IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

LOC687856

similar to Myeloid cell surface antigen CD33 precursor (Siglec-3)

RGD: 1596247
Entrez: 687856

Process Predictions
Disease Predictions

LOC687856 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
immune system process	GO:0002376	204	0.314
immune response	GO:0006955	104	0.198
cell activation	GO:0001775	97	0.166
defense response	GO:0006952	194	0.162
positive regulation of signaling	GO:0023056	270	0.145
intracellular signal transduction	GO:0035556	314	0.140
positive regulation of cell communication	GO:0010647	271	0.137
cellular ion homeostasis	GO:0006873	184	0.125
positive regulation of response to stimulus	GO:0048584	285	0.124
cellular response to external stimulus	GO:0071496	118	0.120
cation homeostasis	GO:0055080	195	0.113
cell migration	GO:0016477	197	0.105
regulation of signal transduction	GO:0009966	318	0.104
divalent inorganic cation homeostasis	GO:0072507	165	0.100
regulation of immune system process	GO:0002682	123	0.099
calcium ion homeostasis	GO:0055074	162	0.096
positive regulation of multicellular organismal process	GO:0051240	387	0.090
positive regulation of transport	GO:0051050	245	0.084
response to bacterium	GO:0009617	200	0.077
positive regulation of transcription factor import into nucleus	GO:0042993	4	0.077
protein phosphorylation	GO:0006468	345	0.077
protein transport	GO:0015031	132	0.074
regulation of cellular amino acid metabolic process	GO:0006521	2	0.074
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.073
response to extracellular stimulus	GO:0009991	380	0.069
response to biotic stimulus	GO:0009607	226	0.065
regulation of multicellular organismal development	GO:2000026	376	0.065
establishment of protein localization	GO:0045184	141	0.064
positive regulation of signal transduction	GO:0009967	175	0.063
positive regulation of molecular function	GO:0044093	230	0.062
regulation of phosphorus metabolic process	GO:0051174	349	0.058
regulation of phosphate metabolic process	GO:0019220	349	0.058
positive regulation of phosphate metabolic process	GO:0045937	262	0.057
protein localization	GO:0008104	191	0.057
immune response activating signal transduction	GO:0002757	15	0.057
g protein coupled receptor signaling pathway	GO:0007186	242	0.055
regulation of intracellular signal transduction	GO:1902531	218	0.054
cytosolic calcium ion homeostasis	GO:0051480	140	0.054
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.052
cellular response to mechanical stimulus	GO:0071260	48	0.052
leukocyte activation	GO:0045321	76	0.052
cellular cation homeostasis	GO:0030003	180	0.052
cellular calcium ion homeostasis	GO:0006874	160	0.052
cellular homeostasis	GO:0019725	252	0.052
anatomical structure morphogenesis	GO:0009653	298	0.049
positive regulation of phosphorus metabolic process	GO:0010562	262	0.048
metal ion homeostasis	GO:0055065	186	0.048
cellular lipid metabolic process	GO:0044255	208	0.048
positive regulation of protein metabolic process	GO:0051247	178	0.047
negative regulation of amine transport	GO:0051953	24	0.047
mapk cascade	GO:0000165	140	0.046
amine metabolic process	GO:0009308	38	0.046
cellular metal ion homeostasis	GO:0006875	172	0.046
immune response regulating signaling pathway	GO:0002764	19	0.045
cell type specific apoptotic process	GO:0097285	134	0.045
regulation of cytokine production	GO:0001817	56	0.045
cation transport	GO:0006812	382	0.044
response to other organism	GO:0051707	220	0.044
nucleic acid templated transcription	GO:0097659	379	0.044
reactive oxygen species metabolic process	GO:0072593	37	0.043
regulation of system process	GO:0044057	208	0.043
inflammatory response	GO:0006954	150	0.043
regulation of phosphorylation	GO:0042325	248	0.043
regulation of cell development	GO:0060284	263	0.043
rna biosynthetic process	GO:0032774	380	0.043
ion homeostasis	GO:0050801	212	0.043
regulation of cell differentiation	GO:0045595	320	0.042
peptidyl amino acid modification	GO:0018193	126	0.041
reactive nitrogen species metabolic process	GO:2001057	1	0.041
chemical homeostasis	GO:0048878	292	0.041
peptidyl tyrosine modification	GO:0018212	72	0.041
positive regulation of phosphorylation	GO:0042327	177	0.041
positive regulation of cellular protein metabolic process	GO:0032270	167	0.040
oxoacid metabolic process	GO:0043436	290	0.040
cytokine production	GO:0001816	61	0.039
regulation of cellular amine metabolic process	GO:0033238	8	0.039
organic acid metabolic process	GO:0006082	292	0.039
locomotion	GO:0040011	237	0.039
homeostatic process	GO:0042592	331	0.039
positive regulation of cellular amine metabolic process	GO:0033240	3	0.038
response to external biotic stimulus	GO:0043207	221	0.038
nitrogen compound transport	GO:0071705	229	0.037
positive regulation of protein phosphorylation	GO:0001934	135	0.037
cellular component biogenesis	GO:0044085	368	0.036
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.036
regulation of catalytic activity	GO:0050790	304	0.035
cellular component assembly	GO:0022607	360	0.035
lymphocyte activation	GO:0046649	43	0.035
regulation of molecular function	GO:0065009	398	0.035
positive regulation of rna biosynthetic process	GO:1902680	197	0.035
cellular response to oxygen containing compound	GO:1901701	386	0.035
regulation of cellular protein metabolic process	GO:0032268	267	0.035
positive regulation of immune system process	GO:0002684	90	0.035
peptidyl tyrosine phosphorylation	GO:0018108	72	0.034
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.034
positive regulation of developmental process	GO:0051094	283	0.033
rna metabolic process	GO:0016070	406	0.033
regulation of transcription dna templated	GO:0006355	374	0.033
cellular component movement	GO:0006928	248	0.033
regulation of immune response	GO:0050776	55	0.033
anion transport	GO:0006820	178	0.032
localization of cell	GO:0051674	202	0.032
regulation of rna biosynthetic process	GO:2001141	381	0.032
regulation of cellular ketone metabolic process	GO:0010565	27	0.032
behavior	GO:0007610	205	0.031
positive regulation of intracellular signal transduction	GO:1902533	138	0.031
regulation of protein metabolic process	GO:0051246	289	0.030
secretion	GO:0046903	307	0.030
cellular amino acid metabolic process	GO:0006520	107	0.030
regulation of rna metabolic process	GO:0051252	391	0.030
regulation of protein phosphorylation	GO:0001932	183	0.030
metal ion transport	GO:0030001	289	0.029
carboxylic acid metabolic process	GO:0019752	289	0.029
positive regulation of mapk cascade	GO:0043410	92	0.029
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.029
regulation of nucleic acid templated transcription	GO:1903506	380	0.029
signal transduction by phosphorylation	GO:0023014	144	0.028
regulation of neurogenesis	GO:0050767	247	0.028
programmed cell death	GO:0012501	392	0.028
cell motility	GO:0048870	202	0.028
positive regulation of cell motility	GO:2000147	97	0.027
positive regulation of transcription dna templated	GO:0045893	197	0.027
female pregnancy	GO:0007565	122	0.027
cellular response to abiotic stimulus	GO:0071214	85	0.027
myeloid leukocyte activation	GO:0002274	36	0.027
regulation of cell projection organization	GO:0031344	175	0.026
neuron differentiation	GO:0030182	368	0.026
protein complex biogenesis	GO:0070271	263	0.026
neuron development	GO:0048666	286	0.026
negative regulation of apoptotic process	GO:0043066	181	0.026
leukocyte cell cell adhesion	GO:0007159	4	0.026
cell projection organization	GO:0030030	302	0.026
response to molecule of bacterial origin	GO:0002237	194	0.026
organic anion transport	GO:0015711	132	0.026
positive regulation of cytokine production	GO:0001819	42	0.025
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.025
protein complex subunit organization	GO:0071822	302	0.025
positive regulation of interferon gamma production	GO:0032729	2	0.025
response to mechanical stimulus	GO:0009612	134	0.025
cellular protein localization	GO:0034613	122	0.025
central nervous system development	GO:0007417	311	0.025
regulation of protein modification process	GO:0031399	194	0.024
apoptotic process	GO:0006915	381	0.024
regulation of response to stress	GO:0080134	126	0.024
response to oxygen levels	GO:0070482	265	0.024
negative regulation of programmed cell death	GO:0043069	183	0.023
cellular ketone metabolic process	GO:0042180	51	0.023
response to corticosteroid	GO:0031960	235	0.023
regulation of defense response	GO:0031347	68	0.023
cellular response to lipid	GO:0071396	201	0.023
positive regulation of cellular biosynthetic process	GO:0031328	295	0.023
response to nutrient	GO:0007584	248	0.022
regulation of secretion	GO:0051046	224	0.022
cellular chemical homeostasis	GO:0055082	247	0.022
transcription dna templated	GO:0006351	377	0.022
regulation of anatomical structure morphogenesis	GO:0022603	141	0.022
cellular amine metabolic process	GO:0044106	38	0.022
positive regulation of cell differentiation	GO:0045597	217	0.022
neurological system process	GO:0050877	219	0.022
regulation of secretion by cell	GO:1903530	208	0.022
regulation of kinase activity	GO:0043549	117	0.022
amine transport	GO:0015837	57	0.022
regulation of calcium ion transport	GO:0051924	77	0.022
carbohydrate derivative metabolic process	GO:1901135	346	0.022
positive regulation of cell development	GO:0010720	176	0.022
muscle contraction	GO:0006936	88	0.021
positive regulation of cell death	GO:0010942	184	0.021
macromolecule localization	GO:0033036	252	0.021
peptide transport	GO:0015833	97	0.021
positive regulation of programmed cell death	GO:0043068	157	0.021
organophosphate metabolic process	GO:0019637	370	0.021
secretion by cell	GO:0032940	248	0.021
brain development	GO:0007420	247	0.021
response to lipopolysaccharide	GO:0032496	191	0.021
positive regulation of immune response	GO:0050778	42	0.020
macromolecular complex subunit organization	GO:0043933	339	0.020
positive regulation of protein modification process	GO:0031401	142	0.020
regulation of mapk cascade	GO:0043408	116	0.020
regulation of locomotion	GO:0040012	148	0.020
single organism catabolic process	GO:0044712	283	0.020
cell adhesion	GO:0007155	110	0.020
negative regulation of neuron differentiation	GO:0045665	62	0.020
response to ethanol	GO:0045471	162	0.019
guanosine containing compound metabolic process	GO:1901068	74	0.019
regulation of protein targeting	GO:1903533	28	0.019
regulation of apoptotic process	GO:0042981	335	0.019
negative regulation of cell differentiation	GO:0045596	99	0.019
negative regulation of developmental process	GO:0051093	125	0.019
myeloid leukocyte differentiation	GO:0002573	20	0.019
regulation of neuron differentiation	GO:0045664	208	0.019
sensory perception	GO:0007600	101	0.019
negative regulation of neurogenesis	GO:0050768	78	0.019
regulation of cellular component organization	GO:0051128	368	0.018
response to monosaccharide	GO:0034284	159	0.018
cytoplasmic transport	GO:0016482	115	0.018
positive regulation of protein kinase activity	GO:0045860	73	0.018
response to cytokine	GO:0034097	215	0.018
response to estradiol	GO:0032355	164	0.018
organic substance catabolic process	GO:1901575	316	0.018
innate immune response activating signal transduction	GO:0002758	9	0.018
regulation of peptide transport	GO:0090087	87	0.018
negative regulation of multicellular organismal process	GO:0051241	203	0.018
regulation of establishment of protein localization	GO:0070201	69	0.018
macromolecular complex assembly	GO:0065003	273	0.018
response to wounding	GO:0009611	254	0.018
intracellular transport	GO:0046907	185	0.018
catabolic process	GO:0009056	351	0.018
reactive oxygen species biosynthetic process	GO:1903409	8	0.018
regulation of nervous system development	GO:0051960	264	0.018
regulation of programmed cell death	GO:0043067	341	0.018
positive regulation of cytokine biosynthetic process	GO:0042108	1	0.018
ras protein signal transduction	GO:0007265	29	0.018
head development	GO:0060322	247	0.018
divalent metal ion transport	GO:0070838	132	0.017
nucleoside metabolic process	GO:0009116	179	0.017
regulation of cellular localization	GO:0060341	263	0.017
regulation of transferase activity	GO:0051338	123	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.017
granulocyte migration	GO:0097530	16	0.017
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.017
regulation of ion transport	GO:0043269	245	0.017
amide transport	GO:0042886	105	0.017
oxidation reduction process	GO:0055114	304	0.017
positive regulation of nervous system development	GO:0051962	178	0.017
positive regulation of biosynthetic process	GO:0009891	319	0.017
neuron projection development	GO:0031175	273	0.017
transmembrane transport	GO:0055085	412	0.016
leukocyte migration	GO:0050900	38	0.016
gtp catabolic process	GO:0006184	71	0.016
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.016
positive regulation of rna metabolic process	GO:0051254	203	0.016
positive regulation of locomotion	GO:0040017	102	0.016
single organism nuclear import	GO:1902593	35	0.016
regulation of behavior	GO:0050795	61	0.016
intracellular protein transport	GO:0006886	79	0.016
negative regulation of response to stimulus	GO:0048585	155	0.016
small gtpase mediated signal transduction	GO:0007264	36	0.016
positive regulation of catalytic activity	GO:0043085	184	0.016
carboxylic acid transport	GO:0046942	115	0.016
gliogenesis	GO:0042063	93	0.016
positive regulation of secretion	GO:0051047	140	0.016
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.016
negative regulation of nervous system development	GO:0051961	79	0.016
single organism cellular localization	GO:1902580	102	0.016
positive regulation of defense response	GO:0031349	37	0.016
positive regulation of intracellular transport	GO:0032388	39	0.016
purine containing compound metabolic process	GO:0072521	253	0.015
response to carbohydrate	GO:0009743	183	0.015
regulation of neuron projection development	GO:0010975	161	0.015
endocytosis	GO:0006897	84	0.015
single organism intracellular transport	GO:1902582	166	0.015
protein complex assembly	GO:0006461	263	0.015
regulation of amine transport	GO:0051952	54	0.015
heterocycle catabolic process	GO:0046700	167	0.015
regulation of cell migration	GO:0030334	128	0.015
organonitrogen compound catabolic process	GO:1901565	179	0.015
protein targeting	GO:0006605	61	0.015
positive regulation of transferase activity	GO:0051347	81	0.015
cytokine biosynthetic process	GO:0042089	3	0.015
positive regulation of gene expression	GO:0010628	244	0.015
regulation of nucleocytoplasmic transport	GO:0046822	28	0.015
positive regulation of response to external stimulus	GO:0032103	51	0.015
regulation of response to external stimulus	GO:0032101	106	0.015
organic acid transport	GO:0015849	116	0.015
positive regulation of neurogenesis	GO:0050769	165	0.014
positive regulation of ion transport	GO:0043270	94	0.014
signal release	GO:0023061	145	0.014
response to vitamin	GO:0033273	131	0.014
negative regulation of cell development	GO:0010721	82	0.014
maternal process involved in female pregnancy	GO:0060135	38	0.014
calcium ion transport	GO:0006816	131	0.014
receptor mediated endocytosis	GO:0006898	42	0.014
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.014
icosanoid metabolic process	GO:0006690	38	0.014
cellular macromolecule localization	GO:0070727	122	0.014
response to decreased oxygen levels	GO:0036293	237	0.014
multicellular organism reproduction	GO:0032504	233	0.014
protein oligomerization	GO:0051259	191	0.014
salivary gland development	GO:0007431	3	0.014
lymphocyte activation involved in immune response	GO:0002285	3	0.014
response to hypoxia	GO:0001666	231	0.013
regulation of mast cell activation	GO:0033003	9	0.013
multicellular organismal homeostasis	GO:0048871	49	0.013
cellular catabolic process	GO:0044248	295	0.013
regulation of cytokine biosynthetic process	GO:0042035	3	0.013
positive regulation of secretion by cell	GO:1903532	128	0.013
nucleobase containing small molecule metabolic process	GO:0055086	316	0.013
regulation of anatomical structure size	GO:0090066	135	0.013
developmental process involved in reproduction	GO:0003006	159	0.013
lipid storage	GO:0019915	1	0.013
negative regulation of cell death	GO:0060548	229	0.013
sequestering of calcium ion	GO:0051208	8	0.013
vesicle mediated transport	GO:0016192	181	0.013
positive regulation of cellular component movement	GO:0051272	102	0.013
cardiovascular system development	GO:0072358	134	0.013
defense response to gram negative bacterium	GO:0050829	3	0.012
immunoglobulin mediated immune response	GO:0016064	4	0.012
cell cell signaling	GO:0007267	335	0.012
sequestering of metal ion	GO:0051238	9	0.012
cellular response to lipopolysaccharide	GO:0071222	55	0.012
response to nutrient levels	GO:0031667	370	0.012
muscle system process	GO:0003012	115	0.012
protein heterooligomerization	GO:0051291	89	0.012
cellular nitrogen compound catabolic process	GO:0044270	163	0.012
regulation of cell proliferation	GO:0042127	359	0.012
regulation of interferon gamma production	GO:0032649	3	0.012
nucleoside phosphate metabolic process	GO:0006753	283	0.012
response to alkaloid	GO:0043279	132	0.012
immune response regulating cell surface receptor signaling pathway	GO:0002768	10	0.012
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.012
learning or memory	GO:0007611	90	0.012
regulation of membrane potential	GO:0042391	110	0.012
cellular response to acid chemical	GO:0071229	75	0.012
establishment of protein localization to organelle	GO:0072594	44	0.012
positive regulation of neuron differentiation	GO:0045666	126	0.012
reproductive process	GO:0022414	372	0.012
nucleoside catabolic process	GO:0009164	126	0.012
sensory perception of pain	GO:0019233	73	0.012
negative regulation of response to tumor cell	GO:0002835	2	0.012
regulation of protein import into nucleus	GO:0042306	24	0.011
cellular response to growth factor stimulus	GO:0071363	162	0.011
positive regulation of reactive oxygen species metabolic process	GO:2000379	16	0.011
positive regulation of cellular component organization	GO:0051130	200	0.011
regulation of protein kinase activity	GO:0045859	105	0.011
regulation of protein serine threonine kinase activity	GO:0071900	64	0.011
negative regulation of metabolic process	GO:0009892	331	0.011
positive regulation of cell projection organization	GO:0031346	111	0.011
positive regulation of cell migration	GO:0030335	96	0.011
positive regulation of angiogenesis	GO:0045766	28	0.011
regulation of intracellular transport	GO:0032386	65	0.011
nucleotide catabolic process	GO:0009166	139	0.011
multicellular organismal signaling	GO:0035637	44	0.011
endoplasmic reticulum to cytosol transport	GO:1903513	4	0.011
microglial cell activation	GO:0001774	14	0.011
regulation of protein localization	GO:0032880	81	0.011
maintenance of location	GO:0051235	17	0.011
cellular response to biotic stimulus	GO:0071216	59	0.011
glycosyl compound metabolic process	GO:1901657	182	0.011
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.011
purine nucleotide metabolic process	GO:0006163	229	0.011
nucleotide metabolic process	GO:0009117	279	0.011
positive regulation of protein localization to nucleus	GO:1900182	15	0.011
cellular response to nitrogen compound	GO:1901699	210	0.011
nucleoside triphosphate metabolic process	GO:0009141	144	0.011
regulation of cell activation	GO:0050865	50	0.011
regulation of smooth muscle cell proliferation	GO:0048660	75	0.010
single organism reproductive process	GO:0044702	297	0.010
monocarboxylic acid metabolic process	GO:0032787	152	0.010
regulation of smooth muscle contraction	GO:0006940	29	0.010
negative regulation of transport	GO:0051051	136	0.010
response to inorganic substance	GO:0010035	377	0.010
response to acid chemical	GO:0001101	222	0.010
negative regulation of innate immune response	GO:0045824	4	0.010
multicellular organismal reproductive process	GO:0048609	233	0.010
lipid metabolic process	GO:0006629	283	0.010
regulation of leukocyte activation	GO:0002694	45	0.010
response to glucose	GO:0009749	136	0.010
regulation of neuron death	GO:1901214	115	0.010
protein localization to organelle	GO:0033365	57	0.010
leukocyte activation involved in immune response	GO:0002366	16	0.010
multicellular organism growth	GO:0035264	1	0.010
positive regulation of apoptotic process	GO:0043065	154	0.010
nucleoside triphosphate catabolic process	GO:0009143	123	0.010

LOC687856 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.022
disease of cellular proliferation	DOID:14566	0.022
organ system cancer	DOID:0050686	0.019
gastrointestinal system cancer	DOID:3119	0.019
intestinal cancer	DOID:10155	0.012
large intestine cancer	DOID:5672	0.012
colorectal cancer	DOID:9256	0.012
colon cancer	DOID:219	0.012

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