IMP: Integrative Multi-species Prediction

Rattus norvegicus

116 known processes

Guk1

guanylate kinase 1

Entrez: 303179
RGD: 1309638
Ensembl: ENSRNOG00000002928
UniProtKB: E9PTV0
UniProtKB: Q71RR7

Process Predictions
Disease Predictions

Guk1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
transcription from rna polymerase ii promoter	GO:0006366	252	0.159
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.149
central nervous system development	GO:0007417	311	0.130
positive regulation of biosynthetic process	GO:0009891	319	0.128
protein phosphorylation	GO:0006468	345	0.101
nucleotide metabolic process	GO:0009117	279	0.097
regulation of phosphorus metabolic process	GO:0051174	349	0.096
regulation of phosphate metabolic process	GO:0019220	349	0.090
apoptotic process	GO:0006915	381	0.086
positive regulation of multicellular organismal process	GO:0051240	387	0.084
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.084
macromolecular complex subunit organization	GO:0043933	339	0.070
positive regulation of cellular biosynthetic process	GO:0031328	295	0.068
positive regulation of apoptotic process	GO:0043065	154	0.067
regulation of phosphorylation	GO:0042325	248	0.065
single organism biosynthetic process	GO:0044711	342	0.065
regulation of system process	GO:0044057	208	0.062
regulation of protein phosphorylation	GO:0001932	183	0.061
rna biosynthetic process	GO:0032774	380	0.060
cellular component assembly	GO:0022607	360	0.059
protein complex assembly	GO:0006461	263	0.059
intracellular signal transduction	GO:0035556	314	0.057
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.057
regulation of apoptotic process	GO:0042981	335	0.056
purine nucleoside metabolic process	GO:0042278	169	0.056
protein complex subunit organization	GO:0071822	302	0.055
ribonucleotide biosynthetic process	GO:0009260	85	0.053
positive regulation of camp metabolic process	GO:0030816	31	0.053
regulation of nucleic acid templated transcription	GO:1903506	380	0.051
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.051
aging	GO:0007568	241	0.050
response to nutrient levels	GO:0031667	370	0.050
regulation of multicellular organismal development	GO:2000026	376	0.050
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.050
nucleic acid templated transcription	GO:0097659	379	0.048
positive regulation of rna biosynthetic process	GO:1902680	197	0.047
positive regulation of transcription dna templated	GO:0045893	197	0.047
positive regulation of cellular component organization	GO:0051130	200	0.046
positive regulation of rna metabolic process	GO:0051254	203	0.046
purine ribonucleotide metabolic process	GO:0009150	227	0.045
rna metabolic process	GO:0016070	406	0.044
carbohydrate derivative metabolic process	GO:1901135	346	0.044
regulation of cellular amine metabolic process	GO:0033238	8	0.044
ribose phosphate biosynthetic process	GO:0046390	87	0.044
positive regulation of cell death	GO:0010942	184	0.043
glycosyl compound metabolic process	GO:1901657	182	0.043
positive regulation of gene expression	GO:0010628	244	0.043
protein complex biogenesis	GO:0070271	263	0.043
programmed cell death	GO:0012501	392	0.043
regulation of rna metabolic process	GO:0051252	391	0.043
guanosine containing compound metabolic process	GO:1901068	74	0.043
positive regulation of neuron apoptotic process	GO:0043525	33	0.042
organophosphate metabolic process	GO:0019637	370	0.042
cellular component biogenesis	GO:0044085	368	0.041
catabolic process	GO:0009056	351	0.041
regulation of programmed cell death	GO:0043067	341	0.041
cellular response to stress	GO:0033554	269	0.040
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.040
response to extracellular stimulus	GO:0009991	380	0.040
cellular amine metabolic process	GO:0044106	38	0.039
regulation of protein metabolic process	GO:0051246	289	0.039
head development	GO:0060322	247	0.039
actin filament based process	GO:0030029	86	0.038
neuron differentiation	GO:0030182	368	0.038
positive regulation of cell communication	GO:0010647	271	0.037
regulation of cell differentiation	GO:0045595	320	0.037
pyrimidine nucleotide biosynthetic process	GO:0006221	9	0.036
protein autophosphorylation	GO:0046777	66	0.036
purine containing compound metabolic process	GO:0072521	253	0.036
regulation of catalytic activity	GO:0050790	304	0.035
regulation of molecular function	GO:0065009	398	0.035
carbohydrate derivative biosynthetic process	GO:1901137	124	0.035
purine ribonucleoside metabolic process	GO:0046128	168	0.035
organophosphate biosynthetic process	GO:0090407	143	0.034
positive regulation of developmental process	GO:0051094	283	0.033
response to decreased oxygen levels	GO:0036293	237	0.032
actin cytoskeleton organization	GO:0030036	73	0.032
response to corticosteroid	GO:0031960	235	0.032
organelle organization	GO:0006996	266	0.032
cell fate determination	GO:0001709	2	0.032
camp metabolic process	GO:0046058	63	0.032
regulation of blood circulation	GO:1903522	110	0.031
nucleobase containing small molecule metabolic process	GO:0055086	316	0.031
regulation of purine nucleotide metabolic process	GO:1900542	115	0.031
regulation of lyase activity	GO:0051339	22	0.031
positive regulation of signaling	GO:0023056	270	0.031
homeostatic process	GO:0042592	331	0.031
ribonucleotide metabolic process	GO:0009259	231	0.031
positive regulation of phosphorus metabolic process	GO:0010562	262	0.031
positive regulation of nervous system development	GO:0051962	178	0.030
regulation of nucleotide metabolic process	GO:0006140	117	0.030
blood circulation	GO:0008015	183	0.030
regulation of cellular component organization	GO:0051128	368	0.029
ribonucleoside metabolic process	GO:0009119	174	0.029
cyclic nucleotide metabolic process	GO:0009187	80	0.029
regulation of nervous system development	GO:0051960	264	0.028
regulation of nucleotide biosynthetic process	GO:0030808	47	0.028
circulatory system process	GO:0003013	183	0.028
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.028
transcription dna templated	GO:0006351	377	0.028
nucleoside catabolic process	GO:0009164	126	0.027
regulation of transcription dna templated	GO:0006355	374	0.027
cyclic nucleotide biosynthetic process	GO:0009190	63	0.027
ribose phosphate metabolic process	GO:0019693	235	0.027
response to alkaloid	GO:0043279	132	0.027
aromatic compound catabolic process	GO:0019439	168	0.026
positive regulation of protein phosphorylation	GO:0001934	135	0.026
regulation of cell development	GO:0060284	263	0.026
positive regulation of cell development	GO:0010720	176	0.026
regulation of rna biosynthetic process	GO:2001141	381	0.026
single organism catabolic process	GO:0044712	283	0.026
response to estrogen	GO:0043627	232	0.026
positive regulation of phosphate metabolic process	GO:0045937	262	0.025
brain development	GO:0007420	247	0.025
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.025
negative regulation of macromolecule metabolic process	GO:0010605	260	0.025
positive regulation of molecular function	GO:0044093	230	0.025
positive regulation of cell differentiation	GO:0045597	217	0.025
macromolecular complex assembly	GO:0065003	273	0.025
neuron projection development	GO:0031175	273	0.024
negative regulation of metabolic process	GO:0009892	331	0.024
cellular chemical homeostasis	GO:0055082	247	0.024
positive regulation of cellular protein metabolic process	GO:0032270	167	0.024
cell cell signaling	GO:0007267	335	0.024
positive regulation of neuron death	GO:1901216	43	0.024
nucleoside phosphate metabolic process	GO:0006753	283	0.023
response to growth factor	GO:0070848	189	0.023
regulation of cellular protein metabolic process	GO:0032268	267	0.023
negative regulation of molecular function	GO:0044092	133	0.022
amine metabolic process	GO:0009308	38	0.022
regulation of neurogenesis	GO:0050767	247	0.022
negative regulation of cell death	GO:0060548	229	0.022
regulation of transferase activity	GO:0051338	123	0.022
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	3	0.022
regulation of purine nucleotide biosynthetic process	GO:1900371	46	0.022
negative regulation of protein phosphorylation	GO:0001933	44	0.021
regulation of protein modification process	GO:0031399	194	0.021
regulation of signal transduction	GO:0009966	318	0.021
cellular response to lipid	GO:0071396	201	0.021
response to ketone	GO:1901654	182	0.021
neuron apoptotic process	GO:0051402	88	0.021
negative regulation of phosphate metabolic process	GO:0045936	80	0.021
signal transduction by phosphorylation	GO:0023014	144	0.021
reproductive process	GO:0022414	372	0.020
regulation of cyclic nucleotide biosynthetic process	GO:0030802	45	0.020
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.020
anterior posterior pattern specification	GO:0009952	1	0.020
nucleoside metabolic process	GO:0009116	179	0.020
immune system process	GO:0002376	204	0.019
regulation of cell proliferation	GO:0042127	359	0.019
positive regulation of nucleotide metabolic process	GO:0045981	91	0.019
regulation of cellular amino acid metabolic process	GO:0006521	2	0.019
gastrulation	GO:0007369	2	0.019
nucleobase containing compound catabolic process	GO:0034655	152	0.019
regulation of camp metabolic process	GO:0030814	43	0.019
negative regulation of cellular metabolic process	GO:0031324	281	0.019
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.019
positive regulation of neurogenesis	GO:0050769	165	0.019
axis specification	GO:0009798	4	0.019
positive regulation of cell proliferation	GO:0008284	249	0.018
negative regulation of multicellular organismal process	GO:0051241	203	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.018
cation homeostasis	GO:0055080	195	0.018
negative regulation of programmed cell death	GO:0043069	183	0.018
response to glucocorticoid	GO:0051384	223	0.018
response to acid chemical	GO:0001101	222	0.018
negative regulation of cell differentiation	GO:0045596	99	0.018
secretion by cell	GO:0032940	248	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.018
purine nucleotide biosynthetic process	GO:0006164	83	0.018
nucleoside phosphate biosynthetic process	GO:1901293	102	0.018
circulatory system development	GO:0072359	134	0.018
organonitrogen compound catabolic process	GO:1901565	179	0.017
neuron development	GO:0048666	286	0.017
response to metal ion	GO:0010038	253	0.017
gtp metabolic process	GO:0046039	72	0.017
cyclic purine nucleotide metabolic process	GO:0052652	62	0.017
regulation of catabolic process	GO:0009894	113	0.017
cell migration	GO:0016477	197	0.017
positive regulation of intracellular signal transduction	GO:1902533	138	0.017
regulation of cellular component movement	GO:0051270	150	0.017
response to oxidative stress	GO:0006979	186	0.016
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.016
developmental growth	GO:0048589	100	0.016
regulation of cell migration	GO:0030334	128	0.016
reproduction	GO:0000003	245	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.016
cation transport	GO:0006812	382	0.016
negative regulation of apoptotic process	GO:0043066	181	0.016
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	34	0.016
regulation of kinase activity	GO:0043549	117	0.016
nucleotide biosynthetic process	GO:0009165	98	0.016
purine containing compound biosynthetic process	GO:0072522	85	0.016
developmental process involved in reproduction	GO:0003006	159	0.016
positive regulation of cellular amine metabolic process	GO:0033240	3	0.016
regulation of dna metabolic process	GO:0051052	60	0.016
regulation of secretion by cell	GO:1903530	208	0.016
camp biosynthetic process	GO:0006171	47	0.015
regulation of cyclase activity	GO:0031279	21	0.015
response to mineralocorticoid	GO:0051385	49	0.015
positive regulation of monooxygenase activity	GO:0032770	5	0.015
positive regulation of neuron differentiation	GO:0045666	126	0.015
organonitrogen compound biosynthetic process	GO:1901566	167	0.015
protein oligomerization	GO:0051259	191	0.015
regulation of neuron apoptotic process	GO:0043523	83	0.015
positive regulation of cellular component biogenesis	GO:0044089	55	0.015
regulation of growth	GO:0040008	105	0.015
cell projection organization	GO:0030030	302	0.015
response to inorganic substance	GO:0010035	377	0.015
positive regulation of purine nucleotide biosynthetic process	GO:1900373	36	0.015
positive regulation of cellular catabolic process	GO:0031331	71	0.015
growth	GO:0040007	165	0.015
negative regulation of cell communication	GO:0010648	158	0.015
positive regulation of response to stimulus	GO:0048584	285	0.015
organic cyclic compound catabolic process	GO:1901361	175	0.015
regulation of locomotion	GO:0040012	148	0.014
response to wounding	GO:0009611	254	0.014
positive regulation of protein metabolic process	GO:0051247	178	0.014
negative regulation of developmental process	GO:0051093	125	0.014
regulation of erk1 and erk2 cascade	GO:0070372	41	0.014
positive regulation of catalytic activity	GO:0043085	184	0.014
heart contraction	GO:0060047	57	0.014
negative regulation of neuron apoptotic process	GO:0043524	45	0.014
positive regulation of cell projection organization	GO:0031346	111	0.014
positive regulation of cellular component movement	GO:0051272	102	0.014
response to oxygen levels	GO:0070482	265	0.014
regulation of secretion	GO:0051046	224	0.014
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.013
positive regulation of programmed cell death	GO:0043068	157	0.013
positive regulation of camp biosynthetic process	GO:0030819	28	0.013
chemical homeostasis	GO:0048878	292	0.013
cellular amino acid metabolic process	GO:0006520	107	0.013
regulation of mapk cascade	GO:0043408	116	0.013
multi organism reproductive process	GO:0044703	262	0.013
protein heterooligomerization	GO:0051291	89	0.013
negative regulation of cell proliferation	GO:0008285	119	0.013
response to lipopolysaccharide	GO:0032496	191	0.013
regulation of hydrolase activity	GO:0051336	143	0.013
positive regulation of signal transduction	GO:0009967	175	0.013
positive regulation of small gtpase mediated signal transduction	GO:0051057	9	0.013
regulation of cell projection organization	GO:0031344	175	0.013
negative regulation of cell cycle phase transition	GO:1901988	4	0.013
response to hypoxia	GO:0001666	231	0.013
heart morphogenesis	GO:0003007	3	0.013
muscle system process	GO:0003012	115	0.013
mapk cascade	GO:0000165	140	0.013
response to corticosterone	GO:0051412	40	0.012
regulation of anatomical structure size	GO:0090066	135	0.012
single organism carbohydrate metabolic process	GO:0044723	118	0.012
response to bacterium	GO:0009617	200	0.012
negative regulation of protein metabolic process	GO:0051248	114	0.012
negative regulation of phosphorus metabolic process	GO:0010563	80	0.012
regulation of cell motility	GO:2000145	131	0.012
cellular ion homeostasis	GO:0006873	184	0.012
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	24	0.012
purine nucleotide catabolic process	GO:0006195	136	0.012
cellular ketone metabolic process	GO:0042180	51	0.012
cellular cation homeostasis	GO:0030003	180	0.012
regulation of cellular component biogenesis	GO:0044087	86	0.012
apoptotic signaling pathway	GO:0097190	27	0.012
single organism reproductive process	GO:0044702	297	0.012
positive regulation of phosphorylation	GO:0042327	177	0.012
positive regulation of neuron projection development	GO:0010976	99	0.012
protein localization	GO:0008104	191	0.012
positive regulation of kinase activity	GO:0033674	77	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.012
cellular response to oxygen containing compound	GO:1901701	386	0.012
heart development	GO:0007507	72	0.012
regulation of neuron differentiation	GO:0045664	208	0.012
cell type specific apoptotic process	GO:0097285	134	0.012
gtp catabolic process	GO:0006184	71	0.012
secretion	GO:0046903	307	0.012
divalent metal ion transport	GO:0070838	132	0.011
regulation of muscle system process	GO:0090257	79	0.011
metal ion transport	GO:0030001	289	0.011
negative regulation of gene expression	GO:0010629	199	0.011
cellular catabolic process	GO:0044248	295	0.011
response to nutrient	GO:0007584	248	0.011
regulation of nucleoside metabolic process	GO:0009118	66	0.011
cell growth	GO:0016049	104	0.011
regulation of cellular ketone metabolic process	GO:0010565	27	0.011
peptide secretion	GO:0002790	86	0.011
regulation of gtp catabolic process	GO:0033124	58	0.011
regulation of heart contraction	GO:0008016	48	0.011
cellular metal ion homeostasis	GO:0006875	172	0.011
sequestering of metal ion	GO:0051238	9	0.011
response to external biotic stimulus	GO:0043207	221	0.011
negative regulation of signaling	GO:0023057	157	0.011
protein dephosphorylation	GO:0006470	38	0.011
negative regulation of response to stimulus	GO:0048585	155	0.011
erk1 and erk2 cascade	GO:0070371	48	0.011
response to estradiol	GO:0032355	164	0.011
response to temperature stimulus	GO:0009266	94	0.011
sex differentiation	GO:0007548	113	0.011
regulation of immune system process	GO:0002682	123	0.011
negative regulation of neurogenesis	GO:0050768	78	0.011
ion homeostasis	GO:0050801	212	0.011
positive regulation of mapk cascade	GO:0043410	92	0.011
guanosine containing compound catabolic process	GO:1901069	71	0.011
positive regulation of organelle organization	GO:0010638	48	0.011
response to molecule of bacterial origin	GO:0002237	194	0.011
g protein coupled receptor signaling pathway	GO:0007186	242	0.011
regulation of cellular catabolic process	GO:0031329	101	0.011
oxoacid metabolic process	GO:0043436	290	0.011
regulation of dna methylation	GO:0044030	6	0.010
cellular nitrogen compound catabolic process	GO:0044270	163	0.010
single organism organelle organization	GO:1902589	180	0.010
mitotic cell cycle checkpoint	GO:0007093	1	0.010
positive regulation of ruffle assembly	GO:1900029	1	0.010
regulation of protein kinase activity	GO:0045859	105	0.010
regulation of neuron death	GO:1901214	115	0.010
response to activity	GO:0014823	73	0.010
regulation of camp biosynthetic process	GO:0030817	38	0.010
calcium ion transport	GO:0006816	131	0.010
reproductive structure development	GO:0048608	128	0.010
carboxylic acid metabolic process	GO:0019752	289	0.010
dna methylation or demethylation	GO:0044728	8	0.010
carbohydrate derivative catabolic process	GO:1901136	147	0.010

Guk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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