.022
positive regulation of signal transduction	GO:0009967	175	0.022
skeletal system morphogenesis	GO:0048705	12	0.022
negative regulation of cellular biosynthetic process	GO:0031327	161	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.022
cellular response to growth factor stimulus	GO:0071363	162	0.021
apoptotic process	GO:0006915	381	0.021
response to corticosteroid	GO:0031960	235	0.021
cellular response to external stimulus	GO:0071496	118	0.021
regulation of response to stress	GO:0080134	126	0.021
negative regulation of gene expression	GO:0010629	199	0.021
bmp signaling pathway	GO:0030509	4	0.021
embryonic skeletal system development	GO:0048706	3	0.021
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.020
vesicle mediated transport	GO:0016192	181	0.020
response to nutrient levels	GO:0031667	370	0.020
cellular response to endogenous stimulus	GO:0071495	377	0.020
embryo implantation	GO:0007566	15	0.019
positive regulation of rna biosynthetic process	GO:1902680	197	0.019
cell substrate adhesion	GO:0031589	29	0.019
developmental growth	GO:0048589	100	0.019
circulatory system development	GO:0072359	134	0.019
negative regulation of organ growth	GO:0046621	3	0.018
protein complex subunit organization	GO:0071822	302	0.018
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.018
multicellular organismal reproductive process	GO:0048609	233	0.018
response to glucose	GO:0009749	136	0.018
regulation of neuron projection development	GO:0010975	161	0.018
protein heterooligomerization	GO:0051291	89	0.018
single organism reproductive process	GO:0044702	297	0.018
ras protein signal transduction	GO:0007265	29	0.018
response to growth factor	GO:0070848	189	0.018
positive regulation of biomineral tissue development	GO:0070169	4	0.017
sexual reproduction	GO:0019953	148	0.017
negative regulation of cardiac muscle tissue growth	GO:0055022	3	0.017
response to oxidative stress	GO:0006979	186	0.017
negative regulation of cell proliferation	GO:0008285	119	0.017
neuron development	GO:0048666	286	0.017
single organism biosynthetic process	GO:0044711	342	0.017
sulfur compound metabolic process	GO:0006790	70	0.017
organ morphogenesis	GO:0009887	75	0.016
elastic fiber assembly	GO:0048251	1	0.016
cartilage development involved in endochondral bone morphogenesis	GO:0060351	3	0.016
formation of primary germ layer	GO:0001704	1	0.016
response to nutrient	GO:0007584	248	0.016
cellular component biogenesis	GO:0044085	368	0.016
macromolecular complex subunit organization	GO:0043933	339	0.016
positive regulation of cellular biosynthetic process	GO:0031328	295	0.016
spermatogenesis	GO:0007283	99	0.016
response to fibroblast growth factor	GO:0071774	29	0.015
regulation of molecular function	GO:0065009	398	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.015
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.015
odontogenesis	GO:0042476	32	0.015
connective tissue development	GO:0061448	33	0.015
cellular component assembly	GO:0022607	360	0.015
neuron differentiation	GO:0030182	368	0.015
regulation of hydrolase activity	GO:0051336	143	0.015
cell adhesion	GO:0007155	110	0.014
multi organism reproductive process	GO:0044703	262	0.014
organophosphate metabolic process	GO:0019637	370	0.014
locomotion	GO:0040011	237	0.014
programmed cell death	GO:0012501	392	0.014
eye morphogenesis	GO:0048592	4	0.014
innate immune response	GO:0045087	35	0.014
female pregnancy	GO:0007565	122	0.014
regulation of nervous system development	GO:0051960	264	0.014
ossification	GO:0001503	70	0.014
endochondral bone morphogenesis	GO:0060350	7	0.014
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.014
cellular response to cytokine stimulus	GO:0071345	127	0.014
secretion by cell	GO:0032940	248	0.014
neuronal action potential	GO:0019228	35	0.014
negative regulation of cell communication	GO:0010648	158	0.013
regulation of cellular component organization	GO:0051128	368	0.013
bone morphogenesis	GO:0060349	11	0.013
regulation of cell development	GO:0060284	263	0.013
response to decreased oxygen levels	GO:0036293	237	0.013
positive regulation of bone mineralization	GO:0030501	4	0.013
small gtpase mediated signal transduction	GO:0007264	36	0.013
macromolecular complex assembly	GO:0065003	273	0.013
response to hexose	GO:0009746	144	0.013
negative regulation of cell death	GO:0060548	229	0.013
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.013
negative regulation of defense response	GO:0031348	19	0.013
response to mechanical stimulus	GO:0009612	134	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.013
blood vessel morphogenesis	GO:0048514	58	0.013
ovulation cycle	GO:0042698	67	0.012
response to inorganic substance	GO:0010035	377	0.012
protein catabolic process	GO:0030163	30	0.012
s shaped body morphogenesis	GO:0072050	2	0.012
neuron death	GO:0070997	127	0.012
positive regulation of cell proliferation	GO:0008284	249	0.012
rho protein signal transduction	GO:0007266	11	0.012
male gamete generation	GO:0048232	99	0.012
transcription from rna polymerase ii promoter	GO:0006366	252	0.012
glycosaminoglycan biosynthetic process	GO:0006024	4	0.012
anatomical structure morphogenesis	GO:0009653	298	0.012
gamete generation	GO:0007276	124	0.012
negative regulation of heart growth	GO:0061117	3	0.012
cellular response to organic cyclic compound	GO:0071407	202	0.012
response to vitamin e	GO:0033197	24	0.012
regulation of programmed cell death	GO:0043067	341	0.012
negative regulation of programmed cell death	GO:0043069	183	0.012
craniofacial suture morphogenesis	GO:0097094	4	0.011
embryonic cranial skeleton morphogenesis	GO:0048701	2	0.011
cellular response to inorganic substance	GO:0071241	65	0.011
myelination	GO:0042552	39	0.011
multicellular organismal macromolecule metabolic process	GO:0044259	21	0.011
proteolysis	GO:0006508	175	0.011
regulation of neuron apoptotic process	GO:0043523	83	0.011
regeneration	GO:0031099	163	0.011
regulation of defense response	GO:0031347	68	0.011
action potential	GO:0001508	54	0.011
response to biotic stimulus	GO:0009607	226	0.011
kidney development	GO:0001822	67	0.011
cellular component movement	GO:0006928	248	0.011
negative regulation of metabolic process	GO:0009892	331	0.011
axis specification	GO:0009798	4	0.011
regulation of neuron death	GO:1901214	115	0.011
response to vitamin	GO:0033273	131	0.011
response to molecule of bacterial origin	GO:0002237	194	0.011
response to organophosphorus	GO:0046683	102	0.010
response to fluoride	GO:1902617	3	0.010
positive regulation of apoptotic process	GO:0043065	154	0.010
cellular homeostasis	GO:0019725	252	0.010
response to hyperoxia	GO:0055093	45	0.010
localization of cell	GO:0051674	202	0.010
anterior posterior pattern specification	GO:0009952	1	0.010
homeostatic process	GO:0042592	331	0.010
cellular response to hormone stimulus	GO:0032870	247	0.010
negative regulation of multicellular organismal process	GO:0051241	203	0.010
cell migration	GO:0016477	197	0.010

Fkbp10 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
musculoskeletal system disease	DOID:17	0.092	Human
disease of anatomical entity	DOID:7	0.092	Human
connective tissue disease	DOID:65	0.020	Human
bone development disease	DOID:0080006	0.020	Human
osteochondrodysplasia	DOID:2256	0.020	Human
bone disease	DOID:0080001	0.020	Human
nervous system disease	DOID:863	0.015

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