IMP: Integrative Multi-species Prediction

Rattus norvegicus

65 known processes

Txn1

thioredoxin 1

(Aliases: Txn)

Ensembl: ENSRNOG00000012081
Entrez: 116484
RGD: 621157
UniProtKB: P11232

Process Predictions
Disease Predictions

Txn1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
catabolic process	GO:0009056	351	0.491
nucleic acid templated transcription	GO:0097659	379	0.212	Mouse
cellular catabolic process	GO:0044248	295	0.181
rna metabolic process	GO:0016070	406	0.173	Mouse
cellular response to stress	GO:0033554	269	0.168
regulation of rna metabolic process	GO:0051252	391	0.154	Mouse
ribonucleotide metabolic process	GO:0009259	231	0.147
regulation of molecular function	GO:0065009	398	0.142	Human
macromolecular complex subunit organization	GO:0043933	339	0.128
homeostatic process	GO:0042592	331	0.119
regulation of cellular localization	GO:0060341	263	0.116	Human Mouse
multicellular organismal homeostasis	GO:0048871	49	0.114
rna biosynthetic process	GO:0032774	380	0.107	Mouse
organophosphate metabolic process	GO:0019637	370	0.106
cellular response to oxygen containing compound	GO:1901701	386	0.103
organic substance catabolic process	GO:1901575	316	0.102
cellular component assembly	GO:0022607	360	0.099
nucleoside phosphate metabolic process	GO:0006753	283	0.099
negative regulation of cellular metabolic process	GO:0031324	281	0.097	Mouse
regulation of transcription dna templated	GO:0006355	374	0.094	Mouse
negative regulation of metabolic process	GO:0009892	331	0.092	Mouse
regulation of nucleic acid templated transcription	GO:1903506	380	0.087	Mouse
regulation of phosphate metabolic process	GO:0019220	349	0.084	Human
transcription dna templated	GO:0006351	377	0.080	Mouse
macromolecular complex assembly	GO:0065003	273	0.080
aging	GO:0007568	241	0.079
ion transmembrane transport	GO:0034220	365	0.074
proteolysis	GO:0006508	175	0.072
metal ion transport	GO:0030001	289	0.072
cell projection organization	GO:0030030	302	0.069
regulation of rna biosynthetic process	GO:2001141	381	0.067	Mouse
immune system process	GO:0002376	204	0.065
multi organism reproductive process	GO:0044703	262	0.064
vesicle mediated transport	GO:0016192	181	0.064
negative regulation of gene expression	GO:0010629	199	0.063	Mouse
neuron development	GO:0048666	286	0.061
transcription from rna polymerase ii promoter	GO:0006366	252	0.061	Mouse
regulation of calcium ion transmembrane transport	GO:1903169	18	0.060
programmed cell death	GO:0012501	392	0.060
secretion by cell	GO:0032940	248	0.059
negative regulation of rna biosynthetic process	GO:1902679	118	0.058	Mouse
cellular component biogenesis	GO:0044085	368	0.057
reproduction	GO:0000003	245	0.056
cation transport	GO:0006812	382	0.056
purine nucleotide metabolic process	GO:0006163	229	0.055
positive regulation of intracellular signal transduction	GO:1902533	138	0.052
positive regulation of cell communication	GO:0010647	271	0.052
protein complex subunit organization	GO:0071822	302	0.052
protein transport	GO:0015031	132	0.051	Human Mouse
multicellular organism reproduction	GO:0032504	233	0.051
oxidation reduction process	GO:0055114	304	0.051	Human Mouse
response to wounding	GO:0009611	254	0.051
positive regulation of phosphate metabolic process	GO:0045937	262	0.050	Human
neuron projection development	GO:0031175	273	0.048
response to glucocorticoid	GO:0051384	223	0.048
inorganic ion transmembrane transport	GO:0098660	229	0.047
neuron differentiation	GO:0030182	368	0.047
response to other organism	GO:0051707	220	0.045
macromolecule localization	GO:0033036	252	0.045	Human Mouse
single organism catabolic process	GO:0044712	283	0.045
positive regulation of signaling	GO:0023056	270	0.044
macromolecule catabolic process	GO:0009057	58	0.043
nucleoside triphosphate metabolic process	GO:0009141	144	0.043
neuron death	GO:0070997	127	0.041
synaptic transmission	GO:0007268	235	0.041
regulation of protein transport	GO:0051223	68	0.039	Human Mouse
negative regulation of transcription dna templated	GO:0045892	116	0.039	Mouse
inorganic cation transmembrane transport	GO:0098662	202	0.039
protein complex assembly	GO:0006461	263	0.039
single organism reproductive process	GO:0044702	297	0.038
response to biotic stimulus	GO:0009607	226	0.038
nucleotide metabolic process	GO:0009117	279	0.037
tissue development	GO:0009888	252	0.037
regulation of calcium ion transmembrane transporter activity	GO:1901019	17	0.037
positive regulation of molecular function	GO:0044093	230	0.037	Human
cation transmembrane transport	GO:0098655	263	0.035
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.035	Mouse
regulation of signal transduction	GO:0009966	318	0.035
nucleobase containing small molecule metabolic process	GO:0055086	316	0.035
purine containing compound metabolic process	GO:0072521	253	0.034
multicellular organismal reproductive process	GO:0048609	233	0.034
establishment of protein localization	GO:0045184	141	0.034	Human Mouse
divalent metal ion transport	GO:0070838	132	0.034
intracellular protein transport	GO:0006886	79	0.033	Human Mouse
regulation of phosphorus metabolic process	GO:0051174	349	0.033	Human
response to acid chemical	GO:0001101	222	0.033
regulation of catabolic process	GO:0009894	113	0.032
organelle organization	GO:0006996	266	0.031
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.031
regulation of cell morphogenesis	GO:0022604	77	0.031
regulation of cell development	GO:0060284	263	0.031
purine nucleoside metabolic process	GO:0042278	169	0.030
pseudopodium assembly	GO:0031269	3	0.030
carbohydrate derivative metabolic process	GO:1901135	346	0.030
inflammatory response	GO:0006954	150	0.030
response to inorganic substance	GO:0010035	377	0.030
regulation of transmembrane transporter activity	GO:0022898	49	0.029
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.029
head development	GO:0060322	247	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.028
calcium ion transport	GO:0006816	131	0.028
glycosyl compound metabolic process	GO:1901657	182	0.028
regulation of catalytic activity	GO:0050790	304	0.028
positive regulation of signal transduction	GO:0009967	175	0.028
synaptic growth at neuromuscular junction	GO:0051124	1	0.028
negative regulation of response to stimulus	GO:0048585	155	0.028	Human
negative regulation of cell death	GO:0060548	229	0.028	Human
regulation of protein modification process	GO:0031399	194	0.028	Human
response to external biotic stimulus	GO:0043207	221	0.028
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.028
negative regulation of rna metabolic process	GO:0051253	123	0.028	Mouse
response to monosaccharide	GO:0034284	159	0.027
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.027	Mouse
protein phosphorylation	GO:0006468	345	0.027	Human
negative regulation of macromolecule metabolic process	GO:0010605	260	0.027	Mouse
response to amine	GO:0014075	46	0.027
anatomical structure morphogenesis	GO:0009653	298	0.027
response to bacterium	GO:0009617	200	0.026
developmental process involved in reproduction	GO:0003006	159	0.026
immune response	GO:0006955	104	0.026
regulation of cellular protein metabolic process	GO:0032268	267	0.025	Human
nucleoside metabolic process	GO:0009116	179	0.025
nucleoside phosphate biosynthetic process	GO:1901293	102	0.025
purine ribonucleoside metabolic process	GO:0046128	168	0.025
defense response	GO:0006952	194	0.025
endocytosis	GO:0006897	84	0.025
response to metal ion	GO:0010038	253	0.025
cellular amino acid metabolic process	GO:0006520	107	0.025
regulation of ion transmembrane transporter activity	GO:0032412	48	0.024
circulatory system process	GO:0003013	183	0.024
negative regulation of cell communication	GO:0010648	158	0.024
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.024	Mouse
single organism organelle organization	GO:1902589	180	0.023
secretion	GO:0046903	307	0.023
regulation of apoptotic process	GO:0042981	335	0.023
negative regulation of biosynthetic process	GO:0009890	168	0.023	Mouse
ribose phosphate metabolic process	GO:0019693	235	0.023
positive regulation of transport	GO:0051050	245	0.023
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.023	Mouse
ribose phosphate biosynthetic process	GO:0046390	87	0.023
positive regulation of transcription dna templated	GO:0045893	197	0.023
response to oxidative stress	GO:0006979	186	0.022	Human
reproductive process	GO:0022414	372	0.022
regulation of ion transport	GO:0043269	245	0.022
anatomical structure homeostasis	GO:0060249	29	0.022
response to peptide	GO:1901652	292	0.021
striated muscle tissue development	GO:0014706	58	0.021
nucleobase containing compound catabolic process	GO:0034655	152	0.021
purine nucleotide catabolic process	GO:0006195	136	0.021
organic cyclic compound catabolic process	GO:1901361	175	0.021
regulation of secretion	GO:0051046	224	0.020
regulation of protein localization	GO:0032880	81	0.020	Human Mouse
chemical homeostasis	GO:0048878	292	0.020
response to hexose	GO:0009746	144	0.020
regulation of intracellular signal transduction	GO:1902531	218	0.019
cell cell signaling	GO:0007267	335	0.019
positive regulation of biosynthetic process	GO:0009891	319	0.019
transmembrane transport	GO:0055085	412	0.019
apoptotic process	GO:0006915	381	0.019
telencephalon development	GO:0021537	62	0.019
regulation of ion transmembrane transport	GO:0034765	121	0.019
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.019
positive regulation of cellular protein metabolic process	GO:0032270	167	0.018	Human
positive regulation of catalytic activity	GO:0043085	184	0.018
embryo development	GO:0009790	49	0.018
reproductive structure development	GO:0048608	128	0.018
protein oligomerization	GO:0051259	191	0.018
regulation of establishment of protein localization	GO:0070201	69	0.017	Human Mouse
negative regulation of skeletal muscle cell differentiation	GO:2001015	1	0.017
calcium ion transmembrane transport	GO:0070588	70	0.017
negative regulation of skeletal muscle tissue development	GO:0048642	3	0.017
small gtpase mediated signal transduction	GO:0007264	36	0.017
locomotion	GO:0040011	237	0.017
response to ethanol	GO:0045471	162	0.017
cellular component morphogenesis	GO:0032989	155	0.016
negative regulation of signaling	GO:0023057	157	0.016
ribonucleoside metabolic process	GO:0009119	174	0.016
gamete generation	GO:0007276	124	0.016
regulation of cellular catabolic process	GO:0031329	101	0.016
purine ribonucleotide metabolic process	GO:0009150	227	0.016
skin morphogenesis	GO:0043589	2	0.016
growth	GO:0040007	165	0.016
regulation of cellular amino acid metabolic process	GO:0006521	2	0.016
regulation of protein kinase activity	GO:0045859	105	0.016
viral genome replication	GO:0019079	2	0.015
protein complex biogenesis	GO:0070271	263	0.015
regulation of neuron death	GO:1901214	115	0.015
positive regulation of cellular biosynthetic process	GO:0031328	295	0.015
regulation of kinase activity	GO:0043549	117	0.015
regulation of protein metabolic process	GO:0051246	289	0.015	Human
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.015
cell morphogenesis	GO:0000902	142	0.015
regulation of programmed cell death	GO:0043067	341	0.014
positive regulation of response to stimulus	GO:0048584	285	0.014
positive regulation of phosphorylation	GO:0042327	177	0.014	Human
response to carbohydrate	GO:0009743	183	0.014
protein localization	GO:0008104	191	0.014	Human Mouse
negative regulation of transport	GO:0051051	136	0.014	Mouse
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.014
carbohydrate derivative biosynthetic process	GO:1901137	124	0.014
regulation of hydrolase activity	GO:0051336	143	0.014
regulation of cell differentiation	GO:0045595	320	0.014
regulation of cellular amine metabolic process	GO:0033238	8	0.014
carboxylic acid transport	GO:0046942	115	0.013
cellular response to growth factor stimulus	GO:0071363	162	0.013
central nervous system development	GO:0007417	311	0.013
regulation of cellular ketone metabolic process	GO:0010565	27	0.013
spliceosomal complex assembly	GO:0000245	2	0.013
negative regulation of multicellular organismal process	GO:0051241	203	0.013
cellular nitrogen compound catabolic process	GO:0044270	163	0.013
cytoplasmic transport	GO:0016482	115	0.013	Human Mouse
positive regulation of cell proliferation	GO:0008284	249	0.012
regulation of protein phosphorylation	GO:0001932	183	0.012	Human
sexual reproduction	GO:0019953	148	0.012
cellular homeostasis	GO:0019725	252	0.012
cellular response to extracellular stimulus	GO:0031668	73	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.012	Mouse
negative regulation of cellular biosynthetic process	GO:0031327	161	0.012	Mouse
positive regulation of phosphorus metabolic process	GO:0010562	262	0.012	Human
blood circulation	GO:0008015	183	0.011
cellular response to endogenous stimulus	GO:0071495	377	0.011
forebrain development	GO:0030900	98	0.011
regulation of anatomical structure morphogenesis	GO:0022603	141	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
single organism membrane organization	GO:0044802	74	0.011
regulation of cellular component organization	GO:0051128	368	0.011
negative regulation of secretion by cell	GO:1903531	72	0.011
single organism cell adhesion	GO:0098602	46	0.011
adult locomotory behavior	GO:0008344	4	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.011	Mouse
single organism behavior	GO:0044708	130	0.011
positive regulation of gene expression	GO:0010628	244	0.011
divalent inorganic cation transport	GO:0072511	134	0.011
positive regulation of transferase activity	GO:0051347	81	0.011
pseudopodium organization	GO:0031268	3	0.010
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.010
cell part morphogenesis	GO:0032990	123	0.010
protein modification by small protein conjugation	GO:0032446	31	0.010
biological adhesion	GO:0022610	110	0.010
positive regulation of rna biosynthetic process	GO:1902680	197	0.010
gtp metabolic process	GO:0046039	72	0.010

Txn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.017
disease of anatomical entity	DOID:7	0.017
brain disease	DOID:936	0.011
central nervous system disease	DOID:331	0.011

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