IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Dhtkd1

dehydrogenase E1 and transketolase domain containing 1

(Aliases: MGC116097)

RGD: 1308092
Entrez: 361272
UniProtKB: Q4KLP0

Process Predictions
Disease Predictions

Dhtkd1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
carboxylic acid metabolic process	GO:0019752	289	0.216
cellular amino acid metabolic process	GO:0006520	107	0.203
alpha amino acid metabolic process	GO:1901605	71	0.196
organic acid metabolic process	GO:0006082	292	0.183
alpha amino acid catabolic process	GO:1901606	20	0.161
cellular amino acid catabolic process	GO:0009063	21	0.090
regulation of phosphorylation	GO:0042325	248	0.074
oxoacid metabolic process	GO:0043436	290	0.071
single organism catabolic process	GO:0044712	283	0.070
catabolic process	GO:0009056	351	0.070
valine metabolic process	GO:0006573	1	0.059
organonitrogen compound catabolic process	GO:1901565	179	0.058
regulation of catalytic activity	GO:0050790	304	0.052
regulation of cellular amino acid metabolic process	GO:0006521	2	0.050
regulation of cellular ketone metabolic process	GO:0010565	27	0.049
cellular catabolic process	GO:0044248	295	0.047
cellular response to endogenous stimulus	GO:0071495	377	0.044
regulation of protein metabolic process	GO:0051246	289	0.044
regulation of multicellular organismal development	GO:2000026	376	0.043
small molecule catabolic process	GO:0044282	59	0.043
cellular amine metabolic process	GO:0044106	38	0.043
nucleobase containing small molecule metabolic process	GO:0055086	316	0.042
organic substance catabolic process	GO:1901575	316	0.042
intracellular signal transduction	GO:0035556	314	0.041
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.041
positive regulation of cellular biosynthetic process	GO:0031328	295	0.041
cofactor metabolic process	GO:0051186	95	0.041
branched chain amino acid metabolic process	GO:0009081	4	0.040
carbohydrate derivative metabolic process	GO:1901135	346	0.040
positive regulation of cellular amine metabolic process	GO:0033240	3	0.039
ion transmembrane transport	GO:0034220	365	0.039
regulation of cellular amine metabolic process	GO:0033238	8	0.038
regulation of phosphate metabolic process	GO:0019220	349	0.038
positive regulation of phosphorus metabolic process	GO:0010562	262	0.037
amine metabolic process	GO:0009308	38	0.036
regulation of phosphorus metabolic process	GO:0051174	349	0.035
regulation of molecular function	GO:0065009	398	0.035
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.034
regulation of cellular protein metabolic process	GO:0032268	267	0.034
transmembrane transport	GO:0055085	412	0.033
response to extracellular stimulus	GO:0009991	380	0.033
positive regulation of cell differentiation	GO:0045597	217	0.033
regulation of secretion	GO:0051046	224	0.032
protein phosphorylation	GO:0006468	345	0.032
positive regulation of multicellular organismal process	GO:0051240	387	0.032
cellular ketone metabolic process	GO:0042180	51	0.032
nucleic acid templated transcription	GO:0097659	379	0.032
organic cyclic compound catabolic process	GO:1901361	175	0.032
mapk cascade	GO:0000165	140	0.030
positive regulation of developmental process	GO:0051094	283	0.029
purine nucleotide metabolic process	GO:0006163	229	0.029
positive regulation of protein metabolic process	GO:0051247	178	0.029
neuron development	GO:0048666	286	0.028
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.028
heterocycle catabolic process	GO:0046700	167	0.028
positive regulation of biosynthetic process	GO:0009891	319	0.028
regulation of protein modification process	GO:0031399	194	0.027
positive regulation of catalytic activity	GO:0043085	184	0.027
positive regulation of phosphate metabolic process	GO:0045937	262	0.027
cation transport	GO:0006812	382	0.026
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.026
neuron differentiation	GO:0030182	368	0.026
positive regulation of protein modification process	GO:0031401	142	0.026
regulation of rna metabolic process	GO:0051252	391	0.025
regulation of cell differentiation	GO:0045595	320	0.025
cellular cation homeostasis	GO:0030003	180	0.025
organic acid catabolic process	GO:0016054	49	0.025
transcription dna templated	GO:0006351	377	0.025
carboxylic acid catabolic process	GO:0046395	49	0.025
sulfur compound biosynthetic process	GO:0044272	19	0.024
regulation of signal transduction	GO:0009966	318	0.024
single organism biosynthetic process	GO:0044711	342	0.024
purine containing compound metabolic process	GO:0072521	253	0.024
regulation of rna biosynthetic process	GO:2001141	381	0.024
organophosphate metabolic process	GO:0019637	370	0.024
purine ribonucleotide metabolic process	GO:0009150	227	0.023
regulation of protein phosphorylation	GO:0001932	183	0.023
rna metabolic process	GO:0016070	406	0.023
regulation of kinase activity	GO:0043549	117	0.023
cellular nitrogen compound catabolic process	GO:0044270	163	0.023
ribonucleotide metabolic process	GO:0009259	231	0.023
positive regulation of signal transduction	GO:0009967	175	0.023
central nervous system development	GO:0007417	311	0.022
cellular response to oxygen containing compound	GO:1901701	386	0.022
cellular response to stress	GO:0033554	269	0.022
positive regulation of molecular function	GO:0044093	230	0.022
response to nutrient levels	GO:0031667	370	0.022
regulation of nervous system development	GO:0051960	264	0.022
response to oxygen levels	GO:0070482	265	0.021
neuron projection development	GO:0031175	273	0.021
regulation of catabolic process	GO:0009894	113	0.021
cellular response to insulin stimulus	GO:0032869	81	0.021
positive regulation of triglyceride biosynthetic process	GO:0010867	4	0.021
pyrimidine nucleobase catabolic process	GO:0006208	3	0.021
cellular response to nitrogen compound	GO:1901699	210	0.021
purine ribonucleoside metabolic process	GO:0046128	168	0.021
regulation of ion transport	GO:0043269	245	0.021
lipid metabolic process	GO:0006629	283	0.021
nucleoside phosphate metabolic process	GO:0006753	283	0.020
cellular response to organonitrogen compound	GO:0071417	197	0.020
divalent metal ion transport	GO:0070838	132	0.020
regulation of intracellular signal transduction	GO:1902531	218	0.020
positive regulation of kinase activity	GO:0033674	77	0.020
regulation of cellular component organization	GO:0051128	368	0.020
regulation of transcription dna templated	GO:0006355	374	0.019
regulation of mapk cascade	GO:0043408	116	0.019
regulation of nucleic acid templated transcription	GO:1903506	380	0.019
branched chain amino acid catabolic process	GO:0009083	4	0.019
cation homeostasis	GO:0055080	195	0.019
programmed cell death	GO:0012501	392	0.019
positive regulation of cellular protein metabolic process	GO:0032270	167	0.019
apoptotic process	GO:0006915	381	0.019
positive regulation of response to stimulus	GO:0048584	285	0.019
ion homeostasis	GO:0050801	212	0.019
serine family amino acid metabolic process	GO:0009069	12	0.019
coenzyme metabolic process	GO:0006732	86	0.019
regulation of apoptotic process	GO:0042981	335	0.019
chemical homeostasis	GO:0048878	292	0.019
anion transmembrane transport	GO:0098656	77	0.019
cation transmembrane transport	GO:0098655	263	0.019
response to alkaloid	GO:0043279	132	0.018
response to growth factor	GO:0070848	189	0.018
positive regulation of phosphorylation	GO:0042327	177	0.018
negative regulation of cell death	GO:0060548	229	0.018
homeostatic process	GO:0042592	331	0.018
insulin like growth factor receptor signaling pathway	GO:0048009	3	0.018
metal ion homeostasis	GO:0055065	186	0.018
negative regulation of macromolecule metabolic process	GO:0010605	260	0.018
reproduction	GO:0000003	245	0.017
regulation of transferase activity	GO:0051338	123	0.017
cell projection organization	GO:0030030	302	0.017
carboxylic acid transport	GO:0046942	115	0.017
positive regulation of mapk cascade	GO:0043410	92	0.017
nucleotide metabolic process	GO:0009117	279	0.017
small gtpase mediated signal transduction	GO:0007264	36	0.017
ras protein signal transduction	GO:0007265	29	0.017
secretion	GO:0046903	307	0.017
metal ion transport	GO:0030001	289	0.017
regulation of secretion by cell	GO:1903530	208	0.017
regulation of membrane potential	GO:0042391	110	0.017
regulation of protein kinase activity	GO:0045859	105	0.017
anatomical structure morphogenesis	GO:0009653	298	0.017
positive regulation of cell development	GO:0010720	176	0.017
ribose phosphate metabolic process	GO:0019693	235	0.017
response to inorganic substance	GO:0010035	377	0.016
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.016
negative regulation of programmed cell death	GO:0043069	183	0.016
cellular response to growth factor stimulus	GO:0071363	162	0.016
anion transport	GO:0006820	178	0.016
positive regulation of fatty acid beta oxidation	GO:0032000	4	0.016
brain development	GO:0007420	247	0.016
cellular component biogenesis	GO:0044085	368	0.016
rna biosynthetic process	GO:0032774	380	0.016
macromolecule localization	GO:0033036	252	0.016
multi organism reproductive process	GO:0044703	262	0.016
positive regulation of protein phosphorylation	GO:0001934	135	0.016
multicellular organism reproduction	GO:0032504	233	0.016
nitrogen compound transport	GO:0071705	229	0.016
aging	GO:0007568	241	0.016
response to purine containing compound	GO:0014074	126	0.016
carbohydrate metabolic process	GO:0005975	130	0.016
chromosome segregation	GO:0007059	2	0.016
regulation of cell development	GO:0060284	263	0.015
negative regulation of cell communication	GO:0010648	158	0.015
positive regulation of cell communication	GO:0010647	271	0.015
glycosyl compound metabolic process	GO:1901657	182	0.015
pyrimidine nucleobase metabolic process	GO:0006206	8	0.015
positive regulation of neurogenesis	GO:0050769	165	0.015
positive regulation of intracellular signal transduction	GO:1902533	138	0.015
regulation of purine nucleotide metabolic process	GO:1900542	115	0.015
ribonucleoside metabolic process	GO:0009119	174	0.015
axis specification	GO:0009798	4	0.015
neurological system process	GO:0050877	219	0.015
neuronal action potential	GO:0019228	35	0.015
response to aluminum ion	GO:0010044	10	0.015
positive regulation of catabolic process	GO:0009896	78	0.015
regulation of hormone levels	GO:0010817	187	0.015
heart morphogenesis	GO:0003007	3	0.015
nucleoside metabolic process	GO:0009116	179	0.015
response to peptide hormone	GO:0043434	278	0.015
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.015
negative regulation of cellular metabolic process	GO:0031324	281	0.014
glycosyl compound catabolic process	GO:1901658	126	0.014
positive regulation of nervous system development	GO:0051962	178	0.014
dephosphorylation	GO:0016311	98	0.014
fatty acid catabolic process	GO:0009062	26	0.014
positive regulation of transferase activity	GO:0051347	81	0.014
regulation of cell proliferation	GO:0042127	359	0.014
cellular lipid metabolic process	GO:0044255	208	0.014
cellular homeostasis	GO:0019725	252	0.014
regulation of cellular catabolic process	GO:0031329	101	0.014
organic anion transport	GO:0015711	132	0.014
cellular response to hormone stimulus	GO:0032870	247	0.014
retinal metabolic process	GO:0042574	3	0.014
regulation of neuron differentiation	GO:0045664	208	0.014
aromatic compound catabolic process	GO:0019439	168	0.014
reproductive process	GO:0022414	372	0.014
cellular chemical homeostasis	GO:0055082	247	0.014
negative regulation of transport	GO:0051051	136	0.014
organic acid transport	GO:0015849	116	0.013
positive regulation of cellular catabolic process	GO:0031331	71	0.013
regulation of cell projection organization	GO:0031344	175	0.013
purine nucleoside metabolic process	GO:0042278	169	0.013
peptidyl amino acid modification	GO:0018193	126	0.013
multicellular organismal reproductive process	GO:0048609	233	0.013
response to metal ion	GO:0010038	253	0.013
behavior	GO:0007610	205	0.013
regulation of neurogenesis	GO:0050767	247	0.013
negative regulation of apoptotic process	GO:0043066	181	0.013
cytokine mediated signaling pathway	GO:0019221	43	0.013
cell part morphogenesis	GO:0032990	123	0.013
response to acid chemical	GO:0001101	222	0.013
blood circulation	GO:0008015	183	0.013
response to peptide	GO:1901652	292	0.013
cellular response to cytokine stimulus	GO:0071345	127	0.013
regulation of transmembrane transport	GO:0034762	122	0.013
cell adhesion	GO:0007155	110	0.013
regulation of programmed cell death	GO:0043067	341	0.013
peptidyl tyrosine phosphorylation	GO:0018108	72	0.013
cell cycle checkpoint	GO:0000075	2	0.013
regulation of cellular localization	GO:0060341	263	0.012
cellular component assembly	GO:0022607	360	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.012
response to carbohydrate	GO:0009743	183	0.012
negative regulation of metabolic process	GO:0009892	331	0.012
single organism reproductive process	GO:0044702	297	0.012
regulation of canonical wnt signaling pathway	GO:0060828	4	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.012
positive regulation of transport	GO:0051050	245	0.012
carbohydrate derivative catabolic process	GO:1901136	147	0.012
negative regulation of rna metabolic process	GO:0051253	123	0.012
positive regulation of cellular component organization	GO:0051130	200	0.012
positive regulation of cell proliferation	GO:0008284	249	0.012
positive regulation of neuron differentiation	GO:0045666	126	0.012
purine containing compound catabolic process	GO:0072523	138	0.012
regulation of homeostatic process	GO:0032844	101	0.012
response to ketone	GO:1901654	182	0.012
lipid biosynthetic process	GO:0008610	128	0.012
regulation of gtpase activity	GO:0043087	57	0.012
multicellular organism growth	GO:0035264	1	0.012
ribonucleoside catabolic process	GO:0042454	126	0.012
response to monosaccharide	GO:0034284	159	0.012
multicellular organismal signaling	GO:0035637	44	0.012
regulation of ion transmembrane transport	GO:0034765	121	0.012
cell type specific apoptotic process	GO:0097285	134	0.011
carbohydrate derivative biosynthetic process	GO:1901137	124	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
peptidyl tyrosine modification	GO:0018212	72	0.011
single organism organelle organization	GO:1902589	180	0.011
proteolysis	GO:0006508	175	0.011
regulation of neuron projection development	GO:0010975	161	0.011
small molecule biosynthetic process	GO:0044283	124	0.011
single organism carbohydrate metabolic process	GO:0044723	118	0.011
gtp metabolic process	GO:0046039	72	0.011
regulation of locomotion	GO:0040012	148	0.011
motor neuron axon guidance	GO:0008045	1	0.011
skeletal system development	GO:0001501	41	0.011
cellular calcium ion homeostasis	GO:0006874	160	0.011
regulation of protein serine threonine kinase activity	GO:0071900	64	0.011
positive regulation of signaling	GO:0023056	270	0.011
response to cytokine	GO:0034097	215	0.011
cell cell signaling	GO:0007267	335	0.011
action potential	GO:0001508	54	0.011
lipid storage	GO:0019915	1	0.011
response to glucocorticoid	GO:0051384	223	0.011
positive regulation of cell projection organization	GO:0031346	111	0.011
head development	GO:0060322	247	0.011
transmission of nerve impulse	GO:0019226	42	0.011
regulation of lipid metabolic process	GO:0019216	68	0.011
response to corticosteroid	GO:0031960	235	0.011
organonitrogen compound biosynthetic process	GO:1901566	167	0.011
beta alanine metabolic process	GO:0019482	3	0.011
signal transduction by phosphorylation	GO:0023014	144	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.011
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.011
reproductive structure development	GO:0048608	128	0.011
inorganic cation transmembrane transport	GO:0098662	202	0.011
response to decreased oxygen levels	GO:0036293	237	0.010
circulatory system process	GO:0003013	183	0.010
cellular response to peptide hormone stimulus	GO:0071375	120	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.010
gastrulation	GO:0007369	2	0.010
regulation of cellular component movement	GO:0051270	150	0.010
dendrite development	GO:0016358	72	0.010
secretion by cell	GO:0032940	248	0.010
regulation of organelle organization	GO:0033043	80	0.010
inorganic ion transmembrane transport	GO:0098660	229	0.010
positive regulation of gtp catabolic process	GO:0033126	48	0.010
positive regulation of cell migration	GO:0030335	96	0.010
negative regulation of multicellular organismal process	GO:0051241	203	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.010
monosaccharide metabolic process	GO:0005996	61	0.010
kidney development	GO:0001822	67	0.010
positive regulation of rna metabolic process	GO:0051254	203	0.010
positive regulation of protein kinase activity	GO:0045860	73	0.010
nucleoside catabolic process	GO:0009164	126	0.010
phospholipid metabolic process	GO:0006644	61	0.010
nucleobase containing compound catabolic process	GO:0034655	152	0.010
negative regulation of signaling	GO:0023057	157	0.010

Dhtkd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.029
inherited metabolic disorder	DOID:655	0.027
nervous system disease	DOID:863	0.027
disease of anatomical entity	DOID:7	0.027
brain disease	DOID:936	0.013
central nervous system disease	DOID:331	0.013

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