Rattus norvegicus

13 known processes

Pf4

platelet factor 4

(Aliases: RATPF4A,Pf4a,Cxcl4,PF-4)

Pf4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
programmed cell deathGO:00125013920.420
Human
response to bacteriumGO:00096172000.299
Rat
response to molecule of bacterial originGO:00022371940.298
Rat
organophosphate metabolic processGO:00196373700.285
Human
defense responseGO:00069521940.202
Rat
response to lipopolysaccharideGO:00324961910.196
Rat
anatomical structure morphogenesisGO:00096532980.193
Human Rat
positive regulation of signalingGO:00230562700.151
Human Rat
nucleic acid templated transcriptionGO:00976593790.150
Human
response to nutrient levelsGO:00316673700.145
Rat
circulatory system developmentGO:00723591340.144
Human Rat
positive regulation of cell proliferationGO:00082842490.140
Rat
regulation of signal transductionGO:00099663180.125
Human Rat
cellular response to stressGO:00335542690.123
Rat
regulation of rna biosynthetic processGO:20011413810.120
Human
calcium ion homeostasisGO:00550741620.120
Rat
homeostatic processGO:00425923310.119
Rat
positive regulation of response to stimulusGO:00485842850.118
Human Rat
intracellular signal transductionGO:00355563140.117
Human Rat
wound healingGO:00420601220.113
Human Rat
positive regulation of cell differentiationGO:00455972170.112
Human Rat
positive regulation of multicellular organismal processGO:00512403870.101
Human Rat
chemical homeostasisGO:00488782920.100
Rat
rna biosynthetic processGO:00327743800.099
Human
cellular component biogenesisGO:00440853680.098
cellular response to oxygen containing compoundGO:19017013860.095
Rat
response to ethanolGO:00454711620.094
inorganic cation transmembrane transportGO:00986622020.094
carbohydrate derivative metabolic processGO:19011353460.093
Human
locomotionGO:00400112370.091
Human Rat
positive regulation of cellular biosynthetic processGO:00313282950.087
Human
rna metabolic processGO:00160704060.086
Human
single organism biosynthetic processGO:00447113420.085
regulation of multicellular organismal developmentGO:20000263760.083
Human Rat
response to glucocorticoidGO:00513842230.083
Rat
regulation of cell differentiationGO:00455953200.081
Human Rat
regulation of rna metabolic processGO:00512523910.080
Human
negative regulation of cellular biosynthetic processGO:00313271610.079
cellular homeostasisGO:00197252520.073
Rat
cell activationGO:0001775970.072
Human
cell migrationGO:00164771970.072
Human Rat
positive regulation of signal transductionGO:00099671750.069
Human Rat
tissue developmentGO:00098882520.068
transcription dna templatedGO:00063513770.067
Human
response to woundingGO:00096112540.067
Human Rat
g protein coupled receptor signaling pathwayGO:00071862420.066
ion transmembrane transportGO:00342203650.064
carboxylic acid transportGO:00469421150.063
organic acid transportGO:00158491160.062
cellular metal ion homeostasisGO:00068751720.062
Rat
positive regulation of transportGO:00510502450.061
Rat
secretionGO:00469033070.060
Rat
agingGO:00075682410.059
metal ion transportGO:00300012890.057
Rat
cell adhesionGO:00071551100.053
cellular component assemblyGO:00226073600.053
positive regulation of intracellular signal transductionGO:19025331380.052
Human Rat
response to inorganic substanceGO:00100353770.052
macromolecular complex assemblyGO:00650032730.051
regulation of cellular component organizationGO:00511283680.051
Rat
cell cell signalingGO:00072673350.051
lipid transportGO:0006869610.051
response to extracellular stimulusGO:00099913800.051
Rat
regulation of nucleic acid templated transcriptionGO:19035063800.051
Human
transcription from rna polymerase ii promoterGO:00063662520.051
Human
vesicle mediated transportGO:00161921810.050
anion transportGO:00068201780.050
cation transportGO:00068123820.049
Rat
positive regulation of gene expressionGO:00106282440.049
Human
positive regulation of nitrogen compound metabolic processGO:00511733340.048
Human
oxoacid metabolic processGO:00434362900.048
regulation of ion transportGO:00432692450.048
Rat
positive regulation of cellular protein metabolic processGO:00322701670.047
cell motilityGO:00488702020.047
Human Rat
regulation of protein metabolic processGO:00512462890.047
positive regulation of macromolecule biosynthetic processGO:00105572470.047
Human
regulation of programmed cell deathGO:00430673410.046
Human
carboxylic acid metabolic processGO:00197522890.046
cellular catabolic processGO:00442482950.044
response to oxidative stressGO:00069791860.044
reproductive processGO:00224143720.044
monocarboxylic acid transportGO:0015718520.043
biological adhesionGO:00226101100.043
cellular response to growth factor stimulusGO:00713631620.042
immune system processGO:00023762040.042
positive regulation of phosphorus metabolic processGO:00105622620.042
Human
cellular chemical homeostasisGO:00550822470.041
Rat
response to monosaccharideGO:00342841590.041
regulation of intracellular signal transductionGO:19025312180.041
Human Rat
blood coagulationGO:0007596260.041
Human
negative regulation of nucleobase containing compound metabolic processGO:00459341530.041
striated muscle tissue developmentGO:0014706580.041
multicellular organism reproductionGO:00325042330.041
chemotaxisGO:0006935660.040
Human Rat
positive regulation of nervous system developmentGO:00519621780.040
Rat
regulation of response to stressGO:00801341260.040
negative regulation of programmed cell deathGO:00430691830.039
Human
regulation of transcription from rna polymerase ii promoterGO:00063572340.038
Human
cation transmembrane transportGO:00986552630.038
organelle organizationGO:00069962660.038
amine metabolic processGO:0009308380.038
organic acid metabolic processGO:00060822920.037
positive regulation of apoptotic processGO:00430651540.037
muscle tissue developmentGO:0060537580.036
inorganic ion transmembrane transportGO:00986602290.036
protein complex assemblyGO:00064612630.036
regulation of cell proliferationGO:00421273590.035
Human Rat
cellular ion homeostasisGO:00068731840.035
Rat
protein phosphorylationGO:00064683450.035
negative regulation of apoptotic processGO:00430661810.034
Human
response to hexoseGO:00097461440.033
cellular divalent inorganic cation homeostasisGO:00725031620.033
Rat
organic anion transportGO:00157111320.033
protein complex subunit organizationGO:00718223020.033
positive regulation of developmental processGO:00510942830.033
Human Rat
negative regulation of macromolecule metabolic processGO:00106052600.033
Human
membrane organizationGO:0061024940.033
negative regulation of cellular metabolic processGO:00313242810.032
nucleobase containing small molecule metabolic processGO:00550863160.032
Human
macromolecular complex subunit organizationGO:00439333390.031
positive regulation of nucleobase containing compound metabolic processGO:00459353190.031
Human
negative regulation of cell deathGO:00605482290.031
Human
positive regulation of cellular component organizationGO:00511302000.031
Rat
regulation of response to external stimulusGO:00321011060.031
Rat
carbohydrate derivative biosynthetic processGO:19011371240.031
central nervous system developmentGO:00074173110.030
Rat
regulation of calcium ion transmembrane transportGO:1903169180.030
positive regulation of catalytic activityGO:00430851840.030
cellular calcium ion homeostasisGO:00068741600.030
Rat
response to growth factorGO:00708481890.030
regulation of phosphate metabolic processGO:00192203490.029
Human
regulation of response to woundingGO:1903034690.029
response to metal ionGO:00100382530.029
regulation of apoptotic processGO:00429813350.029
Human
cell chemotaxisGO:0060326310.029
Human Rat
organ morphogenesisGO:0009887750.029
response to biotic stimulusGO:00096072260.029
Rat
response to decreased oxygen levelsGO:00362932370.029
monocarboxylic acid biosynthetic processGO:0072330480.028
nucleotide metabolic processGO:00091172790.028
Human
lipid metabolic processGO:00066292830.028
positive regulation of biosynthetic processGO:00098913190.028
Human
long chain fatty acid transportGO:0015909140.028
negative regulation of biosynthetic processGO:00098901680.028
Human
response to hypoxiaGO:00016662310.028
apoptotic processGO:00069153810.027
Human
positive regulation of molecular functionGO:00440932300.027
organic substance catabolic processGO:19015753160.027
cell projection organizationGO:00300303020.027
Rat
organophosphate biosynthetic processGO:00904071430.027
divalent inorganic cation homeostasisGO:00725071650.027
Rat
response to other organismGO:00517072200.027
Rat
regulation of catalytic activityGO:00507903040.027
multicellular organismal reproductive processGO:00486092330.026
mapk cascadeGO:00001651400.026
regulation of cellular ketone metabolic processGO:0010565270.026
synaptic transmissionGO:00072682350.026
regulation of molecular functionGO:00650093980.026
protein oligomerizationGO:00512591910.025
anterior posterior pattern specificationGO:000995210.025
regulation of locomotionGO:00400121480.025
Rat
single organism cell adhesionGO:0098602460.025
fatty acid biosynthetic processGO:0006633330.025
cellular amine metabolic processGO:0044106380.025
negative regulation of macromolecule biosynthetic processGO:00105581480.025
Human
cellular amino acid metabolic processGO:00065201070.024
regulation of phosphorus metabolic processGO:00511743490.024
Human
regulation of body fluid levelsGO:0050878900.024
Human
regulation of cell developmentGO:00602842630.024
Rat
positive regulation of protein metabolic processGO:00512471780.024
response to peptideGO:19016522920.024
regulation of phosphorylationGO:00423252480.024
positive regulation of hydrolase activityGO:0051345860.024
response to acid chemicalGO:00011012220.024
cellular lipid metabolic processGO:00442552080.024
granulocyte chemotaxisGO:0071621150.023
Rat
single organism organelle organizationGO:19025891800.023
cellular component morphogenesisGO:00329891550.023
protein complex biogenesisGO:00702712630.022
positive regulation of cellular amine metabolic processGO:003324030.022
positive regulation of neurogenesisGO:00507691650.022
Rat
organic hydroxy compound metabolic processGO:19016151150.022
carbohydrate derivative catabolic processGO:19011361470.022
carboxylic acid biosynthetic processGO:0046394830.022
leukotriene biosynthetic processGO:001937030.022
response to carbohydrateGO:00097431830.022
regulation of calcium ion transportGO:0051924770.022
transmembrane transportGO:00550854120.022
negative regulation of nitrogen compound metabolic processGO:00511721610.021
protein processingGO:0016485680.021
positive regulation of phosphorylationGO:00423271770.021
response to vitaminGO:00332731310.021
Rat
regulation of cellular amino acid metabolic processGO:000652120.021
regulation of anatomical structure morphogenesisGO:00226031410.021
Human Rat
fatty acid transportGO:0015908250.020
regulation of synaptic transmissionGO:00508041410.020
cellular ketone metabolic processGO:0042180510.020
response to external biotic stimulusGO:00432072210.020
Rat
inflammatory responseGO:00069541500.020
Rat
organonitrogen compound biosynthetic processGO:19015661670.020
purine nucleotide metabolic processGO:00061632290.020
Human
glycosyl compound metabolic processGO:19016571820.020
response to amino acidGO:0043200750.020
multi organism reproductive processGO:00447032620.020
nucleobase containing compound catabolic processGO:00346551520.020
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.020
ribose phosphate metabolic processGO:00196932350.020
Human
negative regulation of rna biosynthetic processGO:19026791180.019
reproductionGO:00000032450.019
multi multicellular organism processGO:00447061380.019
divalent metal ion transportGO:00708381320.019
negative regulation of rna metabolic processGO:00512531230.019
reactive oxygen species metabolic processGO:0072593370.019
regulation of nervous system developmentGO:00519602640.019
Rat
neuron deathGO:00709971270.019
Rat
secretion by cellGO:00329402480.019
Rat
response to campGO:0051591910.019
positive regulation of synaptic transmissionGO:0050806620.019
neurological system processGO:00508772190.019
regulation of hydrolase activityGO:00513361430.019
cardiovascular system developmentGO:00723581340.018
Human Rat
positive regulation of cell developmentGO:00107201760.018
Rat
chronic inflammatory responseGO:0002544160.018
cellular component movementGO:00069282480.018
Human Rat
cation homeostasisGO:00550801950.018
Rat
actin filament based processGO:0030029860.018
catabolic processGO:00090563510.018
regulation of cellular amine metabolic processGO:003323880.018
purine containing compound metabolic processGO:00725212530.018
Human
regulation of cellular localizationGO:00603412630.018
positive regulation of cellular amino acid metabolic processGO:004576410.018
positive regulation of response to external stimulusGO:0032103510.018
Rat
ribonucleoside triphosphate metabolic processGO:00091991410.018
signal transduction by phosphorylationGO:00230141440.017
cellular response to oxygen levelsGO:0071453600.017
response to glucoseGO:00097491360.017
lipid biosynthetic processGO:00086101280.017
positive regulation of neuron differentiationGO:00456661260.017
Rat
glycerolipid metabolic processGO:0046486670.017
response to activityGO:0014823730.017
nucleoside phosphate metabolic processGO:00067532830.017
Human
ion homeostasisGO:00508012120.017
Rat
purine ribonucleoside triphosphate catabolic processGO:00092071220.016
metal ion homeostasisGO:00550651860.016
Rat
skeletal muscle cell differentiationGO:003591420.016
growthGO:00400071650.016
glycosyl compound catabolic processGO:19016581260.016
anatomical structure formation involved in morphogenesisGO:0048646830.016
Human Rat
neutrophil migrationGO:1990266120.016
Rat
negative regulation of gene expressionGO:00106291990.016
proteolysisGO:00065081750.016
regulation of chemotaxisGO:0050920290.016
Rat
positive regulation of programmed cell deathGO:00430681570.016
nucleoside metabolic processGO:00091161790.016
regulation of transcription dna templatedGO:00063553740.016
Human
negative regulation of metabolic processGO:00098923310.016
Human
heterocycle catabolic processGO:00467001670.016
response to transition metal nanoparticleGO:19902671220.015
single organismal cell cell adhesionGO:0016337420.015
regulation of cell adhesionGO:0030155520.015
developmental growthGO:00485891000.015
nucleotide catabolic processGO:00091661390.015
regulation of inflammatory responseGO:0050727480.015
cellular response to oxidative stressGO:0034599760.015
digestive system developmentGO:0055123410.015
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.015
Human
nucleoside phosphate catabolic processGO:19012921400.015
protein localizationGO:00081041910.015
Rat
neuron differentiationGO:00301823680.015
Rat
regulation of neurogenesisGO:00507672470.015
Rat
regulation of vesicle mediated transportGO:0060627810.015
purine ribonucleoside metabolic processGO:00461281680.014
peptidyl amino acid modificationGO:00181931260.014
response to insulinGO:00328681330.014
head developmentGO:00603222470.014
Rat
positive regulation of ion transportGO:0043270940.014
Rat
gliogenesisGO:0042063930.014
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.014
muscle structure developmentGO:0061061870.014
aromatic compound catabolic processGO:00194391680.014
single organism catabolic processGO:00447122830.014
cytokine biosynthetic processGO:004208930.014
purine nucleoside catabolic processGO:00061521240.014
peptide transportGO:0015833970.014
cellular macromolecule localizationGO:00707271220.014
negative regulation of multicellular organismal processGO:00512412030.013
Human Rat
response to zinc ionGO:0010043390.013
positive regulation of cell motilityGO:2000147970.013
Rat
calcium ion transmembrane transportGO:0070588700.013
cellular response to hypoxiaGO:0071456510.013
positive regulation of cell communicationGO:00106472710.013
Human Rat
regulation of hormone levelsGO:00108171870.013
muscle organ developmentGO:0007517500.013
negative regulation of molecular functionGO:00440921330.013
ribonucleotide biosynthetic processGO:0009260850.013
behaviorGO:00076102050.013
Rat
pseudopodium organizationGO:003126830.013
skeletal muscle tissue developmentGO:0007519310.013
response to oxygen levelsGO:00704822650.013
positive regulation of rna metabolic processGO:00512542030.013
Human
positive regulation of cell projection organizationGO:00313461110.013
Rat
regulation of membrane potentialGO:00423911100.013
taxisGO:0042330670.013
Human Rat
purine nucleoside metabolic processGO:00422781690.013
immune system developmentGO:0002520410.013
Human
regulation of ion transmembrane transportGO:00347651210.013
icosanoid metabolic processGO:0006690380.013
regulation of neuron differentiationGO:00456642080.013
Rat
immune responseGO:00069551040.012
response to nutrientGO:00075842480.012
Rat
carbohydrate homeostasisGO:0033500750.012
tissue remodelingGO:0048771400.012
positive regulation of secretionGO:00510471400.012
regulation of smooth muscle cell proliferationGO:0048660750.012
glutathione metabolic processGO:0006749150.012
cellular nitrogen compound catabolic processGO:00442701630.012
acute inflammatory responseGO:0002526580.012
Rat
actin cytoskeleton organizationGO:0030036730.012
regulation of cation channel activityGO:2001257230.012
negative regulation of nucleic acid templated transcriptionGO:19035071170.012
lipid localizationGO:0010876620.012
regulation of cellular protein metabolic processGO:00322682670.012
regulation of proteolysisGO:0030162660.012
actin filament organizationGO:0007015420.012
nucleoside triphosphate metabolic processGO:00091411440.012
localization of cellGO:00516742020.012
Human Rat
negative regulation of developmental processGO:00510931250.011
Human Rat
neuron projection developmentGO:00311752730.011
Rat
ribonucleotide metabolic processGO:00092592310.011
Human
regulation of protein modification processGO:00313991940.011
regulation of ion transmembrane transporter activityGO:0032412480.011
regulation of purine nucleotide metabolic processGO:19005421150.011
Human
female pregnancyGO:00075651220.011
cytosolic calcium ion homeostasisGO:00514801400.011
Rat
protein homooligomerizationGO:0051260910.011
alcohol metabolic processGO:0006066770.011
purine ribonucleotide metabolic processGO:00091502270.011
Human
multicellular organismal homeostasisGO:0048871490.011
macromolecule localizationGO:00330362520.011
Rat
cell substrate adhesionGO:0031589290.011
ribonucleotide catabolic processGO:00092611360.011
hemopoiesisGO:0030097340.011
Human
single organism reproductive processGO:00447022970.011
organophosphate catabolic processGO:00464341480.011
skeletal muscle organ developmentGO:0060538330.011
response to cytokineGO:00340972150.011
Human Rat
positive regulation of cell deathGO:00109421840.011
action potentialGO:0001508540.011
sexual reproductionGO:00199531480.011
endomembrane system organizationGO:0010256480.011
regulation of defense responseGO:0031347680.011
cytoskeleton organizationGO:00070101110.011
positive regulation of protein modification processGO:00314011420.010
heart developmentGO:0007507720.010
cellular cation homeostasisGO:00300031800.010
Rat
regulation of growthGO:00400081050.010
regulation of kinase activityGO:00435491170.010
single organism membrane organizationGO:0044802740.010
positive regulation of phosphate metabolic processGO:00459372620.010
Human
connective tissue developmentGO:0061448330.010
negative regulation of innate immune responseGO:004582440.010
regulation of nucleotide metabolic processGO:00061401170.010
Human
axis specificationGO:000979840.010
regulation of hormone secretionGO:00468831060.010
cellular response to organic cyclic compoundGO:00714072020.010

Pf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
vascular diseaseDOID:17800.021
cardiovascular system diseaseDOID:128700.021
disease of anatomical entityDOID:700.021
artery diseaseDOID:005082800.021
nervous system diseaseDOID:86300.016