IMP: Integrative Multi-species Prediction

Rattus norvegicus

82 known processes

Stxbp1

syntaxin binding protein 1

(Aliases: Unc18-1,n-sec1,Munc18-1,ANC18HA,rbSec1,rbSec1A,nSec1,Sec1,NSEC1A,rbSec1B)

RGD: 3785
Ensembl: ENSRNOG00000015420
Entrez: 25558
UniProtKB: P61765

Process Predictions
Disease Predictions

Stxbp1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
synaptic vesicle docking involved in exocytosis	GO:0016081	2	0.994
synaptic vesicle exocytosis	GO:0016079	15	0.937
vesicle docking involved in exocytosis	GO:0006904	4	0.934	Yeast Mouse
positive regulation of exocytosis	GO:0045921	19	0.730
positive regulation of neurotransmitter secretion	GO:0001956	9	0.729
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.675
synaptic vesicle transport	GO:0048489	23	0.667
microvillus assembly	GO:0030033	2	0.655
organic substance catabolic process	GO:1901575	316	0.632
single organism catabolic process	GO:0044712	283	0.624
organophosphate metabolic process	GO:0019637	370	0.597
establishment of vesicle localization	GO:0051650	31	0.596
single organism organelle organization	GO:1902589	180	0.579	Yeast Mouse
regulation of cellular component organization	GO:0051128	368	0.573
establishment of organelle localization	GO:0051656	37	0.571
vesicle fusion	GO:0006906	14	0.547	Yeast
aromatic compound catabolic process	GO:0019439	168	0.539
vesicle docking	GO:0048278	5	0.527	Yeast Mouse
regulation of secretion	GO:0051046	224	0.502
exocytosis	GO:0006887	60	0.498
positive regulation of secretion	GO:0051047	140	0.478
nucleotide metabolic process	GO:0009117	279	0.463
positive regulation of transport	GO:0051050	245	0.461
organelle organization	GO:0006996	266	0.432	Yeast Mouse
regulation of molecular function	GO:0065009	398	0.419
purine ribonucleotide catabolic process	GO:0009154	136	0.417
nucleoside catabolic process	GO:0009164	126	0.410
organelle fusion	GO:0048284	17	0.409	Yeast
protein localization	GO:0008104	191	0.404	Human
neuromuscular synaptic transmission	GO:0007274	2	0.403	Mouse
organic acid metabolic process	GO:0006082	292	0.393
cellular component biogenesis	GO:0044085	368	0.385
organophosphate catabolic process	GO:0046434	148	0.375
nucleotide catabolic process	GO:0009166	139	0.369
regulation of cell maturation	GO:1903429	3	0.367	Fly
synaptic transmission	GO:0007268	235	0.359
membrane fusion	GO:0061025	26	0.359	Yeast
secretion	GO:0046903	307	0.341
catabolic process	GO:0009056	351	0.335
regulation of multicellular organismal development	GO:2000026	376	0.334	Fly
nucleoside phosphate metabolic process	GO:0006753	283	0.333
nucleobase containing small molecule metabolic process	GO:0055086	316	0.329
nucleoside triphosphate metabolic process	GO:0009141	144	0.325
membrane docking	GO:0022406	6	0.322	Yeast Mouse
regulation of neurotransmitter levels	GO:0001505	42	0.316
regulation of neurotransmitter secretion	GO:0046928	19	0.311
protein complex biogenesis	GO:0070271	263	0.307
cellular component assembly	GO:0022607	360	0.304
oxoacid metabolic process	GO:0043436	290	0.291
organelle localization	GO:0051640	55	0.287
establishment of protein localization	GO:0045184	141	0.277
nucleoside triphosphate catabolic process	GO:0009143	123	0.276
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.274
positive regulation of neurotransmitter transport	GO:0051590	9	0.265
synaptic vesicle endocytosis	GO:0048488	4	0.264	Mouse
regulation of secretion by cell	GO:1903530	208	0.255
single organism membrane organization	GO:0044802	74	0.250	Human Yeast
synaptic growth at neuromuscular junction	GO:0051124	1	0.249
vesicle mediated transport	GO:0016192	181	0.237
regulation of vesicle mediated transport	GO:0060627	81	0.234
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.233
regulation of phosphorus metabolic process	GO:0051174	349	0.230
vesicle organization	GO:0016050	29	0.226	Yeast Mouse
purine nucleoside metabolic process	GO:0042278	169	0.224
protein phosphorylation	GO:0006468	345	0.223
protein complex assembly	GO:0006461	263	0.223
cellular catabolic process	GO:0044248	295	0.218
organonitrogen compound catabolic process	GO:1901565	179	0.212
ribonucleotide metabolic process	GO:0009259	231	0.208
protein complex subunit organization	GO:0071822	302	0.207
macromolecular complex assembly	GO:0065003	273	0.205
carbohydrate derivative metabolic process	GO:1901135	346	0.204
glycosyl compound metabolic process	GO:1901657	182	0.203
cytoskeleton dependent cytokinesis	GO:0061640	2	0.202	Fly
anterior posterior pattern specification	GO:0009952	1	0.200	Fly
purine ribonucleoside catabolic process	GO:0046130	124	0.197
carboxylic acid metabolic process	GO:0019752	289	0.197
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.195
positive regulation of secretion by cell	GO:1903532	128	0.186
regulation of cellular localization	GO:0060341	263	0.185
cellular response to oxygen containing compound	GO:1901701	386	0.184
heterocycle catabolic process	GO:0046700	167	0.184
single organism carbohydrate metabolic process	GO:0044723	118	0.182
ribose phosphate metabolic process	GO:0019693	235	0.179
growth	GO:0040007	165	0.179
regulation of cell differentiation	GO:0045595	320	0.177	Fly
positive regulation of cell communication	GO:0010647	271	0.176
secretion by cell	GO:0032940	248	0.176
cellular nitrogen compound catabolic process	GO:0044270	163	0.176
endomembrane system organization	GO:0010256	48	0.172	Human
neurotransmitter transport	GO:0006836	42	0.172
ribonucleoside catabolic process	GO:0042454	126	0.172
cell projection organization	GO:0030030	302	0.169	Mouse
regulation of cellular protein metabolic process	GO:0032268	267	0.158
gtp catabolic process	GO:0006184	71	0.158
multi organism reproductive process	GO:0044703	262	0.154	Fly
glycosyl compound catabolic process	GO:1901658	126	0.153
regulation of exocytosis	GO:0017157	37	0.153
neurotransmitter secretion	GO:0007269	33	0.152
neuron projection development	GO:0031175	273	0.152	Mouse
membrane organization	GO:0061024	94	0.151	Human Yeast
protein transport	GO:0015031	132	0.151
purine nucleotide metabolic process	GO:0006163	229	0.150
cellular macromolecule localization	GO:0070727	122	0.148	Human Fly
nucleoside phosphate catabolic process	GO:1901292	140	0.148
ribonucleotide catabolic process	GO:0009261	136	0.147
pyruvate metabolic process	GO:0006090	27	0.146
cell cycle	GO:0007049	101	0.145	Fly
regulation of phosphate metabolic process	GO:0019220	349	0.142
positive regulation of phosphorus metabolic process	GO:0010562	262	0.141
macromolecule localization	GO:0033036	252	0.140	Human Fly
nucleoside metabolic process	GO:0009116	179	0.140
cellular protein localization	GO:0034613	122	0.137	Human
purine containing compound metabolic process	GO:0072521	253	0.134
organic cyclic compound catabolic process	GO:1901361	175	0.132
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.132
regulation of nervous system development	GO:0051960	264	0.129
olfactory learning	GO:0008355	1	0.128
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.127
neuron differentiation	GO:0030182	368	0.123	Mouse
neuron development	GO:0048666	286	0.123	Mouse
generation of precursor metabolites and energy	GO:0006091	62	0.123
regulation of catalytic activity	GO:0050790	304	0.121
macromolecular complex subunit organization	GO:0043933	339	0.120
purine ribonucleotide metabolic process	GO:0009150	227	0.119
regeneration	GO:0031099	163	0.119
regulation of nucleotide metabolic process	GO:0006140	117	0.116
regulation of protein phosphorylation	GO:0001932	183	0.114
organonitrogen compound biosynthetic process	GO:1901566	167	0.113
regulation of synaptic plasticity	GO:0048167	70	0.112	Mouse
purine containing compound catabolic process	GO:0072523	138	0.111
positive regulation of molecular function	GO:0044093	230	0.110
cell cell signaling	GO:0007267	335	0.109
tissue development	GO:0009888	252	0.108
single organism carbohydrate catabolic process	GO:0044724	40	0.108
regulation of cell development	GO:0060284	263	0.107	Fly
response to nutrient	GO:0007584	248	0.106
establishment of synaptic vesicle localization	GO:0097480	23	0.106
purine ribonucleoside metabolic process	GO:0046128	168	0.105
nucleobase containing compound catabolic process	GO:0034655	152	0.104
positive regulation of catalytic activity	GO:0043085	184	0.103
monocarboxylic acid metabolic process	GO:0032787	152	0.102
protein oligomerization	GO:0051259	191	0.102
positive regulation of synaptic transmission	GO:0050806	62	0.099
single organism biosynthetic process	GO:0044711	342	0.098
gtp metabolic process	GO:0046039	72	0.098
embryonic axis specification	GO:0000578	1	0.095	Fly
positive regulation of response to stimulus	GO:0048584	285	0.094
synaptic vesicle priming	GO:0016082	4	0.094
sexual reproduction	GO:0019953	148	0.092	Fly
vesicle localization	GO:0051648	33	0.091
protein localization to membrane	GO:0072657	36	0.090	Human
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.089
wound healing	GO:0042060	122	0.089	Human
synapse organization	GO:0050808	46	0.088
regulation of organelle organization	GO:0033043	80	0.087	Yeast
regulation of transferase activity	GO:0051338	123	0.086
regulation of synaptic transmission	GO:0050804	141	0.086
synaptic vesicle localization	GO:0097479	24	0.084
cellular amino acid metabolic process	GO:0006520	107	0.084
synapse assembly	GO:0007416	29	0.084
anion transport	GO:0006820	178	0.080
peptidyl amino acid modification	GO:0018193	126	0.079
signal release	GO:0023061	145	0.076
axis specification	GO:0009798	4	0.076	Fly
single organism reproductive process	GO:0044702	297	0.075	Fly
carbohydrate metabolic process	GO:0005975	130	0.074
negative regulation of multicellular organismal process	GO:0051241	203	0.071
guanosine containing compound metabolic process	GO:1901068	74	0.071
carbohydrate catabolic process	GO:0016052	40	0.070
regulation of anion transport	GO:0044070	43	0.069
regulation of embryonic development	GO:0045995	2	0.069	Fly
carbohydrate derivative catabolic process	GO:1901136	147	0.069
tissue regeneration	GO:0042246	36	0.067
multicellular organism reproduction	GO:0032504	233	0.067	Fly
positive regulation of phosphate metabolic process	GO:0045937	262	0.066
ribonucleoside metabolic process	GO:0009119	174	0.066
response to temperature stimulus	GO:0009266	94	0.066
cytoskeleton organization	GO:0007010	111	0.065
intracellular signal transduction	GO:0035556	314	0.065
nitrogen compound transport	GO:0071705	229	0.064
positive regulation of signaling	GO:0023056	270	0.064
intracellular protein transport	GO:0006886	79	0.064
response to peptide hormone	GO:0043434	278	0.064
response to wounding	GO:0009611	254	0.064	Human
purine nucleotide catabolic process	GO:0006195	136	0.063
response to peptide	GO:1901652	292	0.061
positive regulation of protein metabolic process	GO:0051247	178	0.060
response to heat	GO:0009408	60	0.060
regulation of ion transport	GO:0043269	245	0.060
regulation of postsynaptic membrane potential	GO:0060078	25	0.059
negative regulation of metabolic process	GO:0009892	331	0.058
developmental growth	GO:0048589	100	0.058
regulation of protein metabolic process	GO:0051246	289	0.057
sensory perception of mechanical stimulus	GO:0050954	17	0.055
response to estrogen	GO:0043627	232	0.053
regulation of system process	GO:0044057	208	0.052
response to inorganic substance	GO:0010035	377	0.052
cellular response to endogenous stimulus	GO:0071495	377	0.050
multicellular organismal reproductive process	GO:0048609	233	0.048	Fly
positive regulation of cellular component organization	GO:0051130	200	0.048	Yeast
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.048
regulation of protein kinase activity	GO:0045859	105	0.047
regulation of cell cycle	GO:0051726	73	0.047
glycolytic process	GO:0006096	17	0.046
regulation of neuronal synaptic plasticity	GO:0048168	31	0.046
response to amino acid	GO:0043200	75	0.045
response to carbohydrate	GO:0009743	183	0.045
response to glucose	GO:0009749	136	0.045
developmental process involved in reproduction	GO:0003006	159	0.045	Fly
response to monosaccharide	GO:0034284	159	0.044
regulation of protein serine threonine kinase activity	GO:0071900	64	0.043
positive regulation of nucleotide catabolic process	GO:0030813	53	0.043
chemosensory behavior	GO:0007635	2	0.043
developmental maturation	GO:0021700	25	0.042	Mouse Fly
programmed cell death	GO:0012501	392	0.042	Mouse
anterograde axon cargo transport	GO:0008089	1	0.042
reproduction	GO:0000003	245	0.042	Fly
receptor localization to synapse	GO:0097120	2	0.042
single organism cellular localization	GO:1902580	102	0.042	Human Fly
neuron neuron synaptic transmission	GO:0007270	60	0.042	Mouse
response to hexose	GO:0009746	144	0.042
transcription dna templated	GO:0006351	377	0.041
regulation of protein modification process	GO:0031399	194	0.041
regulation of nucleoside metabolic process	GO:0009118	66	0.039
embryonic pattern specification	GO:0009880	1	0.039	Fly
cellular amino acid biosynthetic process	GO:0008652	32	0.038
mitotic cell cycle	GO:0000278	49	0.038	Fly
purine nucleoside catabolic process	GO:0006152	124	0.037
cellular response to nitrogen compound	GO:1901699	210	0.036
positive regulation of map kinase activity	GO:0043406	46	0.036
microtubule based process	GO:0007017	36	0.036
adult locomotory behavior	GO:0008344	4	0.035
regulation of membrane potential	GO:0042391	110	0.035
response to estradiol	GO:0032355	164	0.035
cell cycle process	GO:0022402	57	0.034	Fly
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.034
anatomical structure morphogenesis	GO:0009653	298	0.034	Mouse
protein tetramerization	GO:0051262	38	0.034
response to nutrient levels	GO:0031667	370	0.034
cellular chemical homeostasis	GO:0055082	247	0.033
response to toxic substance	GO:0009636	133	0.033
cellular response to insulin stimulus	GO:0032869	81	0.033
regulation of purine nucleotide metabolic process	GO:1900542	115	0.033
cellular response to stress	GO:0033554	269	0.033
regulation of neuron differentiation	GO:0045664	208	0.033
response to gravity	GO:0009629	13	0.033
cellular response to peptide hormone stimulus	GO:0071375	120	0.032
carboxylic acid biosynthetic process	GO:0046394	83	0.032
regulation of hydrolase activity	GO:0051336	143	0.032
positive regulation of synapse maturation	GO:0090129	2	0.032
single organism membrane fusion	GO:0044801	17	0.032	Yeast
cellular component maintenance	GO:0043954	4	0.032
behavior	GO:0007610	205	0.031
axon development	GO:0061564	96	0.031	Mouse
positive regulation of cellular protein metabolic process	GO:0032270	167	0.031
regulation of cellular amino acid metabolic process	GO:0006521	2	0.031
regulation of purine nucleotide catabolic process	GO:0033121	65	0.031
regulation of neurogenesis	GO:0050767	247	0.031
multicellular organism growth	GO:0035264	1	0.031
olfactory behavior	GO:0042048	2	0.031
chemotaxis	GO:0006935	66	0.030
regulated secretory pathway	GO:0045055	17	0.030
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.030
single organism behavior	GO:0044708	130	0.030
positive regulation of cell differentiation	GO:0045597	217	0.029
axon cargo transport	GO:0008088	1	0.029
regulation of cellular catabolic process	GO:0031329	101	0.029
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.028
positive regulation of protein phosphorylation	GO:0001934	135	0.028
cellular component movement	GO:0006928	248	0.028
regulation of signal transduction	GO:0009966	318	0.028
organ morphogenesis	GO:0009887	75	0.028
gamma aminobutyric acid secretion	GO:0014051	6	0.028
positive regulation of protein modification process	GO:0031401	142	0.028
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.027
cellular macromolecular complex assembly	GO:0034622	58	0.027
positive regulation of hydrolase activity	GO:0051345	86	0.027
neurological system process	GO:0050877	219	0.027
cellular ketone metabolic process	GO:0042180	51	0.027
regulation of protein complex assembly	GO:0043254	33	0.027
positive regulation of intracellular signal transduction	GO:1902533	138	0.027
regulation of nucleotide catabolic process	GO:0030811	65	0.027
cellular response to organonitrogen compound	GO:0071417	197	0.026
gamete generation	GO:0007276	124	0.026	Fly
regulation of excitatory postsynaptic membrane potential	GO:0060079	18	0.026
positive regulation of purine nucleotide catabolic process	GO:0033123	53	0.026
positive regulation of protein kinase activity	GO:0045860	73	0.026
cellular response to hormone stimulus	GO:0032870	247	0.026
positive regulation of cellular amine metabolic process	GO:0033240	3	0.026
epithelium development	GO:0060429	96	0.026
atp metabolic process	GO:0046034	72	0.026
positive regulation of nucleotide metabolic process	GO:0045981	91	0.026
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.025
positive regulation of phosphorylation	GO:0042327	177	0.025
regulation of kinase activity	GO:0043549	117	0.025
regulation of catabolic process	GO:0009894	113	0.025
positive regulation of neuron differentiation	GO:0045666	126	0.025
positive regulation of nervous system development	GO:0051962	178	0.025
respiratory system process	GO:0003016	3	0.025
regulation of intracellular signal transduction	GO:1902531	218	0.025
positive regulation of nucleoside metabolic process	GO:0045979	55	0.025
regulation of protein transport	GO:0051223	68	0.024
cell morphogenesis involved in differentiation	GO:0000904	119	0.024	Mouse
carboxylic acid transport	GO:0046942	115	0.024
cellular amine metabolic process	GO:0044106	38	0.024
response to external biotic stimulus	GO:0043207	221	0.024
response to acid chemical	GO:0001101	222	0.024
response to vitamin	GO:0033273	131	0.024
regulation of cytoskeleton organization	GO:0051493	49	0.024
positive regulation of neurogenesis	GO:0050769	165	0.024
apoptotic signaling pathway	GO:0097190	27	0.023
ras protein signal transduction	GO:0007265	29	0.023
positive regulation of cell development	GO:0010720	176	0.023
negative regulation of biosynthetic process	GO:0009890	168	0.023
regulation of synapse maturation	GO:0090128	2	0.023
positive regulation of neuron projection development	GO:0010976	99	0.023
amine metabolic process	GO:0009308	38	0.022
synaptic vesicle recycling	GO:0036465	5	0.022	Mouse
actin filament based process	GO:0030029	86	0.022
response to ketone	GO:1901654	182	0.022
small gtpase mediated signal transduction	GO:0007264	36	0.022
sensory perception	GO:0007600	101	0.022
chemical homeostasis	GO:0048878	292	0.022
apoptotic process	GO:0006915	381	0.022	Mouse
regulation of cell migration	GO:0030334	128	0.021
negative regulation of protein metabolic process	GO:0051248	114	0.021
cation homeostasis	GO:0055080	195	0.021
positive regulation of transferase activity	GO:0051347	81	0.021
atp catabolic process	GO:0006200	54	0.021
response to insulin	GO:0032868	133	0.021
peptidyl serine modification	GO:0018209	34	0.021
regulation of cellular amine metabolic process	GO:0033238	8	0.021
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.021
negative regulation of catalytic activity	GO:0043086	103	0.020
neuron death	GO:0070997	127	0.020	Mouse
response to oxidative stress	GO:0006979	186	0.020
negative regulation of protein phosphorylation	GO:0001933	44	0.020
divalent inorganic cation transport	GO:0072511	134	0.020
regulation of establishment of protein localization	GO:0070201	69	0.020
regulation of cellular component biogenesis	GO:0044087	86	0.020
regulation of endocytosis	GO:0030100	42	0.020
positive regulation of cell projection organization	GO:0031346	111	0.020
endocytosis	GO:0006897	84	0.020	Mouse
response to extracellular stimulus	GO:0009991	380	0.020
glucose metabolic process	GO:0006006	52	0.019
regulation of rna biosynthetic process	GO:2001141	381	0.019
negative regulation of gene expression	GO:0010629	199	0.019
negative regulation of nervous system development	GO:0051961	79	0.019
cellular carbohydrate metabolic process	GO:0044262	72	0.019
negative regulation of cellular biosynthetic process	GO:0031327	161	0.019
central nervous system development	GO:0007417	311	0.019
regulation of synapse assembly	GO:0051963	15	0.019
axonogenesis	GO:0007409	71	0.019	Mouse
regulation of map kinase activity	GO:0043405	53	0.019
amino acid transport	GO:0006865	70	0.019
cellular response to lipid	GO:0071396	201	0.019
cell junction maintenance	GO:0034331	1	0.019
positive regulation of developmental process	GO:0051094	283	0.019
organic acid biosynthetic process	GO:0016053	83	0.019
organic anion transport	GO:0015711	132	0.018
tube development	GO:0035295	89	0.018
regulation of neuron projection development	GO:0010975	161	0.018
cell morphogenesis	GO:0000902	142	0.018	Mouse
regulation of programmed cell death	GO:0043067	341	0.018	Mouse
regulation of cellular ketone metabolic process	GO:0010565	27	0.018
cell growth	GO:0016049	104	0.018
response to metal ion	GO:0010038	253	0.018
cellular component morphogenesis	GO:0032989	155	0.018	Mouse
rna localization	GO:0006403	4	0.018	Fly
regulation of cell projection organization	GO:0031344	175	0.018
regulation of locomotion	GO:0040012	148	0.018
organophosphate biosynthetic process	GO:0090407	143	0.018
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	4	0.018
regulation of growth	GO:0040008	105	0.018
positive regulation of mapk cascade	GO:0043410	92	0.018
response to growth factor	GO:0070848	189	0.018
regulation of cell proliferation	GO:0042127	359	0.017
positive regulation of protein transport	GO:0051222	41	0.017
insulin receptor signaling pathway	GO:0008286	24	0.017
response to zinc ion	GO:0010043	39	0.017
positive regulation of cell proliferation	GO:0008284	249	0.017
male gamete generation	GO:0048232	99	0.017
positive regulation of smooth muscle cell proliferation	GO:0048661	51	0.017
chromosome segregation	GO:0007059	2	0.017
peptidyl serine phosphorylation	GO:0018105	33	0.017
peptide transport	GO:0015833	97	0.017
positive regulation of transcription dna templated	GO:0045893	197	0.017
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.017
positive regulation of kinase activity	GO:0033674	77	0.017
negative regulation of cellular metabolic process	GO:0031324	281	0.016
peptidyl tyrosine modification	GO:0018212	72	0.016
muscle cell proliferation	GO:0033002	84	0.016
epithelial cell differentiation	GO:0030855	71	0.016
positive regulation of cell migration	GO:0030335	96	0.016
monosaccharide metabolic process	GO:0005996	61	0.016
aging	GO:0007568	241	0.016
response to bacterium	GO:0009617	200	0.016
hormone transport	GO:0009914	121	0.016
purine nucleotide biosynthetic process	GO:0006164	83	0.016
positive regulation of protein serine threonine kinase activity	GO:0071902	52	0.016
reactive oxygen species biosynthetic process	GO:1903409	8	0.016
response to ethanol	GO:0045471	162	0.016
positive regulation of fc receptor mediated stimulatory signaling pathway	GO:0060369	1	0.016
response to lipopolysaccharide	GO:0032496	191	0.016
head development	GO:0060322	247	0.016
regulation of synapse organization	GO:0050807	19	0.016
positive regulation of cellular component movement	GO:0051272	102	0.016
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.016
respiratory gaseous exchange	GO:0007585	4	0.016
membrane depolarization	GO:0051899	32	0.016
gland development	GO:0048732	155	0.016
regulation of cell motility	GO:2000145	131	0.016
carbohydrate phosphorylation	GO:0046835	16	0.015
protein autophosphorylation	GO:0046777	66	0.015
ribonucleotide biosynthetic process	GO:0009260	85	0.015
purine nucleoside monophosphate catabolic process	GO:0009128	55	0.015
amide transport	GO:0042886	105	0.015
adherens junction maintenance	GO:0034334	1	0.015
negative regulation of cellular protein metabolic process	GO:0032269	106	0.015
homeostatic process	GO:0042592	331	0.015
response to radiation	GO:0009314	137	0.015	Fly
microtubule cytoskeleton organization	GO:0000226	25	0.015
cell adhesion	GO:0007155	110	0.015	Human
neuron projection morphogenesis	GO:0048812	122	0.015	Mouse
cellular response to peptide	GO:1901653	133	0.015
regulation of phosphorylation	GO:0042325	248	0.015
negative regulation of cell death	GO:0060548	229	0.015	Mouse
regulation of rab gtpase activity	GO:0032313	3	0.015
skeletal muscle tissue regeneration	GO:0043403	10	0.015
sensory organ development	GO:0007423	74	0.015
negative regulation of cellular component organization	GO:0051129	83	0.015
cortical actin cytoskeleton organization	GO:0030866	2	0.014
digestive tract morphogenesis	GO:0048546	8	0.014
cellular response to oxygen levels	GO:0071453	60	0.014
alpha amino acid catabolic process	GO:1901606	20	0.014
potassium ion transport	GO:0006813	97	0.014
tube morphogenesis	GO:0035239	23	0.014
activation of phospholipase d activity	GO:0031584	2	0.014
positive regulation of cell adhesion	GO:0045785	30	0.014
salivary gland morphogenesis	GO:0007435	1	0.014
alpha amino acid biosynthetic process	GO:1901607	23	0.014
cellular protein complex assembly	GO:0043623	44	0.014
positive regulation of amino acid transport	GO:0051957	13	0.014
regulation of muscle system process	GO:0090257	79	0.014
cell projection morphogenesis	GO:0048858	123	0.014	Mouse
spermatogenesis	GO:0007283	99	0.014
positive regulation of gtp catabolic process	GO:0033126	48	0.014
biological adhesion	GO:0022610	110	0.014	Human
activation of protein kinase b activity	GO:0032148	3	0.014
cellular response to external stimulus	GO:0071496	118	0.014
regulation of protein localization	GO:0032880	81	0.014
cellular response to abiotic stimulus	GO:0071214	85	0.014
monoamine transport	GO:0015844	43	0.014
cellular homeostasis	GO:0019725	252	0.014
negative regulation of macromolecule metabolic process	GO:0010605	260	0.014
response to starvation	GO:0042594	59	0.013
immune response	GO:0006955	104	0.013
peptidyl tyrosine autophosphorylation	GO:0038083	1	0.013
regulation of intracellular protein transport	GO:0033157	34	0.013
memory	GO:0007613	54	0.013
proteolysis	GO:0006508	175	0.013
regulation of g2 m transition of mitotic cell cycle	GO:0010389	4	0.013
regulation of developmental growth	GO:0048638	45	0.013
carbohydrate derivative biosynthetic process	GO:1901137	124	0.013
regulation of cell growth	GO:0001558	85	0.013
glycogen metabolic process	GO:0005977	23	0.013
negative regulation of apoptotic process	GO:0043066	181	0.013	Mouse
negative regulation of developmental process	GO:0051093	125	0.013
oxidation reduction process	GO:0055114	304	0.013
organic acid transport	GO:0015849	116	0.013
hormone secretion	GO:0046879	115	0.013
intracellular transport	GO:0046907	185	0.013
regulation of peptide transport	GO:0090087	87	0.013
detection of chemical stimulus involved in sensory perception of bitter taste	GO:0001580	4	0.013
regulation of peptide secretion	GO:0002791	82	0.013
taxis	GO:0042330	67	0.013
negative regulation of phosphate metabolic process	GO:0045936	80	0.013
meiotic cell cycle process	GO:1903046	3	0.013
negative regulation of secretion	GO:0051048	82	0.012
reactive oxygen species metabolic process	GO:0072593	37	0.012
positive regulation of intracellular protein transport	GO:0090316	20	0.012
response to transition metal nanoparticle	GO:1990267	122	0.012
small molecule catabolic process	GO:0044282	59	0.012
response to corticosteroid	GO:0031960	235	0.012
positive regulation of gene expression	GO:0010628	244	0.012
nucleoside phosphate biosynthetic process	GO:1901293	102	0.012
negative regulation of programmed cell death	GO:0043069	183	0.012	Mouse
positive regulation of signal transduction	GO:0009967	175	0.012
regulation of protein secretion	GO:0050708	28	0.012
cellular response to growth factor stimulus	GO:0071363	162	0.012

Stxbp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.041	Human
nervous system disease	DOID:863	0.041	Human
central nervous system disease	DOID:331	0.016	Human
neurodegenerative disease	DOID:1289	0.014
synucleinopathy	DOID:0050890	0.014
parkinson s disease	DOID:14330	0.014

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