IMP: Integrative Multi-species Prediction

Rattus norvegicus

29 known processes

Gsta4

glutathione S-transferase alpha 4

Ensembl: ENSRNOG00000030449
RGD: 1309970
Entrez: 300850
UniProtKB: P14942
UniProtKB: A9UMW1

Process Predictions
Disease Predictions

Gsta4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
oxidation reduction process	GO:0055114	304	0.664
fatty acid beta oxidation	GO:0006635	22	0.370
organic acid metabolic process	GO:0006082	292	0.325
cellular lipid metabolic process	GO:0044255	208	0.292
carboxylic acid metabolic process	GO:0019752	289	0.267
response to inorganic substance	GO:0010035	377	0.253
monocarboxylic acid catabolic process	GO:0072329	28	0.246
cellular amide metabolic process	GO:0043603	44	0.220
lipid oxidation	GO:0034440	30	0.217
response to glucocorticoid	GO:0051384	223	0.203	Rat
oxoacid metabolic process	GO:0043436	290	0.195
monocarboxylic acid metabolic process	GO:0032787	152	0.177
response to corticosteroid	GO:0031960	235	0.166	Rat
lipid metabolic process	GO:0006629	283	0.163
leydig cell differentiation	GO:0033327	8	0.144
cellular response to hydroperoxide	GO:0071447	2	0.130
glutathione metabolic process	GO:0006749	15	0.125
cellular response to organonitrogen compound	GO:0071417	197	0.124	Rat
peptide metabolic process	GO:0006518	32	0.122
response to metal ion	GO:0010038	253	0.121
response to nutrient levels	GO:0031667	370	0.119	Rat
response to herbicide	GO:0009635	16	0.115
cellular response to endogenous stimulus	GO:0071495	377	0.113	Rat
small molecule biosynthetic process	GO:0044283	124	0.109
response to ethanol	GO:0045471	162	0.106	Rat
gland development	GO:0048732	155	0.104
cellular catabolic process	GO:0044248	295	0.100	Rat
fatty acid oxidation	GO:0019395	29	0.098
fatty acid metabolic process	GO:0006631	99	0.093
response to amino acid	GO:0043200	75	0.090	Rat
tissue development	GO:0009888	252	0.089
cellular response to corticosteroid stimulus	GO:0071384	69	0.089	Rat
response to transition metal nanoparticle	GO:1990267	122	0.085
cellular response to peptide hormone stimulus	GO:0071375	120	0.084	Rat
fatty acid derivative metabolic process	GO:1901568	38	0.083
cellular response to glucocorticoid stimulus	GO:0071385	68	0.082	Rat
response to acid chemical	GO:0001101	222	0.081	Rat
cellular response to steroid hormone stimulus	GO:0071383	93	0.081	Rat
cellular response to organic cyclic compound	GO:0071407	202	0.079	Rat
development of primary sexual characteristics	GO:0045137	107	0.077
hormone metabolic process	GO:0042445	69	0.076
response to toxic substance	GO:0009636	133	0.075
response to estrogen	GO:0043627	232	0.071	Rat
response to bacterium	GO:0009617	200	0.071
single organism biosynthetic process	GO:0044711	342	0.068
cellular amino acid metabolic process	GO:0006520	107	0.066
single organism catabolic process	GO:0044712	283	0.064
fatty acid catabolic process	GO:0009062	26	0.064
cellular modified amino acid metabolic process	GO:0006575	61	0.062
response to molecule of bacterial origin	GO:0002237	194	0.060
organic substance catabolic process	GO:1901575	316	0.059
cellular response to oxygen containing compound	GO:1901701	386	0.059	Rat
carboxylic acid catabolic process	GO:0046395	49	0.058
central nervous system development	GO:0007417	311	0.057	Rat
cellular response to peptide	GO:1901653	133	0.057	Rat
sulfur compound metabolic process	GO:0006790	70	0.056
organic acid catabolic process	GO:0016054	49	0.053
aging	GO:0007568	241	0.052	Rat
protein homooligomerization	GO:0051260	91	0.052
cellular response to stress	GO:0033554	269	0.051
lipid catabolic process	GO:0016042	46	0.051
response to peptide hormone	GO:0043434	278	0.050	Rat
response to wounding	GO:0009611	254	0.048
response to peptide	GO:1901652	292	0.047	Rat
reproductive structure development	GO:0048608	128	0.046
catabolic process	GO:0009056	351	0.046	Rat
gliogenesis	GO:0042063	93	0.043	Rat
protein complex biogenesis	GO:0070271	263	0.042
response to extracellular stimulus	GO:0009991	380	0.042	Rat
cellular response to growth factor stimulus	GO:0071363	162	0.042	Rat
carboxylic acid biosynthetic process	GO:0046394	83	0.042
single organism reproductive process	GO:0044702	297	0.042
small molecule catabolic process	GO:0044282	59	0.041
cellular ketone metabolic process	GO:0042180	51	0.040
protein oligomerization	GO:0051259	191	0.040
cellular lipid catabolic process	GO:0044242	37	0.040
hepaticobiliary system development	GO:0061008	90	0.040
response to estradiol	GO:0032355	164	0.039	Rat
response to genistein	GO:0033595	4	0.039
cellular response to metal ion	GO:0071248	55	0.038
glial cell differentiation	GO:0010001	65	0.038	Rat
cellular response to nitrogen compound	GO:1901699	210	0.037	Rat
cellular response to xenobiotic stimulus	GO:0071466	19	0.037
cellular response to cell matrix adhesion	GO:0071460	5	0.036	Rat
gonad development	GO:0008406	104	0.036
toxin catabolic process	GO:0009407	1	0.036
macromolecular complex subunit organization	GO:0043933	339	0.035
brain development	GO:0007420	247	0.035
protein complex subunit organization	GO:0071822	302	0.035
lipid biosynthetic process	GO:0008610	128	0.035
positive regulation of transport	GO:0051050	245	0.035
benzene containing compound metabolic process	GO:0042537	22	0.035
cellular component biogenesis	GO:0044085	368	0.035
steroid metabolic process	GO:0008202	73	0.035
organophosphate metabolic process	GO:0019637	370	0.034
positive regulation of biosynthetic process	GO:0009891	319	0.034
organic acid biosynthetic process	GO:0016053	83	0.034
response to zinc ion	GO:0010043	39	0.034
response to lipopolysaccharide	GO:0032496	191	0.034
cellular response to insulin stimulus	GO:0032869	81	0.034	Rat
sex differentiation	GO:0007548	113	0.034
membrane organization	GO:0061024	94	0.033
developmental process involved in reproduction	GO:0003006	159	0.032
neurological system process	GO:0050877	219	0.032
single organism intracellular transport	GO:1902582	166	0.032
inflammatory response	GO:0006954	150	0.030
cofactor metabolic process	GO:0051186	95	0.030
response to other organism	GO:0051707	220	0.030
response to vitamin	GO:0033273	131	0.029	Rat
cellular hormone metabolic process	GO:0034754	49	0.029
reproductive process	GO:0022414	372	0.029
response to ketone	GO:1901654	182	0.029
cellular amine metabolic process	GO:0044106	38	0.029
response to biotic stimulus	GO:0009607	226	0.028
cellular response to lipid	GO:0071396	201	0.028	Rat
macromolecular complex assembly	GO:0065003	273	0.027
cellular component assembly	GO:0022607	360	0.027
organ regeneration	GO:0031100	101	0.027	Rat
amine metabolic process	GO:0009308	38	0.027
cellular response to external stimulus	GO:0071496	118	0.027	Rat
liver development	GO:0001889	90	0.027
heterocycle catabolic process	GO:0046700	167	0.026
c21 steroid hormone biosynthetic process	GO:0006700	10	0.026
cell projection organization	GO:0030030	302	0.026
regulation of hormone levels	GO:0010817	187	0.026
cell cell signaling	GO:0007267	335	0.026
protein complex assembly	GO:0006461	263	0.026
chronic inflammatory response	GO:0002544	16	0.026
intracellular transport	GO:0046907	185	0.026
negative regulation of apoptotic process	GO:0043066	181	0.025
cellular response to hormone stimulus	GO:0032870	247	0.025	Rat
response to nitrosative stress	GO:0051409	2	0.025
metal ion transport	GO:0030001	289	0.024
negative regulation of cell death	GO:0060548	229	0.024
multicellular organismal reproductive process	GO:0048609	233	0.024
multi organism reproductive process	GO:0044703	262	0.024
negative regulation of programmed cell death	GO:0043069	183	0.024
homeostatic process	GO:0042592	331	0.023
organonitrogen compound biosynthetic process	GO:1901566	167	0.023
regulation of programmed cell death	GO:0043067	341	0.023
regulation of secretion by cell	GO:1903530	208	0.023
response to monosaccharide	GO:0034284	159	0.023	Rat
response to nicotine	GO:0035094	51	0.023
regulation of cellular amine metabolic process	GO:0033238	8	0.022
response to vitamin e	GO:0033197	24	0.022
renal system development	GO:0072001	67	0.022
urogenital system development	GO:0001655	78	0.022
lipid modification	GO:0030258	52	0.022
monocarboxylic acid biosynthetic process	GO:0072330	48	0.022
neuron development	GO:0048666	286	0.021
xenobiotic metabolic process	GO:0006805	19	0.021
male gonad development	GO:0008584	59	0.021
response to external biotic stimulus	GO:0043207	221	0.020
anion transport	GO:0006820	178	0.020
retinal metabolic process	GO:0042574	3	0.020
response to cytokine	GO:0034097	215	0.020
positive regulation of cellular amine metabolic process	GO:0033240	3	0.020
epithelium development	GO:0060429	96	0.020
tube development	GO:0035295	89	0.019
male sex differentiation	GO:0046661	64	0.019
cellular ion homeostasis	GO:0006873	184	0.019
regulation of ion transport	GO:0043269	245	0.019
regulation of cell differentiation	GO:0045595	320	0.018
programmed cell death	GO:0012501	392	0.018
neuron projection development	GO:0031175	273	0.018
chemical homeostasis	GO:0048878	292	0.018
multicellular organism reproduction	GO:0032504	233	0.018
organic cyclic compound catabolic process	GO:1901361	175	0.018
negative regulation of multicellular organismal process	GO:0051241	203	0.018
regulation of cellular protein metabolic process	GO:0032268	267	0.018
anatomical structure morphogenesis	GO:0009653	298	0.018
response to alkaloid	GO:0043279	132	0.018
cellular response to extracellular stimulus	GO:0031668	73	0.018	Rat
organic hydroxy compound metabolic process	GO:1901615	115	0.018
cation homeostasis	GO:0055080	195	0.017
apoptotic process	GO:0006915	381	0.017
regulation of cell development	GO:0060284	263	0.017
organic anion transport	GO:0015711	132	0.017
cellular response to epidermal growth factor stimulus	GO:0071364	12	0.017	Rat
progesterone biosynthetic process	GO:0006701	3	0.017
negative regulation of metabolic process	GO:0009892	331	0.017
head development	GO:0060322	247	0.016
porphyrin containing compound metabolic process	GO:0006778	8	0.016
neuron death	GO:0070997	127	0.016
cellular cation homeostasis	GO:0030003	180	0.016
neuron differentiation	GO:0030182	368	0.016
icosanoid biosynthetic process	GO:0046456	18	0.016
regulation of molecular function	GO:0065009	398	0.016
cell morphogenesis	GO:0000902	142	0.016
metal ion homeostasis	GO:0055065	186	0.016
organelle organization	GO:0006996	266	0.015
secondary metabolite catabolic process	GO:0090487	1	0.015
positive regulation of multicellular organismal process	GO:0051240	387	0.015
ion homeostasis	GO:0050801	212	0.015
positive regulation of developmental process	GO:0051094	283	0.015
secretion	GO:0046903	307	0.015
tetrapyrrole metabolic process	GO:0033013	11	0.015
single organism membrane organization	GO:0044802	74	0.015
regeneration	GO:0031099	163	0.015	Rat
cation transport	GO:0006812	382	0.015
circulatory system process	GO:0003013	183	0.015
multicellular organismal signaling	GO:0035637	44	0.015
protein homotetramerization	GO:0051289	25	0.015
response to oxidative stress	GO:0006979	186	0.015
divalent inorganic cation transport	GO:0072511	134	0.015
response to decreased oxygen levels	GO:0036293	237	0.015
response to lithium ion	GO:0010226	28	0.014
sensory organ development	GO:0007423	74	0.014
positive regulation of cell proliferation	GO:0008284	249	0.014
reproduction	GO:0000003	245	0.014
transmission of nerve impulse	GO:0019226	42	0.014
cellular chemical homeostasis	GO:0055082	247	0.014
cellular component movement	GO:0006928	248	0.014
positive regulation of cellular biosynthetic process	GO:0031328	295	0.014
regulation of cellular amino acid metabolic process	GO:0006521	2	0.014
transmembrane transport	GO:0055085	412	0.014
synaptic transmission	GO:0007268	235	0.014
regulation of multicellular organismal development	GO:2000026	376	0.014
positive regulation of cell differentiation	GO:0045597	217	0.014
organophosphate biosynthetic process	GO:0090407	143	0.014
regulation of homeostatic process	GO:0032844	101	0.014
transcription from rna polymerase ii promoter	GO:0006366	252	0.014
kidney epithelium development	GO:0072073	19	0.014
positive regulation of neurogenesis	GO:0050769	165	0.013
negative regulation of cell communication	GO:0010648	158	0.013
single organism cellular localization	GO:1902580	102	0.013
eye morphogenesis	GO:0048592	4	0.013
protein tetramerization	GO:0051262	38	0.013
positive regulation of signaling	GO:0023056	270	0.013
response to growth factor	GO:0070848	189	0.013	Rat
peptide biosynthetic process	GO:0043043	3	0.013
ion transmembrane transport	GO:0034220	365	0.013
negative regulation of biosynthetic process	GO:0009890	168	0.013
acute inflammatory response	GO:0002526	58	0.013
regulation of apoptotic process	GO:0042981	335	0.013
alcohol metabolic process	GO:0006066	77	0.013
organic hydroxy compound transport	GO:0015850	77	0.013
regulation of phosphorus metabolic process	GO:0051174	349	0.013
regulation of cellular localization	GO:0060341	263	0.013
axis specification	GO:0009798	4	0.013
heart morphogenesis	GO:0003007	3	0.013
nucleoside phosphate metabolic process	GO:0006753	283	0.013
regulation of lipid biosynthetic process	GO:0046890	38	0.013
response to mercury ion	GO:0046689	15	0.013	Rat
icosanoid metabolic process	GO:0006690	38	0.013
regulation of signal transduction	GO:0009966	318	0.013
cellular homeostasis	GO:0019725	252	0.012
carbohydrate derivative metabolic process	GO:1901135	346	0.012
positive regulation of phosphorus metabolic process	GO:0010562	262	0.012
nitrogen compound transport	GO:0071705	229	0.012
generation of precursor metabolites and energy	GO:0006091	62	0.012
regulation of phosphorylation	GO:0042325	248	0.012
regulation of synaptic transmission	GO:0050804	141	0.012
positive regulation of phosphorylation	GO:0042327	177	0.012
calcium ion transport	GO:0006816	131	0.012
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.012
blood circulation	GO:0008015	183	0.012
neuronal action potential	GO:0019228	35	0.012
regulation of intracellular transport	GO:0032386	65	0.012
rna biosynthetic process	GO:0032774	380	0.012
response to reactive oxygen species	GO:0000302	120	0.012
progesterone metabolic process	GO:0042448	8	0.012
regulation of protein phosphorylation	GO:0001932	183	0.012
cellular component morphogenesis	GO:0032989	155	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.012
cellular macromolecule localization	GO:0070727	122	0.012
locomotion	GO:0040011	237	0.012
development of primary male sexual characteristics	GO:0046546	59	0.012
reactive oxygen species metabolic process	GO:0072593	37	0.012
divalent inorganic cation homeostasis	GO:0072507	165	0.012
epithelial cell differentiation	GO:0030855	71	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.012
divalent metal ion transport	GO:0070838	132	0.012
response to catechin	GO:1902168	1	0.011
regulation of catabolic process	GO:0009894	113	0.011
transcription dna templated	GO:0006351	377	0.011
purine ribonucleotide metabolic process	GO:0009150	227	0.011
positive regulation of cell development	GO:0010720	176	0.011
dephosphorylation	GO:0016311	98	0.011
positive regulation of catalytic activity	GO:0043085	184	0.011
response to axon injury	GO:0048678	59	0.011
positive regulation of ion transport	GO:0043270	94	0.011
negative regulation of signaling	GO:0023057	157	0.011
mesonephros development	GO:0001823	14	0.011
axon development	GO:0061564	96	0.011
regulation of metal ion transport	GO:0010959	118	0.011
sequestering of calcium ion	GO:0051208	8	0.011
reactive oxygen species biosynthetic process	GO:1903409	8	0.011
ras protein signal transduction	GO:0007265	29	0.011
steroid biosynthetic process	GO:0006694	48	0.011
cofactor biosynthetic process	GO:0051188	28	0.011
cellular metal ion homeostasis	GO:0006875	172	0.011
lipid localization	GO:0010876	62	0.011
intracellular signal transduction	GO:0035556	314	0.011
energy derivation by oxidation of organic compounds	GO:0015980	46	0.011
gamete generation	GO:0007276	124	0.011
forebrain development	GO:0030900	98	0.011
regulation of transcription dna templated	GO:0006355	374	0.011
embryonic pattern specification	GO:0009880	1	0.011
regulation of protein modification process	GO:0031399	194	0.011
regulation of catalytic activity	GO:0050790	304	0.011
negative regulation of cellular metabolic process	GO:0031324	281	0.010
multicellular organism growth	GO:0035264	1	0.010
regulation of neuron death	GO:1901214	115	0.010
negative regulation of response to stimulus	GO:0048585	155	0.010
regulation of phosphate metabolic process	GO:0019220	349	0.010
secretion by cell	GO:0032940	248	0.010
sexual reproduction	GO:0019953	148	0.010
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.010
nucleobase containing small molecule metabolic process	GO:0055086	316	0.010
negative regulation of macromolecule metabolic process	GO:0010605	260	0.010

Gsta4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.011
disease of anatomical entity	DOID:7	0.011
cancer	DOID:162	0.010
disease of cellular proliferation	DOID:14566	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network