Rattus norvegicus

20 known processes

Pcna

proliferating cell nuclear antigen

(Aliases: PCNAR,Pcna/cyclin)

Pcna biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
chromatin assembly or disassemblyGO:000633310.569
negative regulation of biosynthetic processGO:00098901680.447
negative regulation of nucleic acid templated transcriptionGO:19035071170.396
cellular response to peptide hormone stimulusGO:00713751200.376
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.376
cellular response to endogenous stimulusGO:00714953770.343
negative regulation of rna biosynthetic processGO:19026791180.319
response to bacteriumGO:00096172000.298
cellular response to oxygen containing compoundGO:19017013860.284
response to molecule of bacterial originGO:00022371940.270
apoptotic processGO:00069153810.265
negative regulation of gene expressionGO:00106291990.256
negative regulation of metabolic processGO:00098923310.239
regulation of rna metabolic processGO:00512523910.235
negative regulation of nitrogen compound metabolic processGO:00511721610.234
negative regulation of cellular biosynthetic processGO:00313271610.229
response to peptideGO:19016522920.227
response to peptide hormoneGO:00434342780.221
negative regulation of rna metabolic processGO:00512531230.221
regulation of apoptotic processGO:00429813350.215
negative regulation of nucleobase containing compound metabolic processGO:00459341530.212
regulation of programmed cell deathGO:00430673410.212
regulation of nucleic acid templated transcriptionGO:19035063800.208
mitotic spindle organizationGO:000705220.202
homeostatic processGO:00425923310.197
neuron differentiationGO:00301823680.192
nucleic acid templated transcriptionGO:00976593790.189
cell type specific apoptotic processGO:00972851340.179
negative regulation of transcription dna templatedGO:00458921160.178
muscle tissue developmentGO:0060537580.177
multicellular organism reproductionGO:00325042330.173
negative regulation of cellular metabolic processGO:00313242810.172
programmed cell deathGO:00125013920.170
rna metabolic processGO:00160704060.168
cellular response to insulin stimulusGO:0032869810.165
cellular response to peptideGO:19016531330.162
transcription from rna polymerase ii promoterGO:00063662520.161
cellular lipid metabolic processGO:00442552080.159
cellular response to organonitrogen compoundGO:00714171970.158
reproductionGO:00000032450.157
response to temperature stimulusGO:0009266940.157
nucleosome organizationGO:003472810.155
rna biosynthetic processGO:00327743800.153
negative regulation of macromolecule biosynthetic processGO:00105581480.149
regulation of transcription dna templatedGO:00063553740.146
negative regulation of macromolecule metabolic processGO:00106052600.140
regulation of rna biosynthetic processGO:20011413810.137
regulation of cellular amine metabolic processGO:003323880.127
head developmentGO:00603222470.127
anterior posterior pattern specificationGO:000995210.125
cell cycleGO:00070491010.123
response to extracellular stimulusGO:00099913800.123
response to lipopolysaccharideGO:00324961910.121
regulation of transcription from rna polymerase ii promoterGO:00063572340.118
brain developmentGO:00074202470.118
dna conformation changeGO:0071103100.113
dna metabolic processGO:0006259960.113
positive regulation of developmental processGO:00510942830.112
organelle organizationGO:00069962660.111
multi organism reproductive processGO:00447032620.110
agingGO:00075682410.104
macromolecule localizationGO:00330362520.103
macromolecular complex assemblyGO:00650032730.100
negative regulation of apoptotic processGO:00430661810.096
central nervous system developmentGO:00074173110.095
regulation of catalytic activityGO:00507903040.095
regulation of cell cycle phase transitionGO:1901987120.092
single organism reproductive processGO:00447022970.091
regulation of multicellular organismal developmentGO:20000263760.089
transcription dna templatedGO:00063513770.089
macromolecular complex subunit organizationGO:00439333390.088
dna replicationGO:0006260370.084
regulation of phosphorylationGO:00423252480.084
protein refoldingGO:004202630.083
cellular component biogenesisGO:00440853680.082
response to purine containing compoundGO:00140741260.082
single organism organelle organizationGO:19025891800.081
positive regulation of multicellular organismal processGO:00512403870.079
mesenchymal cell proliferationGO:001046340.079
protein complex assemblyGO:00064612630.076
multicellular organismal reproductive processGO:00486092330.074
cellular response to nitrogen compoundGO:19016992100.073
cytoskeleton organizationGO:00070101110.073
sexual reproductionGO:00199531480.072
gamete generationGO:00072761240.072
positive regulation of cell proliferationGO:00082842490.071
positive regulation of nitrogen compound metabolic processGO:00511733340.070
embryonic pattern specificationGO:000988010.069
amine metabolic processGO:0009308380.068
response to other organismGO:00517072200.067
regulation of protein metabolic processGO:00512462890.067
positive regulation of molecular functionGO:00440932300.063
positive regulation of cell differentiationGO:00455972170.061
regulation of molecular functionGO:00650093980.061
protein complex biogenesisGO:00702712630.060
regulation of cell proliferationGO:00421273590.060
reproductive processGO:00224143720.060
positive regulation of immune system processGO:0002684900.059
lipid metabolic processGO:00066292830.058
response to nutrientGO:00075842480.057
spermatogenesisGO:0007283990.057
single organism biosynthetic processGO:00447113420.057
nuclear transportGO:0051169490.056
response to inorganic substanceGO:00100353770.056
heat acclimationGO:001028610.055
response to radiationGO:00093141370.054
oxidation reduction processGO:00551143040.054
cellular amine metabolic processGO:0044106380.054
cell projection morphogenesisGO:00488581230.053
nucleocytoplasmic transportGO:0006913480.053
regulation of response to stressGO:00801341260.052
cellular component assemblyGO:00226073600.052
positive regulation of biosynthetic processGO:00098913190.051
negative regulation of cell communicationGO:00106481580.050
positive regulation of dna metabolic processGO:0051054390.049
response to nutrient levelsGO:00316673700.049
chromatin organizationGO:0006325340.048
regulation of phosphorus metabolic processGO:00511743490.047
regulation of cellular protein metabolic processGO:00322682670.047
regulation of cell cycleGO:0051726730.047
response to external biotic stimulusGO:00432072210.046
positive regulation of nucleobase containing compound metabolic processGO:00459353190.046
positive regulation of mesenchymal cell proliferationGO:000205340.046
neuron deathGO:00709971270.045
neuron developmentGO:00486662860.045
cell cycle checkpointGO:000007520.045
positive regulation of apoptotic processGO:00430651540.045
negative regulation of molecular functionGO:00440921330.044
heart contractionGO:0060047570.043
cellular response to hormone stimulusGO:00328702470.043
developmental process involved in reproductionGO:00030061590.042
circadian rhythmGO:0007623880.042
intracellular signal transductionGO:00355563140.042
adult locomotory behaviorGO:000834440.041
negative regulation of cell deathGO:00605482290.041
immune system processGO:00023762040.040
response to biotic stimulusGO:00096072260.040
chromatin modificationGO:0016568330.040
regulation of cellular amino acid metabolic processGO:000652120.039
negative regulation of programmed cell deathGO:00430691830.039
cellular protein catabolic processGO:0044257190.039
negative regulation of cellular protein metabolic processGO:00322691060.039
protein transportGO:00150311320.038
muscle organ developmentGO:0007517500.037
embryonic axis specificationGO:000057810.037
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.037
response to campGO:0051591910.037
glucan metabolic processGO:0044042230.037
cell chemotaxisGO:0060326310.037
response to oxidative stressGO:00069791860.036
positive regulation of gene expressionGO:00106282440.036
neuron apoptotic processGO:0051402880.036
regulation of alternative mrna splicing via spliceosomeGO:000038120.036
regulation of chromosome segregationGO:005198310.036
response to estrogenGO:00436272320.036
organic substance catabolic processGO:19015753160.036
inorganic ion transmembrane transportGO:00986602290.035
positive regulation of nervous system developmentGO:00519621780.035
cell projection organizationGO:00300303020.035
development of primary sexual characteristicsGO:00451371070.035
regulation of cell maturationGO:190342930.035
negative regulation of signalingGO:00230571570.035
mitotic cell cycleGO:0000278490.034
neuron projection developmentGO:00311752730.034
protein phosphorylationGO:00064683450.034
intracellular protein transportGO:0006886790.034
positive regulation of cell developmentGO:00107201760.034
positive regulation of programmed cell deathGO:00430681570.034
cell cycle processGO:0022402570.033
dephosphorylationGO:0016311980.033
chemotaxisGO:0006935660.033
regulation of response to woundingGO:1903034690.032
response to metal ionGO:00100382530.032
innate immune responseGO:0045087350.032
cellular process involved in reproduction in multicellular organismGO:0022412350.031
tissue developmentGO:00098882520.031
peptidyl amino acid modificationGO:00181931260.031
cellular macromolecule localizationGO:00707271220.031
positive regulation of cellular protein metabolic processGO:00322701670.031
regulation of phosphate metabolic processGO:00192203490.030
positive regulation of protein phosphorylationGO:00019341350.030
cellular cation homeostasisGO:00300031800.030
positive regulation of protein metabolic processGO:00512471780.030
wound healingGO:00420601220.030
positive regulation of response to stimulusGO:00485842850.030
regulation of cellular localizationGO:00603412630.029
immune system developmentGO:0002520410.029
response to tumor cellGO:000234740.029
regulation of gene expression epigeneticGO:0040029100.029
regulation of cell differentiationGO:00455953200.029
regulation of cellular ketone metabolic processGO:0010565270.029
cellular response to stressGO:00335542690.029
peptidyl serine modificationGO:0018209340.029
cellular response to growth factor stimulusGO:00713631620.028
male gamete generationGO:0048232990.028
positive regulation of macromolecule biosynthetic processGO:00105572470.028
cellular component morphogenesisGO:00329891550.028
localization of cellGO:00516742020.027
positive regulation of cellular biosynthetic processGO:00313282950.027
circadian regulation of gene expressionGO:003292230.027
cell migrationGO:00164771970.027
posttranscriptional regulation of gene expressionGO:0010608370.027
anatomical structure morphogenesisGO:00096532980.027
chemical homeostasisGO:00488782920.026
cardiovascular system developmentGO:00723581340.026
carboxylic acid biosynthetic processGO:0046394830.026
positive regulation of cellular amine metabolic processGO:003324030.026
regulation of behaviorGO:0050795610.026
behaviorGO:00076102050.025
regulation of neuron deathGO:19012141150.025
regulation of signal transductionGO:00099663180.025
dna packagingGO:000632340.025
positive regulation of neuron projection developmentGO:0010976990.025
endothelium developmentGO:0003158120.025
organonitrogen compound biosynthetic processGO:19015661670.025
regulation of hydrolase activityGO:00513361430.024
positive regulation of wound healingGO:009030360.024
cellular amino acid metabolic processGO:00065201070.024
regulation of cellular component organizationGO:00511283680.024
reactive oxygen species metabolic processGO:0072593370.023
somatic stem cell divisionGO:004810320.023
reproductive system developmentGO:00614581280.023
oxoacid metabolic processGO:00434362900.023
positive regulation of lipid catabolic processGO:005099640.023
regulation of cell developmentGO:00602842630.023
positive regulation of protein modification processGO:00314011420.023
negative regulation of protein metabolic processGO:00512481140.023
regulation of embryonic developmentGO:004599520.023
growthGO:00400071650.022
response to heatGO:0009408600.022
positive regulation of cell projection organizationGO:00313461110.022
sensory perceptionGO:00076001010.022
negative regulation of neuron deathGO:1901215690.022
taxisGO:0042330670.022
cell proliferation in forebrainGO:002184630.022
peptidyl serine phosphorylationGO:0018105330.021
blood circulationGO:00080151830.021
chromatin remodelingGO:000633830.021
regulation of neurogenesisGO:00507672470.021
protein complex subunit organizationGO:00718223020.021
positive regulation of intracellular signal transductionGO:19025331380.021
glycogen metabolic processGO:0005977230.021
regulation of mrna splicing via spliceosomeGO:004802430.021
regulation of defense responseGO:0031347680.021
mrna metabolic processGO:0016071200.021
positive regulation of cellular component organizationGO:00511302000.020
positive regulation of rna biosynthetic processGO:19026801970.020
embryonic digestive tract developmentGO:004856630.020
regenerationGO:00310991630.019
histone methylationGO:001657130.019
response to organophosphorusGO:00466831020.019
inflammatory responseGO:00069541500.019
response to insulinGO:00328681330.019
response to growth factorGO:00708481890.019
regulation of microtubule cytoskeleton organizationGO:0070507140.019
protein oligomerizationGO:00512591910.019
response to oxygen levelsGO:00704822650.019
neurological system processGO:00508772190.019
small gtpase mediated signal transductionGO:0007264360.019
regulation of protein phosphorylationGO:00019321830.019
cytosolic calcium ion homeostasisGO:00514801400.019
negative regulation of catalytic activityGO:00430861030.018
regulation of immune system processGO:00026821230.018
negative regulation of response to stimulusGO:00485851550.018
positive regulation of hydrolase activityGO:0051345860.018
positive regulation of cell deathGO:00109421840.018
response to glucoseGO:00097491360.018
response to hydrogen peroxideGO:0042542890.018
intracellular receptor signaling pathwayGO:0030522350.018
cellular protein localizationGO:00346131220.018
developmental growthGO:00485891000.018
nucleobase containing small molecule metabolic processGO:00550863160.018
male gonad developmentGO:0008584590.018
multicellular organism growthGO:003526410.018
axis specificationGO:000979840.017
carbohydrate derivative biosynthetic processGO:19011371240.017
response to acid chemicalGO:00011012220.017
male sex differentiationGO:0046661640.017
positive regulation of nucleic acid templated transcriptionGO:19035081970.017
ion transmembrane transportGO:00342203650.017
mapk cascadeGO:00001651400.017
regulation of epithelial cell proliferationGO:0050678490.016
response to hypoxiaGO:00016662310.016
microtubule cytoskeleton organizationGO:0000226250.016
regulation of protein kinase activityGO:00458591050.016
cell cell signalingGO:00072673350.016
reactive oxygen species biosynthetic processGO:190340980.016
mrna processingGO:0006397140.016
response to mechanical stimulusGO:00096121340.016
immune responseGO:00069551040.016
positive regulation of catalytic activityGO:00430851840.016
heart developmentGO:0007507720.016
response to cadmium ionGO:0046686350.016
response to light stimulusGO:0009416520.016
intracellular transportGO:00469071850.016
nucleobase containing compound catabolic processGO:00346551520.016
ion homeostasisGO:00508012120.015
cellular metal ion homeostasisGO:00068751720.015
nucleoside phosphate biosynthetic processGO:19012931020.015
response to woundingGO:00096112540.015
striated muscle tissue developmentGO:0014706580.015
transforming growth factor beta3 productionGO:003290720.015
regulation of neuron apoptotic processGO:0043523830.015
cellular chemical homeostasisGO:00550822470.015
negative regulation of chromosome organizationGO:200125110.015
cytoplasmic transportGO:00164821150.015
positive chemotaxisGO:005091890.015
response to monosaccharideGO:00342841590.015
negative regulation of transportGO:00510511360.015
regulation of response to tumor cellGO:000283430.015
positive regulation of neuron differentiationGO:00456661260.015
regulation of dna metabolic processGO:0051052600.014
histone modificationGO:0016570300.014
positive regulation of neurogenesisGO:00507691650.014
positive regulation of transcription dna templatedGO:00458931970.014
positive regulation of cellular amino acid metabolic processGO:004576410.014
catabolic processGO:00090563510.014
olfactory behaviorGO:004204820.014
development of primary male sexual characteristicsGO:0046546590.014
reproductive structure developmentGO:00486081280.014
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.014
positive regulation of cytosolic calcium ion concentrationGO:00072041220.014
palate developmentGO:006002120.014
regulation of protein modification processGO:00313991940.013
tube developmentGO:0035295890.013
rna localizationGO:000640340.013
positive regulation of phosphorus metabolic processGO:00105622620.013
endothelial cell differentiationGO:004544690.013
regulation of mitotic cell cycleGO:0007346270.013
response to hyperoxiaGO:0055093450.013
response to alkaloidGO:00432791320.013
regulation of microtubule based processGO:0032886140.013
mitotic cell cycle checkpointGO:000709310.013
olfactory learningGO:000835510.013
protein homooligomerizationGO:0051260910.013
mitotic cell cycle processGO:1903047350.012
cellular macromolecular complex assemblyGO:0034622580.012
spinal cord developmentGO:0021510270.012
organic hydroxy compound metabolic processGO:19016151150.012
cation transmembrane transportGO:00986552630.012
hematopoietic progenitor cell differentiationGO:000224420.012
cellular ketone metabolic processGO:0042180510.012
protein localizationGO:00081041910.012
regulation of dopamine metabolic processGO:004205350.012
extracellular transportGO:000685810.012
purine containing compound biosynthetic processGO:0072522850.012
response to increased oxygen levelsGO:0036296450.012
regulation of neuron projection developmentGO:00109751610.012
regulation of mesenchymal cell proliferationGO:001046440.012
regulation of kinase activityGO:00435491170.012
gonad developmentGO:00084061040.012
positive regulation of rna metabolic processGO:00512542030.012
macromolecule catabolic processGO:0009057580.012
epithelial cell proliferationGO:0050673540.012
divalent inorganic cation homeostasisGO:00725071650.012
locomotionGO:00400112370.012
cellular nitrogen compound catabolic processGO:00442701630.012
spindle organizationGO:000705120.012
covalent chromatin modificationGO:0016569300.012
energy derivation by oxidation of organic compoundsGO:0015980460.012
sex differentiationGO:00075481130.012
positive regulation of cellular component biogenesisGO:0044089550.012
nucleoside phosphate metabolic processGO:00067532830.012
microtubule based processGO:0007017360.012
response to electrical stimulusGO:0051602560.012
organ regenerationGO:00311001010.012
cellular homeostasisGO:00197252520.011
cytoskeleton dependent cytokinesisGO:006164020.011
cellular response to abiotic stimulusGO:0071214850.011
single organism carbohydrate metabolic processGO:00447231180.011
endothelial cell proliferationGO:0001935200.011
germ cell developmentGO:0007281250.011
single organism behaviorGO:00447081300.011
negative regulation of mitotic cell cycle phase transitionGO:190199130.011
circulatory system processGO:00030131830.011
muscle system processGO:00030121150.011
heterocycle catabolic processGO:00467001670.011
regulation of cell projection organizationGO:00313441750.011
chromosome segregationGO:000705920.011
response to ketoneGO:19016541820.011
cell motilityGO:00488702020.011
energy reserve metabolic processGO:0006112250.011
ras protein signal transductionGO:0007265290.011
synaptic growth at neuromuscular junctionGO:005112410.011
negative regulation of signal transductionGO:0009968830.011
potassium ion transportGO:0006813970.010
rna transportGO:005065830.010
negative regulation of neuron apoptotic processGO:0043524450.010
regulation of intracellular signal transductionGO:19025312180.010
response to carbohydrateGO:00097431830.010
regulation of proteolysisGO:0030162660.010
carbohydrate metabolic processGO:00059751300.010
regulation of intracellular transportGO:0032386650.010
response to cytokineGO:00340972150.010
calcium ion transmembrane transportGO:0070588700.010
regulation of purine nucleotide metabolic processGO:19005421150.010
response to reactive oxygen speciesGO:00003021200.010
signal transduction by phosphorylationGO:00230141440.010

Pcna disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.022
central nervous system diseaseDOID:33100.022
disease of anatomical entityDOID:700.022
cancerDOID:16200.016
organ system cancerDOID:005068600.016
disease of cellular proliferationDOID:1456600.016