IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Mxd4

Max dimerization protein 4

RGD: 1305093
Entrez: 360961
UniProtKB: D3ZJ97

Process Predictions
Disease Predictions

Mxd4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
response to peptide	GO:1901652	292	0.303
response to peptide hormone	GO:0043434	278	0.150
response to nutrient	GO:0007584	248	0.124
reproductive process	GO:0022414	372	0.100
positive regulation of gene expression	GO:0010628	244	0.096
response to nutrient levels	GO:0031667	370	0.080
regulation of nucleic acid templated transcription	GO:1903506	380	0.076
central nervous system development	GO:0007417	311	0.072
cellular component assembly	GO:0022607	360	0.068
regulation of cell differentiation	GO:0045595	320	0.068
regulation of neuron differentiation	GO:0045664	208	0.067
regulation of multicellular organismal development	GO:2000026	376	0.064
tissue development	GO:0009888	252	0.063
brain development	GO:0007420	247	0.061
positive regulation of biosynthetic process	GO:0009891	319	0.060
negative regulation of cellular metabolic process	GO:0031324	281	0.060
neurological system process	GO:0050877	219	0.060
negative regulation of metabolic process	GO:0009892	331	0.058
regulation of programmed cell death	GO:0043067	341	0.058
cellular response to organonitrogen compound	GO:0071417	197	0.057
regulation of rna biosynthetic process	GO:2001141	381	0.056
neuron differentiation	GO:0030182	368	0.056
positive regulation of apoptotic process	GO:0043065	154	0.055
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.055
response to glucocorticoid	GO:0051384	223	0.055
regulation of neurogenesis	GO:0050767	247	0.055
regulation of signal transduction	GO:0009966	318	0.054
cellular component biogenesis	GO:0044085	368	0.053
cell cell signaling	GO:0007267	335	0.053
organic acid metabolic process	GO:0006082	292	0.052
positive regulation of rna metabolic process	GO:0051254	203	0.051
positive regulation of cellular biosynthetic process	GO:0031328	295	0.051
secretion by cell	GO:0032940	248	0.051
negative regulation of protein metabolic process	GO:0051248	114	0.051
cellular response to oxygen containing compound	GO:1901701	386	0.049
regulation of molecular function	GO:0065009	398	0.049
cellular response to peptide hormone stimulus	GO:0071375	120	0.048
vesicle mediated transport	GO:0016192	181	0.048
intracellular signal transduction	GO:0035556	314	0.047
transcription from rna polymerase ii promoter	GO:0006366	252	0.047
response to extracellular stimulus	GO:0009991	380	0.046
regulation of cell proliferation	GO:0042127	359	0.046
transcription dna templated	GO:0006351	377	0.045
positive regulation of secretion by cell	GO:1903532	128	0.045
regulation of cell development	GO:0060284	263	0.045
negative regulation of gene expression	GO:0010629	199	0.044
neuron development	GO:0048666	286	0.044
cellular response to endogenous stimulus	GO:0071495	377	0.044
response to oxygen levels	GO:0070482	265	0.043
positive regulation of transport	GO:0051050	245	0.043
reproduction	GO:0000003	245	0.042
secretion	GO:0046903	307	0.042
positive regulation of cell death	GO:0010942	184	0.040
multicellular organism reproduction	GO:0032504	233	0.040
cellular amino acid metabolic process	GO:0006520	107	0.040
synaptic transmission	GO:0007268	235	0.039
circulatory system process	GO:0003013	183	0.039
cellular component movement	GO:0006928	248	0.039
rna biosynthetic process	GO:0032774	380	0.038
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.037
positive regulation of transcription dna templated	GO:0045893	197	0.037
multi organism reproductive process	GO:0044703	262	0.036
rhythmic process	GO:0048511	156	0.036
negative regulation of rna biosynthetic process	GO:1902679	118	0.036
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.035
proteolysis	GO:0006508	175	0.035
intracellular transport	GO:0046907	185	0.035
negative regulation of biosynthetic process	GO:0009890	168	0.035
exocytosis	GO:0006887	60	0.034
response to mechanical stimulus	GO:0009612	134	0.034
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.034
purine ribonucleotide metabolic process	GO:0009150	227	0.034
regulation of synaptic transmission	GO:0050804	141	0.034
regulation of cellular component movement	GO:0051270	150	0.034
positive regulation of cell differentiation	GO:0045597	217	0.033
protein processing	GO:0016485	68	0.033
regulation of protein metabolic process	GO:0051246	289	0.033
vesicle organization	GO:0016050	29	0.033
ion transmembrane transport	GO:0034220	365	0.033
carboxylic acid metabolic process	GO:0019752	289	0.033
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.032
peptidyl lysine hydroxylation	GO:0017185	1	0.032
macromolecular complex subunit organization	GO:0043933	339	0.032
cell morphogenesis involved in differentiation	GO:0000904	119	0.032
anatomical structure morphogenesis	GO:0009653	298	0.031
cellular chemical homeostasis	GO:0055082	247	0.031
organelle organization	GO:0006996	266	0.031
regulation of nervous system development	GO:0051960	264	0.031
cellular response to peptide	GO:1901653	133	0.031
head development	GO:0060322	247	0.031
rna metabolic process	GO:0016070	406	0.031
cognition	GO:0050890	92	0.030
cellular amine metabolic process	GO:0044106	38	0.030
wound healing	GO:0042060	122	0.030
response to inorganic substance	GO:0010035	377	0.030
negative regulation of molecular function	GO:0044092	133	0.030
regulation of secretion by cell	GO:1903530	208	0.030
positive regulation of cell proliferation	GO:0008284	249	0.029
cation transport	GO:0006812	382	0.029
cellular response to hormone stimulus	GO:0032870	247	0.029
response to hypoxia	GO:0001666	231	0.028
regulation of apoptotic process	GO:0042981	335	0.028
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.028
positive regulation of signaling	GO:0023056	270	0.028
regulation of cellular amine metabolic process	GO:0033238	8	0.027
positive regulation of secretion	GO:0051047	140	0.027
single organism intracellular transport	GO:1902582	166	0.027
regulation of catalytic activity	GO:0050790	304	0.027
cell motility	GO:0048870	202	0.027
positive regulation of cellular amine metabolic process	GO:0033240	3	0.027
aging	GO:0007568	241	0.027
response to wounding	GO:0009611	254	0.027
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.026
negative regulation of multicellular organismal process	GO:0051241	203	0.026
negative regulation of transcription dna templated	GO:0045892	116	0.026
response to carbohydrate	GO:0009743	183	0.026
single organism reproductive process	GO:0044702	297	0.025
response to ketone	GO:1901654	182	0.025
protein localization	GO:0008104	191	0.025
response to ethanol	GO:0045471	162	0.025
cellular component morphogenesis	GO:0032989	155	0.025
regulation of neuron projection development	GO:0010975	161	0.025
regulation of exocytosis	GO:0017157	37	0.025
amine metabolic process	GO:0009308	38	0.025
apoptotic process	GO:0006915	381	0.024
response to glucose	GO:0009749	136	0.024
regulation of cellular protein metabolic process	GO:0032268	267	0.024
multicellular organismal reproductive process	GO:0048609	233	0.024
cell type specific apoptotic process	GO:0097285	134	0.024
cellular response to extracellular stimulus	GO:0031668	73	0.024
negative regulation of cell death	GO:0060548	229	0.024
neuron projection development	GO:0031175	273	0.024
regulation of cell projection organization	GO:0031344	175	0.024
positive regulation of multicellular organismal process	GO:0051240	387	0.024
synaptic growth at neuromuscular junction	GO:0051124	1	0.024
regulation of nucleotide biosynthetic process	GO:0030808	47	0.023
mapk cascade	GO:0000165	140	0.023
neuron fate commitment	GO:0048663	4	0.023
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.023
response to hexose	GO:0009746	144	0.022
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.022
peptidyl amino acid modification	GO:0018193	126	0.022
response to decreased oxygen levels	GO:0036293	237	0.022
positive regulation of nervous system development	GO:0051962	178	0.022
regulation of intracellular signal transduction	GO:1902531	218	0.022
positive regulation of neurogenesis	GO:0050769	165	0.022
organic hydroxy compound transport	GO:0015850	77	0.022
organic anion transport	GO:0015711	132	0.022
regulation of rna metabolic process	GO:0051252	391	0.022
regulation of transcription dna templated	GO:0006355	374	0.022
positive regulation of programmed cell death	GO:0043068	157	0.021
cellular response to external stimulus	GO:0071496	118	0.021
oxoacid metabolic process	GO:0043436	290	0.021
regulation of response to wounding	GO:1903034	69	0.021
response to insulin	GO:0032868	133	0.021
behavior	GO:0007610	205	0.021
biological adhesion	GO:0022610	110	0.021
cellular ketone metabolic process	GO:0042180	51	0.021
regulation of cellular amino acid metabolic process	GO:0006521	2	0.021
regulation of anatomical structure size	GO:0090066	135	0.020
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.020
negative regulation of signaling	GO:0023057	157	0.020
cell projection organization	GO:0030030	302	0.020
skeletal system development	GO:0001501	41	0.020
positive regulation of cell communication	GO:0010647	271	0.020
organophosphate biosynthetic process	GO:0090407	143	0.020
regulation of secretion	GO:0051046	224	0.020
negative regulation of cellular protein metabolic process	GO:0032269	106	0.020
actin filament based process	GO:0030029	86	0.020
glucose metabolic process	GO:0006006	52	0.020
positive regulation of developmental process	GO:0051094	283	0.020
response to organophosphorus	GO:0046683	102	0.019
negative regulation of macromolecule metabolic process	GO:0010605	260	0.019
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.019
regulation of cell cycle	GO:0051726	73	0.019
negative regulation of cellular biosynthetic process	GO:0031327	161	0.019
negative regulation of rna metabolic process	GO:0051253	123	0.019
single organism carbohydrate metabolic process	GO:0044723	118	0.019
nucleic acid templated transcription	GO:0097659	379	0.019
negative regulation of programmed cell death	GO:0043069	183	0.019
response to estrogen	GO:0043627	232	0.019
neuromuscular process	GO:0050905	2	0.019
macromolecule localization	GO:0033036	252	0.019
metal ion transport	GO:0030001	289	0.019
signal transduction by phosphorylation	GO:0023014	144	0.018
negative regulation of neuron death	GO:1901215	69	0.018
positive regulation of neuron differentiation	GO:0045666	126	0.018
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.018
carbohydrate derivative metabolic process	GO:1901135	346	0.018
lipid transport	GO:0006869	61	0.018
purine ribonucleotide biosynthetic process	GO:0009152	81	0.018
regulation of cellular component organization	GO:0051128	368	0.018
multi multicellular organism process	GO:0044706	138	0.017
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.017
monovalent inorganic cation transport	GO:0015672	172	0.017
lipid metabolic process	GO:0006629	283	0.017
learning or memory	GO:0007611	90	0.017
nitrogen compound transport	GO:0071705	229	0.017
neuron projection morphogenesis	GO:0048812	122	0.017
regulation of cell motility	GO:2000145	131	0.017
heart morphogenesis	GO:0003007	3	0.017
regulation of phosphate metabolic process	GO:0019220	349	0.017
carbohydrate derivative biosynthetic process	GO:1901137	124	0.017
regulation of membrane potential	GO:0042391	110	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.017
organic acid transport	GO:0015849	116	0.016
negative regulation of protein maturation	GO:1903318	47	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.016
sensory organ development	GO:0007423	74	0.016
single organism biosynthetic process	GO:0044711	342	0.016
chemical homeostasis	GO:0048878	292	0.016
cyclic nucleotide biosynthetic process	GO:0009190	63	0.016
metal ion homeostasis	GO:0055065	186	0.016
carbohydrate metabolic process	GO:0005975	130	0.016
calcium ion homeostasis	GO:0055074	162	0.016
ion homeostasis	GO:0050801	212	0.016
hexose metabolic process	GO:0019318	58	0.016
response to corticosteroid	GO:0031960	235	0.016
negative regulation of catalytic activity	GO:0043086	103	0.016
cellular metal ion homeostasis	GO:0006875	172	0.016
sensory perception	GO:0007600	101	0.016
positive regulation of molecular function	GO:0044093	230	0.016
cellular response to growth factor stimulus	GO:0071363	162	0.016
reactive oxygen species metabolic process	GO:0072593	37	0.016
transmembrane transport	GO:0055085	412	0.016
protein transport	GO:0015031	132	0.016
response to acid chemical	GO:0001101	222	0.016
cellular catabolic process	GO:0044248	295	0.016
positive regulation of cell development	GO:0010720	176	0.016
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.015
cell morphogenesis	GO:0000902	142	0.015
negative regulation of apoptotic process	GO:0043066	181	0.015
regulation of mapk cascade	GO:0043408	116	0.015
sexual reproduction	GO:0019953	148	0.015
lipid storage	GO:0019915	1	0.015
organ morphogenesis	GO:0009887	75	0.015
cation transmembrane transport	GO:0098655	263	0.015
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.015
regulation of cellular localization	GO:0060341	263	0.015
cellular response to organic cyclic compound	GO:0071407	202	0.015
cation homeostasis	GO:0055080	195	0.015
cellular response to stress	GO:0033554	269	0.015
positive regulation of cellular component organization	GO:0051130	200	0.015
regulation of phosphorus metabolic process	GO:0051174	349	0.015
localization of cell	GO:0051674	202	0.015
ribonucleotide biosynthetic process	GO:0009260	85	0.015
regulation of camp biosynthetic process	GO:0030817	38	0.015
positive regulation of cell projection organization	GO:0031346	111	0.014
positive regulation of catalytic activity	GO:0043085	184	0.014
response to growth factor	GO:0070848	189	0.014
blood circulation	GO:0008015	183	0.014
regulation of proteolysis	GO:0030162	66	0.014
negative regulation of osteoblast differentiation	GO:0045668	2	0.014
positive regulation of smooth muscle cell apoptotic process	GO:0034393	2	0.014
cytoplasmic transport	GO:0016482	115	0.014
cytosolic calcium ion homeostasis	GO:0051480	140	0.014
regulation of protein maturation	GO:1903317	50	0.014
multicellular organism growth	GO:0035264	1	0.014
type b pancreatic cell proliferation	GO:0044342	3	0.014
response to lipopolysaccharide	GO:0032496	191	0.014
protein complex assembly	GO:0006461	263	0.013
cyclic purine nucleotide metabolic process	GO:0052652	62	0.013
positive regulation of rna biosynthetic process	GO:1902680	197	0.013
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.013
protein oligomerization	GO:0051259	191	0.013
cellular cation homeostasis	GO:0030003	180	0.013
single organism organelle organization	GO:1902589	180	0.013
negative regulation of protein processing	GO:0010955	47	0.013
monosaccharide metabolic process	GO:0005996	61	0.013
response to fatty acid	GO:0070542	65	0.013
neuron apoptotic process	GO:0051402	88	0.013
nucleotide biosynthetic process	GO:0009165	98	0.013
divalent inorganic cation homeostasis	GO:0072507	165	0.013
purine nucleotide biosynthetic process	GO:0006164	83	0.013
male gamete generation	GO:0048232	99	0.013
regulation of blood circulation	GO:1903522	110	0.013
heart process	GO:0003015	57	0.013
response to biotic stimulus	GO:0009607	226	0.013
cellular ion homeostasis	GO:0006873	184	0.013
positive regulation of exocytosis	GO:0045921	19	0.013
regulation of vesicle mediated transport	GO:0060627	81	0.013
cell migration	GO:0016477	197	0.013
maintenance of location	GO:0051235	17	0.012
positive regulation of intracellular signal transduction	GO:1902533	138	0.012
camp biosynthetic process	GO:0006171	47	0.012
cell part morphogenesis	GO:0032990	123	0.012
response to monosaccharide	GO:0034284	159	0.012
heart contraction	GO:0060047	57	0.012
response to oxidative stress	GO:0006979	186	0.012
amide transport	GO:0042886	105	0.012
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.012
regulation of protein processing	GO:0070613	50	0.012
purine nucleotide metabolic process	GO:0006163	229	0.012
response to purine containing compound	GO:0014074	126	0.012
organelle localization	GO:0051640	55	0.012
cell substrate adhesion	GO:0031589	29	0.012
cell cycle	GO:0007049	101	0.012
negative regulation of cellular component organization	GO:0051129	83	0.012
axonogenesis	GO:0007409	71	0.012
intra golgi vesicle mediated transport	GO:0006891	3	0.012
regulation of cell migration	GO:0030334	128	0.012
response to vitamin	GO:0033273	131	0.012
membrane fusion	GO:0061025	26	0.012
gamete generation	GO:0007276	124	0.012
cyclic nucleotide metabolic process	GO:0009187	80	0.012
regulation of cellular ketone metabolic process	GO:0010565	27	0.012
regulation of neuron death	GO:1901214	115	0.012
cellular response to nitrogen compound	GO:1901699	210	0.012
carboxylic acid transport	GO:0046942	115	0.012
regulation of heart contraction	GO:0008016	48	0.012
protein heterooligomerization	GO:0051291	89	0.012
cellular response to insulin stimulus	GO:0032869	81	0.012
regulation of establishment of planar polarity	GO:0090175	2	0.012
cell adhesion	GO:0007155	110	0.012
signal release	GO:0023061	145	0.012
negative regulation of innate immune response	GO:0045824	4	0.011
positive regulation of protein phosphorylation	GO:0001934	135	0.011
muscle system process	GO:0003012	115	0.011
negative regulation of proteolysis	GO:0045861	41	0.011
regulation of phosphorylation	GO:0042325	248	0.011
positive regulation of phosphorylation	GO:0042327	177	0.011
positive regulation of cellular protein metabolic process	GO:0032270	167	0.011
positive regulation of ion transport	GO:0043270	94	0.011
negative regulation of peptidase activity	GO:0010466	38	0.011
receptor mediated endocytosis	GO:0006898	42	0.011
organophosphate metabolic process	GO:0019637	370	0.011
neuron death	GO:0070997	127	0.011
tube development	GO:0035295	89	0.011
sensory perception of pain	GO:0019233	73	0.011
dendrite development	GO:0016358	72	0.011
organonitrogen compound biosynthetic process	GO:1901566	167	0.011
forebrain development	GO:0030900	98	0.011
developmental process involved in reproduction	GO:0003006	159	0.011
appendage morphogenesis	GO:0035107	4	0.011
response to other organism	GO:0051707	220	0.011
protein phosphorylation	GO:0006468	345	0.011
regulation of ion transport	GO:0043269	245	0.011
positive regulation of protein metabolic process	GO:0051247	178	0.011
negative regulation of jnk cascade	GO:0046329	4	0.011
connective tissue development	GO:0061448	33	0.011
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.011
vascular process in circulatory system	GO:0003018	96	0.011
positive regulation of response to stimulus	GO:0048584	285	0.011
negative regulation of endopeptidase activity	GO:0010951	36	0.011
epithelial cell differentiation	GO:0030855	71	0.011
regulation of cell cycle g2 m phase transition	GO:1902749	4	0.011
ribose phosphate metabolic process	GO:0019693	235	0.011
circadian rhythm	GO:0007623	88	0.011
glial cell development	GO:0021782	19	0.011
regulation of response to stress	GO:0080134	126	0.011
response to estradiol	GO:0032355	164	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
golgi vesicle transport	GO:0048193	22	0.010
positive regulation of phosphorus metabolic process	GO:0010562	262	0.010
positive regulation of neuron projection development	GO:0010976	99	0.010
cellular response to nutrient levels	GO:0031669	60	0.010
developmental induction	GO:0031128	2	0.010
regulation of response to external stimulus	GO:0032101	106	0.010
odontogenesis	GO:0042476	32	0.010
neuron neuron synaptic transmission	GO:0007270	60	0.010
membrane organization	GO:0061024	94	0.010
insulin like growth factor receptor signaling pathway	GO:0048009	3	0.010
response to molecule of bacterial origin	GO:0002237	194	0.010
maternal process involved in female pregnancy	GO:0060135	38	0.010
nucleoside phosphate biosynthetic process	GO:1901293	102	0.010
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.010
purine containing compound biosynthetic process	GO:0072522	85	0.010
eye development	GO:0001654	50	0.010

Mxd4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.023
disease of anatomical entity	DOID:7	0.014
eye and adnexa disease	DOID:1492	0.014
nervous system disease	DOID:863	0.014
sensory system disease	DOID:0050155	0.014
inherited metabolic disorder	DOID:655	0.012

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