IMP: Integrative Multi-species Prediction

Rattus norvegicus

340 known processes

Gja1

gap junction protein, alpha 1

(Aliases: Cx43,MGC93610)

Entrez: 24392
RGD: 2690
Ensembl: ENSRNOG00000000805
UniProtKB: P08050

Process Predictions
Disease Predictions

Gja1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
sodium ion transport	GO:0006814	82	0.903
positive regulation of multicellular organismal process	GO:0051240	387	0.601
regulation of ion transport	GO:0043269	245	0.596
cation transport	GO:0006812	382	0.562
growth	GO:0040007	165	0.554
single organism behavior	GO:0044708	130	0.531
positive regulation of signaling	GO:0023056	270	0.512
regulation of molecular function	GO:0065009	398	0.463
behavior	GO:0007610	205	0.454
organic substance catabolic process	GO:1901575	316	0.446
cellular component movement	GO:0006928	248	0.443	Mouse
regulation of metal ion transport	GO:0010959	118	0.430
transmembrane transport	GO:0055085	412	0.427
locomotion	GO:0040011	237	0.421	Mouse
cellular chemical homeostasis	GO:0055082	247	0.418
cell motility	GO:0048870	202	0.412	Mouse
nucleic acid templated transcription	GO:0097659	379	0.412
reproductive process	GO:0022414	372	0.404	Rat
monovalent inorganic cation transport	GO:0015672	172	0.399	Rat
cellular response to organic cyclic compound	GO:0071407	202	0.396
response to lipopolysaccharide	GO:0032496	191	0.387	Rat
cell growth	GO:0016049	104	0.385
response to estrogen	GO:0043627	232	0.385	Rat
positive regulation of cell proliferation	GO:0008284	249	0.382
response to external biotic stimulus	GO:0043207	221	0.379	Rat
anatomical structure morphogenesis	GO:0009653	298	0.377
regulation of multicellular organismal development	GO:2000026	376	0.375
response to other organism	GO:0051707	220	0.363	Rat
response to extracellular stimulus	GO:0009991	380	0.362
negative regulation of metabolic process	GO:0009892	331	0.357
cell cell signaling	GO:0007267	335	0.356
cellular component assembly	GO:0022607	360	0.355
regulation of cellular protein metabolic process	GO:0032268	267	0.354
response to bacterium	GO:0009617	200	0.340	Rat
regulation of cell differentiation	GO:0045595	320	0.338	Mouse
biological adhesion	GO:0022610	110	0.337
regulation of hydrolase activity	GO:0051336	143	0.332
cellular homeostasis	GO:0019725	252	0.326
response to corticosteroid	GO:0031960	235	0.326
regulation of cellular component movement	GO:0051270	150	0.325
response to glucocorticoid	GO:0051384	223	0.324
metal ion transport	GO:0030001	289	0.321
negative regulation of cellular metabolic process	GO:0031324	281	0.316
regulation of cellular component organization	GO:0051128	368	0.308
regulation of receptor mediated endocytosis	GO:0048259	17	0.308
negative regulation of multicellular organismal process	GO:0051241	203	0.305
regeneration	GO:0031099	163	0.299	Mouse
response to monosaccharide	GO:0034284	159	0.299
negative regulation of gene expression	GO:0010629	199	0.295	Mouse
regulation of rna metabolic process	GO:0051252	391	0.292
single organism reproductive process	GO:0044702	297	0.288	Rat
response to oxidative stress	GO:0006979	186	0.288	Rat
cellular component biogenesis	GO:0044085	368	0.286
organelle organization	GO:0006996	266	0.285
ion transmembrane transport	GO:0034220	365	0.278	Mouse
synaptic transmission	GO:0007268	235	0.278
carboxylic acid metabolic process	GO:0019752	289	0.264
response to nutrient levels	GO:0031667	370	0.259
regulation of growth	GO:0040008	105	0.258
macromolecule catabolic process	GO:0009057	58	0.257
positive regulation of protein metabolic process	GO:0051247	178	0.257
positive regulation of cell migration	GO:0030335	96	0.257
cellular response to endogenous stimulus	GO:0071495	377	0.256
cellular catabolic process	GO:0044248	295	0.250
homeostatic process	GO:0042592	331	0.250
positive regulation of locomotion	GO:0040017	102	0.246
receptor mediated endocytosis	GO:0006898	42	0.246
positive regulation of transport	GO:0051050	245	0.244
cellular response to external stimulus	GO:0071496	118	0.243
organic acid metabolic process	GO:0006082	292	0.243
cellular response to abiotic stimulus	GO:0071214	85	0.242
response to interleukin 1	GO:0070555	55	0.241
response to molecule of bacterial origin	GO:0002237	194	0.241	Rat
regulation of membrane potential	GO:0042391	110	0.237	Mouse
response to reactive oxygen species	GO:0000302	120	0.235	Rat
protein complex subunit organization	GO:0071822	302	0.235
protein complex assembly	GO:0006461	263	0.235
response to radiation	GO:0009314	137	0.235
central nervous system development	GO:0007417	311	0.235
regulation of nervous system development	GO:0051960	264	0.234
response to inorganic substance	GO:0010035	377	0.233	Rat
vesicle mediated transport	GO:0016192	181	0.230
response to biotic stimulus	GO:0009607	226	0.229	Rat
positive regulation of cellular component organization	GO:0051130	200	0.226
regulation of catalytic activity	GO:0050790	304	0.225
multicellular organism reproduction	GO:0032504	233	0.224	Rat
negative regulation of growth	GO:0045926	37	0.222
positive regulation of cell differentiation	GO:0045597	217	0.221	Mouse
multi multicellular organism process	GO:0044706	138	0.218	Rat
wound healing	GO:0042060	122	0.217
negative regulation of cellular biosynthetic process	GO:0031327	161	0.213
developmental growth	GO:0048589	100	0.211
positive regulation of molecular function	GO:0044093	230	0.209
positive regulation of protein modification process	GO:0031401	142	0.209
response to ketone	GO:1901654	182	0.207	Rat
intracellular signal transduction	GO:0035556	314	0.206
response to hydrogen peroxide	GO:0042542	89	0.204	Rat
regulation of protein modification process	GO:0031399	194	0.203
negative regulation of macromolecule metabolic process	GO:0010605	260	0.199
regulation of intracellular signal transduction	GO:1902531	218	0.198
positive regulation of cell motility	GO:2000147	97	0.195
chemical homeostasis	GO:0048878	292	0.194
regulation of phosphate metabolic process	GO:0019220	349	0.193
positive regulation of response to stimulus	GO:0048584	285	0.192
regulation of response to stress	GO:0080134	126	0.190
regulation of neurogenesis	GO:0050767	247	0.189
leukocyte activation	GO:0045321	76	0.188
positive regulation of cell communication	GO:0010647	271	0.186
positive regulation of developmental process	GO:0051094	283	0.185	Mouse
signal transduction by phosphorylation	GO:0023014	144	0.183
neurological system process	GO:0050877	219	0.181
positive regulation of erk1 and erk2 cascade	GO:0070374	29	0.180
apoptotic process	GO:0006915	381	0.180
blood circulation	GO:0008015	183	0.174
protein phosphorylation	GO:0006468	345	0.170
immune system process	GO:0002376	204	0.170
tissue development	GO:0009888	252	0.170
positive regulation of cell development	GO:0010720	176	0.168
synapse organization	GO:0050808	46	0.168
calcium ion transport	GO:0006816	131	0.167
cellular response to oxygen containing compound	GO:1901701	386	0.167	Rat
ventricular cardiac muscle cell action potential	GO:0086005	2	0.166
positive regulation of cellular component movement	GO:0051272	102	0.166
oxoacid metabolic process	GO:0043436	290	0.165
endocytosis	GO:0006897	84	0.165
cellular metal ion homeostasis	GO:0006875	172	0.163
regulation of phosphorylation	GO:0042325	248	0.163
cell adhesion	GO:0007155	110	0.162
regulation of protein metabolic process	GO:0051246	289	0.162
positive regulation of hydrolase activity	GO:0051345	86	0.158
cognition	GO:0050890	92	0.157
regulation of cell proliferation	GO:0042127	359	0.157
cell projection organization	GO:0030030	302	0.156
protein complex biogenesis	GO:0070271	263	0.156
response to metal ion	GO:0010038	253	0.155
response to carbohydrate	GO:0009743	183	0.151
positive regulation of nervous system development	GO:0051962	178	0.150
regulation of cell projection organization	GO:0031344	175	0.148
regulation of cell development	GO:0060284	263	0.146
female pregnancy	GO:0007565	122	0.146	Rat
neuron differentiation	GO:0030182	368	0.145
multi organism reproductive process	GO:0044703	262	0.145	Rat
positive regulation of catalytic activity	GO:0043085	184	0.145
negative regulation of ion transport	GO:0043271	51	0.143
cellular protein localization	GO:0034613	122	0.143
nitrogen compound transport	GO:0071705	229	0.142
regulation of nucleic acid templated transcription	GO:1903506	380	0.142
response to purine containing compound	GO:0014074	126	0.141
response to organophosphorus	GO:0046683	102	0.141
ion homeostasis	GO:0050801	212	0.139
cellular response to organonitrogen compound	GO:0071417	197	0.138
protein localization	GO:0008104	191	0.138
negative regulation of developmental process	GO:0051093	125	0.138
regulation of programmed cell death	GO:0043067	341	0.138
cellular ketone metabolic process	GO:0042180	51	0.137
glial cell differentiation	GO:0010001	65	0.135
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.133
regulation of neuron projection development	GO:0010975	161	0.133
cellular amino acid metabolic process	GO:0006520	107	0.132
regulation of cell motility	GO:2000145	131	0.132
cell migration	GO:0016477	197	0.132	Mouse
regulation of protein phosphorylation	GO:0001932	183	0.132
rna biosynthetic process	GO:0032774	380	0.131
cellular response to growth factor stimulus	GO:0071363	162	0.131
secretion by cell	GO:0032940	248	0.128
regulation of catabolic process	GO:0009894	113	0.128
protein catabolic process	GO:0030163	30	0.128
programmed cell death	GO:0012501	392	0.126
response to hexose	GO:0009746	144	0.125
response to peptide hormone	GO:0043434	278	0.124
positive regulation of ion transport	GO:0043270	94	0.123
cellular response to hormone stimulus	GO:0032870	247	0.122
negative regulation of cell differentiation	GO:0045596	99	0.121
regulation of signal transduction	GO:0009966	318	0.120
negative regulation of molecular function	GO:0044092	133	0.120
placenta development	GO:0001890	22	0.119	Rat
regulation of actin filament based process	GO:0032970	42	0.118
protein maturation	GO:0051604	68	0.118
regulation of protein catabolic process	GO:0042176	16	0.118
peptidyl amino acid modification	GO:0018193	126	0.117
long term synaptic potentiation	GO:0060291	21	0.116
heart process	GO:0003015	57	0.115	Mouse
regulation of phosphorus metabolic process	GO:0051174	349	0.115
myeloid leukocyte activation	GO:0002274	36	0.114
positive regulation of signal transduction	GO:0009967	175	0.114
cellular response to peptide hormone stimulus	GO:0071375	120	0.114
response to hypoxia	GO:0001666	231	0.114
single organism cell adhesion	GO:0098602	46	0.113
response to decreased oxygen levels	GO:0036293	237	0.113
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.113
regulation of anatomical structure size	GO:0090066	135	0.112
tissue regeneration	GO:0042246	36	0.112	Mouse
regulation of cellular ketone metabolic process	GO:0010565	27	0.111
regulation of homotypic cell cell adhesion	GO:0034110	4	0.111
cytoskeleton organization	GO:0007010	111	0.111
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.110
regulation of system process	GO:0044057	208	0.110
cellular response to mechanical stimulus	GO:0071260	48	0.110
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.108
cellular response to stress	GO:0033554	269	0.108	Rat
regulation of vesicle mediated transport	GO:0060627	81	0.108
proteolysis	GO:0006508	175	0.105
negative regulation of signaling	GO:0023057	157	0.105
amine metabolic process	GO:0009308	38	0.104
transcription dna templated	GO:0006351	377	0.104
cellular response to glucocorticoid stimulus	GO:0071385	68	0.103
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.103
response to growth factor	GO:0070848	189	0.103
positive regulation of neuron projection development	GO:0010976	99	0.103
negative regulation of rna metabolic process	GO:0051253	123	0.102
cell part morphogenesis	GO:0032990	123	0.102
response to dexamethasone	GO:0071548	49	0.100
posttranscriptional regulation of gene expression	GO:0010608	37	0.099
cell morphogenesis involved in differentiation	GO:0000904	119	0.098
axonogenesis	GO:0007409	71	0.097
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.097
head development	GO:0060322	247	0.097
cellular response to nitrogen compound	GO:1901699	210	0.096
negative regulation of cellular protein metabolic process	GO:0032269	106	0.096
cellular macromolecule localization	GO:0070727	122	0.095
circulatory system process	GO:0003013	183	0.095
secretion	GO:0046903	307	0.095
reproductive system development	GO:0061458	128	0.094	Rat
axon development	GO:0061564	96	0.094
response to insulin	GO:0032868	133	0.093
cellular response to cgmp	GO:0071321	2	0.093
regulation of cell adhesion	GO:0030155	52	0.092
regulation of endocytosis	GO:0030100	42	0.092
cation homeostasis	GO:0055080	195	0.092
macromolecule localization	GO:0033036	252	0.091
regulation of heart contraction	GO:0008016	48	0.091	Mouse
erk1 and erk2 cascade	GO:0070371	48	0.091
regulation of cellular amino acid metabolic process	GO:0006521	2	0.090
establishment of protein localization	GO:0045184	141	0.090
cellular response to low density lipoprotein particle stimulus	GO:0071404	3	0.090
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.090
negative regulation of nervous system development	GO:0051961	79	0.089
localization of cell	GO:0051674	202	0.088	Mouse
regulation of cell migration	GO:0030334	128	0.088
positive regulation of intracellular signal transduction	GO:1902533	138	0.087
response to nicotine	GO:0035094	51	0.087
aging	GO:0007568	241	0.087	Rat
cellular ion homeostasis	GO:0006873	184	0.087
cellular response to steroid hormone stimulus	GO:0071383	93	0.087
brain development	GO:0007420	247	0.087
response to peptide	GO:1901652	292	0.087
cardiac muscle contraction	GO:0060048	27	0.086
regulation of cell cell adhesion	GO:0022407	14	0.086
macromolecular complex subunit organization	GO:0043933	339	0.086
response to mechanical stimulus	GO:0009612	134	0.086
response to cytokine	GO:0034097	215	0.085
multicellular organismal reproductive process	GO:0048609	233	0.085	Rat
response to cycloheximide	GO:0046898	6	0.085
regulation of response to external stimulus	GO:0032101	106	0.085
organophosphate metabolic process	GO:0019637	370	0.085
regulation of blood circulation	GO:1903522	110	0.085
cellular amine metabolic process	GO:0044106	38	0.084
regulation of synaptic transmission	GO:0050804	141	0.084
heart contraction	GO:0060047	57	0.084	Mouse
single organism catabolic process	GO:0044712	283	0.084
gliogenesis	GO:0042063	93	0.084
actin filament based process	GO:0030029	86	0.083
regulation of cell growth	GO:0001558	85	0.083
negative regulation of peptidase activity	GO:0010466	38	0.083
response to wounding	GO:0009611	254	0.083
cellular response to corticosteroid stimulus	GO:0071384	69	0.083
peptidyl tyrosine phosphorylation	GO:0018108	72	0.083
regulation of neuron differentiation	GO:0045664	208	0.083
positive regulation of behavior	GO:0048520	38	0.082
macromolecular complex assembly	GO:0065003	273	0.082
negative regulation of apoptotic process	GO:0043066	181	0.082
negative regulation of wound healing	GO:0061045	8	0.082
positive regulation of cell projection organization	GO:0031346	111	0.081
cellular response to interleukin 1	GO:0071347	37	0.081
negative regulation of programmed cell death	GO:0043069	183	0.080
response to nutrient	GO:0007584	248	0.080
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.080
negative regulation of response to stimulus	GO:0048585	155	0.080
regulation of platelet activation	GO:0010543	2	0.079
heart development	GO:0007507	72	0.079
heart morphogenesis	GO:0003007	3	0.078	Mouse
response to oxygen levels	GO:0070482	265	0.078
negative regulation of cell communication	GO:0010648	158	0.078
positive regulation of protein phosphorylation	GO:0001934	135	0.078
positive regulation of protein kinase activity	GO:0045860	73	0.077
epithelium development	GO:0060429	96	0.077
learning or memory	GO:0007611	90	0.077
cellular response to lipid	GO:0071396	201	0.076
cellular response to camp	GO:0071320	26	0.076
protein localization to organelle	GO:0033365	57	0.075
plasminogen activation	GO:0031639	2	0.075
positive regulation of biosynthetic process	GO:0009891	319	0.075
cell type specific apoptotic process	GO:0097285	134	0.074
regulation of kinase activity	GO:0043549	117	0.074
negative regulation of response to wounding	GO:1903035	23	0.074
regulation of transferase activity	GO:0051338	123	0.072
single organismal cell cell adhesion	GO:0016337	42	0.072
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.072
protein oligomerization	GO:0051259	191	0.071
taxis	GO:0042330	67	0.071
regulation of behavior	GO:0050795	61	0.070
regulation of wound healing	GO:0061041	14	0.070
muscle system process	GO:0003012	115	0.070
regulation of secretion by cell	GO:1903530	208	0.069
regulation of protein maturation	GO:1903317	50	0.068
protein targeting	GO:0006605	61	0.068
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.068
positive regulation of cellular protein metabolic process	GO:0032270	167	0.067
cell morphogenesis	GO:0000902	142	0.067
nucleoside phosphate metabolic process	GO:0006753	283	0.066
energy derivation by oxidation of organic compounds	GO:0015980	46	0.066
regulation of apoptotic process	GO:0042981	335	0.066
synapse assembly	GO:0007416	29	0.065
single organism biosynthetic process	GO:0044711	342	0.065
negative regulation of cell death	GO:0060548	229	0.065
regulation of rna biosynthetic process	GO:2001141	381	0.065
response to cgmp	GO:0070305	3	0.064
regulation of smooth muscle cell proliferation	GO:0048660	75	0.064
smooth muscle cell proliferation	GO:0048659	77	0.064
membrane hyperpolarization	GO:0060081	11	0.063
anterior posterior pattern specification	GO:0009952	1	0.063
regulation of blood vessel size	GO:0050880	89	0.063
cellular response to insulin stimulus	GO:0032869	81	0.062
regulation of locomotion	GO:0040012	148	0.062
cardiac muscle cell action potential involved in contraction	GO:0086002	2	0.062
positive regulation of phosphate metabolic process	GO:0045937	262	0.061
cellular component morphogenesis	GO:0032989	155	0.061
response to temperature stimulus	GO:0009266	94	0.061
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.060
positive regulation of programmed cell death	GO:0043068	157	0.060
positive regulation of nucleocytoplasmic transport	GO:0046824	17	0.059
synaptic growth at neuromuscular junction	GO:0051124	1	0.059
cardiac muscle cell contraction	GO:0086003	10	0.059
vascular endothelial growth factor receptor signaling pathway	GO:0048010	8	0.059
muscle contraction	GO:0006936	88	0.059
cellular response to ketone	GO:1901655	51	0.059
platelet activation	GO:0030168	8	0.059
sexual reproduction	GO:0019953	148	0.059
negative regulation of signal transduction	GO:0009968	83	0.059
forebrain development	GO:0030900	98	0.058
regulation of cellular component size	GO:0032535	51	0.058
inorganic cation transmembrane transport	GO:0098662	202	0.058
muscle cell proliferation	GO:0033002	84	0.058
regulation of cellular amine metabolic process	GO:0033238	8	0.057
rna metabolic process	GO:0016070	406	0.057
regulation of tube size	GO:0035150	89	0.057
transcription from rna polymerase ii promoter	GO:0006366	252	0.057
regulation of synaptic plasticity	GO:0048167	70	0.057
cellular cation homeostasis	GO:0030003	180	0.057
positive regulation of neurogenesis	GO:0050769	165	0.057
nucleobase containing small molecule metabolic process	GO:0055086	316	0.056
maternal process involved in female pregnancy	GO:0060135	38	0.056	Rat
regulation of muscle contraction	GO:0006937	53	0.056
negative regulation of endopeptidase activity	GO:0010951	36	0.055
negative regulation of protein processing	GO:0010955	47	0.055
organic cyclic compound catabolic process	GO:1901361	175	0.055
cellular response to follicle stimulating hormone stimulus	GO:0071372	13	0.054
amino acid transport	GO:0006865	70	0.054
response to camp	GO:0051591	91	0.054
reproduction	GO:0000003	245	0.053	Rat
response to atp	GO:0033198	13	0.053
cation transmembrane transport	GO:0098655	263	0.053
negative regulation of cardiac muscle tissue development	GO:0055026	3	0.053
negative regulation of neurogenesis	GO:0050768	78	0.053
mapk cascade	GO:0000165	140	0.053
regulation of secretion	GO:0051046	224	0.053
regulation of response to wounding	GO:1903034	69	0.052
regulation of peptidase activity	GO:0052547	55	0.052
female gonad development	GO:0008585	53	0.052
regulation of protein kinase activity	GO:0045859	105	0.051
cellular response to alcohol	GO:0097306	87	0.051
anion transport	GO:0006820	178	0.051
organonitrogen compound biosynthetic process	GO:1901566	167	0.051
epithelial cell differentiation	GO:0030855	71	0.051	Mouse
positive regulation of secretion by cell	GO:1903532	128	0.051
calcium ion homeostasis	GO:0055074	162	0.051
small molecule biosynthetic process	GO:0044283	124	0.051
regulation of transcription dna templated	GO:0006355	374	0.051
neuron development	GO:0048666	286	0.050
positive regulation of map kinase activity	GO:0043406	46	0.050
carbohydrate derivative metabolic process	GO:1901135	346	0.050
divalent inorganic cation homeostasis	GO:0072507	165	0.050
glycosyl compound metabolic process	GO:1901657	182	0.049
action potential	GO:0001508	54	0.049
response to acid chemical	GO:0001101	222	0.049
actin cytoskeleton organization	GO:0030036	73	0.049
negative regulation of transport	GO:0051051	136	0.048
regulation of proteolysis	GO:0030162	66	0.048
developmental process involved in reproduction	GO:0003006	159	0.047	Rat
purine nucleotide metabolic process	GO:0006163	229	0.047
regulation of protein processing	GO:0070613	50	0.047
cellular response to oxidative stress	GO:0034599	76	0.047	Rat
cellular response to cytokine stimulus	GO:0071345	127	0.047
ameboidal type cell migration	GO:0001667	26	0.047
negative regulation of protein maturation	GO:1903318	47	0.046
response to glucose	GO:0009749	136	0.046
negative regulation of biosynthetic process	GO:0009890	168	0.046
circulatory system development	GO:0072359	134	0.046
positive regulation of protein import into nucleus	GO:0042307	14	0.046
response to estradiol	GO:0032355	164	0.045	Rat
regulation of blood coagulation	GO:0030193	9	0.045
positive regulation of epithelial cell migration	GO:0010634	13	0.045
negative regulation of protein metabolic process	GO:0051248	114	0.045
glucose homeostasis	GO:0042593	75	0.045	Rat
positive regulation of cell death	GO:0010942	184	0.044
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.044
gamete generation	GO:0007276	124	0.044
cerebellum morphogenesis	GO:0021587	2	0.044
negative regulation of coagulation	GO:0050819	7	0.044
positive regulation of response to external stimulus	GO:0032103	51	0.044
response to antibiotic	GO:0046677	39	0.043
response to toxic substance	GO:0009636	133	0.043
positive regulation of cell adhesion	GO:0045785	30	0.043
regulation of stem cell differentiation	GO:2000736	2	0.043
positive regulation of phosphorylation	GO:0042327	177	0.042
positive regulation of synaptic transmission	GO:0050806	62	0.042
developmental growth involved in morphogenesis	GO:0060560	33	0.042
response to mineralocorticoid	GO:0051385	49	0.042
purine containing compound metabolic process	GO:0072521	253	0.042
cellular nitrogen compound catabolic process	GO:0044270	163	0.042
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.042
response to transforming growth factor beta	GO:0071559	46	0.042
positive regulation of protein transport	GO:0051222	41	0.041
response to light stimulus	GO:0009416	52	0.041
regulation of vascular endothelial growth factor receptor signaling pathway	GO:0030947	3	0.041
positive regulation of endocytosis	GO:0045807	28	0.041
positive regulation of keratinocyte migration	GO:0051549	2	0.041
negative regulation of proteolysis	GO:0045861	41	0.041
carbohydrate metabolic process	GO:0005975	130	0.041
regulation of anatomical structure morphogenesis	GO:0022603	141	0.041
nucleobase containing compound catabolic process	GO:0034655	152	0.040
regulation of cytoskeleton organization	GO:0051493	49	0.040
negative regulation of rna biosynthetic process	GO:1902679	118	0.040
regulation of organelle organization	GO:0033043	80	0.040
cellular macromolecular complex assembly	GO:0034622	58	0.040
positive regulation of apoptotic process	GO:0043065	154	0.040
negative regulation of hemostasis	GO:1900047	6	0.040
response to ethanol	GO:0045471	162	0.039
carbohydrate homeostasis	GO:0033500	75	0.039	Rat
cellular response to reactive oxygen species	GO:0034614	55	0.039
cellular response to dexamethasone stimulus	GO:0071549	36	0.039
positive regulation of fibroblast proliferation	GO:0048146	15	0.039
cellular calcium ion homeostasis	GO:0006874	160	0.039
regulation of calcium ion transport	GO:0051924	77	0.039
positive regulation of cellular biosynthetic process	GO:0031328	295	0.039
positive regulation of neuron differentiation	GO:0045666	126	0.038
vasculogenesis	GO:0001570	3	0.038
positive regulation of transcription factor import into nucleus	GO:0042993	4	0.038
vascular process in circulatory system	GO:0003018	96	0.038
odontogenesis	GO:0042476	32	0.038
negative regulation of cell growth	GO:0030308	33	0.038
positive regulation of secretion	GO:0051047	140	0.037
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.037
regulation of mapk cascade	GO:0043408	116	0.037
cellular response to atp	GO:0071318	5	0.037
positive regulation of phosphorus metabolic process	GO:0010562	262	0.037
heterocycle catabolic process	GO:0046700	167	0.036
regulation of cellular component biogenesis	GO:0044087	86	0.036
negative regulation of sodium ion transport	GO:0010766	2	0.036
divalent inorganic cation transport	GO:0072511	134	0.036
single organism carbohydrate metabolic process	GO:0044723	118	0.036
negative regulation of cell proliferation	GO:0008285	119	0.036
reactive oxygen species metabolic process	GO:0072593	37	0.036
ribose phosphate metabolic process	GO:0019693	235	0.036
blood vessel morphogenesis	GO:0048514	58	0.036	Mouse
positive regulation of membrane potential	GO:0045838	16	0.036
microtubule based process	GO:0007017	36	0.035
hair cell differentiation	GO:0035315	2	0.035
cellular macromolecule catabolic process	GO:0044265	29	0.035
cell projection morphogenesis	GO:0048858	123	0.035
immune response	GO:0006955	104	0.035
signal release	GO:0023061	145	0.035
positive regulation of organelle organization	GO:0010638	48	0.035
hindbrain morphogenesis	GO:0021575	2	0.035
positive regulation of cellular amine metabolic process	GO:0033240	3	0.035
positive regulation of cytoplasmic transport	GO:1903651	32	0.035
inorganic ion transmembrane transport	GO:0098660	229	0.034
cellular response to metal ion	GO:0071248	55	0.034
gastrulation	GO:0007369	2	0.034
neuron projection morphogenesis	GO:0048812	122	0.034
response to vitamin d	GO:0033280	34	0.034
regulation of erk1 and erk2 cascade	GO:0070372	41	0.034
regulation of smoothened signaling pathway	GO:0008589	2	0.034
positive regulation of odontogenesis of dentin containing tooth	GO:0042488	1	0.034
neural crest cell development	GO:0014032	2	0.034
neuron projection development	GO:0031175	273	0.033
adult locomotory behavior	GO:0008344	4	0.033
catabolic process	GO:0009056	351	0.033
hormone transport	GO:0009914	121	0.033
response to fibroblast growth factor	GO:0071774	29	0.033
negative regulation of response to external stimulus	GO:0032102	37	0.033
organic anion transport	GO:0015711	132	0.033
cellular response to hexose stimulus	GO:0071331	65	0.033	Rat
embryo implantation	GO:0007566	15	0.032

Gja1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.190
nervous system disease	DOID:863	0.190
musculoskeletal system disease	DOID:17	0.118
central nervous system disease	DOID:331	0.115
disease of metabolism	DOID:0014667	0.035

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