IMP: Integrative Multi-species Prediction

Rattus norvegicus

149 known processes

Nos3

nitric oxide synthase 3, endothelial cell

(Aliases: eNos)

Entrez: 24600
RGD: 3186
Ensembl: ENSRNOG00000009348
UniProtKB: Q62600

Process Predictions
Disease Predictions

Nos3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cell proliferation	GO:0042127	359	0.605
anatomical structure morphogenesis	GO:0009653	298	0.531	Mouse
tissue development	GO:0009888	252	0.529
intracellular signal transduction	GO:0035556	314	0.498	Rat
response to mechanical stimulus	GO:0009612	134	0.486
negative regulation of response to stimulus	GO:0048585	155	0.454	Mouse
cellular component movement	GO:0006928	248	0.442	Human
negative regulation of multicellular organismal process	GO:0051241	203	0.421	Mouse Rat
blood circulation	GO:0008015	183	0.416	Human Mouse Rat Fly
response to hypoxia	GO:0001666	231	0.412
homeostatic process	GO:0042592	331	0.396	Rat
regulation of cellular component organization	GO:0051128	368	0.381
response to decreased oxygen levels	GO:0036293	237	0.373
lymphoid progenitor cell differentiation	GO:0002320	2	0.371
blood vessel morphogenesis	GO:0048514	58	0.369	Mouse
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.352	Mouse
regulation of molecular function	GO:0065009	398	0.352	Human Mouse Rat
response to nutrient	GO:0007584	248	0.342	Rat
blood vessel development	GO:0001568	69	0.339	Mouse
regulation of phosphorus metabolic process	GO:0051174	349	0.329	Human Rat
negative regulation of signaling	GO:0023057	157	0.323	Rat
response to extracellular stimulus	GO:0009991	380	0.318	Rat
regulation of intracellular signal transduction	GO:1902531	218	0.316
positive regulation of phosphorus metabolic process	GO:0010562	262	0.305	Human
regulation of cellular component movement	GO:0051270	150	0.293
regulation of system process	GO:0044057	208	0.286	Mouse Rat Fly
apoptotic process	GO:0006915	381	0.270
positive regulation of multicellular organismal process	GO:0051240	387	0.261	Mouse Rat
pro t cell differentiation	GO:0002572	1	0.258
myeloid progenitor cell differentiation	GO:0002318	1	0.257
cellular response to cytokine stimulus	GO:0071345	127	0.256
cation transport	GO:0006812	382	0.256	Mouse Rat
programmed cell death	GO:0012501	392	0.251
cellular component assembly	GO:0022607	360	0.250
circulatory system development	GO:0072359	134	0.246	Mouse
negative regulation of organ growth	GO:0046621	3	0.235
regulation of cell growth	GO:0001558	85	0.232
regulation of protein metabolic process	GO:0051246	289	0.222	Rat
cellular metal ion homeostasis	GO:0006875	172	0.220	Rat
response to cytokine	GO:0034097	215	0.219
response to estrogen	GO:0043627	232	0.216
response to fluid shear stress	GO:0034405	16	0.215	Human
cellular response to oxygen containing compound	GO:1901701	386	0.206
cellular calcium ion homeostasis	GO:0006874	160	0.205	Rat
potassium ion transport	GO:0006813	97	0.202	Mouse
actin filament based process	GO:0030029	86	0.201
heart contraction	GO:0060047	57	0.197	Mouse Rat Fly
multi organism reproductive process	GO:0044703	262	0.194
positive regulation of response to stimulus	GO:0048584	285	0.190
defense response	GO:0006952	194	0.189	Rat
ribonucleotide metabolic process	GO:0009259	231	0.188	Human
positive regulation of cellular component organization	GO:0051130	200	0.183
regulation of nucleotide metabolic process	GO:0006140	117	0.178	Human
negative regulation of developmental process	GO:0051093	125	0.178
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.177
s shaped body morphogenesis	GO:0072050	2	0.176
positive regulation of phosphate metabolic process	GO:0045937	262	0.174	Human
cardiovascular system development	GO:0072358	134	0.172	Mouse
negative regulation of growth	GO:0045926	37	0.172
gland development	GO:0048732	155	0.171
regulation of vasculature development	GO:1901342	44	0.171	Mouse
negative regulation of cellular metabolic process	GO:0031324	281	0.169	Rat
single organism reproductive process	GO:0044702	297	0.168	Mouse
response to oxygen levels	GO:0070482	265	0.165
cellular response to endogenous stimulus	GO:0071495	377	0.164
regulation of organ growth	GO:0046620	13	0.164
organelle organization	GO:0006996	266	0.164
divalent inorganic cation transport	GO:0072511	134	0.162	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.160	Human
regulation of ion transport	GO:0043269	245	0.160	Mouse Rat
nucleoside phosphate metabolic process	GO:0006753	283	0.159	Human
carbohydrate derivative metabolic process	GO:1901135	346	0.157	Human Rat
endothelium development	GO:0003158	12	0.155
reproductive process	GO:0022414	372	0.152
regulation of neurogenesis	GO:0050767	247	0.150
cytoskeleton organization	GO:0007010	111	0.149
muscle system process	GO:0003012	115	0.149	Mouse
female pregnancy	GO:0007565	122	0.148
oxoacid metabolic process	GO:0043436	290	0.147	Human Rat
cellular ion homeostasis	GO:0006873	184	0.147	Rat
cellular component biogenesis	GO:0044085	368	0.145
regulation of blood vessel size	GO:0050880	89	0.145	Mouse Rat
epithelial cell differentiation	GO:0030855	71	0.144
cellular cation homeostasis	GO:0030003	180	0.143	Rat
regulation of blood pressure	GO:0008217	83	0.143	Human Rat
regulation of nervous system development	GO:0051960	264	0.142
regulation of tube size	GO:0035150	89	0.142	Mouse Rat
regulation of signal transduction	GO:0009966	318	0.140
purine ribonucleotide biosynthetic process	GO:0009152	81	0.140	Human
localization of cell	GO:0051674	202	0.138	Human
signal transduction by phosphorylation	GO:0023014	144	0.138
muscle structure development	GO:0061061	87	0.138
carbohydrate derivative biosynthetic process	GO:1901137	124	0.136	Human
regulation of multicellular organismal development	GO:2000026	376	0.135	Mouse
negative regulation of apoptotic process	GO:0043066	181	0.135	Rat
calcium ion homeostasis	GO:0055074	162	0.134	Rat
organic substance catabolic process	GO:1901575	316	0.133	Human Rat
actin cytoskeleton organization	GO:0030036	73	0.131
positive regulation of cell differentiation	GO:0045597	217	0.130
negative regulation of cell communication	GO:0010648	158	0.130	Rat
regulation of blood circulation	GO:1903522	110	0.130	Mouse Rat Fly
positive regulation of cell motility	GO:2000147	97	0.129
negative regulation of programmed cell death	GO:0043069	183	0.129	Rat
regulation of anatomical structure size	GO:0090066	135	0.129	Mouse Rat
cell motility	GO:0048870	202	0.129	Human
regulation of anatomical structure morphogenesis	GO:0022603	141	0.128	Mouse
cellular homeostasis	GO:0019725	252	0.128	Rat
negative regulation of cell proliferation	GO:0008285	119	0.127
renal system development	GO:0072001	67	0.126
response to growth factor	GO:0070848	189	0.126
positive regulation of signal transduction	GO:0009967	175	0.125
circulatory system process	GO:0003013	183	0.125	Human Mouse Rat Fly
glycosaminoglycan biosynthetic process	GO:0006024	4	0.123
response to inorganic substance	GO:0010035	377	0.121
growth	GO:0040007	165	0.121
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	34	0.120	Human
negative regulation of cell death	GO:0060548	229	0.119	Rat
nucleoside triphosphate metabolic process	GO:0009141	144	0.117
single organism behavior	GO:0044708	130	0.115	Rat
immune system process	GO:0002376	204	0.114
heart development	GO:0007507	72	0.112
nucleobase containing small molecule metabolic process	GO:0055086	316	0.112	Human
metal ion homeostasis	GO:0055065	186	0.111	Rat
mesoderm development	GO:0007498	2	0.111
cell cell signaling	GO:0007267	335	0.111	Rat
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	10	0.111
regulation of phosphate metabolic process	GO:0019220	349	0.109	Human Rat
nitrogen compound transport	GO:0071705	229	0.109	Rat
secretion	GO:0046903	307	0.108	Rat
positive regulation of programmed cell death	GO:0043068	157	0.108
regulation of cellular ketone metabolic process	GO:0010565	27	0.106
organic acid metabolic process	GO:0006082	292	0.106	Human Rat
response to peptide hormone	GO:0043434	278	0.105
response to wounding	GO:0009611	254	0.104
transmembrane transport	GO:0055085	412	0.104	Rat
regulation of muscle contraction	GO:0006937	53	0.103
organ regeneration	GO:0031100	101	0.102
secretion by cell	GO:0032940	248	0.102	Rat
regulation of neuron differentiation	GO:0045664	208	0.100
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.099	Human
cellular response to stress	GO:0033554	269	0.099
neuron differentiation	GO:0030182	368	0.099
organ growth	GO:0035265	24	0.099
locomotion	GO:0040011	237	0.098	Human
response to nutrient levels	GO:0031667	370	0.097	Rat
response to biotic stimulus	GO:0009607	226	0.096
regulation of cell development	GO:0060284	263	0.096
regulation of growth	GO:0040008	105	0.096
regulation of cell differentiation	GO:0045595	320	0.095
cation homeostasis	GO:0055080	195	0.095	Rat
cell growth	GO:0016049	104	0.094
response to carbohydrate	GO:0009743	183	0.094
regulation of cardiac muscle tissue development	GO:0055024	12	0.094
cardiac muscle tissue growth	GO:0055017	20	0.093
regulation of phosphorylation	GO:0042325	248	0.093	Rat
positive regulation of cell development	GO:0010720	176	0.093
cardiac muscle cell development	GO:0055013	16	0.092
vasculogenesis	GO:0001570	3	0.092
vascular process in circulatory system	GO:0003018	96	0.091	Mouse Rat
response to corticosteroid	GO:0031960	235	0.091
purine containing compound metabolic process	GO:0072521	253	0.091	Human
kidney development	GO:0001822	67	0.090
macromolecule localization	GO:0033036	252	0.089
cellular response to external stimulus	GO:0071496	118	0.089
positive regulation of molecular function	GO:0044093	230	0.089	Human
cellular response to abiotic stimulus	GO:0071214	85	0.089
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.088
regulation of b cell differentiation	GO:0045577	1	0.088
regulation of homeostatic process	GO:0032844	101	0.088
nucleotide metabolic process	GO:0009117	279	0.088	Human
response to molecule of bacterial origin	GO:0002237	194	0.088
glycosyl compound metabolic process	GO:1901657	182	0.087	Rat
cellular chemical homeostasis	GO:0055082	247	0.087	Rat
cellular ketone metabolic process	GO:0042180	51	0.086
positive regulation of cell communication	GO:0010647	271	0.086	Rat
regulation of secretion by cell	GO:1903530	208	0.086	Rat
protein complex subunit organization	GO:0071822	302	0.086
positive regulation of lipid kinase activity	GO:0090218	2	0.085
cell migration	GO:0016477	197	0.085	Human
multi multicellular organism process	GO:0044706	138	0.084
positive regulation of transport	GO:0051050	245	0.084	Rat
behavior	GO:0007610	205	0.084	Rat
divalent metal ion transport	GO:0070838	132	0.084	Mouse
ribose phosphate metabolic process	GO:0019693	235	0.083	Human
response to monosaccharide	GO:0034284	159	0.083
regulation of cardiac muscle contraction	GO:0055117	17	0.083
positive regulation of developmental process	GO:0051094	283	0.082	Mouse
negative regulation of cell differentiation	GO:0045596	99	0.081
regulation of membrane potential	GO:0042391	110	0.081
multicellular organism reproduction	GO:0032504	233	0.080	Mouse
carboxylic acid metabolic process	GO:0019752	289	0.080	Human Rat
multicellular organism growth	GO:0035264	1	0.080
aging	GO:0007568	241	0.080
divalent inorganic cation homeostasis	GO:0072507	165	0.080	Rat
ion transmembrane transport	GO:0034220	365	0.080	Rat
positive regulation of blood circulation	GO:1903524	65	0.079	Rat
organophosphate biosynthetic process	GO:0090407	143	0.079	Human
purine ribonucleotide metabolic process	GO:0009150	227	0.078	Human
purine nucleotide metabolic process	GO:0006163	229	0.078	Human
purine ribonucleoside metabolic process	GO:0046128	168	0.077
regulation of protein phosphorylation	GO:0001932	183	0.077	Rat
cardiac muscle cell contraction	GO:0086003	10	0.077
organophosphate metabolic process	GO:0019637	370	0.076	Human
chemical homeostasis	GO:0048878	292	0.076	Rat
regulation of cellular protein metabolic process	GO:0032268	267	0.076	Rat
regulation of nucleotide biosynthetic process	GO:0030808	47	0.075	Human
ras protein signal transduction	GO:0007265	29	0.075
neurological system process	GO:0050877	219	0.075	Rat
positive regulation of cell proliferation	GO:0008284	249	0.075
positive regulation of phosphorylation	GO:0042327	177	0.075
developmental growth	GO:0048589	100	0.074
regulation of purine nucleotide metabolic process	GO:1900542	115	0.074	Human
purine nucleoside metabolic process	GO:0042278	169	0.074
regulation of catalytic activity	GO:0050790	304	0.074	Human Mouse Rat
metanephric mesenchymal cell migration	GO:0035789	2	0.073
negative regulation of metabolic process	GO:0009892	331	0.073	Mouse Rat
positive regulation of phosphatidylinositol 3 kinase activity	GO:0043552	2	0.073
regulation of apoptotic process	GO:0042981	335	0.072
positive regulation of protein phosphorylation	GO:0001934	135	0.072
response to estradiol	GO:0032355	164	0.072
positive regulation of cell migration	GO:0030335	96	0.072
regulation of cellular localization	GO:0060341	263	0.072	Rat
negative regulation of transport	GO:0051051	136	0.072	Mouse Rat
skeletal muscle tissue development	GO:0007519	31	0.072
single organism organelle organization	GO:1902589	180	0.071
heart growth	GO:0060419	20	0.071
response to glucose	GO:0009749	136	0.071
muscle cell proliferation	GO:0033002	84	0.071
regulation of striated muscle contraction	GO:0006942	21	0.070
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.069
regulation of behavior	GO:0050795	61	0.069
vasoconstriction	GO:0042310	54	0.069	Rat
protein localization	GO:0008104	191	0.069
nucleotide biosynthetic process	GO:0009165	98	0.069	Human
negative regulation of cardiac muscle tissue growth	GO:0055022	3	0.069
response to glucocorticoid	GO:0051384	223	0.068
lymphocyte activation	GO:0046649	43	0.068
regulation of catabolic process	GO:0009894	113	0.068
cardiocyte differentiation	GO:0035051	22	0.067
protein phosphorylation	GO:0006468	345	0.067	Rat
multicellular organismal reproductive process	GO:0048609	233	0.067	Mouse
cell chemotaxis	GO:0060326	31	0.067
positive regulation of biosynthetic process	GO:0009891	319	0.066	Human
synaptic transmission	GO:0007268	235	0.066
organonitrogen compound biosynthetic process	GO:1901566	167	0.066	Human
regulation of angiogenesis	GO:0045765	39	0.066	Mouse
regulation of metal ion transport	GO:0010959	118	0.065	Mouse Rat
cardiac muscle cell proliferation	GO:0060038	6	0.065
tissue remodeling	GO:0048771	40	0.065	Mouse Rat
kidney morphogenesis	GO:0060993	13	0.065
immunoglobulin mediated immune response	GO:0016064	4	0.065
positive regulation of signaling	GO:0023056	270	0.065	Rat
regulation of immune system process	GO:0002682	123	0.065
regulation of cellular catabolic process	GO:0031329	101	0.064
regulation of camp biosynthetic process	GO:0030817	38	0.064
regeneration	GO:0031099	163	0.064
response to alkaloid	GO:0043279	132	0.064	Rat
ion homeostasis	GO:0050801	212	0.062	Rat
positive regulation of locomotion	GO:0040017	102	0.062
regulation of developmental growth	GO:0048638	45	0.062
regulation of programmed cell death	GO:0043067	341	0.062
purine nucleotide biosynthetic process	GO:0006164	83	0.062	Human
regulation of heart growth	GO:0060420	12	0.062
cellular amino acid metabolic process	GO:0006520	107	0.061	Human Rat
cellular response to nitrogen compound	GO:1901699	210	0.061
ribose phosphate biosynthetic process	GO:0046390	87	0.061	Human
response to ketone	GO:1901654	182	0.061
gastrulation	GO:0007369	2	0.060
nucleoside triphosphate catabolic process	GO:0009143	123	0.060
salivary gland morphogenesis	GO:0007435	1	0.059
positive regulation of catalytic activity	GO:0043085	184	0.059	Human
calcium ion transport	GO:0006816	131	0.059	Mouse
negative regulation of nervous system development	GO:0051961	79	0.058
positive regulation of immune system process	GO:0002684	90	0.058
kidney mesenchyme development	GO:0072074	2	0.058
b cell differentiation	GO:0030183	2	0.058
metanephric comma shaped body morphogenesis	GO:0072278	2	0.058
positive regulation of cellular biosynthetic process	GO:0031328	295	0.057	Human
response to metal ion	GO:0010038	253	0.057
negative regulation of cell development	GO:0010721	82	0.057
reproduction	GO:0000003	245	0.057	Mouse
positive regulation of mesenchymal cell proliferation	GO:0002053	4	0.057
negative regulation of osteoblast differentiation	GO:0045668	2	0.057
metal ion transport	GO:0030001	289	0.057	Mouse Rat
regulation of cellular amino acid metabolic process	GO:0006521	2	0.056
monovalent inorganic cation transport	GO:0015672	172	0.056	Mouse Rat
mapk cascade	GO:0000165	140	0.056
regulation of immunoglobulin mediated immune response	GO:0002889	2	0.055
heart morphogenesis	GO:0003007	3	0.055
response to purine containing compound	GO:0014074	126	0.055
positive regulation of epidermis development	GO:0045684	1	0.054
regulation of cellular amine metabolic process	GO:0033238	8	0.054
single organism catabolic process	GO:0044712	283	0.054	Human Rat
regulation of calcium ion transport	GO:0051924	77	0.054	Mouse
muscle contraction	GO:0006936	88	0.054
nucleoside phosphate biosynthetic process	GO:1901293	102	0.054	Human
cardiac muscle contraction	GO:0060048	27	0.054
b cell mediated immunity	GO:0019724	4	0.053
digestive tract development	GO:0048565	39	0.053
nucleoside metabolic process	GO:0009116	179	0.053
cell differentiation involved in kidney development	GO:0061005	4	0.053
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.053
positive regulation of nucleotide metabolic process	GO:0045981	91	0.052	Human
negative regulation of molecular function	GO:0044092	133	0.052	Mouse
catabolic process	GO:0009056	351	0.052	Human Rat
sensory perception	GO:0007600	101	0.052	Rat
response to interleukin 1	GO:0070555	55	0.052	Rat
small gtpase mediated signal transduction	GO:0007264	36	0.052
negative regulation of macromolecule metabolic process	GO:0010605	260	0.052	Rat
renal system process	GO:0003014	40	0.051
cell migration involved in kidney development	GO:0035787	2	0.051
regulation of immunoglobulin production	GO:0002637	4	0.051
muscle tissue development	GO:0060537	58	0.051
regulation of cell morphogenesis	GO:0022604	77	0.051
metanephric mesenchyme development	GO:0072075	2	0.050
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.050
positive regulation of gene expression	GO:0010628	244	0.050
reproductive system development	GO:0061458	128	0.049	Mouse
regulation of muscle tissue development	GO:1901861	25	0.049
regulation of locomotion	GO:0040012	148	0.049
striated muscle cell development	GO:0055002	26	0.049
epithelial cell proliferation	GO:0050673	54	0.049	Rat
negative regulation of transcription regulatory region dna binding	GO:2000678	2	0.049
ribonucleoside metabolic process	GO:0009119	174	0.049
cellular response to glucocorticoid stimulus	GO:0071385	68	0.049
heart process	GO:0003015	57	0.049	Mouse Rat Fly
rna metabolic process	GO:0016070	406	0.049
protein complex assembly	GO:0006461	263	0.048
negative regulation of protein metabolic process	GO:0051248	114	0.048	Rat
regulation of actin filament based movement	GO:1903115	12	0.048
urogenital system development	GO:0001655	78	0.048
positive regulation of vasodilation	GO:0045909	29	0.048	Rat
negative regulation of heart growth	GO:0061117	3	0.047
organic anion transport	GO:0015711	132	0.047
striated muscle tissue development	GO:0014706	58	0.047
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.047
chemotaxis	GO:0006935	66	0.047
coronary vasculature morphogenesis	GO:0060977	3	0.047
regulation of cellular response to growth factor stimulus	GO:0090287	15	0.046
cellular response to hormone stimulus	GO:0032870	247	0.046
negative regulation of signal transduction	GO:0009968	83	0.046
regulation of transcription regulatory region dna binding	GO:2000677	4	0.046
regulation of fat cell differentiation	GO:0045598	3	0.046
vasculature development	GO:0001944	70	0.045	Mouse
negative regulation of response to external stimulus	GO:0032102	37	0.045
positive regulation of cellular protein metabolic process	GO:0032270	167	0.045
morphogenesis of an epithelium	GO:0002009	20	0.045
ovulation cycle process	GO:0022602	50	0.045	Mouse
positive regulation of hydrolase activity	GO:0051345	86	0.045
positive regulation of immunoglobulin production	GO:0002639	4	0.045
ribonucleotide biosynthetic process	GO:0009260	85	0.044	Human
regulation of mesenchymal cell proliferation	GO:0010464	4	0.044
regulation of cell motility	GO:2000145	131	0.044
regulation of epithelial cell proliferation	GO:0050678	49	0.044
inflammatory response	GO:0006954	150	0.044
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.044
response to vitamin	GO:0033273	131	0.044	Rat
neuron projection development	GO:0031175	273	0.044
mechanoreceptor differentiation	GO:0042490	2	0.044
cellular response to mechanical stimulus	GO:0071260	48	0.044
positive regulation of cellular component movement	GO:0051272	102	0.044
single organism biosynthetic process	GO:0044711	342	0.043	Human
negative regulation of developmental growth	GO:0048640	15	0.043
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.043
metanephric glomerulus morphogenesis	GO:0072275	1	0.042
negative regulation of cellular biosynthetic process	GO:0031327	161	0.042
positive regulation of neurogenesis	GO:0050769	165	0.041
digestive system development	GO:0055123	41	0.041
sexual reproduction	GO:0019953	148	0.041	Mouse
response to vitamin d	GO:0033280	34	0.041	Rat
regulation of cyclic nucleotide biosynthetic process	GO:0030802	45	0.040	Human
negative regulation of cell growth	GO:0030308	33	0.040
regulation of mapk cascade	GO:0043408	116	0.040
response to organophosphorus	GO:0046683	102	0.040
cyclic purine nucleotide metabolic process	GO:0052652	62	0.040	Human
response to dexamethasone	GO:0071548	49	0.039	Rat
nucleoside catabolic process	GO:0009164	126	0.039
response to lipopolysaccharide	GO:0032496	191	0.039
cellular catabolic process	GO:0044248	295	0.039	Human Rat
sensory organ development	GO:0007423	74	0.039
cytosolic calcium ion homeostasis	GO:0051480	140	0.039	Rat
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.039
positive regulation of purine nucleotide biosynthetic process	GO:1900373	36	0.039	Human
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	5	0.038
response to hexose	GO:0009746	144	0.038
positive regulation of cytoskeleton organization	GO:0051495	26	0.038
amine metabolic process	GO:0009308	38	0.038
regulation of actin filament based process	GO:0032970	42	0.038
response to camp	GO:0051591	91	0.038
positive regulation of nervous system development	GO:0051962	178	0.038
regulation of sodium ion transport	GO:0002028	21	0.038	Mouse Rat
g protein coupled receptor signaling pathway	GO:0007186	242	0.038	Rat
negative regulation of biosynthetic process	GO:0009890	168	0.037
cellular response to organic cyclic compound	GO:0071407	202	0.037
camera type eye development	GO:0043010	48	0.037
proteolysis	GO:0006508	175	0.037
organonitrogen compound catabolic process	GO:1901565	179	0.037	Human Rat
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.037	Rat
positive regulation of transcription dna templated	GO:0045893	197	0.037
regulation of cell projection organization	GO:0031344	175	0.036
response to nicotine	GO:0035094	51	0.036	Rat
cation transmembrane transport	GO:0098655	263	0.036	Rat
macromolecular complex subunit organization	GO:0043933	339	0.036
macromolecular complex assembly	GO:0065003	273	0.036
negative regulation of gene expression	GO:0010629	199	0.036
t helper 1 type immune response	GO:0042088	1	0.036
response to tumor necrosis factor	GO:0034612	56	0.036
cellular amine metabolic process	GO:0044106	38	0.036
bone remodeling	GO:0046849	23	0.036
cellular response to organonitrogen compound	GO:0071417	197	0.036
response to bacterium	GO:0009617	200	0.036
anterior posterior pattern specification	GO:0009952	1	0.036
epithelium development	GO:0060429	96	0.036
striated muscle contraction	GO:0006941	44	0.035
single organism intracellular transport	GO:1902582	166	0.035
reactive oxygen species metabolic process	GO:0072593	37	0.035
mrna transcription from rna polymerase ii promoter	GO:0042789	1	0.035
negative regulation of intracellular signal transduction	GO:1902532	38	0.035
transcription dna templated	GO:0006351	377	0.035
aminoglycan biosynthetic process	GO:0006023	4	0.035
tube development	GO:0035295	89	0.035	Mouse
regulation of metanephros development	GO:0072215	4	0.035
negative regulation of blood vessel morphogenesis	GO:2000181	10	0.035
regulation of ion transmembrane transport	GO:0034765	121	0.035	Rat
regulation of organelle organization	GO:0033043	80	0.035
response to ethanol	GO:0045471	162	0.034
cell projection organization	GO:0030030	302	0.034
response to acid chemical	GO:0001101	222	0.034
metanephric s shaped body morphogenesis	GO:0072284	2	0.034
regulation of cardiac muscle cell contraction	GO:0086004	11	0.034
regulation of muscle system process	GO:0090257	79	0.034	Mouse
positive regulation of protein serine threonine kinase activity	GO:0071902	52	0.034
muscle cell differentiation	GO:0042692	52	0.034
cell morphogenesis involved in differentiation	GO:0000904	119	0.034
regulation of protein modification process	GO:0031399	194	0.034	Rat
muscle organ development	GO:0007517	50	0.034
cell migration involved in metanephros development	GO:0035788	2	0.034
guanosine containing compound catabolic process	GO:1901069	71	0.033
regulation of cellular component biogenesis	GO:0044087	86	0.033
t cell activation	GO:0042110	29	0.032
cardiac cell development	GO:0055006	16	0.032
hair cell differentiation	GO:0035315	2	0.032
positive regulation of intracellular signal transduction	GO:1902533	138	0.032
cellular response to insulin stimulus	GO:0032869	81	0.032
response to mineralocorticoid	GO:0051385	49	0.032
negative regulation of epithelial cell proliferation	GO:0050680	16	0.032
regulation of cell migration	GO:0030334	128	0.032
gliogenesis	GO:0042063	93	0.031
hematopoietic progenitor cell differentiation	GO:0002244	2	0.031
response to other organism	GO:0051707	220	0.031
regulation of neural precursor cell proliferation	GO:2000177	16	0.031
nucleobase containing compound catabolic process	GO:0034655	152	0.031
neuron development	GO:0048666	286	0.031
chemosensory behavior	GO:0007635	2	0.031
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.031	Human
gamete generation	GO:0007276	124	0.031	Mouse
purine ribonucleotide catabolic process	GO:0009154	136	0.031
protein complex biogenesis	GO:0070271	263	0.031
multicellular organismal homeostasis	GO:0048871	49	0.031
central nervous system development	GO:0007417	311	0.030
angiogenesis	GO:0001525	53	0.030	Mouse
purine ribonucleoside catabolic process	GO:0046130	124	0.030
tissue morphogenesis	GO:0048729	22	0.030
establishment of protein localization	GO:0045184	141	0.030
muscle cell development	GO:0055001	26	0.030
platelet derived growth factor receptor alpha signaling pathway	GO:0035790	1	0.030
negative regulation of endothelial cell proliferation	GO:0001937	5	0.030
camp biosynthetic process	GO:0006171	47	0.030
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.030
regulation of vasoconstriction	GO:0019229	44	0.030	Rat
positive regulation of kinase activity	GO:0033674	77	0.030
carbohydrate derivative catabolic process	GO:1901136	147	0.029
positive regulation of cellular amine metabolic process	GO:0033240	3	0.029
developmental process involved in reproduction	GO:0003006	159	0.029	Mouse
protein localization to organelle	GO:0033365	57	0.029
cellular component morphogenesis	GO:0032989	155	0.029
regulation of stem cell differentiation	GO:2000736	2	0.029
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.029
positive regulation of protein metabolic process	GO:0051247	178	0.029
positive regulation of rna metabolic process	GO:0051254	203	0.029
mesenchymal to epithelial transition	GO:0060231	3	0.029
organic acid transport	GO:0015849	116	0.029
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure	GO:0001999	1	0.029
regulation of ossification	GO:0030278	32	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.028
negative regulation of protein phosphorylation	GO:0001933	44	0.028	Rat
regulation of muscle organ development	GO:0048634	26	0.028
kidney epithelium development	GO:0072073	19	0.028
cytokine mediated signaling pathway	GO:0019221	43	0.028
dna metabolic process	GO:0006259	96	0.028
purine nucleoside catabolic process	GO:0006152	124	0.028

Nos3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
cardiovascular system disease	DOID:1287	0.122	Human
disease of anatomical entity	DOID:7	0.122	Human
vascular disease	DOID:178	0.036	Human
urinary system disease	DOID:18	0.029

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