IMP: Integrative Multi-species Prediction

Rattus norvegicus

131 known processes

Hdac4

histone deacetylase 4

RGD: 619979
Ensembl: ENSRNOG00000020372
Entrez: 363287
UniProtKB: Q99P99

Process Predictions
Disease Predictions

Hdac4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of multicellular organismal development	GO:2000026	376	0.148	Mouse
nucleic acid templated transcription	GO:0097659	379	0.122	Human Mouse Fly
rna metabolic process	GO:0016070	406	0.115	Human Mouse Fly
rna biosynthetic process	GO:0032774	380	0.109	Human Mouse Fly
anatomical structure morphogenesis	GO:0009653	298	0.105
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.094	Human Mouse
regulation of transcription dna templated	GO:0006355	374	0.093	Human Mouse Fly
regulation of cellular component organization	GO:0051128	368	0.087
positive regulation of rna metabolic process	GO:0051254	203	0.082	Human Mouse
regulation of nucleic acid templated transcription	GO:1903506	380	0.078	Human Mouse Fly
cell projection organization	GO:0030030	302	0.078
behavior	GO:0007610	205	0.072	Fly
positive regulation of multicellular organismal process	GO:0051240	387	0.071
cell part morphogenesis	GO:0032990	123	0.069
positive regulation of biosynthetic process	GO:0009891	319	0.067
reproductive process	GO:0022414	372	0.064
oxoacid metabolic process	GO:0043436	290	0.063	Mouse
regulation of rna biosynthetic process	GO:2001141	381	0.063	Human Mouse Fly
cell cell signaling	GO:0007267	335	0.063
synaptic growth at neuromuscular junction	GO:0051124	1	0.062
positive regulation of rna biosynthetic process	GO:1902680	197	0.061	Human Mouse
neuron projection development	GO:0031175	273	0.060
regulation of molecular function	GO:0065009	398	0.060	Human
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.058	Human Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.058	Human Mouse
regulation of signal transduction	GO:0009966	318	0.056
cell morphogenesis	GO:0000902	142	0.056
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.055	Human Mouse
neuron development	GO:0048666	286	0.054
carboxylic acid metabolic process	GO:0019752	289	0.054	Mouse
negative regulation of metabolic process	GO:0009892	331	0.053	Human Mouse
neuron differentiation	GO:0030182	368	0.051	Rat
locomotion	GO:0040011	237	0.051
cell morphogenesis involved in differentiation	GO:0000904	119	0.051
positive regulation of developmental process	GO:0051094	283	0.051
central nervous system development	GO:0007417	311	0.051
organic acid metabolic process	GO:0006082	292	0.049	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	295	0.049	Human Mouse
cellular ketone metabolic process	GO:0042180	51	0.048
neuron projection morphogenesis	GO:0048812	122	0.048
single organism reproductive process	GO:0044702	297	0.047
regulation of rna metabolic process	GO:0051252	391	0.047	Human Mouse Fly
negative regulation of cellular metabolic process	GO:0031324	281	0.047	Human Mouse
cellular component morphogenesis	GO:0032989	155	0.047
negative regulation of macromolecule metabolic process	GO:0010605	260	0.046	Human Mouse
protein complex subunit organization	GO:0071822	302	0.045
regulation of cell projection organization	GO:0031344	175	0.045
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.045
transcription from rna polymerase ii promoter	GO:0006366	252	0.045	Human Mouse
positive regulation of cellular component organization	GO:0051130	200	0.045
regulation of system process	GO:0044057	208	0.044	Mouse
regulation of nervous system development	GO:0051960	264	0.044
regulation of phosphate metabolic process	GO:0019220	349	0.043
cell migration	GO:0016477	197	0.043
regulation of cell development	GO:0060284	263	0.043	Mouse
positive regulation of programmed cell death	GO:0043068	157	0.043
regulation of neurogenesis	GO:0050767	247	0.042
positive regulation of cell communication	GO:0010647	271	0.042
hormone transport	GO:0009914	121	0.041
macromolecular complex subunit organization	GO:0043933	339	0.041
head development	GO:0060322	247	0.041
regulation of cell differentiation	GO:0045595	320	0.040	Human Mouse
cellular component movement	GO:0006928	248	0.039
dendrite development	GO:0016358	72	0.039
regulation of cell morphogenesis	GO:0022604	77	0.039
dendrite morphogenesis	GO:0048813	43	0.039
regulation of cellular amino acid metabolic process	GO:0006521	2	0.039
signal release	GO:0023061	145	0.039
positive regulation of gene expression	GO:0010628	244	0.039	Human Mouse
regulation of phosphorus metabolic process	GO:0051174	349	0.039
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.038	Human Mouse
tissue development	GO:0009888	252	0.038	Mouse
cellular component biogenesis	GO:0044085	368	0.038
protein complex biogenesis	GO:0070271	263	0.038
protein complex assembly	GO:0006461	263	0.037
cellular amino acid metabolic process	GO:0006520	107	0.037
cell projection morphogenesis	GO:0048858	123	0.037
regulation of anatomical structure morphogenesis	GO:0022603	141	0.037
cellular response to endogenous stimulus	GO:0071495	377	0.036
regulation of secretion by cell	GO:1903530	208	0.036
positive regulation of signaling	GO:0023056	270	0.036
macromolecular complex assembly	GO:0065003	273	0.035
negative regulation of gene expression	GO:0010629	199	0.035	Human Mouse
regulation of cellular ketone metabolic process	GO:0010565	27	0.035
secretion by cell	GO:0032940	248	0.034
regulation of cellular amine metabolic process	GO:0033238	8	0.034
secretion	GO:0046903	307	0.033
response to other organism	GO:0051707	220	0.033	Rat
positive regulation of molecular function	GO:0044093	230	0.033	Human
cellular amine metabolic process	GO:0044106	38	0.033
developmental process involved in reproduction	GO:0003006	159	0.032
regulation of neuron differentiation	GO:0045664	208	0.032
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.032
cellular response to oxygen containing compound	GO:1901701	386	0.031	Rat
cellular component assembly	GO:0022607	360	0.031
negative regulation of multicellular organismal process	GO:0051241	203	0.031	Mouse
transcription dna templated	GO:0006351	377	0.031	Human Mouse Fly
intracellular signal transduction	GO:0035556	314	0.031	Mouse
positive regulation of transcription dna templated	GO:0045893	197	0.030	Human Mouse
amine metabolic process	GO:0009308	38	0.030
carbohydrate derivative metabolic process	GO:1901135	346	0.030
regulation of intracellular signal transduction	GO:1902531	218	0.030
organic substance catabolic process	GO:1901575	316	0.029	Mouse
regulation of cellular localization	GO:0060341	263	0.029
regulation of hormone levels	GO:0010817	187	0.028
positive regulation of response to stimulus	GO:0048584	285	0.028
localization of cell	GO:0051674	202	0.028
negative regulation of cellular component organization	GO:0051129	83	0.028
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.028
cell motility	GO:0048870	202	0.027
positive regulation of cell development	GO:0010720	176	0.027
gonad development	GO:0008406	104	0.026
response to extracellular stimulus	GO:0009991	380	0.026
multicellular organismal reproductive process	GO:0048609	233	0.026
positive regulation of catalytic activity	GO:0043085	184	0.026
organic cyclic compound catabolic process	GO:1901361	175	0.026
nucleoside phosphate metabolic process	GO:0006753	283	0.026
regulation of neuron projection development	GO:0010975	161	0.026
positive regulation of phosphorus metabolic process	GO:0010562	262	0.026
regulation of apoptotic process	GO:0042981	335	0.026
positive regulation of signal transduction	GO:0009967	175	0.025
programmed cell death	GO:0012501	392	0.025
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.025
small gtpase mediated signal transduction	GO:0007264	36	0.025
nucleobase containing small molecule metabolic process	GO:0055086	316	0.025
multicellular organism reproduction	GO:0032504	233	0.025
regulation of protein metabolic process	GO:0051246	289	0.024	Human
reproductive structure development	GO:0048608	128	0.024
response to nutrient levels	GO:0031667	370	0.024
muscle system process	GO:0003012	115	0.024	Mouse
response to wounding	GO:0009611	254	0.024
purine nucleotide metabolic process	GO:0006163	229	0.024
positive regulation of apoptotic process	GO:0043065	154	0.024
regulation of catalytic activity	GO:0050790	304	0.024
brain development	GO:0007420	247	0.024
cellular response to hormone stimulus	GO:0032870	247	0.024
positive regulation of phosphate metabolic process	GO:0045937	262	0.024
ras protein signal transduction	GO:0007265	29	0.024
vesicle mediated transport	GO:0016192	181	0.023
positive regulation of neurogenesis	GO:0050769	165	0.023
cellular response to stress	GO:0033554	269	0.023
single organism catabolic process	GO:0044712	283	0.023	Mouse
regulation of cellular protein metabolic process	GO:0032268	267	0.023	Human
cardiovascular system development	GO:0072358	134	0.023
macromolecule localization	GO:0033036	252	0.023
protein phosphorylation	GO:0006468	345	0.022
regulation of hydrolase activity	GO:0051336	143	0.022
neurological system process	GO:0050877	219	0.022	Fly
apoptotic process	GO:0006915	381	0.022
cellular nitrogen compound catabolic process	GO:0044270	163	0.022
reproduction	GO:0000003	245	0.022
nucleotide metabolic process	GO:0009117	279	0.022
regulation of secretion	GO:0051046	224	0.022
negative regulation of cell communication	GO:0010648	158	0.022
positive regulation of nervous system development	GO:0051962	178	0.022
purine containing compound metabolic process	GO:0072521	253	0.022
cation transport	GO:0006812	382	0.022
negative regulation of rna metabolic process	GO:0051253	123	0.022	Human Mouse
glycosyl compound metabolic process	GO:1901657	182	0.022
regulation of anatomical structure size	GO:0090066	135	0.021
positive regulation of cellular amine metabolic process	GO:0033240	3	0.021
synaptic transmission	GO:0007268	235	0.021
multi organism reproductive process	GO:0044703	262	0.021
cellular response to growth factor stimulus	GO:0071363	162	0.021
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.021	Human Mouse
purine ribonucleotide metabolic process	GO:0009150	227	0.021
ribonucleotide metabolic process	GO:0009259	231	0.021
purine containing compound catabolic process	GO:0072523	138	0.021
peptidyl amino acid modification	GO:0018193	126	0.021	Human
purine ribonucleoside metabolic process	GO:0046128	168	0.021
ribose phosphate metabolic process	GO:0019693	235	0.020
forebrain development	GO:0030900	98	0.020
positive regulation of phosphorylation	GO:0042327	177	0.020
regulation of cell motility	GO:2000145	131	0.020
axonogenesis	GO:0007409	71	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.020
response to peptide	GO:1901652	292	0.020
regulation of synaptic plasticity	GO:0048167	70	0.020
nucleoside triphosphate metabolic process	GO:0009141	144	0.020
development of primary sexual characteristics	GO:0045137	107	0.020
purine nucleoside catabolic process	GO:0006152	124	0.020
organonitrogen compound catabolic process	GO:1901565	179	0.020
transmembrane transport	GO:0055085	412	0.020
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.019	Human Mouse
homeostatic process	GO:0042592	331	0.019
regulation of protein modification process	GO:0031399	194	0.019	Human
metal ion transport	GO:0030001	289	0.019
sex differentiation	GO:0007548	113	0.019
negative regulation of response to stimulus	GO:0048585	155	0.019
negative regulation of rna biosynthetic process	GO:1902679	118	0.019	Human Mouse
regulation of locomotion	GO:0040012	148	0.019
hormone secretion	GO:0046879	115	0.019
response to growth factor	GO:0070848	189	0.019
cellular catabolic process	GO:0044248	295	0.019	Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.018
negative regulation of transport	GO:0051051	136	0.018
circulatory system development	GO:0072359	134	0.018
cell adhesion	GO:0007155	110	0.018
response to oxygen levels	GO:0070482	265	0.018
cellular response to organonitrogen compound	GO:0071417	197	0.018
regulation of cellular component movement	GO:0051270	150	0.018
protein oligomerization	GO:0051259	191	0.018
negative regulation of transcription dna templated	GO:0045892	116	0.018	Human Mouse
biological adhesion	GO:0022610	110	0.018
regulation of proteasomal protein catabolic process	GO:0061136	4	0.018
epithelium development	GO:0060429	96	0.018
positive regulation of cell death	GO:0010942	184	0.018
protein autophosphorylation	GO:0046777	66	0.017
growth	GO:0040007	165	0.017
cellular response to nitrogen compound	GO:1901699	210	0.017
response to lipopolysaccharide	GO:0032496	191	0.017	Rat
nucleoside phosphate catabolic process	GO:1901292	140	0.017
regulation of dendrite development	GO:0050773	59	0.017
protein localization	GO:0008104	191	0.017
divalent inorganic cation transport	GO:0072511	134	0.017
positive regulation of neuron differentiation	GO:0045666	126	0.017
response to metal ion	GO:0010038	253	0.017
regulation of transferase activity	GO:0051338	123	0.017
positive regulation of cell differentiation	GO:0045597	217	0.017
positive regulation of protein metabolic process	GO:0051247	178	0.017	Human
response to molecule of bacterial origin	GO:0002237	194	0.017	Rat
regulation of protein kinase activity	GO:0045859	105	0.017
oxidation reduction process	GO:0055114	304	0.017
negative regulation of signaling	GO:0023057	157	0.017
response to external biotic stimulus	GO:0043207	221	0.017	Rat
cellular homeostasis	GO:0019725	252	0.017
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.017	Human Mouse
regulation of hormone secretion	GO:0046883	106	0.017
negative regulation of phosphate metabolic process	GO:0045936	80	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.016	Human Mouse
regulation of cell proliferation	GO:0042127	359	0.016
organophosphate metabolic process	GO:0019637	370	0.016
heterocycle catabolic process	GO:0046700	167	0.016
developmental growth	GO:0048589	100	0.016
embryonic pattern specification	GO:0009880	1	0.016
response to biotic stimulus	GO:0009607	226	0.016	Rat
regulation of programmed cell death	GO:0043067	341	0.016
chemical homeostasis	GO:0048878	292	0.016
positive regulation of cellular protein metabolic process	GO:0032270	167	0.016	Human
regulation of cellular component biogenesis	GO:0044087	86	0.016
glycosyl compound catabolic process	GO:1901658	126	0.016
nucleotide catabolic process	GO:0009166	139	0.016
gastrulation	GO:0007369	2	0.016
bmp signaling pathway	GO:0030509	4	0.016
response to glucose	GO:0009749	136	0.016
chromosome segregation	GO:0007059	2	0.015
response to hexose	GO:0009746	144	0.015
taxis	GO:0042330	67	0.015
negative regulation of nervous system development	GO:0051961	79	0.015
aromatic compound catabolic process	GO:0019439	168	0.015
negative regulation of biosynthetic process	GO:0009890	168	0.015	Human Mouse
ribonucleoside metabolic process	GO:0009119	174	0.015
nucleoside triphosphate catabolic process	GO:0009143	123	0.015
appendage morphogenesis	GO:0035107	4	0.015
nucleoside catabolic process	GO:0009164	126	0.015
nucleobase containing compound catabolic process	GO:0034655	152	0.015
gamete generation	GO:0007276	124	0.015
negative regulation of molecular function	GO:0044092	133	0.015	Human
positive regulation of transport	GO:0051050	245	0.015
sexual reproduction	GO:0019953	148	0.015
positive regulation of neuron projection development	GO:0010976	99	0.015
reproductive system development	GO:0061458	128	0.015
catabolic process	GO:0009056	351	0.015	Mouse
purine nucleoside metabolic process	GO:0042278	169	0.015
nitrogen compound transport	GO:0071705	229	0.014
nucleoside metabolic process	GO:0009116	179	0.014
proteolysis	GO:0006508	175	0.014
single organism biosynthetic process	GO:0044711	342	0.014
regulation of catabolic process	GO:0009894	113	0.014	Mouse
actin filament based process	GO:0030029	86	0.014
organelle organization	GO:0006996	266	0.014
response to decreased oxygen levels	GO:0036293	237	0.014
urogenital system development	GO:0001655	78	0.014
mapk cascade	GO:0000165	140	0.014
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.014
positive regulation of mapk cascade	GO:0043410	92	0.014
cellular chemical homeostasis	GO:0055082	247	0.014
positive regulation of cell projection organization	GO:0031346	111	0.014
response to glucocorticoid	GO:0051384	223	0.014
axon development	GO:0061564	96	0.014
motor neuron axon guidance	GO:0008045	1	0.014
negative regulation of cell proliferation	GO:0008285	119	0.014	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.014
response to acid chemical	GO:0001101	222	0.014
response to hypoxia	GO:0001666	231	0.014
response to inorganic substance	GO:0010035	377	0.014
cell growth	GO:0016049	104	0.014
anterior posterior pattern specification	GO:0009952	1	0.014
positive regulation of protein modification process	GO:0031401	142	0.014	Human
response to carbohydrate	GO:0009743	183	0.013
response to ethanol	GO:0045471	162	0.013
limb morphogenesis	GO:0035108	4	0.013
single organism behavior	GO:0044708	130	0.013	Fly
cellular ion homeostasis	GO:0006873	184	0.013
embryonic appendage morphogenesis	GO:0035113	4	0.013
regulation of protein phosphorylation	GO:0001932	183	0.013
mesoderm development	GO:0007498	2	0.013
regulation of growth	GO:0040008	105	0.013
axis specification	GO:0009798	4	0.013
positive regulation of catabolic process	GO:0009896	78	0.013
positive regulation of protein phosphorylation	GO:0001934	135	0.013
response to monosaccharide	GO:0034284	159	0.013
ribonucleoside catabolic process	GO:0042454	126	0.013
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.013	Human Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.013
synapse assembly	GO:0007416	29	0.013
regulation of phosphorylation	GO:0042325	248	0.013
regulation of organelle organization	GO:0033043	80	0.013
aging	GO:0007568	241	0.013
dephosphorylation	GO:0016311	98	0.013
rhythmic process	GO:0048511	156	0.013
lipid metabolic process	GO:0006629	283	0.013
regulation of axonogenesis	GO:0050770	37	0.013
circulatory system process	GO:0003013	183	0.013	Mouse
response to nutrient	GO:0007584	248	0.013
ribonucleotide catabolic process	GO:0009261	136	0.013
salivary gland morphogenesis	GO:0007435	1	0.012
negative regulation of neurogenesis	GO:0050768	78	0.012
cognition	GO:0050890	92	0.012	Fly
olfactory behavior	GO:0042048	2	0.012
purine ribonucleotide catabolic process	GO:0009154	136	0.012
regulation of cell growth	GO:0001558	85	0.012
salivary gland development	GO:0007431	3	0.012
multicellular organism growth	GO:0035264	1	0.012
ion transmembrane transport	GO:0034220	365	0.012
rho protein signal transduction	GO:0007266	11	0.012
regulation of synaptic transmission	GO:0050804	141	0.012
cellular protein localization	GO:0034613	122	0.012
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	41	0.012
negative regulation of cell death	GO:0060548	229	0.012
organonitrogen compound biosynthetic process	GO:1901566	167	0.012
regulation of purine nucleotide metabolic process	GO:1900542	115	0.012
cytoskeleton organization	GO:0007010	111	0.012
regulation of response to stress	GO:0080134	126	0.012
regulation of cell migration	GO:0030334	128	0.012
purine nucleotide catabolic process	GO:0006195	136	0.012
mitotic spindle organization	GO:0007052	2	0.012
response to cytokine	GO:0034097	215	0.012
regulation of vesicle mediated transport	GO:0060627	81	0.012
b cell differentiation	GO:0030183	2	0.012
cell type specific apoptotic process	GO:0097285	134	0.012
ion homeostasis	GO:0050801	212	0.011
membrane organization	GO:0061024	94	0.011
multi multicellular organism process	GO:0044706	138	0.011
carboxylic acid transport	GO:0046942	115	0.011
positive regulation of hydrolase activity	GO:0051345	86	0.011
carbohydrate derivative catabolic process	GO:1901136	147	0.011
amide transport	GO:0042886	105	0.011
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.011	Human Mouse
cellular response to organic cyclic compound	GO:0071407	202	0.011
cellular response to peptide	GO:1901653	133	0.011
regulation of mapk cascade	GO:0043408	116	0.011
embryo development	GO:0009790	49	0.011
negative regulation of secretion	GO:0051048	82	0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.011
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.011
regulation of cellular catabolic process	GO:0031329	101	0.011	Mouse
male sex differentiation	GO:0046661	64	0.011
organophosphate catabolic process	GO:0046434	148	0.011
regulation of kinase activity	GO:0043549	117	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
non canonical wnt signaling pathway	GO:0035567	3	0.010
spindle organization	GO:0007051	2	0.010
negative regulation of programmed cell death	GO:0043069	183	0.010
regulation of nucleoside metabolic process	GO:0009118	66	0.010
negative regulation of catalytic activity	GO:0043086	103	0.010
regulation of membrane potential	GO:0042391	110	0.010
regulation of cell adhesion	GO:0030155	52	0.010
actin cytoskeleton organization	GO:0030036	73	0.010
heart development	GO:0007507	72	0.010
male mating behavior	GO:0060179	3	0.010
cellular calcium ion homeostasis	GO:0006874	160	0.010
regulation of purine nucleotide catabolic process	GO:0033121	65	0.010
signal transduction by phosphorylation	GO:0023014	144	0.010
response to estradiol	GO:0032355	164	0.010
positive regulation of cell proliferation	GO:0008284	249	0.010
purine ribonucleoside catabolic process	GO:0046130	124	0.010
blood circulation	GO:0008015	183	0.010	Mouse
synapse organization	GO:0050808	46	0.010
regulation of ion transport	GO:0043269	245	0.010

Hdac4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.019
disease of anatomical entity	DOID:7	0.019
connective tissue disease	DOID:65	0.017
bone disease	DOID:0080001	0.017
nervous system disease	DOID:863	0.014

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