IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Fat4

FAT tumor suppressor homolog 4 (Drosophila)

(Aliases: RGD1564291)

RGD: 1564291
Entrez: 310341
Ensembl: ENSRNOG00000028335

Process Predictions
Disease Predictions

Fat4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
regulation of nucleic acid templated transcription	GO:1903506	380	0.101
nucleic acid templated transcription	GO:0097659	379	0.100
regulation of programmed cell death	GO:0043067	341	0.095
regulation of rna biosynthetic process	GO:2001141	381	0.077
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.077
rna biosynthetic process	GO:0032774	380	0.077
apoptotic process	GO:0006915	381	0.076
regulation of transcription dna templated	GO:0006355	374	0.073
rna metabolic process	GO:0016070	406	0.070
positive regulation of biosynthetic process	GO:0009891	319	0.063
transcription dna templated	GO:0006351	377	0.063
positive regulation of gene expression	GO:0010628	244	0.059
regulation of rna metabolic process	GO:0051252	391	0.058
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.057
regulation of apoptotic process	GO:0042981	335	0.057
organic acid metabolic process	GO:0006082	292	0.056
oxoacid metabolic process	GO:0043436	290	0.054
regulation of cellular component organization	GO:0051128	368	0.053
anatomical structure morphogenesis	GO:0009653	298	0.053
cellular response to oxygen containing compound	GO:1901701	386	0.051
cellular component movement	GO:0006928	248	0.050
regulation of phosphorylation	GO:0042325	248	0.049
neuron development	GO:0048666	286	0.047
tissue development	GO:0009888	252	0.047
regulation of cell proliferation	GO:0042127	359	0.046
regulation of multicellular organismal development	GO:2000026	376	0.046
programmed cell death	GO:0012501	392	0.045
response to peptide hormone	GO:0043434	278	0.045
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.044
reproductive process	GO:0022414	372	0.043
protein phosphorylation	GO:0006468	345	0.042
regulation of canonical wnt signaling pathway	GO:0060828	4	0.041
regulation of phosphate metabolic process	GO:0019220	349	0.041
neuron differentiation	GO:0030182	368	0.040
cellular amino acid metabolic process	GO:0006520	107	0.040
intracellular signal transduction	GO:0035556	314	0.040
head development	GO:0060322	247	0.039
response to extracellular stimulus	GO:0009991	380	0.038
homeostatic process	GO:0042592	331	0.038
behavior	GO:0007610	205	0.038
macromolecule localization	GO:0033036	252	0.037
positive regulation of response to stimulus	GO:0048584	285	0.037
cellular response to growth factor stimulus	GO:0071363	162	0.037
regulation of cellular protein metabolic process	GO:0032268	267	0.036
regulation of cell differentiation	GO:0045595	320	0.036
cellular macromolecule localization	GO:0070727	122	0.035
positive regulation of rna metabolic process	GO:0051254	203	0.035
cellular response to lipid	GO:0071396	201	0.035
response to decreased oxygen levels	GO:0036293	237	0.035
non canonical wnt signaling pathway	GO:0035567	3	0.035
regulation of anatomical structure morphogenesis	GO:0022603	141	0.035
cell cell signaling	GO:0007267	335	0.035
regulation of cellular localization	GO:0060341	263	0.034
negative regulation of response to stimulus	GO:0048585	155	0.034
cell projection organization	GO:0030030	302	0.033
regulation of system process	GO:0044057	208	0.033
regulation of cellular amine metabolic process	GO:0033238	8	0.033
positive regulation of cellular biosynthetic process	GO:0031328	295	0.033
cell type specific apoptotic process	GO:0097285	134	0.033
response to hypoxia	GO:0001666	231	0.033
negative regulation of signaling	GO:0023057	157	0.033
regulation of protein phosphorylation	GO:0001932	183	0.033
response to estrogen	GO:0043627	232	0.033
regulation of protein metabolic process	GO:0051246	289	0.032
positive regulation of multicellular organismal process	GO:0051240	387	0.032
regulation of nervous system development	GO:0051960	264	0.032
cellular component assembly	GO:0022607	360	0.032
cellular component biogenesis	GO:0044085	368	0.032
carboxylic acid metabolic process	GO:0019752	289	0.032
brain development	GO:0007420	247	0.031
organelle organization	GO:0006996	266	0.031
response to acid chemical	GO:0001101	222	0.031
negative regulation of cellular metabolic process	GO:0031324	281	0.031
carbohydrate derivative metabolic process	GO:1901135	346	0.031
single organism biosynthetic process	GO:0044711	342	0.031
chemical homeostasis	GO:0048878	292	0.030
motor neuron axon guidance	GO:0008045	1	0.030
positive regulation of transcription dna templated	GO:0045893	197	0.030
positive regulation of developmental process	GO:0051094	283	0.030
neuron projection development	GO:0031175	273	0.030
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.030
response to growth factor	GO:0070848	189	0.030
regulation of neuron differentiation	GO:0045664	208	0.029
positive regulation of rna biosynthetic process	GO:1902680	197	0.029
amine metabolic process	GO:0009308	38	0.029
response to nutrient	GO:0007584	248	0.028
gland development	GO:0048732	155	0.028
cellular amine metabolic process	GO:0044106	38	0.028
single organism reproductive process	GO:0044702	297	0.028
positive regulation of signaling	GO:0023056	270	0.028
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.028
cell morphogenesis	GO:0000902	142	0.027
regulation of molecular function	GO:0065009	398	0.027
regulation of phosphorus metabolic process	GO:0051174	349	0.027
regulation of cellular ketone metabolic process	GO:0010565	27	0.027
regulation of cell development	GO:0060284	263	0.026
cellular ketone metabolic process	GO:0042180	51	0.026
response to oxygen levels	GO:0070482	265	0.026
response to nutrient levels	GO:0031667	370	0.026
ossification	GO:0001503	70	0.026
negative regulation of cell death	GO:0060548	229	0.026
negative regulation of cell communication	GO:0010648	158	0.025
regulation of cellular amino acid metabolic process	GO:0006521	2	0.025
positive regulation of cell proliferation	GO:0008284	249	0.025
muscle structure development	GO:0061061	87	0.024
cellular response to endogenous stimulus	GO:0071495	377	0.024
positive regulation of molecular function	GO:0044093	230	0.024
multicellular organism reproduction	GO:0032504	233	0.024
cellular protein localization	GO:0034613	122	0.024
cell projection morphogenesis	GO:0048858	123	0.024
cell growth	GO:0016049	104	0.023
response to peptide	GO:1901652	292	0.023
cardiovascular system development	GO:0072358	134	0.023
blood circulation	GO:0008015	183	0.022
cellular response to stress	GO:0033554	269	0.022
negative regulation of multicellular organismal process	GO:0051241	203	0.022
positive regulation of cellular amine metabolic process	GO:0033240	3	0.022
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.022
negative regulation of metabolic process	GO:0009892	331	0.022
response to corticosteroid	GO:0031960	235	0.022
intracellular transport	GO:0046907	185	0.022
negative regulation of gene expression	GO:0010629	199	0.022
positive regulation of phosphate metabolic process	GO:0045937	262	0.022
cellular cation homeostasis	GO:0030003	180	0.021
positive regulation of protein metabolic process	GO:0051247	178	0.021
regulation of catalytic activity	GO:0050790	304	0.021
cellular response to organic cyclic compound	GO:0071407	202	0.021
central nervous system development	GO:0007417	311	0.021
regulation of cell projection organization	GO:0031344	175	0.021
developmental process involved in reproduction	GO:0003006	159	0.021
regulation of locomotion	GO:0040012	148	0.021
single organism intracellular transport	GO:1902582	166	0.021
secretion	GO:0046903	307	0.021
muscle system process	GO:0003012	115	0.021
catabolic process	GO:0009056	351	0.021
negative regulation of macromolecule metabolic process	GO:0010605	260	0.020
multi organism reproductive process	GO:0044703	262	0.020
regulation of cellular component movement	GO:0051270	150	0.020
negative regulation of cell development	GO:0010721	82	0.020
positive regulation of phosphorylation	GO:0042327	177	0.020
protein transport	GO:0015031	132	0.020
neuron projection morphogenesis	GO:0048812	122	0.020
cellular catabolic process	GO:0044248	295	0.020
cellular response to acid chemical	GO:0071229	75	0.019
taxis	GO:0042330	67	0.019
macromolecular complex assembly	GO:0065003	273	0.019
mapk cascade	GO:0000165	140	0.019
female pregnancy	GO:0007565	122	0.019
circulatory system development	GO:0072359	134	0.019
positive regulation of catalytic activity	GO:0043085	184	0.019
cellular homeostasis	GO:0019725	252	0.019
positive regulation of cell differentiation	GO:0045597	217	0.019
multicellular organismal reproductive process	GO:0048609	233	0.019
response to inorganic substance	GO:0010035	377	0.019
growth	GO:0040007	165	0.019
response to glucocorticoid	GO:0051384	223	0.018
salivary gland development	GO:0007431	3	0.018
cellular ion homeostasis	GO:0006873	184	0.018
neuron apoptotic process	GO:0051402	88	0.018
regulation of response to stress	GO:0080134	126	0.018
macromolecular complex subunit organization	GO:0043933	339	0.018
cellular component morphogenesis	GO:0032989	155	0.018
circulatory system process	GO:0003013	183	0.018
lipid metabolic process	GO:0006629	283	0.018
cell morphogenesis involved in differentiation	GO:0000904	119	0.018
regulation of protein modification process	GO:0031399	194	0.018
nucleobase containing small molecule metabolic process	GO:0055086	316	0.017
response to wounding	GO:0009611	254	0.017
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.017
cation homeostasis	GO:0055080	195	0.017
cellular response to nitrogen compound	GO:1901699	210	0.017
positive regulation of phosphorus metabolic process	GO:0010562	262	0.017
multi multicellular organism process	GO:0044706	138	0.017
regulation of neurogenesis	GO:0050767	247	0.017
regulation of transferase activity	GO:0051338	123	0.017
single organism catabolic process	GO:0044712	283	0.017
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.017
single organism cellular localization	GO:1902580	102	0.017
protein complex subunit organization	GO:0071822	302	0.017
response to carbohydrate	GO:0009743	183	0.017
cellular chemical homeostasis	GO:0055082	247	0.017
response to retinoic acid	GO:0032526	63	0.017
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.017
positive regulation of programmed cell death	GO:0043068	157	0.016
regulation of growth	GO:0040008	105	0.016
locomotion	GO:0040011	237	0.016
positive regulation of cellular protein metabolic process	GO:0032270	167	0.016
regulation of intracellular signal transduction	GO:1902531	218	0.016
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.016
gastrulation	GO:0007369	2	0.016
positive regulation of apoptotic process	GO:0043065	154	0.016
negative regulation of protein metabolic process	GO:0051248	114	0.016
divalent inorganic cation homeostasis	GO:0072507	165	0.016
neurological system process	GO:0050877	219	0.016
ribose phosphate metabolic process	GO:0019693	235	0.016
negative regulation of canonical wnt signaling pathway	GO:0090090	4	0.016
rhythmic process	GO:0048511	156	0.015
protein localization	GO:0008104	191	0.015
defense response	GO:0006952	194	0.015
axis specification	GO:0009798	4	0.015
protein oligomerization	GO:0051259	191	0.015
small gtpase mediated signal transduction	GO:0007264	36	0.015
anterior posterior pattern specification	GO:0009952	1	0.015
protein complex assembly	GO:0006461	263	0.015
positive regulation of cellular component organization	GO:0051130	200	0.015
regulation of cell growth	GO:0001558	85	0.015
cellular response to hormone stimulus	GO:0032870	247	0.015
negative regulation of rna biosynthetic process	GO:1902679	118	0.015
regulation of signal transduction	GO:0009966	318	0.015
positive regulation of neurogenesis	GO:0050769	165	0.015
positive regulation of cell communication	GO:0010647	271	0.015
dendrite development	GO:0016358	72	0.015
regulation of blood circulation	GO:1903522	110	0.015
cell part morphogenesis	GO:0032990	123	0.015
calcium ion homeostasis	GO:0055074	162	0.015
cellular calcium ion homeostasis	GO:0006874	160	0.015
nucleotide metabolic process	GO:0009117	279	0.015
proteolysis	GO:0006508	175	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.015
positive regulation of cell death	GO:0010942	184	0.015
positive regulation of signal transduction	GO:0009967	175	0.015
negative regulation of cell proliferation	GO:0008285	119	0.015
negative regulation of apoptotic process	GO:0043066	181	0.015
localization of cell	GO:0051674	202	0.015
response to estradiol	GO:0032355	164	0.014
regulation of catabolic process	GO:0009894	113	0.014
protein complex biogenesis	GO:0070271	263	0.014
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.014
regulation of homeostatic process	GO:0032844	101	0.014
nucleobase containing compound catabolic process	GO:0034655	152	0.014
ribonucleotide metabolic process	GO:0009259	231	0.014
positive regulation of cell development	GO:0010720	176	0.014
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.014
regulation of cell morphogenesis	GO:0022604	77	0.014
negative regulation of signal transduction	GO:0009968	83	0.014
regulation of stem cell differentiation	GO:2000736	2	0.014
cytosolic calcium ion homeostasis	GO:0051480	140	0.014
eye morphogenesis	GO:0048592	4	0.014
negative regulation of phosphate metabolic process	GO:0045936	80	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.014
cell cycle	GO:0007049	101	0.014
cell migration	GO:0016477	197	0.013
regulation of mapk cascade	GO:0043408	116	0.013
reproduction	GO:0000003	245	0.013
regulation of neuron apoptotic process	GO:0043523	83	0.013
maintenance of location	GO:0051235	17	0.013
metal ion homeostasis	GO:0055065	186	0.013
organonitrogen compound biosynthetic process	GO:1901566	167	0.013
reproductive structure development	GO:0048608	128	0.013
secretion by cell	GO:0032940	248	0.013
salivary gland morphogenesis	GO:0007435	1	0.013
regulation of secretion by cell	GO:1903530	208	0.013
negative regulation of cellular component organization	GO:0051129	83	0.013
transcription from rna polymerase ii promoter	GO:0006366	252	0.013
negative regulation of cellular biosynthetic process	GO:0031327	161	0.013
positive regulation of protein modification process	GO:0031401	142	0.013
organic cyclic compound catabolic process	GO:1901361	175	0.013
establishment of protein localization	GO:0045184	141	0.013
vasculature development	GO:0001944	70	0.013
regulation of proteasomal protein catabolic process	GO:0061136	4	0.013
organ morphogenesis	GO:0009887	75	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.013
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.013
nucleotide catabolic process	GO:0009166	139	0.013
purine nucleotide metabolic process	GO:0006163	229	0.013
positive regulation of protein phosphorylation	GO:0001934	135	0.013
heart contraction	GO:0060047	57	0.013
negative regulation of phosphorus metabolic process	GO:0010563	80	0.012
cellular response to organonitrogen compound	GO:0071417	197	0.012
angiogenesis	GO:0001525	53	0.012
regulation of cell cycle	GO:0051726	73	0.012
positive regulation of neuron differentiation	GO:0045666	126	0.012
response to insulin	GO:0032868	133	0.012
carbohydrate derivative biosynthetic process	GO:1901137	124	0.012
regulation of protein kinase activity	GO:0045859	105	0.012
negative regulation of developmental process	GO:0051093	125	0.012
epithelium development	GO:0060429	96	0.012
positive regulation of neuron projection development	GO:0010976	99	0.012
ion homeostasis	GO:0050801	212	0.012
axon development	GO:0061564	96	0.012
vesicle mediated transport	GO:0016192	181	0.012
positive regulation of nervous system development	GO:0051962	178	0.012
positive regulation of endothelial cell migration	GO:0010595	4	0.012
regulation of protein transport	GO:0051223	68	0.012
developmental growth	GO:0048589	100	0.012
retinal ganglion cell axon guidance	GO:0031290	1	0.012
regulation of neuron projection development	GO:0010975	161	0.012
regulation of cell motility	GO:2000145	131	0.012
blood vessel development	GO:0001568	69	0.012
nucleoside phosphate metabolic process	GO:0006753	283	0.012
regulation of protein localization	GO:0032880	81	0.012
organophosphate metabolic process	GO:0019637	370	0.012
negative regulation of programmed cell death	GO:0043069	183	0.011
single organism organelle organization	GO:1902589	180	0.011
response to cytokine	GO:0034097	215	0.011
positive regulation of intracellular signal transduction	GO:1902533	138	0.011
protein localization to organelle	GO:0033365	57	0.011
regulation of anatomical structure size	GO:0090066	135	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.011
regulation of neuron death	GO:1901214	115	0.011
intracellular protein transport	GO:0006886	79	0.011
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.011
embryonic pattern specification	GO:0009880	1	0.011
small molecule biosynthetic process	GO:0044283	124	0.011
regulation of establishment of protein localization	GO:0070201	69	0.011
negative regulation of biosynthetic process	GO:0009890	168	0.011
establishment of tissue polarity	GO:0007164	2	0.011
negative regulation of transport	GO:0051051	136	0.011
purine nucleotide catabolic process	GO:0006195	136	0.011
regulation of kinase activity	GO:0043549	117	0.011
cellular response to peptide	GO:1901653	133	0.011
regulation of fat cell differentiation	GO:0045598	3	0.011
purine ribonucleotide metabolic process	GO:0009150	227	0.011
multicellular organismal signaling	GO:0035637	44	0.011
regulation of response to external stimulus	GO:0032101	106	0.011
negative regulation of transcription dna templated	GO:0045892	116	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.011
neuron death	GO:0070997	127	0.011
ras protein signal transduction	GO:0007265	29	0.011
cell adhesion	GO:0007155	110	0.011
cytoplasmic transport	GO:0016482	115	0.011
action potential	GO:0001508	54	0.011
regulation of membrane potential	GO:0042391	110	0.011
response to vitamin	GO:0033273	131	0.011
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.011
response to purine containing compound	GO:0014074	126	0.010
aging	GO:0007568	241	0.010
response to organophosphorus	GO:0046683	102	0.010
cellular metal ion homeostasis	GO:0006875	172	0.010
immune system process	GO:0002376	204	0.010
negative regulation of cell differentiation	GO:0045596	99	0.010
regulation of ossification	GO:0030278	32	0.010
negative regulation of neuron differentiation	GO:0045665	62	0.010
g protein coupled receptor signaling pathway	GO:0007186	242	0.010
negative regulation of neurogenesis	GO:0050768	78	0.010
positive regulation of cellular component movement	GO:0051272	102	0.010
regulation of cellular catabolic process	GO:0031329	101	0.010
nitrogen compound transport	GO:0071705	229	0.010
oxidation reduction process	GO:0055114	304	0.010
purine containing compound catabolic process	GO:0072523	138	0.010
response to metal ion	GO:0010038	253	0.010
carbohydrate derivative catabolic process	GO:1901136	147	0.010
response to mechanical stimulus	GO:0009612	134	0.010
purine ribonucleotide catabolic process	GO:0009154	136	0.010
cation transport	GO:0006812	382	0.010
heart morphogenesis	GO:0003007	3	0.010
sex differentiation	GO:0007548	113	0.010
regulation of hormone levels	GO:0010817	187	0.010
negative regulation of molecular function	GO:0044092	133	0.010

Fat4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.018
nervous system disease	DOID:863	0.018
disease of cellular proliferation	DOID:14566	0.011
muscular disease	DOID:0080000	0.010
musculoskeletal system disease	DOID:17	0.010

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