IMP: Integrative Multi-species Prediction

Rattus norvegicus

18 known processes

Gsta2

glutathione S-transferase A2

(Aliases: Gsta1)

Ensembl: ENSRNOG00000000201
RGD: 2754
Entrez: 24422
UniProtKB: P00502
UniProtKB: B6DYP7

Process Predictions
Disease Predictions

Gsta2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chlorinated hydrocarbon metabolic process	GO:0042196	4	0.514
halogenated hydrocarbon metabolic process	GO:0042197	4	0.509
xenobiotic metabolic process	GO:0006805	19	0.368
alkaloid metabolic process	GO:0009820	3	0.323
response to xenobiotic stimulus	GO:0009410	23	0.315
organic acid metabolic process	GO:0006082	292	0.267
cellular response to xenobiotic stimulus	GO:0071466	19	0.246
cellular catabolic process	GO:0044248	295	0.216
carboxylic acid metabolic process	GO:0019752	289	0.206
liver development	GO:0001889	90	0.196
cellular lipid metabolic process	GO:0044255	208	0.195
lipid metabolic process	GO:0006629	283	0.193
xenobiotic catabolic process	GO:0042178	7	0.174
monocarboxylic acid metabolic process	GO:0032787	152	0.141
hepaticobiliary system development	GO:0061008	90	0.139
response to peptide hormone	GO:0043434	278	0.136	Rat
acylglycerol metabolic process	GO:0006639	21	0.112
cellular amino acid metabolic process	GO:0006520	107	0.110
cellular ketone metabolic process	GO:0042180	51	0.108
oxoacid metabolic process	GO:0043436	290	0.105
drug metabolic process	GO:0017144	11	0.098
secondary metabolic process	GO:0019748	15	0.088
pyridine containing compound metabolic process	GO:0072524	32	0.085
exogenous drug catabolic process	GO:0042738	1	0.084
alpha amino acid metabolic process	GO:1901605	71	0.075
response to metal ion	GO:0010038	253	0.068	Rat
cellular response to peptide hormone stimulus	GO:0071375	120	0.064	Rat
isoprenoid metabolic process	GO:0006720	45	0.062
coumarin metabolic process	GO:0009804	5	0.061
catabolic process	GO:0009056	351	0.060
terpenoid metabolic process	GO:0006721	37	0.059
nicotine metabolic process	GO:0018933	1	0.058
response to nutrient	GO:0007584	248	0.056	Rat
organic cyclic compound catabolic process	GO:1901361	175	0.048
cellular component morphogenesis	GO:0032989	155	0.046
phenylpropanoid catabolic process	GO:0046271	3	0.045
fatty acid metabolic process	GO:0006631	99	0.045
response to toxic substance	GO:0009636	133	0.044	Rat
response to inorganic substance	GO:0010035	377	0.043	Rat
triglyceride catabolic process	GO:0019433	3	0.043
glycerolipid metabolic process	GO:0046486	67	0.043
coenzyme metabolic process	GO:0006732	86	0.042
reproductive process	GO:0022414	372	0.042
linoleic acid metabolic process	GO:0043651	4	0.041
drug catabolic process	GO:0042737	1	0.040
response to oxidative stress	GO:0006979	186	0.038
single organism catabolic process	GO:0044712	283	0.038
aromatic amino acid family catabolic process	GO:0009074	7	0.037
estrogen catabolic process	GO:0006711	1	0.037
insecticide metabolic process	GO:0017143	4	0.037
toxin catabolic process	GO:0009407	1	0.036
triglyceride metabolic process	GO:0006641	21	0.035
cellular modified amino acid metabolic process	GO:0006575	61	0.035
organic hydroxy compound metabolic process	GO:1901615	115	0.034
naphthalene metabolic process	GO:0018931	2	0.033
response to extracellular stimulus	GO:0009991	380	0.033	Rat
response to ionizing radiation	GO:0010212	59	0.032
epoxygenase p450 pathway	GO:0019373	1	0.032
single organism biosynthetic process	GO:0044711	342	0.031
cellular nitrogen compound catabolic process	GO:0044270	163	0.031
gland development	GO:0048732	155	0.030
organic substance catabolic process	GO:1901575	316	0.030
response to peptide	GO:1901652	292	0.030	Rat
small molecule catabolic process	GO:0044282	59	0.029
response to nutrient levels	GO:0031667	370	0.029	Rat
multi organism reproductive process	GO:0044703	262	0.029
steroid metabolic process	GO:0008202	73	0.029
aromatic compound catabolic process	GO:0019439	168	0.029
cell projection organization	GO:0030030	302	0.029
naphthalene containing compound metabolic process	GO:0090420	2	0.028
response to insulin	GO:0032868	133	0.027	Rat
response to acid chemical	GO:0001101	222	0.027	Rat
response to sulfur dioxide	GO:0010477	3	0.027
secondary metabolite catabolic process	GO:0090487	1	0.026
neutral lipid metabolic process	GO:0006638	21	0.026
protein homooligomerization	GO:0051260	91	0.025
negative regulation of metabolic process	GO:0009892	331	0.025
anatomical structure morphogenesis	GO:0009653	298	0.025
heterocycle catabolic process	GO:0046700	167	0.024
response to mercury ion	GO:0046689	15	0.024	Rat
cellular hormone metabolic process	GO:0034754	49	0.024
reproduction	GO:0000003	245	0.024
long chain fatty acid metabolic process	GO:0001676	32	0.023
cofactor metabolic process	GO:0051186	95	0.023
carboxylic acid catabolic process	GO:0046395	49	0.023
response to cadmium ion	GO:0046686	35	0.022
diterpenoid metabolic process	GO:0016101	33	0.022
regulation of hormone levels	GO:0010817	187	0.021
heart morphogenesis	GO:0003007	3	0.020
negative regulation of macromolecule metabolic process	GO:0010605	260	0.020
response to external biotic stimulus	GO:0043207	221	0.019
chemosensory behavior	GO:0007635	2	0.019
sulfur compound metabolic process	GO:0006790	70	0.019
retinoid metabolic process	GO:0001523	24	0.019
cellular component assembly	GO:0022607	360	0.019
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.019
arachidonic acid metabolic process	GO:0019369	20	0.019
chromosome segregation	GO:0007059	2	0.018
response to cesium ion	GO:0010164	2	0.018
oxidation reduction process	GO:0055114	304	0.018
response to bacterium	GO:0009617	200	0.018
coumarin catabolic process	GO:0046226	3	0.018
cellular response to cytokine stimulus	GO:0071345	127	0.017
trichloroethylene metabolic process	GO:0018979	1	0.017
cell fate determination	GO:0001709	2	0.017
benzene containing compound metabolic process	GO:0042537	22	0.017
cellular response to lipid	GO:0071396	201	0.017	Rat
response to glucocorticoid	GO:0051384	223	0.017	Rat
cell part morphogenesis	GO:0032990	123	0.017
alpha amino acid catabolic process	GO:1901606	20	0.017
olfactory behavior	GO:0042048	2	0.016
dicarboxylic acid metabolic process	GO:0043648	42	0.016
unsaturated fatty acid metabolic process	GO:0033559	39	0.016
response to radiation	GO:0009314	137	0.016
cellular modified amino acid biosynthetic process	GO:0042398	18	0.016
cellular response to ethanol	GO:0071361	13	0.016
fibrinolysis	GO:0042730	2	0.016
lipid storage	GO:0019915	1	0.015
response to wounding	GO:0009611	254	0.015
organonitrogen compound catabolic process	GO:1901565	179	0.015
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.015
cellular response to alcohol	GO:0097306	87	0.015
regulation of response to stress	GO:0080134	126	0.015
response to amino acid	GO:0043200	75	0.015	Rat
cellular response to oxygen containing compound	GO:1901701	386	0.015	Rat
4 chlorobiphenyl metabolic process	GO:0018880	1	0.015
response to corticosteroid	GO:0031960	235	0.015	Rat
cellular component biogenesis	GO:0044085	368	0.014
cellular response to peptide	GO:1901653	133	0.014	Rat
circulatory system process	GO:0003013	183	0.014
negative regulation of gene expression	GO:0010629	199	0.014
neuron projection development	GO:0031175	273	0.014
macromolecule localization	GO:0033036	252	0.014
cellular response to endogenous stimulus	GO:0071495	377	0.014	Rat
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.014
cellular lipid catabolic process	GO:0044242	37	0.014
cellular macromolecular complex assembly	GO:0034622	58	0.014
negative regulation of cellular metabolic process	GO:0031324	281	0.014
organelle organization	GO:0006996	266	0.014
regulation of cellular amine metabolic process	GO:0033238	8	0.014
aging	GO:0007568	241	0.014
cell projection morphogenesis	GO:0048858	123	0.013
response to vitamin	GO:0033273	131	0.013	Rat
positive regulation of cell projection organization	GO:0031346	111	0.013
response to other organism	GO:0051707	220	0.013
axis specification	GO:0009798	4	0.013
regulation of cellular component organization	GO:0051128	368	0.013
phenylpropanoid metabolic process	GO:0009698	5	0.013
isoquinoline alkaloid metabolic process	GO:0033076	2	0.013
neuron projection morphogenesis	GO:0048812	122	0.013
reproductive structure development	GO:0048608	128	0.013
peptide biosynthetic process	GO:0043043	3	0.013
regulation of cell projection organization	GO:0031344	175	0.013
multicellular organism reproduction	GO:0032504	233	0.013
cell morphogenesis	GO:0000902	142	0.013
regulation of cellular ketone metabolic process	GO:0010565	27	0.012
lipid catabolic process	GO:0016042	46	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.012
icosanoid metabolic process	GO:0006690	38	0.012
cellular amine metabolic process	GO:0044106	38	0.012
nucleoside metabolic process	GO:0009116	179	0.012
gastrulation	GO:0007369	2	0.012
lauric acid metabolic process	GO:0048252	4	0.012
plasminogen activation	GO:0031639	2	0.012
glycosyl compound metabolic process	GO:1901657	182	0.012
fatty acid derivative metabolic process	GO:1901568	38	0.012
cell morphogenesis involved in differentiation	GO:0000904	119	0.012
response to ethanol	GO:0045471	162	0.012	Rat
positive regulation of response to stimulus	GO:0048584	285	0.012
organic acid biosynthetic process	GO:0016053	83	0.011
toxin metabolic process	GO:0009404	9	0.011
multicellular organismal reproductive process	GO:0048609	233	0.011
positive regulation of tolerance induction	GO:0002645	1	0.011
negative regulation of protein metabolic process	GO:0051248	114	0.011
locomotor rhythm	GO:0045475	1	0.011
positive regulation of cellular amine metabolic process	GO:0033240	3	0.011
dopamine metabolic process	GO:0042417	12	0.011
meiotic cell cycle process	GO:1903046	3	0.011
defense response to gram negative bacterium	GO:0050829	3	0.011
organic acid catabolic process	GO:0016054	49	0.011
response to herbicide	GO:0009635	16	0.011	Rat
positive regulation of skeletal muscle tissue regeneration	GO:0043415	1	0.011
developmental process involved in reproduction	GO:0003006	159	0.011
cardiac chamber development	GO:0003205	1	0.011
positive regulation of gene expression	GO:0010628	244	0.011
regulation of cellular amino acid metabolic process	GO:0006521	2	0.011
urea cycle	GO:0000050	5	0.011
regeneration	GO:0031099	163	0.010	Rat
protein phosphorylation	GO:0006468	345	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.010
tissue development	GO:0009888	252	0.010
pyrimidine nucleobase catabolic process	GO:0006208	3	0.010
response to growth factor	GO:0070848	189	0.010	Rat
response to reactive oxygen species	GO:0000302	120	0.010
response to transition metal nanoparticle	GO:1990267	122	0.010	Rat
cellular amino acid catabolic process	GO:0009063	21	0.010
negative regulation of multicellular organismal process	GO:0051241	203	0.010
regulation of neuron differentiation	GO:0045664	208	0.010
ribonucleoside metabolic process	GO:0009119	174	0.010
actin crosslink formation	GO:0051764	3	0.010

Gsta2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
primary ciliary dyskinesia	DOID:9562	0.012
disease of anatomical entity	DOID:7	0.012
immune system disease	DOID:2914	0.012
musculoskeletal system disease	DOID:17	0.012
hematopoietic system disease	DOID:74	0.011
nervous system disease	DOID:863	0.011

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