Rattus norvegicus

133 known processes

Ide

insulin degrading enzyme

(Aliases: INSDEGM)

Ide biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
macromolecule localizationGO:00330362520.289
regulation of cellular localizationGO:00603412630.250
cellular component biogenesisGO:00440853680.186
macromolecular complex assemblyGO:00650032730.171
protein complex subunit organizationGO:00718223020.163
protein complex assemblyGO:00064612630.145
single organism intracellular transportGO:19025821660.140
regulation of cellular component organizationGO:00511283680.137
Human
macromolecular complex subunit organizationGO:00439333390.136
cellular component assemblyGO:00226073600.124
regulation of cellular protein metabolic processGO:00322682670.122
nucleic acid templated transcriptionGO:00976593790.112
single organism biosynthetic processGO:00447113420.107
rna metabolic processGO:00160704060.106
cellular response to organonitrogen compoundGO:00714171970.105
regulation of secretionGO:00510462240.105
regulation of rna metabolic processGO:00512523910.104
negative regulation of metabolic processGO:00098923310.098
positive regulation of cellular biosynthetic processGO:00313282950.096
intracellular transportGO:00469071850.095
cellular protein localizationGO:00346131220.094
regulation of rna biosynthetic processGO:20011413810.089
secretionGO:00469033070.087
transcription dna templatedGO:00063513770.086
positive regulation of biosynthetic processGO:00098913190.086
regulation of t cell chemotaxisGO:001081910.080
establishment of protein localizationGO:00451841410.079
regulation of phosphorus metabolic processGO:00511743490.076
vesicle mediated transportGO:00161921810.071
protein complex biogenesisGO:00702712630.069
secretion by cellGO:00329402480.068
cellular response to stressGO:00335542690.068
positive regulation of nitrogen compound metabolic processGO:00511733340.066
response to decreased oxygen levelsGO:00362932370.061
oxoacid metabolic processGO:00434362900.060
cellular homeostasisGO:00197252520.059
Human
single organism carbohydrate metabolic processGO:00447231180.058
Fly
cytoplasmic transportGO:00164821150.057
regulation of protein transportGO:0051223680.057
regulation of protein import into nucleusGO:0042306240.057
cellular catabolic processGO:00442482950.056
positive regulation of gene expressionGO:00106282440.056
carbohydrate metabolic processGO:00059751300.055
Fly
regulation of transcription dna templatedGO:00063553740.055
protein transportGO:00150311320.054
nucleocytoplasmic transportGO:0006913480.052
cellular response to oxygen containing compoundGO:19017013860.052
negative regulation of cellular metabolic processGO:00313242810.050
positive regulation of transportGO:00510502450.049
protein phosphorylationGO:00064683450.049
negative regulation of macromolecule metabolic processGO:00106052600.049
positive regulation of macromolecule biosynthetic processGO:00105572470.049
regulation of cellular catabolic processGO:00313291010.049
single organism catabolic processGO:00447122830.048
ribose phosphate metabolic processGO:00196932350.048
protein localizationGO:00081041910.048
response to hexoseGO:00097461440.048
cellular response to endogenous stimulusGO:00714953770.047
protein modification by small protein conjugation or removalGO:0070647350.047
regulation of establishment of protein localizationGO:0070201690.046
negative regulation of cellular protein metabolic processGO:00322691060.046
regulation of protein localizationGO:0032880810.045
positive regulation of nucleobase containing compound metabolic processGO:00459353190.045
protein heterooligomerizationGO:0051291890.045
cellular component movementGO:00069282480.045
metal ion transportGO:00300012890.044
cellular response to peptide hormone stimulusGO:00713751200.041
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.039
organic cyclic compound catabolic processGO:19013611750.038
cell differentiation involved in kidney developmentGO:006100540.038
nucleoside phosphate metabolic processGO:00067532830.038
positive regulation of rna metabolic processGO:00512542030.038
nucleotide metabolic processGO:00091172790.036
ribonucleotide metabolic processGO:00092592310.036
cation homeostasisGO:00550801950.035
negative regulation of protein phosphorylationGO:0001933440.034
response to peptide hormoneGO:00434342780.034
response to extracellular stimulusGO:00099913800.034
Fly
regulation of cell developmentGO:00602842630.033
negative regulation of protein metabolic processGO:00512481140.033
regulation of molecular functionGO:00650093980.033
regulation of multicellular organismal developmentGO:20000263760.032
organelle localizationGO:0051640550.032
intracellular protein transportGO:0006886790.032
cellular macromolecule localizationGO:00707271220.031
response to nutrient levelsGO:00316673700.031
Fly
protein oligomerizationGO:00512591910.030
purine nucleotide metabolic processGO:00061632290.030
peptidyl amino acid modificationGO:00181931260.030
organonitrogen compound catabolic processGO:19015651790.030
positive regulation of phosphorus metabolic processGO:00105622620.030
homeostatic processGO:00425923310.030
Human
neurological system processGO:00508772190.030
nuclear transportGO:0051169490.030
organelle organizationGO:00069962660.030
carbohydrate derivative metabolic processGO:19011353460.029
organic acid metabolic processGO:00060822920.029
regulation of secretion by cellGO:19035302080.029
nucleoside metabolic processGO:00091161790.029
carbohydrate derivative biosynthetic processGO:19011371240.029
neuron projection developmentGO:00311752730.028
transcription from rna polymerase ii promoterGO:00063662520.028
single organism organelle organizationGO:19025891800.028
purine ribonucleotide metabolic processGO:00091502270.028
development of primary female sexual characteristicsGO:0046545560.028
cytoskeleton organizationGO:00070101110.028
response to transition metal nanoparticleGO:19902671220.027
negative regulation of phosphate metabolic processGO:0045936800.027
protein deubiquitinationGO:001657940.027
regulation of phosphate metabolic processGO:00192203490.027
multi organism reproductive processGO:00447032620.027
Fly
response to metal ionGO:00100382530.027
regulation of catalytic activityGO:00507903040.027
heart morphogenesisGO:000300730.026
proteolysisGO:00065081750.026
single organism cellular localizationGO:19025801020.026
cellular amino acid metabolic processGO:00065201070.026
memoryGO:0007613540.025
immune system processGO:00023762040.025
Fly
positive regulation of nucleotide metabolic processGO:0045981910.025
regulation of protein metabolic processGO:00512462890.025
response to monosaccharideGO:00342841590.025
ribose phosphate biosynthetic processGO:0046390870.025
positive regulation of molecular functionGO:00440932300.025
regulation of nucleocytoplasmic transportGO:0046822280.025
cellular ion homeostasisGO:00068731840.025
amine metabolic processGO:0009308380.025
glycoprotein biosynthetic processGO:0009101190.025
organophosphate biosynthetic processGO:00904071430.024
nucleoside phosphate biosynthetic processGO:19012931020.024
protein localization to organelleGO:0033365570.024
regulation of canonical wnt signaling pathwayGO:006082840.024
rna biosynthetic processGO:00327743800.024
spindle organizationGO:000705120.024
neuromuscular synaptic transmissionGO:000727420.024
negative regulation of transportGO:00510511360.024
positive regulation of cell differentiationGO:00455972170.024
response to nutrientGO:00075842480.024
cellular carbohydrate metabolic processGO:0044262720.024
Fly
positive regulation of secretionGO:00510471400.024
protein import into nucleusGO:0006606350.024
organophosphate metabolic processGO:00196373700.023
regulation of cellular ketone metabolic processGO:0010565270.023
small gtpase mediated signal transductionGO:0007264360.023
cellular ketone metabolic processGO:0042180510.023
response to growth factorGO:00708481890.023
macroautophagyGO:001623640.023
purine ribonucleoside triphosphate metabolic processGO:00092051400.023
carboxylic acid metabolic processGO:00197522890.023
regulation of ion transportGO:00432692450.023
positive regulation of purine nucleotide metabolic processGO:1900544910.022
regulation of intracellular transportGO:0032386650.022
positive regulation of protein metabolic processGO:00512471780.022
positive regulation of transcription dna templatedGO:00458931970.022
g protein coupled receptor signaling pathwayGO:00071862420.022
response to purine containing compoundGO:00140741260.022
positive regulation of cell developmentGO:00107201760.022
nucleotide biosynthetic processGO:0009165980.022
nucleobase containing small molecule metabolic processGO:00550863160.021
lipid metabolic processGO:00066292830.021
glycerolipid metabolic processGO:0046486670.021
synaptic growth at neuromuscular junctionGO:005112410.021
negative regulation of cell communicationGO:00106481580.021
Fly
catabolic processGO:00090563510.021
response to oxygen levelsGO:00704822650.021
response to cadmium ionGO:0046686350.021
female sex differentiationGO:0046660590.021
negative regulation of cell deathGO:00605482290.021
negative regulation of nucleic acid templated transcriptionGO:19035071170.020
positive regulation of rna biosynthetic processGO:19026801970.020
cellular response to nitrogen compoundGO:19016992100.020
cellular response to organic cyclic compoundGO:00714072020.020
cellular chemical homeostasisGO:00550822470.020
regulation of protein modification processGO:00313991940.020
positive regulation of nucleic acid templated transcriptionGO:19035081970.020
regulation of nucleotide metabolic processGO:00061401170.020
divalent inorganic cation homeostasisGO:00725071650.020
reproductive system developmentGO:00614581280.020
signal releaseGO:00230611450.020
synaptic transmissionGO:00072682350.020
cellular protein complex assemblyGO:0043623440.020
dna metabolic processGO:0006259960.020
cell cycleGO:00070491010.020
positive regulation of cell proliferationGO:00082842490.020
defense responseGO:00069521940.020
Fly
positive regulation of cellular component organizationGO:00511302000.020
Human
response to peptideGO:19016522920.020
positive regulation of cellular catabolic processGO:0031331710.019
intracellular signal transductionGO:00355563140.019
Fly
regulation of cell differentiationGO:00455953200.019
cation transportGO:00068123820.019
neuron differentiationGO:00301823680.019
lipid biosynthetic processGO:00086101280.019
regulation of protein kinase activityGO:00458591050.019
purine nucleotide biosynthetic processGO:0006164830.019
negative regulation of cellular component organizationGO:0051129830.019
proteolysis involved in cellular protein catabolic processGO:0051603190.019
negative regulation of response to stimulusGO:00485851550.019
Fly
negative regulation of rna biosynthetic processGO:19026791180.018
cell cell signalingGO:00072673350.018
negative regulation of apoptotic processGO:00430661810.018
transmembrane transportGO:00550854120.018
organic substance catabolic processGO:19015753160.018
cellular cation homeostasisGO:00300031800.018
response to inorganic substanceGO:00100353770.018
behaviorGO:00076102050.018
Fly
cellular response to peptideGO:19016531330.018
chemical homeostasisGO:00488782920.018
response to ethanolGO:00454711620.018
regulation of response to stressGO:00801341260.018
Fly
protein importGO:0017038370.017
regulation of transcription from rna polymerase ii promoterGO:00063572340.017
regulation of gtpase activityGO:0043087570.017
ribonucleoside catabolic processGO:00424541260.017
growthGO:00400071650.017
Fly
ribonucleotide biosynthetic processGO:0009260850.017
regulation of catabolic processGO:00098941130.017
cell morphogenesisGO:00009021420.017
organophosphate catabolic processGO:00464341480.017
maintenance of locationGO:0051235170.017
purine ribonucleotide catabolic processGO:00091541360.017
regulation of intracellular protein transportGO:0033157340.016
protein targetingGO:0006605610.016
regulation of cellular carbohydrate metabolic processGO:0010675390.016
Fly
protein modification by small protein conjugationGO:0032446310.016
negative regulation of phosphorus metabolic processGO:0010563800.016
regulation of nucleic acid templated transcriptionGO:19035063800.016
protein o linked glycosylationGO:000649320.016
positive regulation of triglyceride metabolic processGO:009020840.016
positive regulation of multicellular organismal processGO:00512403870.016
positive regulation of phosphorylationGO:00423271770.015
tissue developmentGO:00098882520.015
cell projection organizationGO:00300303020.015
positive regulation of catabolic processGO:0009896780.015
sex differentiationGO:00075481130.015
positive regulation of signalingGO:00230562700.015
glycosyl compound metabolic processGO:19016571820.015
glycoprotein metabolic processGO:0009100240.015
lipid transportGO:0006869610.015
protein ubiquitinationGO:0016567280.015
ribonucleoside metabolic processGO:00091191740.015
response to hypoxiaGO:00016662310.015
regulation of nervous system developmentGO:00519602640.015
nucleoside triphosphate catabolic processGO:00091431230.015
chromosome segregationGO:000705920.015
development of primary sexual characteristicsGO:00451371070.015
synaptic vesicle localizationGO:0097479240.015
hormone metabolic processGO:0042445690.015
regulation of protein phosphorylationGO:00019321830.015
cellular response to lipidGO:00713962010.015
cellular response to growth factor stimulusGO:00713631620.015
cognitionGO:0050890920.014
regulation of body fluid levelsGO:0050878900.014
single organism membrane organizationGO:0044802740.014
negative regulation of protein transportGO:0051224170.014
ion homeostasisGO:00508012120.014
lymphocyte chemotaxisGO:004824730.014
positive regulation of protein modification processGO:00314011420.014
regulation of cell motilityGO:20001451310.014
regulation of rab protein signal transductionGO:003248330.014
neuron developmentGO:00486662860.014
hormone biosynthetic processGO:0042446250.014
regulation of cellular amino acid metabolic processGO:000652120.014
negative regulation of signalingGO:00230571570.014
Fly
cellular response to hormone stimulusGO:00328702470.014
negative regulation of multicellular organismal processGO:00512412030.014
regulation of membrane potentialGO:00423911100.014
lipid localizationGO:0010876620.014
cellular amine metabolic processGO:0044106380.013
enzyme linked receptor protein signaling pathwayGO:00071671160.013
regulation of hormone levelsGO:00108171870.013
regulation of hydrolase activityGO:00513361430.013
regulation of purine nucleotide metabolic processGO:19005421150.013
negative regulation of rna metabolic processGO:00512531230.013
eye morphogenesisGO:004859240.013
negative regulation of protein modification processGO:0031400520.013
regulation of gtp catabolic processGO:0033124580.013
transmission of nerve impulseGO:0019226420.013
regulation of apoptotic processGO:00429813350.013
secretion by tissueGO:0032941370.013
cellular nitrogen compound catabolic processGO:00442701630.013
positive regulation of cytosolic calcium ion concentrationGO:00072041220.013
organ morphogenesisGO:0009887750.013
cellular lipid metabolic processGO:00442552080.013
single organism nuclear importGO:1902593350.013
cellular response to molecule of bacterial originGO:0071219560.013
female gonad developmentGO:0008585530.013
protein glycosylationGO:0006486140.013
cellular response to oxygen levelsGO:0071453600.013
positive regulation of phosphate metabolic processGO:00459372620.013
actin filament based processGO:0030029860.012
reproductive structure developmentGO:00486081280.012
alpha amino acid metabolic processGO:1901605710.012
mitotic cell cycleGO:0000278490.012
generation of precursor metabolites and energyGO:0006091620.012
divalent inorganic cation transportGO:00725111340.012
centrosome organizationGO:005129710.012
regulation of proteolysisGO:0030162660.012
purine nucleoside triphosphate catabolic processGO:00091461220.012
positive regulation of cellular amino acid metabolic processGO:004576410.012
multicellular organismal reproductive processGO:00486092330.012
Fly
regulation of nucleoside metabolic processGO:0009118660.012
negative regulation of developmental processGO:00510931250.012
lipid storageGO:001991510.012
neuronal action potentialGO:0019228350.012
positive regulation of cellular protein metabolic processGO:00322701670.012
regulation of lymphocyte chemotaxisGO:190162310.012
anatomical structure morphogenesisGO:00096532980.012
response to tumor necrosis factorGO:0034612560.012
cellular response to abiotic stimulusGO:0071214850.012
cellular response to extracellular stimulusGO:0031668730.012
negative regulation of catalytic activityGO:00430861030.012
metal ion homeostasisGO:00550651860.012
action potentialGO:0001508540.012
negative regulation of canonical wnt signaling pathwayGO:009009040.012
circadian regulation of gene expressionGO:003292230.012
reproductive processGO:00224143720.012
Fly
cellular metal ion homeostasisGO:00068751720.012
synapse organizationGO:0050808460.012
wnt signaling pathwayGO:0016055170.012
vesicle localizationGO:0051648330.011
protein autophosphorylationGO:0046777660.011
mitotic spindle organizationGO:000705220.011
response to estrogenGO:00436272320.011
negative regulation of molecular functionGO:00440921330.011
positive regulation of signal transductionGO:00099671750.011
positive regulation of immune system processGO:0002684900.011
Fly
regulation of nucleotide catabolic processGO:0030811650.011
positive regulation of retinal cell programmed cell deathGO:004667010.011
protein localization to nucleusGO:0034504390.011
male gamete generationGO:0048232990.011
negative regulation of programmed cell deathGO:00430691830.011
positive regulation of cytoplasmic transportGO:1903651320.011
positive regulation of catalytic activityGO:00430851840.011
rna localizationGO:000640340.011
response to cytokineGO:00340972150.011
coenzyme metabolic processGO:0006732860.011
cell activationGO:0001775970.011
establishment of protein localization to organelleGO:0072594440.011
negative regulation of intracellular signal transductionGO:1902532380.011
Fly
positive regulation of homeostatic processGO:0032846490.011
purine ribonucleotide biosynthetic processGO:0009152810.011
negative regulation of signal transductionGO:0009968830.011
Fly
learning or memoryGO:0007611900.011
acylglycerol metabolic processGO:0006639210.011
purine containing compound biosynthetic processGO:0072522850.011
protein maturationGO:0051604680.011
sex determinationGO:000753020.010
negative regulation of secretionGO:0051048820.010
regulation of cytoplasmic transportGO:1903649540.010
heterocycle catabolic processGO:00467001670.010
regulation of neurogenesisGO:00507672470.010
pyruvate metabolic processGO:0006090270.010
negative regulation of actin filament polymerizationGO:003083740.010
regulation of alternative mrna splicing via spliceosomeGO:000038120.010
sequestering of metal ionGO:005123890.010
positive regulation of transcription factor import into nucleusGO:004299340.010
response to activityGO:0014823730.010
female pregnancyGO:00075651220.010
nuclear importGO:0051170350.010
regulation of programmed cell deathGO:00430673410.010
nucleotide catabolic processGO:00091661390.010

Ide disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.027
cancerDOID:16200.027
disease of anatomical entityDOID:700.024
nervous system diseaseDOID:86300.024
organ system cancerDOID:005068600.015
musculoskeletal system diseaseDOID:1700.014
muscle tissue diseaseDOID:6600.014
myopathyDOID:42300.014
muscular diseaseDOID:008000000.014
disease of metabolismDOID:001466700.012
central nervous system diseaseDOID:33100.011