Rattus norvegicus

17 known processes

Pdk4

pyruvate dehydrogenase kinase, isozyme 4

Pdk4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regenerationGO:00310991630.742
response to insulinGO:00328681330.647
Human
organ regenerationGO:00311001010.468
cellular response to endogenous stimulusGO:00714953770.432
Human
oxidation reduction processGO:00551143040.347
monocarboxylic acid metabolic processGO:00327871520.346
Human
macromolecule localizationGO:00330362520.325
macromolecular complex subunit organizationGO:00439333390.307
protein complex assemblyGO:00064612630.291
macromolecular complex assemblyGO:00650032730.272
ion transmembrane transportGO:00342203650.270
protein complex subunit organizationGO:00718223020.266
response to estrogenGO:00436272320.263
cellular response to peptide hormone stimulusGO:00713751200.212
Human
protein homooligomerizationGO:0051260910.204
transmembrane transportGO:00550854120.197
organic substance catabolic processGO:19015753160.194
reproductive processGO:00224143720.185
protein complex biogenesisGO:00702712630.182
regulation of phosphorus metabolic processGO:00511743490.178
Human
response to peptideGO:19016522920.178
Human
circulatory system developmentGO:00723591340.176
protein oligomerizationGO:00512591910.172
response to external biotic stimulusGO:00432072210.163
cardiovascular system developmentGO:00723581340.163
nucleic acid templated transcriptionGO:00976593790.154
anatomical structure morphogenesisGO:00096532980.154
response to hexoseGO:00097461440.151
cellular component assemblyGO:00226073600.144
cellular component biogenesisGO:00440853680.140
regulation of cellular protein metabolic processGO:00322682670.134
response to growth factorGO:00708481890.134
regulation of programmed cell deathGO:00430673410.120
Human
response to temperature stimulusGO:0009266940.119
neuron developmentGO:00486662860.115
secretionGO:00469033070.114
regulation of transforming growth factor beta3 productionGO:003291020.114
fatty acid oxidationGO:0019395290.112
response to hypoxiaGO:00016662310.105
cellular response to oxygen containing compoundGO:19017013860.105
Human
regulation of molecular functionGO:00650093980.104
fatty acid metabolic processGO:0006631990.103
Human
response to biotic stimulusGO:00096072260.103
cellular response to hormone stimulusGO:00328702470.103
Human
protein transportGO:00150311320.102
cellular protein localizationGO:00346131220.102
response to other organismGO:00517072200.097
positive regulation of locomotionGO:00400171020.096
choline transportGO:001587140.095
cellular response to peptideGO:19016531330.094
Human
response to ketoneGO:19016541820.093
epithelium developmentGO:0060429960.091
positive regulation of signalingGO:00230562700.091
cellular carbohydrate metabolic processGO:0044262720.088
Human
single organism reproductive processGO:00447022970.087
lipid oxidationGO:0034440300.086
carboxylic acid metabolic processGO:00197522890.085
Human
regulation of rna metabolic processGO:00512523910.084
homeostatic processGO:00425923310.083
gland developmentGO:00487321550.083
positive regulation of transforming growth factor beta3 productionGO:003291620.082
regulation of cellular localizationGO:00603412630.082
transcription dna templatedGO:00063513770.082
response to organophosphorusGO:00466831020.081
regulation of telomerase activityGO:005197220.080
positive regulation of developmental processGO:00510942830.079
cellular lipid metabolic processGO:00442552080.078
Human
negative regulation of nucleic acid templated transcriptionGO:19035071170.076
apoptotic processGO:00069153810.075
Human
response to woundingGO:00096112540.073
regulation of phagocytosis engulfmentGO:006009940.071
regulation of transcription from rna polymerase ii promoterGO:00063572340.069
catabolic processGO:00090563510.069
multi organism reproductive processGO:00447032620.068
cellular response to organonitrogen compoundGO:00714171970.067
Human
neuron differentiationGO:00301823680.066
establishment of protein localizationGO:00451841410.066
divalent metal ion transportGO:00708381320.066
positive regulation of cell motilityGO:2000147970.066
cellular component morphogenesisGO:00329891550.066
response to glucocorticoidGO:00513842230.065
positive regulation of signal transductionGO:00099671750.065
negative regulation of cellular metabolic processGO:00313242810.065
oxoacid metabolic processGO:00434362900.064
Human
response to carbohydrateGO:00097431830.064
single organism catabolic processGO:00447122830.063
fatty acid catabolic processGO:0009062260.063
regulation of phosphate metabolic processGO:00192203490.063
response to corticosteroidGO:00319602350.063
response to metforminGO:190155810.063
cellular response to corticosteroid stimulusGO:0071384690.063
positive regulation of catalytic activityGO:00430851840.060
regulation of catalytic activityGO:00507903040.060
regulation of locomotionGO:00400121480.060
vitamin d receptor signaling pathwayGO:007056110.059
signal releaseGO:00230611450.059
protein localizationGO:00081041910.059
positive regulation of cell communicationGO:00106472710.058
programmed cell deathGO:00125013920.058
Human
cellular response to growth factor stimulusGO:00713631620.058
regulation of transcription dna templatedGO:00063553740.058
response to glucoseGO:00097491360.057
cellular catabolic processGO:00442482950.057
cell morphogenesis involved in differentiationGO:00009041190.056
endothelium developmentGO:0003158120.056
reproductionGO:00000032450.055
chemical homeostasisGO:00488782920.055
nitrogen compound transportGO:00717052290.055
positive regulation of response to stimulusGO:00485842850.055
agingGO:00075682410.054
response to purine containing compoundGO:00140741260.054
cellular response to insulin stimulusGO:0032869810.054
Human
rna biosynthetic processGO:00327743800.053
negative regulation of transportGO:00510511360.053
nucleoside phosphate metabolic processGO:00067532830.052
organophosphate metabolic processGO:00196373700.051
positive regulation of cell developmentGO:00107201760.051
regulation of cellular component movementGO:00512701500.050
positive regulation of cell proliferationGO:00082842490.049
response to metal ionGO:00100382530.048
negative regulation of metabolic processGO:00098923310.048
regulation of peptide hormone secretionGO:0090276800.048
tissue developmentGO:00098882520.048
positive regulation of cellular biosynthetic processGO:00313282950.048
reproductive system developmentGO:00614581280.048
lipid catabolic processGO:0016042460.047
g protein coupled receptor signaling pathwayGO:00071862420.047
response to oxygen levelsGO:00704822650.046
regulation of protein metabolic processGO:00512462890.046
response to lipopolysaccharideGO:00324961910.046
dna metabolic processGO:0006259960.046
positive regulation of multicellular organismal processGO:00512403870.046
carbohydrate metabolic processGO:00059751300.045
Human
regulation of cell proliferationGO:00421273590.045
regulation of signal transductionGO:00099663180.045
organic cyclic compound catabolic processGO:19013611750.045
regulation of cellular ketone metabolic processGO:0010565270.045
Human
neuron projection morphogenesisGO:00488121220.044
insulin secretionGO:0030073690.044
response to reactive oxygen speciesGO:00003021200.044
transcription from rna polymerase ii promoterGO:00063662520.043
response to peptide hormoneGO:00434342780.043
Human
positive regulation of cell differentiationGO:00455972170.043
negative regulation of multicellular organismal processGO:00512412030.043
regulation of response to external stimulusGO:00321011060.043
immune system processGO:00023762040.043
response to monosaccharideGO:00342841590.043
cellular chemical homeostasisGO:00550822470.043
positive regulation of phosphorus metabolic processGO:00105622620.042
response to acid chemicalGO:00011012220.042
Human
positive regulation of gene expressionGO:00106282440.041
endothelial cell differentiationGO:004544690.041
regulation of endothelial cell apoptotic processGO:200035130.041
sensory perceptionGO:00076001010.041
regulation of protein phosphorylationGO:00019321830.041
epithelial cell differentiationGO:0030855710.040
negative regulation of transcription dna templatedGO:00458921160.040
hormone secretionGO:00468791150.040
alcohol metabolic processGO:0006066770.040
positive regulation of rna metabolic processGO:00512542030.039
negative regulation of macromolecule metabolic processGO:00106052600.039
regulation of anatomical structure morphogenesisGO:00226031410.039
regulation of cell migrationGO:00303341280.039
vitamin a metabolic processGO:000677620.039
regulation of secretion by cellGO:19035302080.039
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.039
secretion by cellGO:00329402480.039
cytoplasmic transportGO:00164821150.039
response to ethanolGO:00454711620.038
positive regulation of phagocytosis engulfmentGO:006010040.037
regulation of apoptotic processGO:00429813350.037
Human
regulation of response to stressGO:00801341260.037
regulation of protein modification processGO:00313991940.037
lipid localizationGO:0010876620.037
protein localization to organelleGO:0033365570.036
response to oxidative stressGO:00069791860.036
central nervous system developmentGO:00074173110.036
purine ribonucleotide metabolic processGO:00091502270.036
lipid metabolic processGO:00066292830.036
Human
immune responseGO:00069551040.035
positive regulation of phosphate metabolic processGO:00459372620.035
regulation of cell developmentGO:00602842630.035
positive regulation of cellular component movementGO:00512721020.035
negative regulation of apoptotic processGO:00430661810.035
Human
response to molecule of fungal originGO:000223830.035
single organism behaviorGO:00447081300.034
inflammatory responseGO:00069541500.034
positive regulation of neuron differentiationGO:00456661260.034
growthGO:00400071650.034
single organism biosynthetic processGO:00447113420.034
Human
regulation of cellular component organizationGO:00511283680.033
negative regulation of nucleobase containing compound metabolic processGO:00459341530.033
carbohydrate derivative metabolic processGO:19011353460.033
protein phosphorylationGO:00064683450.033
multicellular organismal reproductive processGO:00486092330.033
cellular calcium ion homeostasisGO:00068741600.033
cellular response to cytokine stimulusGO:00713451270.033
hormone transportGO:00099141210.033
positive regulation of protein metabolic processGO:00512471780.032
cell morphogenesisGO:00009021420.032
developmental process involved in reproductionGO:00030061590.032
gliogenesisGO:0042063930.032
regulation of cytokine productionGO:0001817560.032
regulation of nervous system developmentGO:00519602640.032
enzyme linked receptor protein signaling pathwayGO:00071671160.032
Human
cell growthGO:00160491040.032
response to coldGO:0009409290.031
negative regulation of gene expressionGO:00106291990.031
aromatic compound catabolic processGO:00194391680.031
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.031
positive regulation of isotype switchingGO:004583010.031
response to inorganic substanceGO:00100353770.031
positive regulation of focal adhesion assemblyGO:005189420.030
response to decreased oxygen levelsGO:00362932370.030
cofactor metabolic processGO:0051186950.030
Human
regulation of cell motilityGO:20001451310.030
positive regulation of neuron projection developmentGO:0010976990.030
negative regulation of rna metabolic processGO:00512531230.030
single organism intracellular transportGO:19025821660.030
regulation of peptide transportGO:0090087870.030
regulation of cellular amine metabolic processGO:003323880.030
multicellular organism growthGO:003526410.030
regulation of multicellular organismal developmentGO:20000263760.029
heart developmentGO:0007507720.029
response to nutrientGO:00075842480.029
ribonucleotide metabolic processGO:00092592310.029
protein heterooligomerizationGO:0051291890.029
intracellular transportGO:00469071850.029
antibiotic transportGO:004289120.028
sodium ion transportGO:0006814820.028
cellular divalent inorganic cation homeostasisGO:00725031620.028
positive regulation of nucleobase containing compound metabolic processGO:00459353190.028
positive regulation of transcription dna templatedGO:00458931970.028
negative regulation of molecular functionGO:00440921330.028
rna metabolic processGO:00160704060.028
response to fatty acidGO:0070542650.028
Human
negative regulation of biosynthetic processGO:00098901680.027
negative regulation of programmed cell deathGO:00430691830.027
Human
positive regulation of cardiac muscle cell proliferationGO:006004540.027
cell migrationGO:00164771970.027
response to nutrient levelsGO:00316673700.027
Human
vesicle mediated transportGO:00161921810.027
positive regulation of nervous system developmentGO:00519621780.027
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.027
response to progesteroneGO:0032570480.027
regulation of rna biosynthetic processGO:20011413810.027
regulation of hormone secretionGO:00468831060.026
positive regulation of biomineral tissue developmentGO:007016940.026
signal transduction by phosphorylationGO:00230141440.026
single organism nuclear importGO:1902593350.026
negative regulation of rna biosynthetic processGO:19026791180.026
regulation of hydrolase activityGO:00513361430.026
ribonucleoside catabolic processGO:00424541260.026
cellular macromolecule localizationGO:00707271220.026
female pregnancyGO:00075651220.026
rhythmic processGO:00485111560.026
regulation of nucleic acid templated transcriptionGO:19035063800.026
development of primary sexual characteristicsGO:00451371070.026
response to radiationGO:00093141370.025
cellular response to nitrogen compoundGO:19016992100.025
Human
response to mechanical stimulusGO:00096121340.025
amide transportGO:00428861050.025
multicellular organism reproductionGO:00325042330.025
negative regulation of pancreatic stellate cell proliferationGO:200023010.025
cellular response to organic cyclic compoundGO:00714072020.025
regulation of cellular amino acid metabolic processGO:000652120.025
glucose homeostasisGO:0042593750.025
organic acid metabolic processGO:00060822920.025
Human
mrna transcriptionGO:000929920.025
heart morphogenesisGO:000300730.025
purine nucleotide catabolic processGO:00061951360.024
regulation of kinase activityGO:00435491170.024
cellular amine metabolic processGO:0044106380.024
single organism carbohydrate metabolic processGO:00447231180.024
Human
negative regulation of macromolecule biosynthetic processGO:00105581480.024
lipid transportGO:0006869610.024
nucleoside phosphate catabolic processGO:19012921400.024
neuron projection developmentGO:00311752730.023
nucleobase containing small molecule metabolic processGO:00550863160.023
nucleoside triphosphate catabolic processGO:00091431230.023
regulation of neurogenesisGO:00507672470.023
purine containing compound metabolic processGO:00725212530.023
amine metabolic processGO:0009308380.023
wound healingGO:00420601220.023
cell type specific apoptotic processGO:00972851340.023
negative regulation of bone resorptionGO:004577950.022
positive regulation of cell migrationGO:0030335960.022
positive regulation of rna biosynthetic processGO:19026801970.022
pancreatic stellate cell proliferationGO:007234320.022
reproductive structure developmentGO:00486081280.022
positive regulation of cyclic nucleotide biosynthetic processGO:0030804340.022
cellular protein complex assemblyGO:0043623440.022
response to cytokineGO:00340972150.022
positive regulation of phosphorylationGO:00423271770.022
carbohydrate derivative catabolic processGO:19011361470.021
monocarboxylic acid catabolic processGO:0072329280.021
intracellular signal transductionGO:00355563140.021
muscle system processGO:00030121150.021
glycogen metabolic processGO:0005977230.021
carbohydrate biosynthetic processGO:0016051420.021
positive regulation of protein phosphorylationGO:00019341350.021
heterocycle catabolic processGO:00467001670.021
positive regulation of nitrogen compound metabolic processGO:00511733340.021
organ morphogenesisGO:0009887750.021
inorganic ion transmembrane transportGO:00986602290.021
negative regulation of developmental processGO:00510931250.021
regulation of immune responseGO:0050776550.021
regulation of cell differentiationGO:00455953200.020
nucleotide metabolic processGO:00091172790.020
glucan metabolic processGO:0044042230.020
gamete generationGO:00072761240.020
nuclear transportGO:0051169490.020
regulation of blood circulationGO:19035221100.020
dephosphorylationGO:0016311980.020
positive regulation of cellular amine metabolic processGO:003324030.020
single organism organelle organizationGO:19025891800.020
peptide transportGO:0015833970.020
peptide secretionGO:0002790860.020
negative regulation of response to stimulusGO:00485851550.020
cellular response to stressGO:00335542690.020
Human
regulation of catabolic processGO:00098941130.020
regulation of protein kinase activityGO:00458591050.020
regulation of cellular catabolic processGO:00313291010.019
positive regulation of macromolecule biosynthetic processGO:00105572470.019
cellular response to glucocorticoid stimulusGO:0071385680.019
hepaticobiliary system developmentGO:0061008900.019
response to interleukin 1GO:0070555550.019
membrane organizationGO:0061024940.019
response to extracellular stimulusGO:00099913800.019
Human
liver developmentGO:0001889900.019
cellular metal ion homeostasisGO:00068751720.019
positive regulation of cellular component organizationGO:00511302000.019
bmp signaling pathwayGO:003050940.019
cellular lipid catabolic processGO:0044242370.019
positive regulation of cell deathGO:00109421840.019
respiratory gaseous exchangeGO:000758540.019
negative regulation of cell deathGO:00605482290.019
Human
carbohydrate homeostasisGO:0033500750.019
cellular response to lipidGO:00713962010.019
Human
cell cell signalingGO:00072673350.018
positive regulation of cellular amino acid metabolic processGO:004576410.018
regulation of insulin secretionGO:0050796650.018
regulation of phosphorylationGO:00423252480.018
nucleobase containing compound catabolic processGO:00346551520.018
positive regulation of immune system processGO:0002684900.018
organophosphate catabolic processGO:00464341480.018
response to toxic substanceGO:00096361330.018
regulation of immune system processGO:00026821230.018
regulation of intracellular signal transductionGO:19025312180.018
release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001480840.018
cytokine mediated signaling pathwayGO:0019221430.018
learning or memoryGO:0007611900.018
tissue regenerationGO:0042246360.018
sequestering of triglycerideGO:003073010.018
smooth muscle cell migrationGO:0014909360.018
anatomical structure formation involved in morphogenesisGO:0048646830.018
regulation of hormone levelsGO:00108171870.018
positive regulation of biosynthetic processGO:00098913190.018
regulation of transferase activityGO:00513381230.018
negative regulation of blood pressureGO:0045776290.017
glutathione transportGO:003463520.017
head developmentGO:00603222470.017
cellular homeostasisGO:00197252520.017
response to cocaineGO:0042220390.017
regulation of map kinase activityGO:0043405530.017
positive regulation of neurogenesisGO:00507691650.017
regulation of vasculature developmentGO:1901342440.017
negative regulation of cellular biosynthetic processGO:00313271610.017
cation transmembrane transportGO:00986552630.017
positive regulation of protein modification processGO:00314011420.017
glycosyl compound metabolic processGO:19016571820.017
regulation of body fluid levelsGO:0050878900.017
response to epidermal growth factorGO:0070849180.017
cellular component movementGO:00069282480.017
response to bacteriumGO:00096172000.017
development of primary female sexual characteristicsGO:0046545560.017
regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094730.017
organelle organizationGO:00069962660.017
organophosphate biosynthetic processGO:00904071430.017
negative regulation of secretion by cellGO:1903531720.016
regulation of neuron differentiationGO:00456642080.016
positive regulation of cell morphogenesis involved in differentiationGO:0010770410.016
negative regulation of cell differentiationGO:0045596990.016
smad protein complex assemblyGO:000718310.016
gastrulationGO:000736920.016
fertilizationGO:000956630.016
defense response to gram positive bacteriumGO:005083020.016
peptide hormone secretionGO:0030072840.016
cognitionGO:0050890920.016
mesoderm developmentGO:000749820.016
blood vessel developmentGO:0001568690.016
metal ion transportGO:00300012890.016
response to ionizing radiationGO:0010212590.016
cell projection morphogenesisGO:00488581230.016
coenzyme metabolic processGO:0006732860.016
Human
establishment of protein localization to organelleGO:0072594440.016
cellular macromolecular complex assemblyGO:0034622580.016
glial cell differentiationGO:0010001650.016
small molecule catabolic processGO:0044282590.016
cellular cation homeostasisGO:00300031800.016
polysaccharide metabolic processGO:0005976250.016
leukocyte activationGO:0045321760.016
cellular amino acid metabolic processGO:00065201070.016
positive regulation of molecular functionGO:00440932300.016
response to dexamethasoneGO:0071548490.015
negative regulation of secretionGO:0051048820.015
regulation of system processGO:00440572080.015
cellular response to monosaccharide stimulusGO:0071326670.015
positive regulation of programmed cell deathGO:00430681570.015
angiogenesis involved in coronary vascular morphogenesisGO:006097830.015
cation transportGO:00068123820.015
amino acid betaine transportGO:001583810.015
positive regulation of adherens junction organizationGO:190339320.015
cell morphogenesis involved in neuron differentiationGO:00486671060.015
lipid storageGO:001991510.015
metal ion homeostasisGO:00550651860.015
negative regulation of catalytic activityGO:00430861030.015
positive regulation of map kinase activityGO:0043406460.015
regulation of response to woundingGO:1903034690.015
carboxylic acid catabolic processGO:0046395490.015
nucleoside triphosphate metabolic processGO:00091411440.014
regulation of protein processingGO:0070613500.014
regulation of nucleotide catabolic processGO:0030811650.014
organ formationGO:004864530.014
sexual reproductionGO:00199531480.014
toxin transportGO:190199830.014
regulation of secretionGO:00510462240.014
ribose phosphate metabolic processGO:00196932350.014
gonad developmentGO:00084061040.014
negative regulation of homeostatic processGO:0032845470.014
purine nucleotide metabolic processGO:00061632290.014
glycerol 3 phosphate metabolic processGO:000607220.014
small gtpase mediated signal transductionGO:0007264360.014
hemostasisGO:0007599260.014
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.014
purine nucleoside metabolic processGO:00422781690.014
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178270.014
placenta developmentGO:0001890220.014
serotonin receptor signaling pathwayGO:0007210100.014
coronary vasculature morphogenesisGO:006097730.014
smooth muscle cell proliferationGO:0048659770.014
urinary bladder smooth muscle contractionGO:001483240.014
tube developmentGO:0035295890.014
cellular response to hexose stimulusGO:0071331650.014
ras protein signal transductionGO:0007265290.014
response to vitaminGO:00332731310.014
negative regulation of nitrogen compound metabolic processGO:00511721610.014
negative regulation of multicellular organismal metabolic processGO:004425240.014
kidney developmentGO:0001822670.014
anion transmembrane transportGO:0098656770.013
regulation of cell projection organizationGO:00313441750.013
innate immune responseGO:0045087350.013
spermatogenesisGO:0007283990.013
protein importGO:0017038370.013
regulation of defense responseGO:0031347680.013
nucleoside metabolic processGO:00091161790.013
defense response to gram negative bacteriumGO:005082930.013
response to calcium ionGO:0051592590.013
catecholamine transportGO:0051937370.013
endothelial cell morphogenesisGO:000188610.013
ribonucleotide catabolic processGO:00092611360.013
regulation of growthGO:00400081050.013
ion homeostasisGO:00508012120.013
positive regulation of protein tyrosine kinase activityGO:006109820.013
biological adhesionGO:00226101100.013
negative regulation of response to woundingGO:1903035230.013
regulation of homeostatic processGO:00328441010.013
regulation of the force of heart contraction by chemical signalGO:000305720.013
immune system developmentGO:0002520410.013
regulation of establishment of protein localizationGO:0070201690.013
regulation of sodium ion transmembrane transporter activityGO:200064940.013
nucleocytoplasmic transportGO:0006913480.013
energy derivation by oxidation of organic compoundsGO:0015980460.013
positive regulation of insulin secretionGO:0032024360.013
negative regulation of collagen biosynthetic processGO:003296640.013
purine containing compound catabolic processGO:00725231380.013
negative regulation of signalingGO:00230571570.013
ribonucleoside triphosphate metabolic processGO:00091991410.013
regulation of sodium ion transportGO:0002028210.013
regulation of neuron projection developmentGO:00109751610.013
organonitrogen compound biosynthetic processGO:19015661670.013

Pdk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.073
musculoskeletal system diseaseDOID:1700.073
nutrition diseaseDOID:37400.068
acquired metabolic diseaseDOID:006015800.068
disease of metabolismDOID:001466700.068
obesityDOID:997000.068
overnutritionDOID:65400.068
muscle tissue diseaseDOID:6600.031
muscular diseaseDOID:008000000.031
myopathyDOID:42300.031
nervous system diseaseDOID:86300.020
central nervous system diseaseDOID:33100.018
connective tissue diseaseDOID:6500.016
cardiovascular system diseaseDOID:128700.014