IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Xirp1

xin actin-binding repeat containing 1

(Aliases: Cmya1)

RGD: 1304776
Entrez: 316071

Process Predictions
Disease Predictions

Xirp1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
nucleic acid templated transcription	GO:0097659	379	0.418
negative regulation of cell death	GO:0060548	229	0.299
circulatory system process	GO:0003013	183	0.265
regulation of cell development	GO:0060284	263	0.208
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.204
transcription dna templated	GO:0006351	377	0.186
positive regulation of rna biosynthetic process	GO:1902680	197	0.173
cellular component movement	GO:0006928	248	0.170
transcription from rna polymerase ii promoter	GO:0006366	252	0.168
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.158
rna biosynthetic process	GO:0032774	380	0.143
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.140
response to external biotic stimulus	GO:0043207	221	0.134
striated muscle contraction	GO:0006941	44	0.134
neuron development	GO:0048666	286	0.133
regulation of nervous system development	GO:0051960	264	0.130
cellular response to endogenous stimulus	GO:0071495	377	0.127
locomotion	GO:0040011	237	0.123
regulation of rna biosynthetic process	GO:2001141	381	0.116
blood circulation	GO:0008015	183	0.113
regulation of system process	GO:0044057	208	0.113
response to peptide hormone	GO:0043434	278	0.108
response to mechanical stimulus	GO:0009612	134	0.107
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.104
muscle system process	GO:0003012	115	0.104
rna metabolic process	GO:0016070	406	0.103
positive regulation of biosynthetic process	GO:0009891	319	0.103
neuron differentiation	GO:0030182	368	0.100
regulation of neuron differentiation	GO:0045664	208	0.099
regulation of neurogenesis	GO:0050767	247	0.097
neuron projection development	GO:0031175	273	0.095
anatomical structure morphogenesis	GO:0009653	298	0.091
positive regulation of transcription dna templated	GO:0045893	197	0.091
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.089
regulation of programmed cell death	GO:0043067	341	0.087
response to purine containing compound	GO:0014074	126	0.087
regulation of neuron projection development	GO:0010975	161	0.081
regulation of blood circulation	GO:1903522	110	0.081
regulation of cell differentiation	GO:0045595	320	0.076
regulation of cellular component organization	GO:0051128	368	0.076
regulation of neuron death	GO:1901214	115	0.076
muscle contraction	GO:0006936	88	0.073
apoptotic process	GO:0006915	381	0.073
heart process	GO:0003015	57	0.072
negative regulation of apoptotic process	GO:0043066	181	0.071
ion homeostasis	GO:0050801	212	0.069
response to tumor necrosis factor	GO:0034612	56	0.068
negative regulation of programmed cell death	GO:0043069	183	0.067
regulation of transcription dna templated	GO:0006355	374	0.063
striated muscle tissue development	GO:0014706	58	0.061
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.059
cellular response to nitrogen compound	GO:1901699	210	0.058
cellular component morphogenesis	GO:0032989	155	0.056
positive regulation of rna metabolic process	GO:0051254	203	0.055
positive regulation of gene expression	GO:0010628	244	0.055
regulation of rna metabolic process	GO:0051252	391	0.055
regulation of apoptotic process	GO:0042981	335	0.054
regulation of multicellular organismal development	GO:2000026	376	0.052
negative regulation of cellular metabolic process	GO:0031324	281	0.050
response to peptide	GO:1901652	292	0.050
cardiac muscle contraction	GO:0060048	27	0.050
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.049
regulation of cell projection organization	GO:0031344	175	0.048
defense response	GO:0006952	194	0.048
neuron death	GO:0070997	127	0.046
regulation of nucleic acid templated transcription	GO:1903506	380	0.046
positive regulation of neurogenesis	GO:0050769	165	0.045
heart contraction	GO:0060047	57	0.045
vascular process in circulatory system	GO:0003018	96	0.043
positive regulation of cell differentiation	GO:0045597	217	0.043
positive regulation of cell proliferation	GO:0008284	249	0.043
positive regulation of nervous system development	GO:0051962	178	0.042
cellular component assembly	GO:0022607	360	0.042
regulation of cellular component movement	GO:0051270	150	0.042
programmed cell death	GO:0012501	392	0.042
negative regulation of rna biosynthetic process	GO:1902679	118	0.041
positive regulation of cell development	GO:0010720	176	0.041
regulation of signal transduction	GO:0009966	318	0.041
response to growth factor	GO:0070848	189	0.040
muscle structure development	GO:0061061	87	0.040
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.039
positive regulation of signal transduction	GO:0009967	175	0.039
positive regulation of protein metabolic process	GO:0051247	178	0.039
regulation of anatomical structure morphogenesis	GO:0022603	141	0.038
cell motility	GO:0048870	202	0.038
cellular cation homeostasis	GO:0030003	180	0.038
regulation of phosphorus metabolic process	GO:0051174	349	0.037
homeostatic process	GO:0042592	331	0.037
aging	GO:0007568	241	0.035
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.035
heterocycle catabolic process	GO:0046700	167	0.034
cellular ion homeostasis	GO:0006873	184	0.033
cellular calcium ion homeostasis	GO:0006874	160	0.033
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.033
regulation of catalytic activity	GO:0050790	304	0.032
positive regulation of developmental process	GO:0051094	283	0.032
cardiovascular system development	GO:0072358	134	0.031
regulation of cell morphogenesis	GO:0022604	77	0.031
response to nutrient levels	GO:0031667	370	0.031
protein complex biogenesis	GO:0070271	263	0.030
cell projection organization	GO:0030030	302	0.030
muscle cell development	GO:0055001	26	0.030
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.030
muscle tissue development	GO:0060537	58	0.030
circulatory system development	GO:0072359	134	0.030
regulation of membrane potential	GO:0042391	110	0.030
cellular metal ion homeostasis	GO:0006875	172	0.030
metal ion transport	GO:0030001	289	0.030
cellular response to insulin stimulus	GO:0032869	81	0.030
positive regulation of intracellular signal transduction	GO:1902533	138	0.030
amine metabolic process	GO:0009308	38	0.029
positive regulation of multicellular organismal process	GO:0051240	387	0.029
cell migration	GO:0016477	197	0.029
reactive oxygen species metabolic process	GO:0072593	37	0.029
chemical homeostasis	GO:0048878	292	0.029
cellular response to growth factor stimulus	GO:0071363	162	0.029
response to biotic stimulus	GO:0009607	226	0.029
carbohydrate derivative metabolic process	GO:1901135	346	0.029
positive regulation of neuron differentiation	GO:0045666	126	0.028
tissue development	GO:0009888	252	0.028
positive regulation of cellular biosynthetic process	GO:0031328	295	0.028
positive regulation of phosphorylation	GO:0042327	177	0.028
cellular response to cytokine stimulus	GO:0071345	127	0.027
cellular response to tumor necrosis factor	GO:0071356	46	0.027
cellular response to external stimulus	GO:0071496	118	0.027
cellular amine metabolic process	GO:0044106	38	0.027
cellular response to oxygen containing compound	GO:1901701	386	0.027
negative regulation of metabolic process	GO:0009892	331	0.027
negative regulation of macromolecule metabolic process	GO:0010605	260	0.026
cellular homeostasis	GO:0019725	252	0.026
regulation of growth	GO:0040008	105	0.026
regulation of heart contraction	GO:0008016	48	0.026
response to extracellular stimulus	GO:0009991	380	0.026
response to radiation	GO:0009314	137	0.025
cellular response to organonitrogen compound	GO:0071417	197	0.025
cellular response to hormone stimulus	GO:0032870	247	0.025
negative regulation of rna metabolic process	GO:0051253	123	0.025
positive regulation of phosphate metabolic process	GO:0045937	262	0.025
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.024
cytosolic calcium ion homeostasis	GO:0051480	140	0.024
regulation of cell proliferation	GO:0042127	359	0.024
response to estrogen	GO:0043627	232	0.024
muscle organ development	GO:0007517	50	0.023
response to temperature stimulus	GO:0009266	94	0.023
protein complex subunit organization	GO:0071822	302	0.023
potassium ion transport	GO:0006813	97	0.023
cellular component biogenesis	GO:0044085	368	0.023
positive regulation of response to stimulus	GO:0048584	285	0.023
macromolecular complex assembly	GO:0065003	273	0.022
positive regulation of phosphorus metabolic process	GO:0010562	262	0.022
organic cyclic compound catabolic process	GO:1901361	175	0.022
regulation of intracellular signal transduction	GO:1902531	218	0.022
regulation of muscle system process	GO:0090257	79	0.022
regulation of phosphorylation	GO:0042325	248	0.022
cellular chemical homeostasis	GO:0055082	247	0.022
growth	GO:0040007	165	0.021
negative regulation of signal transduction	GO:0009968	83	0.021
response to mineralocorticoid	GO:0051385	49	0.021
response to hypoxia	GO:0001666	231	0.021
regulation of molecular function	GO:0065009	398	0.021
positive regulation of molecular function	GO:0044093	230	0.021
ribonucleoside metabolic process	GO:0009119	174	0.020
striated muscle cell development	GO:0055002	26	0.020
regulation of ion transmembrane transport	GO:0034765	121	0.020
positive regulation of protein modification process	GO:0031401	142	0.020
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.020
response to nutrient	GO:0007584	248	0.020
monovalent inorganic cation transport	GO:0015672	172	0.020
positive regulation of neuron projection development	GO:0010976	99	0.020
regulation of protein modification process	GO:0031399	194	0.020
positive regulation of apoptotic process	GO:0043065	154	0.020
divalent inorganic cation homeostasis	GO:0072507	165	0.020
regulation of phosphate metabolic process	GO:0019220	349	0.019
regulation of muscle contraction	GO:0006937	53	0.019
positive regulation of cellular protein metabolic process	GO:0032270	167	0.019
response to insulin	GO:0032868	133	0.019
respiratory system development	GO:0060541	45	0.019
neuron projection morphogenesis	GO:0048812	122	0.019
single organism biosynthetic process	GO:0044711	342	0.019
response to decreased oxygen levels	GO:0036293	237	0.019
positive regulation of kinase activity	GO:0033674	77	0.019
response to estradiol	GO:0032355	164	0.019
skeletal muscle tissue regeneration	GO:0043403	10	0.018
negative regulation of transcription dna templated	GO:0045892	116	0.018
cell growth	GO:0016049	104	0.018
response to other organism	GO:0051707	220	0.018
neurological system process	GO:0050877	219	0.018
regulation of metal ion transport	GO:0010959	118	0.018
cardiac muscle tissue morphogenesis	GO:0055008	1	0.018
cellular potassium ion transport	GO:0071804	72	0.018
macromolecular complex subunit organization	GO:0043933	339	0.018
regulation of cell migration	GO:0030334	128	0.017
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.017
cell type specific apoptotic process	GO:0097285	134	0.017
cation homeostasis	GO:0055080	195	0.017
negative regulation of cellular biosynthetic process	GO:0031327	161	0.017
proteolysis	GO:0006508	175	0.017
transmembrane transport	GO:0055085	412	0.017
single organism carbohydrate metabolic process	GO:0044723	118	0.017
cell morphogenesis involved in differentiation	GO:0000904	119	0.017
regulation of protein metabolic process	GO:0051246	289	0.016
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.016
organic substance catabolic process	GO:1901575	316	0.016
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.016
positive regulation of signaling	GO:0023056	270	0.016
regulation of cellular protein metabolic process	GO:0032268	267	0.016
organophosphate metabolic process	GO:0019637	370	0.016
heart morphogenesis	GO:0003007	3	0.016
response to alkaloid	GO:0043279	132	0.016
regulation of transmembrane transport	GO:0034762	122	0.015
catabolic process	GO:0009056	351	0.015
regulation of catabolic process	GO:0009894	113	0.015
positive regulation of blood circulation	GO:1903524	65	0.015
regulation of anatomical structure size	GO:0090066	135	0.015
regulation of cell growth	GO:0001558	85	0.015
l glutamate import	GO:0051938	2	0.015
response to glucocorticoid	GO:0051384	223	0.015
locomotor rhythm	GO:0045475	1	0.015
sodium ion transmembrane transport	GO:0035725	67	0.015
lipid metabolic process	GO:0006629	283	0.015
gliogenesis	GO:0042063	93	0.015
response to cytokine	GO:0034097	215	0.014
phospholipid metabolic process	GO:0006644	61	0.014
potassium ion transmembrane transport	GO:0071805	71	0.014
positive regulation of catalytic activity	GO:0043085	184	0.014
cellular response to peptide	GO:1901653	133	0.014
response to toxic substance	GO:0009636	133	0.014
protein maturation	GO:0051604	68	0.014
regulation of blood vessel size	GO:0050880	89	0.014
organ morphogenesis	GO:0009887	75	0.014
calcium ion homeostasis	GO:0055074	162	0.014
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.014
lipid biosynthetic process	GO:0008610	128	0.014
negative regulation of biosynthetic process	GO:0009890	168	0.014
protein complex assembly	GO:0006461	263	0.014
negative regulation of transporter activity	GO:0032410	13	0.014
negative regulation of growth	GO:0045926	37	0.013
regulation of blood pressure	GO:0008217	83	0.013
ribonucleoside catabolic process	GO:0042454	126	0.013
response to transforming growth factor beta	GO:0071559	46	0.013
positive regulation of cell death	GO:0010942	184	0.013
localization of cell	GO:0051674	202	0.013
negative regulation of neuron death	GO:1901215	69	0.013
regulation of response to external stimulus	GO:0032101	106	0.013
intracellular signal transduction	GO:0035556	314	0.013
epithelial cell proliferation	GO:0050673	54	0.013
small gtpase mediated signal transduction	GO:0007264	36	0.013
cardiac ventricle development	GO:0003231	1	0.013
heart development	GO:0007507	72	0.013
regulation of hormone levels	GO:0010817	187	0.013
response to organophosphorus	GO:0046683	102	0.013
actin mediated cell contraction	GO:0070252	12	0.013
organonitrogen compound catabolic process	GO:1901565	179	0.013
pseudopodium assembly	GO:0031269	3	0.012
purine nucleotide metabolic process	GO:0006163	229	0.012
response to activity	GO:0014823	73	0.012
cellular response to mechanical stimulus	GO:0071260	48	0.012
negative regulation of cell communication	GO:0010648	158	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.012
response to ketone	GO:1901654	182	0.012
regulation of actin filament based movement	GO:1903115	12	0.012
cellular macromolecular complex assembly	GO:0034622	58	0.012
response to molecule of bacterial origin	GO:0002237	194	0.012
muscle cell differentiation	GO:0042692	52	0.012
cold acclimation	GO:0009631	1	0.012
multicellular organismal reproductive process	GO:0048609	233	0.012
positive regulation of cardiac muscle contraction	GO:0060452	4	0.012
reactive nitrogen species metabolic process	GO:2001057	1	0.012
organelle organization	GO:0006996	266	0.012
cellular protein complex assembly	GO:0043623	44	0.012
regulation of neuron apoptotic process	GO:0043523	83	0.012
cation transmembrane transport	GO:0098655	263	0.012
vasodilation	GO:0042311	44	0.012
tissue remodeling	GO:0048771	40	0.012
protein phosphorylation	GO:0006468	345	0.012
skeletal muscle tissue development	GO:0007519	31	0.012
cardiac muscle cell contraction	GO:0086003	10	0.012
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.012
cellular amino acid metabolic process	GO:0006520	107	0.012
positive regulation of potassium ion transmembrane transport	GO:1901381	4	0.012
cell cell signaling	GO:0007267	335	0.011
regulation of cellular amino acid metabolic process	GO:0006521	2	0.011
cell part morphogenesis	GO:0032990	123	0.011
regulation of proteolysis	GO:0030162	66	0.011
cellular response to organic cyclic compound	GO:0071407	202	0.011
sodium ion transport	GO:0006814	82	0.011
regulation of transferase activity	GO:0051338	123	0.011
protein processing	GO:0016485	68	0.011
inorganic cation transmembrane transport	GO:0098662	202	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.011
nucleotide metabolic process	GO:0009117	279	0.011
regulation of cell motility	GO:2000145	131	0.011
cellular response to molecule of bacterial origin	GO:0071219	56	0.011
regulation of locomotion	GO:0040012	148	0.011
response to muscle stretch	GO:0035994	2	0.010
coronary vasculature morphogenesis	GO:0060977	3	0.010
reproduction	GO:0000003	245	0.010
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.010
positive regulation of smooth muscle cell migration	GO:0014911	27	0.010
positive regulation of cell communication	GO:0010647	271	0.010
eye development	GO:0001654	50	0.010
response to camp	GO:0051591	91	0.010
motor neuron axon guidance	GO:0008045	1	0.010
carbohydrate metabolic process	GO:0005975	130	0.010
cellular catabolic process	GO:0044248	295	0.010
regulation of protein phosphorylation	GO:0001932	183	0.010
regulation of establishment of planar polarity	GO:0090175	2	0.010
regulation of membrane repolarization	GO:0060306	1	0.010
ras protein signal transduction	GO:0007265	29	0.010
regulation of organ formation	GO:0003156	2	0.010
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.010

Xirp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
cardiovascular system disease	DOID:1287	0.355
disease of anatomical entity	DOID:7	0.355
musculoskeletal system disease	DOID:17	0.123
muscular disease	DOID:0080000	0.104
myopathy	DOID:423	0.104
heart disease	DOID:114	0.104
cardiomyopathy	DOID:0050700	0.104
muscle tissue disease	DOID:66	0.104
intrinsic cardiomyopathy	DOID:0060036	0.060
dilated cardiomyopathy	DOID:12930	0.060
inherited metabolic disorder	DOID:655	0.016
disease of metabolism	DOID:0014667	0.016
nervous system disease	DOID:863	0.012

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