IMP: Integrative Multi-species Prediction

Rattus norvegicus

5 known processes

Tpi1

triosephosphate isomerase 1

(Aliases: MGC156639,Tpi)

Entrez: 24849
Ensembl: ENSRNOG00000015290
RGD: 3896
UniProtKB: P48500

Process Predictions
Disease Predictions

Tpi1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
carbohydrate catabolic process	GO:0016052	40	1.000
single organism carbohydrate catabolic process	GO:0044724	40	0.999
generation of precursor metabolites and energy	GO:0006091	62	0.981
monocarboxylic acid metabolic process	GO:0032787	152	0.892
coenzyme metabolic process	GO:0006732	86	0.888
carboxylic acid metabolic process	GO:0019752	289	0.876
organic acid metabolic process	GO:0006082	292	0.866
oxoacid metabolic process	GO:0043436	290	0.835
glycolytic process	GO:0006096	17	0.791
monosaccharide metabolic process	GO:0005996	61	0.716
single organism catabolic process	GO:0044712	283	0.712
pyridine containing compound metabolic process	GO:0072524	32	0.669
single organism biosynthetic process	GO:0044711	342	0.591
gluconeogenesis	GO:0006094	15	0.583
carbohydrate metabolic process	GO:0005975	130	0.535
nucleobase containing small molecule metabolic process	GO:0055086	316	0.530
organic substance catabolic process	GO:1901575	316	0.521
response to organophosphorus	GO:0046683	102	0.516
single organism carbohydrate metabolic process	GO:0044723	118	0.492
glucose metabolic process	GO:0006006	52	0.482
organophosphate metabolic process	GO:0019637	370	0.473
response to camp	GO:0051591	91	0.462
purine ribonucleoside biosynthetic process	GO:0046129	21	0.443
pyruvate metabolic process	GO:0006090	27	0.390
catabolic process	GO:0009056	351	0.384
hexose biosynthetic process	GO:0019319	15	0.325
regulation of programmed cell death	GO:0043067	341	0.296
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.294
hexose metabolic process	GO:0019318	58	0.276
cellular response to peptide hormone stimulus	GO:0071375	120	0.271
pyridine nucleotide metabolic process	GO:0019362	28	0.241
carbohydrate biosynthetic process	GO:0016051	42	0.241
purine ribonucleotide biosynthetic process	GO:0009152	81	0.230
response to peptide hormone	GO:0043434	278	0.206
regulation of neurogenesis	GO:0050767	247	0.198
cofactor metabolic process	GO:0051186	95	0.190
regulation of apoptotic process	GO:0042981	335	0.180
response to nutrient	GO:0007584	248	0.179
response to hypoxia	GO:0001666	231	0.176
response to oxidative stress	GO:0006979	186	0.175
lactate metabolic process	GO:0006089	3	0.171
nucleoside triphosphate metabolic process	GO:0009141	144	0.167
nucleoside phosphate metabolic process	GO:0006753	283	0.163
organophosphate biosynthetic process	GO:0090407	143	0.162
nucleotide metabolic process	GO:0009117	279	0.161
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.147
positive regulation of programmed cell death	GO:0043068	157	0.146
response to decreased oxygen levels	GO:0036293	237	0.133
liver development	GO:0001889	90	0.129
gland development	GO:0048732	155	0.127
response to peptide	GO:1901652	292	0.123
programmed cell death	GO:0012501	392	0.120
response to purine containing compound	GO:0014074	126	0.118
apoptotic process	GO:0006915	381	0.113
proteolysis	GO:0006508	175	0.112
response to extracellular stimulus	GO:0009991	380	0.109
purine nucleotide biosynthetic process	GO:0006164	83	0.106
protein complex biogenesis	GO:0070271	263	0.103
cellular response to endogenous stimulus	GO:0071495	377	0.103
cellular response to oxygen containing compound	GO:1901701	386	0.101
ribonucleoside biosynthetic process	GO:0042455	25	0.101
nad metabolic process	GO:0019674	15	0.100
cellular component assembly	GO:0022607	360	0.099
response to hexose	GO:0009746	144	0.095
response to temperature stimulus	GO:0009266	94	0.095
response to inorganic substance	GO:0010035	377	0.091
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.089
response to estrogen	GO:0043627	232	0.088
carboxylic acid biosynthetic process	GO:0046394	83	0.086
alpha amino acid metabolic process	GO:1901605	71	0.085
negative regulation of metabolic process	GO:0009892	331	0.083
response to other organism	GO:0051707	220	0.079
regulation of neuron apoptotic process	GO:0043523	83	0.078
response to metal ion	GO:0010038	253	0.071
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.070
response to nutrient levels	GO:0031667	370	0.069
monosaccharide biosynthetic process	GO:0046364	16	0.068
purine nucleotide metabolic process	GO:0006163	229	0.067
response to atp	GO:0033198	13	0.066
protein processing	GO:0016485	68	0.063
regeneration	GO:0031099	163	0.063
purine containing compound biosynthetic process	GO:0072522	85	0.063
cell type specific apoptotic process	GO:0097285	134	0.062
small molecule biosynthetic process	GO:0044283	124	0.062
cellular response to peptide	GO:1901653	133	0.062
glycosyl compound metabolic process	GO:1901657	182	0.062
growth	GO:0040007	165	0.061
macromolecular complex assembly	GO:0065003	273	0.061
homeostatic process	GO:0042592	331	0.061
regulation of rna biosynthetic process	GO:2001141	381	0.060
single organism reproductive process	GO:0044702	297	0.060
negative regulation of macromolecule metabolic process	GO:0010605	260	0.060
cellular cation homeostasis	GO:0030003	180	0.059
single organism organelle organization	GO:1902589	180	0.059
purine nucleoside monophosphate biosynthetic process	GO:0009127	20	0.058
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	20	0.057
negative regulation of neuron apoptotic process	GO:0043524	45	0.056
neuron apoptotic process	GO:0051402	88	0.056
response to hydrogen peroxide	GO:0042542	89	0.056
carbohydrate derivative metabolic process	GO:1901135	346	0.055
cellular ketone metabolic process	GO:0042180	51	0.053
organic hydroxy compound metabolic process	GO:1901615	115	0.053
positive regulation of phosphorus metabolic process	GO:0010562	262	0.053
organonitrogen compound biosynthetic process	GO:1901566	167	0.052
positive regulation of apoptotic process	GO:0043065	154	0.049
transmembrane transport	GO:0055085	412	0.049
organ regeneration	GO:0031100	101	0.049
ion homeostasis	GO:0050801	212	0.048
hepaticobiliary system development	GO:0061008	90	0.048
cellular response to organonitrogen compound	GO:0071417	197	0.047
cellular carbohydrate metabolic process	GO:0044262	72	0.047
single organism membrane fusion	GO:0044801	17	0.046
response to oxygen levels	GO:0070482	265	0.045
negative regulation of rna metabolic process	GO:0051253	123	0.045
purine nucleoside biosynthetic process	GO:0042451	21	0.044
purine ribonucleotide metabolic process	GO:0009150	227	0.043
cellular ion homeostasis	GO:0006873	184	0.041
cation homeostasis	GO:0055080	195	0.041
rna biosynthetic process	GO:0032774	380	0.040
regulation of rna metabolic process	GO:0051252	391	0.040
negative regulation of mitotic cell cycle phase transition	GO:1901991	3	0.040
nucleoside monophosphate metabolic process	GO:0009123	93	0.040
adp metabolic process	GO:0046031	8	0.040
cellular component biogenesis	GO:0044085	368	0.039
dna templated transcription initiation	GO:0006352	4	0.039
nucleoside metabolic process	GO:0009116	179	0.039
response to monosaccharide	GO:0034284	159	0.039
post embryonic organ development	GO:0048569	2	0.038
cellular homeostasis	GO:0019725	252	0.038
reproduction	GO:0000003	245	0.038
reproductive process	GO:0022414	372	0.038
cellular chemical homeostasis	GO:0055082	247	0.038
immune system process	GO:0002376	204	0.038
negative regulation of gene expression	GO:0010629	199	0.037
regulation of transcription dna templated	GO:0006355	374	0.037
response to transition metal nanoparticle	GO:1990267	122	0.036
membrane organization	GO:0061024	94	0.036
protein complex assembly	GO:0006461	263	0.035
response to bacterium	GO:0009617	200	0.035
nucleoside triphosphate biosynthetic process	GO:0009142	8	0.035
regulation of cell proliferation	GO:0042127	359	0.035
response to carbohydrate	GO:0009743	183	0.034
regulation of phosphorus metabolic process	GO:0051174	349	0.034
regulation of cell differentiation	GO:0045595	320	0.034
cellular response to hormone stimulus	GO:0032870	247	0.033
response to glucose	GO:0009749	136	0.033
cellular metal ion homeostasis	GO:0006875	172	0.032
purine nucleoside metabolic process	GO:0042278	169	0.032
carbohydrate derivative biosynthetic process	GO:1901137	124	0.032
organic acid biosynthetic process	GO:0016053	83	0.032
developmental process involved in reproduction	GO:0003006	159	0.032
nucleotide biosynthetic process	GO:0009165	98	0.031
cellular catabolic process	GO:0044248	295	0.031
organelle organization	GO:0006996	266	0.031
response to molecule of bacterial origin	GO:0002237	194	0.031
oxidoreduction coenzyme metabolic process	GO:0006733	31	0.031
nitrogen compound transport	GO:0071705	229	0.031
ion transmembrane transport	GO:0034220	365	0.030
negative regulation of neuron death	GO:1901215	69	0.030
regulation of protein maturation	GO:1903317	50	0.030
response to external biotic stimulus	GO:0043207	221	0.030
regulation of nervous system development	GO:0051960	264	0.030
organelle fusion	GO:0048284	17	0.030
regulation of multicellular organismal development	GO:2000026	376	0.030
tissue development	GO:0009888	252	0.029
regulation of nucleic acid templated transcription	GO:1903506	380	0.029
protein homooligomerization	GO:0051260	91	0.029
sexual reproduction	GO:0019953	148	0.028
membrane fusion	GO:0061025	26	0.028
purine nucleoside diphosphate metabolic process	GO:0009135	9	0.027
purine ribonucleoside metabolic process	GO:0046128	168	0.027
regulation of system process	GO:0044057	208	0.027
cell cycle phase transition	GO:0044770	21	0.027
cytosolic calcium ion homeostasis	GO:0051480	140	0.027
single organism behavior	GO:0044708	130	0.027
negative regulation of cellular metabolic process	GO:0031324	281	0.027
response to cytokine	GO:0034097	215	0.026
mitochondrion organization	GO:0007005	35	0.026
multicellular organism reproduction	GO:0032504	233	0.026
positive regulation of cell death	GO:0010942	184	0.026
male gamete generation	GO:0048232	99	0.026
purine ribonucleoside catabolic process	GO:0046130	124	0.026
reproductive structure development	GO:0048608	128	0.025
chemical homeostasis	GO:0048878	292	0.025
sex differentiation	GO:0007548	113	0.025
multicellular organismal reproductive process	GO:0048609	233	0.025
response to reactive oxygen species	GO:0000302	120	0.025
cell cycle checkpoint	GO:0000075	2	0.024
positive regulation of cellular component organization	GO:0051130	200	0.024
nucleic acid templated transcription	GO:0097659	379	0.024
ribose phosphate metabolic process	GO:0019693	235	0.024
calcium ion homeostasis	GO:0055074	162	0.024
organonitrogen compound catabolic process	GO:1901565	179	0.024
ribose phosphate biosynthetic process	GO:0046390	87	0.023
multi organism reproductive process	GO:0044703	262	0.023
mitotic spindle organization	GO:0007052	2	0.023
regulation of cell cycle process	GO:0010564	31	0.023
response to estradiol	GO:0032355	164	0.023
atp metabolic process	GO:0046034	72	0.023
rna metabolic process	GO:0016070	406	0.022
reproductive system development	GO:0061458	128	0.022
oxidation reduction process	GO:0055114	304	0.022
neuron death	GO:0070997	127	0.022
glutamate catabolic process	GO:0006538	1	0.022
female gonad development	GO:0008585	53	0.021
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.021
positive regulation of rna biosynthetic process	GO:1902680	197	0.021
regulation of growth	GO:0040008	105	0.021
cellular response to nitrogen compound	GO:1901699	210	0.021
purine containing compound metabolic process	GO:0072521	253	0.021
purine ribonucleoside monophosphate catabolic process	GO:0009169	55	0.021
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.021
behavior	GO:0007610	205	0.021
ribonucleoside triphosphate biosynthetic process	GO:0009201	7	0.020
negative regulation of cell proliferation	GO:0008285	119	0.020
neuron differentiation	GO:0030182	368	0.020
transcription from rna polymerase ii promoter	GO:0006366	252	0.020
myoblast fusion	GO:0007520	2	0.020
response to wounding	GO:0009611	254	0.020
response to insulin	GO:0032868	133	0.020
transcription dna templated	GO:0006351	377	0.020
mitotic dna damage checkpoint	GO:0044773	1	0.020
protein complex subunit organization	GO:0071822	302	0.019
regulation of cell development	GO:0060284	263	0.019
positive regulation of cellular biosynthetic process	GO:0031328	295	0.019
organic cyclic compound catabolic process	GO:1901361	175	0.019
protein nitrosylation	GO:0017014	2	0.019
purine nucleoside catabolic process	GO:0006152	124	0.019
response to lipopolysaccharide	GO:0032496	191	0.019
epithelium development	GO:0060429	96	0.019
regulation of cysteine type endopeptidase activity	GO:2000116	32	0.019
positive regulation of multicellular organismal process	GO:0051240	387	0.019
regulation of phosphorylation	GO:0042325	248	0.019
positive regulation of developmental process	GO:0051094	283	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.018
ribonucleotide biosynthetic process	GO:0009260	85	0.018
positive regulation of neurogenesis	GO:0050769	165	0.018
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.018
energy derivation by oxidation of organic compounds	GO:0015980	46	0.018
ribonucleoside catabolic process	GO:0042454	126	0.018
epithelial cell differentiation	GO:0030855	71	0.018
response to acid chemical	GO:0001101	222	0.017
regulation of carbohydrate catabolic process	GO:0043470	14	0.017
positive regulation of gene expression	GO:0010628	244	0.017
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.017
negative regulation of molecular function	GO:0044092	133	0.017
nucleoside diphosphate metabolic process	GO:0009132	14	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.017
metal ion transport	GO:0030001	289	0.017
metal ion homeostasis	GO:0055065	186	0.016
ribonucleoside monophosphate biosynthetic process	GO:0009156	24	0.016
regulation of molecular function	GO:0065009	398	0.016
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.016
regulation of ion transport	GO:0043269	245	0.016
anatomical structure morphogenesis	GO:0009653	298	0.016
calcium ion transport	GO:0006816	131	0.016
positive regulation of biosynthetic process	GO:0009891	319	0.015
monocarboxylic acid biosynthetic process	GO:0072330	48	0.015
cellular calcium ion homeostasis	GO:0006874	160	0.015
spermatogenesis	GO:0007283	99	0.015
negative regulation of proteolysis	GO:0045861	41	0.015
protein homotetramerization	GO:0051289	25	0.015
response to interleukin 1	GO:0070555	55	0.015
wound healing	GO:0042060	122	0.015
ribonucleotide metabolic process	GO:0009259	231	0.015
regulation of cell growth	GO:0001558	85	0.015
regulation of neuron death	GO:1901214	115	0.014
regulation of phosphate metabolic process	GO:0019220	349	0.014
positive regulation of cellular amine metabolic process	GO:0033240	3	0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	31	0.014
negative regulation of programmed cell death	GO:0043069	183	0.014
negative regulation of cellular biosynthetic process	GO:0031327	161	0.014
divalent inorganic cation homeostasis	GO:0072507	165	0.014
neurological system process	GO:0050877	219	0.014
nucleoside phosphate biosynthetic process	GO:1901293	102	0.014
cell cell signaling	GO:0007267	335	0.014
g2 dna damage checkpoint	GO:0031572	1	0.014
g protein coupled receptor signaling pathway	GO:0007186	242	0.014
negative regulation of cell cycle phase transition	GO:1901988	4	0.013
neuron development	GO:0048666	286	0.013
response to corticosteroid	GO:0031960	235	0.013
positive regulation of neuron differentiation	GO:0045666	126	0.013
cell cycle	GO:0007049	101	0.013
behavioral response to ethanol	GO:0048149	1	0.013
purine ribonucleoside diphosphate biosynthetic process	GO:0009180	9	0.013
positive regulation of rna metabolic process	GO:0051254	203	0.013
female pregnancy	GO:0007565	122	0.013
protein maturation	GO:0051604	68	0.013
regulation of peptidase activity	GO:0052547	55	0.013
cation transport	GO:0006812	382	0.013
glycosyl compound biosynthetic process	GO:1901659	25	0.013
cellular amine metabolic process	GO:0044106	38	0.013
ribonucleotide catabolic process	GO:0009261	136	0.013
negative regulation of apoptotic process	GO:0043066	181	0.013
heterocycle catabolic process	GO:0046700	167	0.013
mitotic cell cycle	GO:0000278	49	0.012
carboxylic acid transport	GO:0046942	115	0.012
head development	GO:0060322	247	0.012
syncytium formation by plasma membrane fusion	GO:0000768	3	0.012
regulation of cellular protein metabolic process	GO:0032268	267	0.012
regulation of purine nucleotide metabolic process	GO:1900542	115	0.012
aging	GO:0007568	241	0.012
negative regulation of cell death	GO:0060548	229	0.012
response to glucocorticoid	GO:0051384	223	0.012
alpha amino acid catabolic process	GO:1901606	20	0.012
gonad development	GO:0008406	104	0.012
placenta development	GO:0001890	22	0.012
negative regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043154	17	0.012
negative regulation of protein metabolic process	GO:0051248	114	0.012
cellular amino acid biosynthetic process	GO:0008652	32	0.012
macromolecular complex subunit organization	GO:0043933	339	0.011
development of primary female sexual characteristics	GO:0046545	56	0.011
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.011
neuron projection development	GO:0031175	273	0.011
regulation of metal ion transport	GO:0010959	118	0.011
aldehyde biosynthetic process	GO:0046184	4	0.011
nucleotide catabolic process	GO:0009166	139	0.011
regulation of cellular response to growth factor stimulus	GO:0090287	15	0.011
development of primary sexual characteristics	GO:0045137	107	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
spindle organization	GO:0007051	2	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.011
divalent inorganic cation transport	GO:0072511	134	0.011
female sex differentiation	GO:0046660	59	0.011
nucleoside biosynthetic process	GO:0009163	25	0.011
muscle structure development	GO:0061061	87	0.011
cellular response to growth factor stimulus	GO:0071363	162	0.011
positive regulation of neuron projection development	GO:0010976	99	0.010
male sex differentiation	GO:0046661	64	0.010
response to ketone	GO:1901654	182	0.010
response to biotic stimulus	GO:0009607	226	0.010
protein transmembrane transport	GO:0071806	2	0.010
multi multicellular organism process	GO:0044706	138	0.010
synaptic transmission	GO:0007268	235	0.010
ossification	GO:0001503	70	0.010
central nervous system development	GO:0007417	311	0.010
cellular modified amino acid metabolic process	GO:0006575	61	0.010

Tpi1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.012
	disease of anatomical entity	DOID:7	0	0.012

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