IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

RGD1565168

similar to RAP2A, member of RAS oncogene family

Entrez: 366733
RGD: 1565168
Ensembl: ENSRNOG00000033736
UniProtKB: F1LX77

Process Predictions
Disease Predictions

RGD1565168 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
head development	GO:0060322	247	0.176
central nervous system development	GO:0007417	311	0.154
response to inorganic substance	GO:0010035	377	0.139
negative regulation of transport	GO:0051051	136	0.113
cellular metal ion homeostasis	GO:0006875	172	0.106
cellular calcium ion homeostasis	GO:0006874	160	0.102
divalent inorganic cation homeostasis	GO:0072507	165	0.098
brain development	GO:0007420	247	0.096
chemical homeostasis	GO:0048878	292	0.094
locomotion	GO:0040011	237	0.090
neurological system process	GO:0050877	219	0.088
cation homeostasis	GO:0055080	195	0.086
regulation of cellular localization	GO:0060341	263	0.077
heart contraction	GO:0060047	57	0.075
immune system process	GO:0002376	204	0.072
regulation of cell proliferation	GO:0042127	359	0.066
positive regulation of multicellular organismal process	GO:0051240	387	0.063	Rat
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.063
apoptotic process	GO:0006915	381	0.062
positive regulation of rna metabolic process	GO:0051254	203	0.058
intracellular signal transduction	GO:0035556	314	0.058	Rat
negative regulation of cellular biosynthetic process	GO:0031327	161	0.055
renal system process	GO:0003014	40	0.053
response to nutrient levels	GO:0031667	370	0.052
response to acid chemical	GO:0001101	222	0.050
calcium ion homeostasis	GO:0055074	162	0.050
cation transport	GO:0006812	382	0.049
positive regulation of programmed cell death	GO:0043068	157	0.048
homeostatic process	GO:0042592	331	0.048
forebrain development	GO:0030900	98	0.047
negative regulation of response to stimulus	GO:0048585	155	0.047
response to insulin	GO:0032868	133	0.047
positive regulation of apoptotic process	GO:0043065	154	0.046
negative regulation of ion transport	GO:0043271	51	0.046
rna metabolic process	GO:0016070	406	0.045
regulation of programmed cell death	GO:0043067	341	0.045
regulation of blood circulation	GO:1903522	110	0.044
positive regulation of cell proliferation	GO:0008284	249	0.044
cell migration	GO:0016477	197	0.044
secretion	GO:0046903	307	0.043
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.043
cellular ion homeostasis	GO:0006873	184	0.043
cellular response to nitrogen compound	GO:1901699	210	0.043
regulation of cell differentiation	GO:0045595	320	0.043	Rat
regulation of rna metabolic process	GO:0051252	391	0.041
regulation of apoptotic process	GO:0042981	335	0.040
programmed cell death	GO:0012501	392	0.039
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.039	Rat
positive regulation of cell death	GO:0010942	184	0.038
regulation of nervous system development	GO:0051960	264	0.038	Rat
negative regulation of cell communication	GO:0010648	158	0.038
response to estrogen	GO:0043627	232	0.038
positive regulation of cell differentiation	GO:0045597	217	0.037	Rat
regulation of neurogenesis	GO:0050767	247	0.037	Rat
positive regulation of response to stimulus	GO:0048584	285	0.037	Rat
response to reactive oxygen species	GO:0000302	120	0.036
regulation of phosphorus metabolic process	GO:0051174	349	0.036	Rat
regulation of secretion by cell	GO:1903530	208	0.036
response to hypoxia	GO:0001666	231	0.036
reproductive process	GO:0022414	372	0.035
transcription dna templated	GO:0006351	377	0.035
regulation of cellular amine metabolic process	GO:0033238	8	0.035
positive regulation of signaling	GO:0023056	270	0.035	Rat
rna biosynthetic process	GO:0032774	380	0.034
response to estradiol	GO:0032355	164	0.034
organophosphate metabolic process	GO:0019637	370	0.034	Rat
transcription from rna polymerase ii promoter	GO:0006366	252	0.033
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	51	0.033
positive regulation of gene expression	GO:0010628	244	0.033
amide transport	GO:0042886	105	0.032
nucleic acid templated transcription	GO:0097659	379	0.032
response to peptide hormone	GO:0043434	278	0.032
regulation of ion transport	GO:0043269	245	0.032
negative regulation of programmed cell death	GO:0043069	183	0.032
regulation of cellular component organization	GO:0051128	368	0.031	Rat
regulation of transmembrane transport	GO:0034762	122	0.031
negative regulation of cell death	GO:0060548	229	0.031
cellular cation homeostasis	GO:0030003	180	0.031
response to glucocorticoid	GO:0051384	223	0.030
cellular amino acid metabolic process	GO:0006520	107	0.030
positive regulation of cellular protein metabolic process	GO:0032270	167	0.029	Rat
cellular homeostasis	GO:0019725	252	0.029
single organism reproductive process	GO:0044702	297	0.029
metal ion homeostasis	GO:0055065	186	0.029
sensory perception	GO:0007600	101	0.029
cellular response to oxygen containing compound	GO:1901701	386	0.029
cellular ketone metabolic process	GO:0042180	51	0.029
positive regulation of phosphorus metabolic process	GO:0010562	262	0.029	Rat
negative regulation of apoptotic process	GO:0043066	181	0.028
epithelium development	GO:0060429	96	0.028
positive regulation of biosynthetic process	GO:0009891	319	0.028
positive regulation of transcription dna templated	GO:0045893	197	0.027
regulation of heart contraction	GO:0008016	48	0.027
epithelial cell differentiation	GO:0030855	71	0.027
cellular amine metabolic process	GO:0044106	38	0.026
blood circulation	GO:0008015	183	0.026
cellular response to endogenous stimulus	GO:0071495	377	0.026	Rat
cellular response to organic cyclic compound	GO:0071407	202	0.026
cellular chemical homeostasis	GO:0055082	247	0.026
regulation of transcription dna templated	GO:0006355	374	0.025
multi organism reproductive process	GO:0044703	262	0.025
amine metabolic process	GO:0009308	38	0.025
localization of cell	GO:0051674	202	0.025
response to peptide	GO:1901652	292	0.024
cellular response to lipid	GO:0071396	201	0.024
regulation of locomotion	GO:0040012	148	0.024
response to metal ion	GO:0010038	253	0.024
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.024	Rat
muscle cell proliferation	GO:0033002	84	0.024
positive regulation of heart contraction	GO:0045823	15	0.024
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.023
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.023
negative regulation of cell proliferation	GO:0008285	119	0.023
heart process	GO:0003015	57	0.023
response to decreased oxygen levels	GO:0036293	237	0.022
cellular response to reactive oxygen species	GO:0034614	55	0.022
regulation of immunoglobulin production	GO:0002637	4	0.022
cytosolic calcium ion homeostasis	GO:0051480	140	0.022
telencephalon development	GO:0021537	62	0.022
circulatory system process	GO:0003013	183	0.022
response to wounding	GO:0009611	254	0.022
regulation of cellular amino acid metabolic process	GO:0006521	2	0.022
multicellular organismal reproductive process	GO:0048609	233	0.022
sensory organ development	GO:0007423	74	0.021
cation transmembrane transport	GO:0098655	263	0.021
multicellular organism reproduction	GO:0032504	233	0.021
regulation of cellular ketone metabolic process	GO:0010565	27	0.021
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.020
inorganic ion transmembrane transport	GO:0098660	229	0.020
neuron development	GO:0048666	286	0.020	Rat
organic acid metabolic process	GO:0006082	292	0.020
response to oxygen levels	GO:0070482	265	0.020
regulation of hormone levels	GO:0010817	187	0.020
cell motility	GO:0048870	202	0.020
anatomical structure morphogenesis	GO:0009653	298	0.020
positive regulation of nervous system development	GO:0051962	178	0.019	Rat
cellular response to external stimulus	GO:0071496	118	0.019
response to vitamin	GO:0033273	131	0.019
gamete generation	GO:0007276	124	0.019
peptidyl amino acid modification	GO:0018193	126	0.019
cellular response to stress	GO:0033554	269	0.019
metal ion transport	GO:0030001	289	0.019
regulation of anatomical structure morphogenesis	GO:0022603	141	0.019
response to oxidative stress	GO:0006979	186	0.018
regulation of multicellular organismal development	GO:2000026	376	0.018	Rat
cellular response to metal ion	GO:0071248	55	0.018
embryonic skeletal system morphogenesis	GO:0048704	3	0.018
positive regulation of protein modification process	GO:0031401	142	0.018	Rat
urinary bladder smooth muscle contraction	GO:0014832	4	0.018
signal release	GO:0023061	145	0.018
response to glucose	GO:0009749	136	0.018
regulation of molecular function	GO:0065009	398	0.018	Rat
camera type eye morphogenesis	GO:0048593	2	0.018
cell projection organization	GO:0030030	302	0.018	Rat
response to growth factor	GO:0070848	189	0.017	Rat
regulation of saliva secretion	GO:0046877	3	0.017
response to monosaccharide	GO:0034284	159	0.017
single organism biosynthetic process	GO:0044711	342	0.017
cellular component movement	GO:0006928	248	0.017
regulation of catalytic activity	GO:0050790	304	0.017	Rat
growth	GO:0040007	165	0.017
eye development	GO:0001654	50	0.017
multicellular organismal signaling	GO:0035637	44	0.017
positive regulation of rna biosynthetic process	GO:1902680	197	0.017
positive regulation of cell communication	GO:0010647	271	0.017	Rat
g protein coupled receptor signaling pathway	GO:0007186	242	0.016
regulation of mapk cascade	GO:0043408	116	0.016	Rat
monovalent inorganic cation transport	GO:0015672	172	0.016
peptide secretion	GO:0002790	86	0.016
positive regulation of cardiac muscle cell proliferation	GO:0060045	4	0.016
cellular response to abiotic stimulus	GO:0071214	85	0.015
positive regulation of developmental process	GO:0051094	283	0.015	Rat
carboxylic acid metabolic process	GO:0019752	289	0.015
regulation of cell motility	GO:2000145	131	0.015
regulation of ion transmembrane transport	GO:0034765	121	0.015
regulation of phosphate metabolic process	GO:0019220	349	0.015	Rat
regulation of homeostatic process	GO:0032844	101	0.015
detection of chemical stimulus involved in sensory perception of bitter taste	GO:0001580	4	0.015
response to cytokine	GO:0034097	215	0.015
circadian rhythm	GO:0007623	88	0.015
positive regulation of signal transduction	GO:0009967	175	0.015	Rat
regulation of neuron projection development	GO:0010975	161	0.015	Rat
regulation of membrane potential	GO:0042391	110	0.015
regulation of sensory perception	GO:0051931	29	0.015
sexual reproduction	GO:0019953	148	0.014
oxoacid metabolic process	GO:0043436	290	0.014
ion homeostasis	GO:0050801	212	0.014
negative regulation of metabolic process	GO:0009892	331	0.014
aging	GO:0007568	241	0.014
tissue development	GO:0009888	252	0.014
negative regulation of signaling	GO:0023057	157	0.014
muscle structure development	GO:0061061	87	0.014
developmental induction	GO:0031128	2	0.014
regulation of rna biosynthetic process	GO:2001141	381	0.014
secretion by cell	GO:0032940	248	0.014
defense response	GO:0006952	194	0.014
peptide transport	GO:0015833	97	0.014
negative regulation of cell development	GO:0010721	82	0.014
positive regulation of blood circulation	GO:1903524	65	0.014
regulation of phosphorylation	GO:0042325	248	0.014	Rat
carbohydrate derivative metabolic process	GO:1901135	346	0.014	Rat
regulation of immune system process	GO:0002682	123	0.014
regulation of cell development	GO:0060284	263	0.014	Rat
signal transduction by phosphorylation	GO:0023014	144	0.014	Rat
negative regulation of multicellular organismal process	GO:0051241	203	0.013
transmembrane transport	GO:0055085	412	0.013
regulation of cellular protein metabolic process	GO:0032268	267	0.013	Rat
behavior	GO:0007610	205	0.013
nucleoside phosphate metabolic process	GO:0006753	283	0.013	Rat
cellular response to inorganic substance	GO:0071241	65	0.013
response to biotic stimulus	GO:0009607	226	0.013
positive regulation of intracellular signal transduction	GO:1902533	138	0.013	Rat
regulation of cellular component movement	GO:0051270	150	0.013
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.013
phototransduction visible light	GO:0007603	2	0.013
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.013
positive regulation of catalytic activity	GO:0043085	184	0.013	Rat
anion transport	GO:0006820	178	0.013
camp metabolic process	GO:0046058	63	0.013
eye morphogenesis	GO:0048592	4	0.013
insulin secretion	GO:0030073	69	0.013
response to light stimulus	GO:0009416	52	0.013
response to electrical stimulus	GO:0051602	56	0.013
negative regulation of secretion	GO:0051048	82	0.013
ras protein signal transduction	GO:0007265	29	0.012
peptide hormone secretion	GO:0030072	84	0.012
regulation of nucleic acid templated transcription	GO:1903506	380	0.012
tube development	GO:0035295	89	0.012
potassium ion transport	GO:0006813	97	0.012
positive regulation of camp mediated signaling	GO:0043950	2	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.012
mapk cascade	GO:0000165	140	0.012	Rat
organic anion transport	GO:0015711	132	0.012
learning or memory	GO:0007611	90	0.012
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.012
organ morphogenesis	GO:0009887	75	0.012
reproduction	GO:0000003	245	0.012
action potential	GO:0001508	54	0.012
positive regulation of saliva secretion	GO:0046878	3	0.012
hormone secretion	GO:0046879	115	0.012
nucleotide metabolic process	GO:0009117	279	0.012	Rat
regulation of purine nucleotide metabolic process	GO:1900542	115	0.011	Rat
sequestering of calcium ion	GO:0051208	8	0.011
response to vitamin d	GO:0033280	34	0.011
negative regulation of signal transduction	GO:0009968	83	0.011
camera type eye development	GO:0043010	48	0.011
rhythmic process	GO:0048511	156	0.011
ossification	GO:0001503	70	0.011
positive regulation of cellular component organization	GO:0051130	200	0.011	Rat
positive regulation of cellular amine metabolic process	GO:0033240	3	0.011
positive regulation of secretion by cell	GO:1903532	128	0.011
positive regulation of blood pressure by epinephrine norepinephrine	GO:0003321	2	0.011
cellular response to organonitrogen compound	GO:0071417	197	0.011
regulation of peptide secretion	GO:0002791	82	0.011
calcium ion transport into cytosol	GO:0060402	38	0.011
negative regulation of homeostatic process	GO:0032845	47	0.011
positive regulation of protein phosphorylation	GO:0001934	135	0.011	Rat
sequestering of metal ion	GO:0051238	9	0.011
urinary tract smooth muscle contraction	GO:0014848	4	0.010
response to carbohydrate	GO:0009743	183	0.010
intracellular transport	GO:0046907	185	0.010
regulation of blood vessel size	GO:0050880	89	0.010
nitrogen compound transport	GO:0071705	229	0.010
cell morphogenesis involved in differentiation	GO:0000904	119	0.010
regulation of neuron death	GO:1901214	115	0.010
regulation of signal transduction	GO:0009966	318	0.010	Rat
positive regulation of ion transport	GO:0043270	94	0.010
maintenance of location	GO:0051235	17	0.010
negative regulation of developmental process	GO:0051093	125	0.010
regulation of blood pressure	GO:0008217	83	0.010
response to extracellular stimulus	GO:0009991	380	0.010

RGD1565168 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.013
acquired metabolic disease	DOID:0060158	0.010
nutrition disease	DOID:374	0.010
obesity	DOID:9970	0.010
overnutrition	DOID:654	0.010

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