Rattus norvegicus

0 known processes

Hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Hcn4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
inorganic cation transmembrane transportGO:00986622020.454
Human
regulation of multicellular organismal developmentGO:20000263760.255
cation transmembrane transportGO:00986552630.250
Human Mouse Rat
positive regulation of cell proliferationGO:00082842490.247
brain developmentGO:00074202470.181
Rat
neurological system processGO:00508772190.180
cellular cation homeostasisGO:00300031800.172
Rat
heart contractionGO:0060047570.156
Human Mouse Rat
response to estrogenGO:00436272320.140
regulation of heart contractionGO:0008016480.138
Human Mouse Rat
regulation of ion transportGO:00432692450.132
Human
response to cytokineGO:00340972150.130
cellular divalent inorganic cation homeostasisGO:00725031620.128
Rat
metal ion homeostasisGO:00550651860.124
Rat
cellular ion homeostasisGO:00068731840.124
Rat
cell cell signalingGO:00072673350.123
anatomical structure morphogenesisGO:00096532980.113
localization of cellGO:00516742020.112
cytosolic calcium ion homeostasisGO:00514801400.106
Rat
locomotionGO:00400112370.105
cell projection organizationGO:00300303020.104
regulation of synaptic transmissionGO:00508041410.102
cellular component movementGO:00069282480.101
ion transmembrane transportGO:00342203650.101
Human Mouse Rat
neuron projection developmentGO:00311752730.096
secretionGO:00469033070.095
regulation of cell developmentGO:00602842630.095
cellular response to oxygen containing compoundGO:19017013860.094
Human
defense responseGO:00069521940.093
regulation of nervous system developmentGO:00519602640.092
regulation of membrane potentialGO:00423911100.091
Human
regulation of signal transductionGO:00099663180.086
cellular homeostasisGO:00197252520.086
Rat
nucleic acid templated transcriptionGO:00976593790.085
synaptic transmissionGO:00072682350.084
regulation of cell proliferationGO:00421273590.084
positive regulation of cellular biosynthetic processGO:00313282950.083
sensory perception of painGO:0019233730.082
negative regulation of multicellular organismal processGO:00512412030.082
chemical homeostasisGO:00488782920.081
Rat
secretion by cellGO:00329402480.080
metal ion transportGO:00300012890.080
Human
response to other organismGO:00517072200.079
axon developmentGO:0061564960.078
negative regulation of transportGO:00510511360.077
cellular chemical homeostasisGO:00550822470.076
Rat
regulation of neurogenesisGO:00507672470.074
positive regulation of nervous system developmentGO:00519621780.074
response to metal ionGO:00100382530.073
positive regulation of response to stimulusGO:00485842850.072
regulation of phosphate metabolic processGO:00192203490.071
homeostatic processGO:00425923310.071
Rat
circulatory system developmentGO:00723591340.071
neuron deathGO:00709971270.070
cation transportGO:00068123820.070
Human Mouse Rat
positive regulation of nitrogen compound metabolic processGO:00511733340.069
positive regulation of biosynthetic processGO:00098913190.069
regulation of neuron differentiationGO:00456642080.068
ion homeostasisGO:00508012120.066
Rat
cell migrationGO:00164771970.065
inorganic ion transmembrane transportGO:00986602290.064
Human
positive regulation of cell differentiationGO:00455972170.063
positive regulation of neurogenesisGO:00507691650.063
organ morphogenesisGO:0009887750.063
response to external biotic stimulusGO:00432072210.061
neuron differentiationGO:00301823680.060
regulation of blood pressureGO:0008217830.059
divalent inorganic cation homeostasisGO:00725071650.058
Rat
regulation of nucleic acid templated transcriptionGO:19035063800.058
action potentialGO:0001508540.057
regulation of secretionGO:00510462240.057
regulation of neuron projection developmentGO:00109751610.057
rna metabolic processGO:00160704060.057
dicarboxylic acid transportGO:0006835340.057
neuron developmentGO:00486662860.056
regulation of growthGO:00400081050.056
sensory perceptionGO:00076001010.055
detection of stimulusGO:0051606240.054
positive regulation of nucleobase containing compound metabolic processGO:00459353190.053
response to nutrient levelsGO:00316673700.053
immune system processGO:00023762040.052
signal transduction by phosphorylationGO:00230141440.052
positive regulation of signal transductionGO:00099671750.052
regulation of cell differentiationGO:00455953200.051
muscle contractionGO:0006936880.051
transmission of nerve impulseGO:0019226420.051
organic anion transportGO:00157111320.051
amine metabolic processGO:0009308380.049
rna biosynthetic processGO:00327743800.049
cellular component morphogenesisGO:00329891550.048
programmed cell deathGO:00125013920.047
intracellular signal transductionGO:00355563140.046
regulation of rna biosynthetic processGO:20011413810.046
positive regulation of phosphorylationGO:00423271770.046
response to inorganic substanceGO:00100353770.044
response to decreased oxygen levelsGO:00362932370.044
development of primary sexual characteristicsGO:00451371070.044
cellular response to lipidGO:00713962010.044
regulation of transcription dna templatedGO:00063553740.044
regulation of locomotionGO:00400121480.043
positive regulation of signalingGO:00230562700.043
cell projection morphogenesisGO:00488581230.043
multi organism reproductive processGO:00447032620.042
muscle system processGO:00030121150.042
negative regulation of signalingGO:00230571570.041
regulation of g protein coupled receptor protein signaling pathwayGO:0008277280.041
positive regulation of secretion by cellGO:19035321280.041
positive regulation of multicellular organismal processGO:00512403870.041
Rat
regulation of rna metabolic processGO:00512523910.041
response to peptide hormoneGO:00434342780.041
cellular amine metabolic processGO:0044106380.041
response to peptideGO:19016522920.041
reproductive processGO:00224143720.041
tissue developmentGO:00098882520.040
regulation of apoptotic processGO:00429813350.040
response to oxygen levelsGO:00704822650.038
organic substance catabolic processGO:19015753160.038
regulation of secretion by cellGO:19035302080.038
cellular response to stressGO:00335542690.037
organelle organizationGO:00069962660.037
positive regulation of protein metabolic processGO:00512471780.037
regulation of intracellular signal transductionGO:19025312180.037
single organism biosynthetic processGO:00447113420.036
regulation of programmed cell deathGO:00430673410.036
monovalent inorganic cation transportGO:00156721720.036
Human
positive regulation of epithelial cell proliferationGO:0050679320.036
response to extracellular stimulusGO:00099913800.036
regulation of cellular component organizationGO:00511283680.036
negative regulation of cell communicationGO:00106481580.036
negative regulation of ion transportGO:0043271510.035
developmental growth involved in morphogenesisGO:0060560330.035
positive regulation of developmental processGO:00510942830.035
positive regulation of catalytic activityGO:00430851840.035
cellular response to hormone stimulusGO:00328702470.035
cardiovascular system developmentGO:00723581340.035
regulation of muscle system processGO:0090257790.035
response to lipopolysaccharideGO:00324961910.035
behaviorGO:00076102050.034
negative regulation of cellular biosynthetic processGO:00313271610.034
oxoacid metabolic processGO:00434362900.034
regulation of system processGO:00440572080.034
Human Mouse Rat
regulation of molecular functionGO:00650093980.034
inflammatory responseGO:00069541500.034
defecationGO:003042110.033
positive regulation of cell developmentGO:00107201760.033
positive regulation of intracellular signal transductionGO:19025331380.033
cell morphogenesisGO:00009021420.032
positive regulation of molecular functionGO:00440932300.031
epithelial cell proliferationGO:0050673540.031
regulation of peptide transportGO:0090087870.031
response to calcium ionGO:0051592590.031
response to acid chemicalGO:00011012220.031
regulation of phosphorylationGO:00423252480.031
response to growth factorGO:00708481890.030
cellular metal ion homeostasisGO:00068751720.030
Rat
cellular response to drugGO:0035690300.030
regulation of blood circulationGO:19035221100.030
Human Mouse Rat
negative regulation of developmental processGO:00510931250.029
cellular amino acid metabolic processGO:00065201070.029
regulation of cellular amine metabolic processGO:003323880.029
organic hydroxy compound metabolic processGO:19016151150.029
regulation of defecationGO:200029210.029
developmental growthGO:00485891000.029
response to estradiolGO:00323551640.029
negative regulation of secretion by cellGO:1903531720.029
carboxylic acid transportGO:00469421150.029
synaptic transmission cholinergicGO:0007271110.028
anterior posterior pattern specificationGO:000995210.028
heart processGO:0003015570.028
Human Mouse Rat
growthGO:00400071650.028
enzyme linked receptor protein signaling pathwayGO:00071671160.028
positive regulation of phosphate metabolic processGO:00459372620.028
developmental process involved in reproductionGO:00030061590.028
actin filament based processGO:0030029860.027
regulation of peptide hormone secretionGO:0090276800.027
anion transportGO:00068201780.027
circulatory system processGO:00030131830.027
Human Mouse Rat
apoptotic processGO:00069153810.026
positive regulation of nucleic acid templated transcriptionGO:19035081970.026
blood circulationGO:00080151830.026
Human Mouse Rat
positive regulation of cellular component organizationGO:00511302000.026
potassium ion transportGO:0006813970.026
Human
cation homeostasisGO:00550801950.026
Rat
organic acid metabolic processGO:00060822920.026
cellular component biogenesisGO:00440853680.026
Rat
negative regulation of cellular component organizationGO:0051129830.026
protein complex subunit organizationGO:00718223020.025
Rat
response to mechanical stimulusGO:00096121340.025
response to molecule of bacterial originGO:00022371940.025
regulation of cellular protein metabolic processGO:00322682670.025
multicellular organism reproductionGO:00325042330.025
regulation of homeostatic processGO:00328441010.025
micturitionGO:006007340.025
cellular component assemblyGO:00226073600.025
Rat
protein phosphorylationGO:00064683450.025
motor neuron axon guidanceGO:000804510.025
axonogenesisGO:0007409710.025
neuron projection morphogenesisGO:00488121220.025
amino acid transportGO:0006865700.025
negative regulation of programmed cell deathGO:00430691830.024
positive regulation of cellular amine metabolic processGO:003324030.024
single organism organelle organizationGO:19025891800.024
regulation of phosphorus metabolic processGO:00511743490.024
regulation of behaviorGO:0050795610.024
cell morphogenesis involved in neuron differentiationGO:00486671060.024
transcription dna templatedGO:00063513770.024
cellular ketone metabolic processGO:0042180510.024
negative regulation of neuron differentiationGO:0045665620.024
organic acid transportGO:00158491160.023
response to biotic stimulusGO:00096072260.023
positive regulation of leukocyte activationGO:0002696300.023
positive regulation of synaptic transmissionGO:0050806620.023
positive regulation of phosphorus metabolic processGO:00105622620.023
regulation of cellular localizationGO:00603412630.023
response to radiationGO:00093141370.023
regulation of catalytic activityGO:00507903040.023
regulation of cellular component movementGO:00512701500.023
regulation of organic acid transportGO:0032890350.023
epithelium developmentGO:0060429960.022
regulation of neuron deathGO:19012141150.022
positive regulation of secretionGO:00510471400.022
regulation of amino acid transportGO:0051955250.022
anatomical structure formation involved in morphogenesisGO:0048646830.022
eye morphogenesisGO:004859240.022
catabolic processGO:00090563510.022
response to ethanolGO:00454711620.022
glutamate secretionGO:0014047190.022
cell motilityGO:00488702020.022
positive regulation of protein modification processGO:00314011420.022
negative regulation of apoptotic processGO:00430661810.021
calcium ion homeostasisGO:00550741620.021
Rat
negative regulation of cell deathGO:00605482290.021
leukocyte activationGO:0045321760.021
transmembrane transportGO:00550854120.021
Human Mouse Rat
negative regulation of nervous system developmentGO:0051961790.021
steroid metabolic processGO:0008202730.021
response to light stimulusGO:0009416520.021
muscle tissue developmentGO:0060537580.021
single organism reproductive processGO:00447022970.021
regulation of transcription from rna polymerase ii promoterGO:00063572340.021
neuron projection guidanceGO:0097485240.020
mapk cascadeGO:00001651400.020
regulation of cell migrationGO:00303341280.020
negative regulation of cell developmentGO:0010721820.020
response to bacteriumGO:00096172000.020
acid secretionGO:0046717480.020
smooth muscle cell proliferationGO:0048659770.020
response to transition metal nanoparticleGO:19902671220.020
neuropeptide signaling pathwayGO:0007218290.020
multicellular organismal signalingGO:0035637440.020
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.020
lipid biosynthetic processGO:00086101280.020
regulation of cellular amino acid metabolic processGO:000652120.019
protein complex biogenesisGO:00702712630.019
Rat
regulation of protein metabolic processGO:00512462890.019
cellular response to growth factor stimulusGO:00713631620.019
negative regulation of macromolecule metabolic processGO:00106052600.019
positive regulation of response to foodGO:003209730.019
regulation of smooth muscle cell proliferationGO:0048660750.019
regulation of cellular ketone metabolic processGO:0010565270.019
retina morphogenesis in camera type eyeGO:006004210.019
regulation of amine transportGO:0051952540.019
sexual reproductionGO:00199531480.019
positive regulation of transcription dna templatedGO:00458931970.019
gonad developmentGO:00084061040.019
detection of chemical stimulusGO:0009593100.019
cytoskeleton organizationGO:00070101110.018
cellular response to abiotic stimulusGO:0071214850.018
head developmentGO:00603222470.018
Rat
positive regulation of cell projection organizationGO:00313461110.018
cell morphogenesis involved in differentiationGO:00009041190.018
carbohydrate derivative metabolic processGO:19011353460.018
transcription from rna polymerase ii promoterGO:00063662520.018
regulation of protein modification processGO:00313991940.018
regulation of peptide secretionGO:0002791820.018
nucleoside phosphate metabolic processGO:00067532830.018
positive regulation of macromolecule biosynthetic processGO:00105572470.018
negative regulation of luteinizing hormone secretionGO:003368540.018
biological adhesionGO:00226101100.017
negative regulation of cell differentiationGO:0045596990.017
muscle structure developmentGO:0061061870.017
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.017
positive regulation of smooth muscle cell proliferationGO:0048661510.017
reactive oxygen species metabolic processGO:0072593370.017
glutamate receptor signaling pathwayGO:0007215430.017
cellular response to metal ionGO:0071248550.017
positive regulation of transferase activityGO:0051347810.017
negative regulation of cellular metabolic processGO:00313242810.017
positive regulation of cellular protein metabolic processGO:00322701670.017
negative regulation of secretionGO:0051048820.017
negative regulation of biosynthetic processGO:00098901680.017
positive regulation of protein phosphorylationGO:00019341350.017
multicellular organismal reproductive processGO:00486092330.017
negative regulation of nucleobase containing compound metabolic processGO:00459341530.017
vesicle mediated transportGO:00161921810.017
positive regulation of rna metabolic processGO:00512542030.017
negative regulation of nitrogen compound metabolic processGO:00511721610.016
nitrogen compound transportGO:00717052290.016
central nervous system developmentGO:00074173110.016
Rat
regulation of epithelial cell proliferationGO:0050678490.016
positive regulation of cell communicationGO:00106472710.016
smooth muscle contraction involved in micturitionGO:006008310.016
organonitrogen compound biosynthetic processGO:19015661670.016
cellular calcium ion homeostasisGO:00068741600.016
Rat
positive regulation of lymphocyte proliferationGO:0050671200.016
response to alkaloidGO:00432791320.016
regulation of heart rateGO:0002027160.016
Human
regulation of cell cycleGO:0051726730.016
calcium ion importGO:0070509220.016
striated muscle contractionGO:0006941440.015
positive regulation of cellular amino acid metabolic processGO:004576410.015
proteolysisGO:00065081750.015
axon guidanceGO:0007411240.015
neuronal action potentialGO:0019228350.015
protein complex assemblyGO:00064612630.015
Rat
regulation of anion transportGO:0044070430.015
positive regulation of programmed cell deathGO:00430681570.015
positive regulation of protein kinase activityGO:0045860730.015
nucleotide metabolic processGO:00091172790.015
cell adhesionGO:00071551100.015
regulation of ion homeostasisGO:2000021630.015
regulation of protein kinase activityGO:00458591050.015
regulation of cellular component biogenesisGO:0044087860.015
blood vessel developmentGO:0001568690.014
muscle cell proliferationGO:0033002840.014
gamete generationGO:00072761240.014
cellular catabolic processGO:00442482950.014
positive regulation of serotonin secretionGO:001406410.014
nucleobase containing small molecule metabolic processGO:00550863160.014
neuromuscular processGO:005090520.014
sensory organ developmentGO:0007423740.014
camera type eye morphogenesisGO:004859320.014
reproductionGO:00000032450.014
negative regulation of response to stimulusGO:00485851550.014
response to insulinGO:00328681330.014
regulation of mapk cascadeGO:00434081160.014
organic cyclic compound catabolic processGO:19013611750.014
macromolecular complex assemblyGO:00650032730.013
Rat
cell growthGO:00160491040.013
muscle organ developmentGO:0007517500.013
rhythmic processGO:00485111560.013
regulation of protein phosphorylationGO:00019321830.013
excretionGO:0007588240.013
hormone transportGO:00099141210.013
ovulation cycle processGO:0022602500.013
regulation of neuron apoptotic processGO:0043523830.013
g protein coupled receptor signaling pathwayGO:00071862420.013
positive regulation of neuron projection developmentGO:0010976990.013
positive regulation of transportGO:00510502450.013
regulation of metal ion transportGO:00109591180.013
anatomical structure homeostasisGO:0060249290.013
peptidyl amino acid modificationGO:00181931260.013
immune responseGO:00069551040.013
positive regulation of mapk cascadeGO:0043410920.013
positive regulation of cytosolic calcium ion concentrationGO:00072041220.013
steroid biosynthetic processGO:0006694480.013
lipid metabolic processGO:00066292830.013
cellular response to acid chemicalGO:0071229750.013
protein catabolic processGO:0030163300.012
positive regulation of apoptotic processGO:00430651540.012
negative regulation of hormone secretionGO:0046888460.012
striated muscle tissue developmentGO:0014706580.012
regulation of axonogenesisGO:0050770370.012
adaptation of signaling pathwayGO:0023058100.012
cell part morphogenesisGO:00329901230.012
negative regulation of calcium ion importGO:009028120.012
negative regulation of cell projection organizationGO:0031345500.012
dendrite developmentGO:0016358720.012
forebrain developmentGO:0030900980.012
amide transportGO:00428861050.012
positive regulation of gene expressionGO:00106282440.012
axis specificationGO:000979840.012
regulation of immunoglobulin mediated immune responseGO:000288920.012
actin filament organizationGO:0007015420.012
regulation of cell motilityGO:20001451310.012
regulation of cellular response to stressGO:0080135490.012
locomotory exploration behaviorGO:003564110.012
regulation of hormone secretionGO:00468831060.012
vasculature developmentGO:0001944700.012
regulation of neurological system processGO:0031644430.011
heart morphogenesisGO:000300730.011
regulation of immune system processGO:00026821230.011
positive regulation of kinase activityGO:0033674770.011
regulation of isotype switchingGO:004519110.011
response to fatty acidGO:0070542650.011
regulation of action potentialGO:0098900140.011
regulation of cellular catabolic processGO:00313291010.011
positive regulation of cellular component movementGO:00512721020.011
cellular response to peptide hormone stimulusGO:00713751200.011
positive regulation of neuron differentiationGO:00456661260.011
positive regulation of cellular catabolic processGO:0031331710.011
positive regulation of rna biosynthetic processGO:19026801970.011
regulation of kinase activityGO:00435491170.011
negative regulation of neuron deathGO:1901215690.011
purine nucleotide metabolic processGO:00061632290.011
response to hypoxiaGO:00016662310.011
gliogenesisGO:0042063930.011
negative regulation of chronic inflammatory responseGO:000267720.011
carboxylic acid metabolic processGO:00197522890.011
positive regulation of locomotionGO:00400171020.011
cognitionGO:0050890920.011
cellular response to organic cyclic compoundGO:00714072020.011
Human
positive regulation of blood circulationGO:1903524650.011
Rat
positive regulation of mononuclear cell proliferationGO:0032946200.011
negative regulation of rna biosynthetic processGO:19026791180.011
regulation of developmental growthGO:0048638450.011
cytoplasmic transportGO:00164821150.010
learning or memoryGO:0007611900.010
actin cytoskeleton organizationGO:0030036730.010
agingGO:00075682410.010
Rat
regulation of muscle contractionGO:0006937530.010
negative regulation of defecationGO:200029310.010
regulation of transferase activityGO:00513381230.010
activation of protein kinase activityGO:0032147470.010
response to woundingGO:00096112540.010
positive regulation of cell deathGO:00109421840.010
ribonucleoside triphosphate catabolic processGO:00092031220.010
peptide secretionGO:0002790860.010
multicellular organismal response to stressGO:0033555250.010
regulation of anatomical structure morphogenesisGO:00226031410.010
response to activityGO:0014823730.010
regulation of glucose transportGO:0010827180.010

Hcn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.035
disease of anatomical entityDOID:700.035
Human
musculoskeletal system diseaseDOID:1700.032
eye and adnexa diseaseDOID:149200.023
sensory system diseaseDOID:005015500.023
connective tissue diseaseDOID:6500.019
eye diseaseDOID:561400.013