Rattus norvegicus

36 known processes

Hcn2

hyperpolarization activated cyclic nucleotide-gated potassium channel 2

Hcn2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neurological system processGO:00508772190.251
cellular component biogenesisGO:00440853680.129
Rat
positive regulation of phosphorus metabolic processGO:00105622620.095
macromolecular complex assemblyGO:00650032730.080
Rat
transmission of nerve impulseGO:0019226420.075
regulation of phosphate metabolic processGO:00192203490.075
cellular component assemblyGO:00226073600.074
Rat
protein complex subunit organizationGO:00718223020.071
Rat
action potentialGO:0001508540.061
multicellular organismal signalingGO:0035637440.060
positive regulation of cell proliferationGO:00082842490.060
rna metabolic processGO:00160704060.058
regulation of membrane repolarizationGO:006030610.054
regulation of membrane potentialGO:00423911100.054
Human Mouse
organic acid metabolic processGO:00060822920.052
oxoacid metabolic processGO:00434362900.051
regulation of cellular component organizationGO:00511283680.048
membrane repolarizationGO:008600910.048
carbohydrate derivative metabolic processGO:19011353460.048
regulation of muscle system processGO:0090257790.047
synaptic transmissionGO:00072682350.047
positive regulation of nitrogen compound metabolic processGO:00511733340.046
metal ion homeostasisGO:00550651860.046
Rat
sensory perceptionGO:00076001010.045
regulation of system processGO:00440572080.044
cardiovascular system developmentGO:00723581340.043
regulation of molecular functionGO:00650093980.040
blood circulationGO:00080151830.039
neuronal action potentialGO:0019228350.038
regulation of phosphorus metabolic processGO:00511743490.038
nucleic acid templated transcriptionGO:00976593790.037
heart processGO:0003015570.037
cellular cation homeostasisGO:00300031800.036
Rat
cellular response to oxygen containing compoundGO:19017013860.035
Human
heart contractionGO:0060047570.035
regulation of cell proliferationGO:00421273590.035
cellular chemical homeostasisGO:00550822470.035
Rat
transcription dna templatedGO:00063513770.034
nucleobase containing small molecule metabolic processGO:00550863160.034
regulation of rna biosynthetic processGO:20011413810.033
response to growth factorGO:00708481890.033
regulation of ion transportGO:00432692450.033
Human
positive regulation of nucleobase containing compound metabolic processGO:00459353190.033
cellular divalent inorganic cation homeostasisGO:00725031620.033
Rat
ribose phosphate metabolic processGO:00196932350.032
purine containing compound metabolic processGO:00725212530.032
transmembrane transportGO:00550854120.032
Human Rat
potassium ion transportGO:0006813970.032
Human
cation transmembrane transportGO:00986552630.032
Human Rat
cellular ion homeostasisGO:00068731840.030
Rat
carbohydrate derivative biosynthetic processGO:19011371240.029
response to oxygen levelsGO:00704822650.028
circulatory system processGO:00030131830.028
nucleoside phosphate biosynthetic processGO:19012931020.028
purine ribonucleotide biosynthetic processGO:0009152810.028
positive regulation of phosphate metabolic processGO:00459372620.028
cation transportGO:00068123820.027
Human Rat
homeostatic processGO:00425923310.027
Rat
nucleoside phosphate metabolic processGO:00067532830.026
cellular response to endogenous stimulusGO:00714953770.026
Human
protein complex biogenesisGO:00702712630.025
Rat
defense responseGO:00069521940.024
inorganic ion transmembrane transportGO:00986602290.024
Human
purine nucleotide biosynthetic processGO:0006164830.024
single organism biosynthetic processGO:00447113420.024
negative regulation of cellular metabolic processGO:00313242810.024
positive regulation of gene expressionGO:00106282440.024
striated muscle contractionGO:0006941440.023
nucleotide metabolic processGO:00091172790.023
nucleotide biosynthetic processGO:0009165980.023
ion homeostasisGO:00508012120.023
Rat
cell projection organizationGO:00300303020.022
regulation of cellular localizationGO:00603412630.022
regulation of rna metabolic processGO:00512523910.022
muscle system processGO:00030121150.022
response to metal ionGO:00100382530.021
positive regulation of biosynthetic processGO:00098913190.021
inorganic cation transmembrane transportGO:00986622020.021
Human
response to cytokineGO:00340972150.021
regulation of nucleotide metabolic processGO:00061401170.021
cation homeostasisGO:00550801950.021
Rat
response to inorganic substanceGO:00100353770.020
purine nucleotide metabolic processGO:00061632290.020
response to decreased oxygen levelsGO:00362932370.020
carboxylic acid metabolic processGO:00197522890.020
cell cell signalingGO:00072673350.020
negative regulation of metabolic processGO:00098923310.019
regulation of signal transductionGO:00099663180.019
intracellular signal transductionGO:00355563140.019
organophosphate metabolic processGO:00196373700.019
regulation of blood circulationGO:19035221100.019
metal ion transportGO:00300012890.019
Human
mechanoreceptor differentiationGO:004249020.019
negative regulation of cell communicationGO:00106481580.019
negative regulation of transportGO:00510511360.019
cellular response to nitrogen compoundGO:19016992100.018
Human
positive regulation of cellular component organizationGO:00511302000.018
ion transmembrane transportGO:00342203650.018
Human Rat
ribonucleotide metabolic processGO:00092592310.018
positive regulation of macromolecule biosynthetic processGO:00105572470.018
positive regulation of cellular biosynthetic processGO:00313282950.018
monovalent inorganic cation transportGO:00156721720.018
Human
protein complex assemblyGO:00064612630.017
Rat
negative regulation of cellular component organizationGO:0051129830.017
regulation of catalytic activityGO:00507903040.017
monosaccharide metabolic processGO:0005996610.017
positive regulation of nucleotide metabolic processGO:0045981910.017
rna biosynthetic processGO:00327743800.017
sodium ion transmembrane transportGO:0035725670.017
Human
positive regulation of protein metabolic processGO:00512471780.017
negative regulation of multicellular organismal processGO:00512412030.016
positive regulation of response to stimulusGO:00485842850.016
response to hypoxiaGO:00016662310.016
regulation of multicellular organismal developmentGO:20000263760.016
nitrogen compound transportGO:00717052290.016
single organism carbohydrate metabolic processGO:00447231180.016
negative regulation of gene expressionGO:00106291990.016
cellular amino acid metabolic processGO:00065201070.015
response to acid chemicalGO:00011012220.015
regulation of transmembrane transportGO:00347621220.015
Human
g protein coupled receptor signaling pathwayGO:00071862420.015
circulatory system developmentGO:00723591340.015
ribonucleotide biosynthetic processGO:0009260850.015
cellular metal ion homeostasisGO:00068751720.015
Rat
positive regulation of synaptic vesicle transportGO:190280530.015
heart developmentGO:0007507720.015
response to peptideGO:19016522920.015
organophosphate biosynthetic processGO:00904071430.014
cellular response to growth factor stimulusGO:00713631620.014
inner ear receptor cell differentiationGO:006011320.014
regulation of nucleic acid templated transcriptionGO:19035063800.014
regulation of anatomical structure sizeGO:00900661350.014
single organism organelle organizationGO:19025891800.014
central nervous system developmentGO:00074173110.014
cellular response to insulin stimulusGO:0032869810.014
cellular amine metabolic processGO:0044106380.014
regulation of potassium ion transportGO:0043266290.014
gonad developmentGO:00084061040.014
protein oligomerizationGO:00512591910.014
Rat
regulation of cellular amino acid metabolic processGO:000652120.014
cellular potassium ion transportGO:0071804720.013
Human
cellular protein complex assemblyGO:0043623440.013
purine ribonucleotide metabolic processGO:00091502270.013
purine nucleoside metabolic processGO:00422781690.013
response to peptide hormoneGO:00434342780.013
calcium ion dependent exocytosis of neurotransmitterGO:004879120.013
organic cyclic compound catabolic processGO:19013611750.013
positive regulation of cell developmentGO:00107201760.013
cyclic purine nucleotide metabolic processGO:0052652620.013
purine containing compound biosynthetic processGO:0072522850.013
phototransduction visible lightGO:000760320.013
response to nutrient levelsGO:00316673700.013
lipid metabolic processGO:00066292830.013
hair cell differentiationGO:003531520.013
apoptotic processGO:00069153810.013
auditory receptor cell differentiationGO:004249120.013
cellular ketone metabolic processGO:0042180510.013
response to glucocorticoidGO:00513842230.013
positive regulation of rna biosynthetic processGO:19026801970.013
cyclic nucleotide biosynthetic processGO:0009190630.013
single organism reproductive processGO:00447022970.012
positive regulation of neurogenesisGO:00507691650.012
regulation of cellular amine metabolic processGO:003323880.012
muscle structure developmentGO:0061061870.012
regulation of cellular ketone metabolic processGO:0010565270.012
intracellular protein transportGO:0006886790.012
ear developmentGO:0043583210.012
organelle organizationGO:00069962660.012
actin filament based processGO:0030029860.012
positive regulation of purine nucleotide metabolic processGO:1900544910.012
negative regulation of secretion by cellGO:1903531720.012
macromolecule localizationGO:00330362520.012
axonogenesisGO:0007409710.012
regulation of apoptotic processGO:00429813350.012
brain developmentGO:00074202470.012
positive regulation of signalingGO:00230562700.012
positive regulation of nucleic acid templated transcriptionGO:19035081970.012
sex differentiationGO:00075481130.012
cellular calcium ion homeostasisGO:00068741600.012
Rat
regulation of secretion by cellGO:19035302080.012
cytosolic calcium ion homeostasisGO:00514801400.012
Rat
negative regulation of nucleobase containing compound metabolic processGO:00459341530.012
response to mechanical stimulusGO:00096121340.012
peptide secretionGO:0002790860.012
divalent inorganic cation homeostasisGO:00725071650.011
Rat
cellular response to cytokine stimulusGO:00713451270.011
amine metabolic processGO:0009308380.011
neuron projection developmentGO:00311752730.011
bmp signaling pathwayGO:003050940.011
circadian rhythmGO:0007623880.011
regulation of neurogenesisGO:00507672470.011
cellular macromolecular complex assemblyGO:0034622580.011
sensory perception of light stimulusGO:005095330.011
protein maturationGO:0051604680.011
cell morphogenesis involved in differentiationGO:00009041190.011
neuron differentiationGO:00301823680.011
regulation of cell projection organizationGO:00313441750.011
detection of calcium ionGO:000551310.011
cytoplasmic transportGO:00164821150.011
positive regulation of cell communicationGO:00106472710.011
negative regulation of macromolecule metabolic processGO:00106052600.010
rhythmic processGO:00485111560.010
potassium ion transmembrane transportGO:0071805710.010
Human
response to amino acidGO:0043200750.010
negative regulation of response to stimulusGO:00485851550.010
regulation of heart contractionGO:0008016480.010
negative regulation of rna biosynthetic processGO:19026791180.010
positive regulation of transportGO:00510502450.010
anatomical structure morphogenesisGO:00096532980.010
heart morphogenesisGO:000300730.010
cardiac muscle cell action potential involved in contractionGO:008600220.010
regulation of ion transmembrane transportGO:00347651210.010
Human

Hcn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.038
eye diseaseDOID:561400.038
sensory system diseaseDOID:005015500.038
disease of anatomical entityDOID:700.038
eye and adnexa diseaseDOID:149200.038
retinal diseaseDOID:567900.038
musculoskeletal system diseaseDOID:1700.035
long qt syndromeDOID:284300.023
muscle tissue diseaseDOID:6600.013
muscular diseaseDOID:008000000.013
myopathyDOID:42300.013
cardiovascular system diseaseDOID:128700.012
retinal degenerationDOID:846600.010