Rattus norvegicus

100 known processes

Sirt2

sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)

(Aliases: MGC105900)

Sirt2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to stressGO:00335542690.148
Human Mouse
single organism biosynthetic processGO:00447113420.133
response to other organismGO:00517072200.133
Human Mouse
organic acid metabolic processGO:00060822920.114
response to nutrientGO:00075842480.114
cellular amino acid metabolic processGO:00065201070.106
lipid metabolic processGO:00066292830.098
Mouse
intracellular signal transductionGO:00355563140.098
Human Rat
apoptotic processGO:00069153810.095
oxoacid metabolic processGO:00434362900.091
negative regulation of metabolic processGO:00098923310.084
Human Yeast Mouse Rat
carboxylic acid metabolic processGO:00197522890.080
response to extracellular stimulusGO:00099913800.079
Mouse
cellular response to hormone stimulusGO:00328702470.076
negative regulation of signalingGO:00230571570.072
Rat
macromolecule localizationGO:00330362520.072
Mouse
glycerolipid metabolic processGO:0046486670.070
response to lipopolysaccharideGO:00324961910.069
response to insulinGO:00328681330.067
organic substance catabolic processGO:19015753160.065
Human Mouse
positive regulation of multicellular organismal processGO:00512403870.065
Mouse
anatomical structure morphogenesisGO:00096532980.063
Fly
cellular lipid metabolic processGO:00442552080.063
Mouse
negative regulation of nervous system developmentGO:0051961790.061
protein transportGO:00150311320.059
response to oxidative stressGO:00069791860.058
Mouse
organonitrogen compound catabolic processGO:19015651790.056
hormone transportGO:00099141210.056
Rat
cellular catabolic processGO:00442482950.055
Human Mouse
organic acid biosynthetic processGO:0016053830.055
regulation of cell proliferationGO:00421273590.053
response to estrogenGO:00436272320.053
negative regulation of cellular metabolic processGO:00313242810.052
Human Yeast Mouse Rat
regulation of nervous system developmentGO:00519602640.051
cellular response to endogenous stimulusGO:00714953770.051
Mouse
cellular component biogenesisGO:00440853680.050
Mouse
response to hypoxiaGO:00016662310.050
Human
lipid biosynthetic processGO:00086101280.049
regulation of phosphorus metabolic processGO:00511743490.049
Mouse Rat
homeostatic processGO:00425923310.049
response to decreased oxygen levelsGO:00362932370.049
Human
cation transportGO:00068123820.049
response to molecule of bacterial originGO:00022371940.049
Human
nitrogen compound transportGO:00717052290.048
Rat
organophosphate metabolic processGO:00196373700.048
chemical homeostasisGO:00488782920.047
response to nutrient levelsGO:00316673700.047
Mouse
regulation of rna biosynthetic processGO:20011413810.047
Human Yeast Mouse
response to carbohydrateGO:00097431830.046
cellular amide metabolic processGO:0043603440.044
cellular response to oxygen containing compoundGO:19017013860.044
Mouse
negative regulation of response to stimulusGO:00485851550.044
Human Mouse Rat
single organism catabolic processGO:00447122830.044
Mouse
carbohydrate derivative metabolic processGO:19011353460.044
response to toxic substanceGO:00096361330.043
cell cell signalingGO:00072673350.043
Rat
sexual reproductionGO:00199531480.043
Mouse
ion homeostasisGO:00508012120.042
regulation of intracellular signal transductionGO:19025312180.042
Rat
learning or memoryGO:0007611900.042
response to transition metal nanoparticleGO:19902671220.040
cellular homeostasisGO:00197252520.040
programmed cell deathGO:00125013920.040
protein localizationGO:00081041910.040
Mouse
amine metabolic processGO:0009308380.039
regulation of phosphate metabolic processGO:00192203490.039
Mouse Rat
organic anion transportGO:00157111320.039
proteolysisGO:00065081750.039
Human Mouse
cellular chemical homeostasisGO:00550822470.038
cellular response to oxidative stressGO:0034599760.038
Mouse
agingGO:00075682410.037
Yeast Rat Fly
negative regulation of developmental processGO:00510931250.037
organic acid transportGO:00158491160.037
monocarboxylic acid transportGO:0015718520.037
regulation of programmed cell deathGO:00430673410.037
carboxylic acid transportGO:00469421150.037
positive regulation of molecular functionGO:00440932300.037
Mouse
catabolic processGO:00090563510.036
Human Mouse
central nervous system developmentGO:00074173110.036
negative regulation of macromolecule metabolic processGO:00106052600.036
Human Yeast Mouse
anion transportGO:00068201780.036
multi organism reproductive processGO:00447032620.035
Mouse
organonitrogen compound biosynthetic processGO:19015661670.034
positive regulation of nitrogen compound metabolic processGO:00511733340.034
Yeast Mouse
regulation of cellular catabolic processGO:00313291010.034
Human Mouse
regulation of multicellular organismal developmentGO:20000263760.034
regulation of proteasomal protein catabolic processGO:006113640.032
Human Mouse
response to peptideGO:19016522920.032
response to estradiolGO:00323551640.032
establishment of organelle localizationGO:0051656370.031
regulation of synaptic growth at neuromuscular junctionGO:000858210.031
regulation of signal transductionGO:00099663180.031
Rat
transcription dna templatedGO:00063513770.030
Human Yeast Mouse
secretionGO:00469033070.030
Rat
insulin receptor signaling pathwayGO:0008286240.029
divalent inorganic cation homeostasisGO:00725071650.029
signal releaseGO:00230611450.029
Rat
metal ion transportGO:00300012890.029
nucleoside phosphate metabolic processGO:00067532830.029
protein complex assemblyGO:00064612630.029
Mouse
carbohydrate derivative catabolic processGO:19011361470.029
regulation of rna metabolic processGO:00512523910.028
Human Yeast Mouse
regulation of catabolic processGO:00098941130.028
Human Mouse
apoptotic signaling pathwayGO:0097190270.028
regulation of cellular component organizationGO:00511283680.028
Mouse
negative regulation of cell communicationGO:00106481580.027
Rat
synaptic transmissionGO:00072682350.027
heterocycle catabolic processGO:00467001670.027
cellular amine metabolic processGO:0044106380.027
hormone secretionGO:00468791150.027
Rat
positive regulation of cellular biosynthetic processGO:00313282950.027
Yeast Mouse
response to inorganic substanceGO:00100353770.027
reproductive processGO:00224143720.027
Mouse
protein phosphorylationGO:00064683450.026
Mouse
protein modification by small protein conjugation or removalGO:0070647350.026
regulation of protein modification processGO:00313991940.026
Mouse
cellular calcium ion homeostasisGO:00068741600.026
lipid transportGO:0006869610.026
brain developmentGO:00074202470.026
Human
positive regulation of nucleobase containing compound metabolic processGO:00459353190.025
Yeast Mouse
response to reactive oxygen speciesGO:00003021200.025
carbohydrate metabolic processGO:00059751300.025
gamete generationGO:00072761240.025
Mouse
cation homeostasisGO:00550801950.025
protein localization to membraneGO:0072657360.025
glycosyl compound metabolic processGO:19016571820.025
nucleobase containing small molecule metabolic processGO:00550863160.025
peptide transportGO:0015833970.025
Rat
positive regulation of apoptotic processGO:00430651540.025
Mouse
cellular response to peptideGO:19016531330.024
regulation of catalytic activityGO:00507903040.024
macromolecular complex assemblyGO:00650032730.024
Mouse
regulation of response to stressGO:00801341260.024
Human Mouse
cellular response to organonitrogen compoundGO:00714171970.024
Mouse
positive regulation of signalingGO:00230562700.024
Rat
cellular macromolecule localizationGO:00707271220.024
Mouse
positive regulation of cellular component organizationGO:00511302000.024
Mouse
regulation of body fluid levelsGO:0050878900.024
regulation of hormone secretionGO:00468831060.024
Rat
positive regulation of cellular amine metabolic processGO:003324030.024
cellular response to extracellular stimulusGO:0031668730.024
Mouse
transmembrane transportGO:00550854120.023
carboxylic acid biosynthetic processGO:0046394830.023
single organism reproductive processGO:00447022970.023
Mouse
establishment of protein localizationGO:00451841410.023
gland developmentGO:00487321550.023
peptide biosynthetic processGO:004304330.023
regulation of protein transportGO:0051223680.023
regulation of cell morphogenesisGO:0022604770.023
transcription from rna polymerase ii promoterGO:00063662520.023
Human Mouse
cellular protein localizationGO:00346131220.023
Mouse
organophosphate biosynthetic processGO:00904071430.023
hexose transportGO:0008645290.023
positive regulation of transportGO:00510502450.022
Rat
negative regulation of apoptotic processGO:00430661810.022
regulation of vesicle mediated transportGO:0060627810.022
behaviorGO:00076102050.022
response to ketoneGO:19016541820.022
protein complex subunit organizationGO:00718223020.022
Mouse
regulation of cell growthGO:0001558850.022
positive regulation of protein modification processGO:00314011420.022
calcium ion homeostasisGO:00550741620.022
amino acid transportGO:0006865700.022
reproductionGO:00000032450.022
Mouse
regulation of molecular functionGO:00650093980.022
Mouse
response to peptide hormoneGO:00434342780.021
regulation of cellular protein metabolic processGO:00322682670.021
Human Mouse
insulin secretionGO:0030073690.021
Rat
response to oxygen levelsGO:00704822650.021
Human
regulation of cell differentiationGO:00455953200.021
negative regulation of molecular functionGO:00440921330.021
cellular amino acid biosynthetic processGO:0008652320.021
regulation of peptide hormone secretionGO:0090276800.021
Rat
cellular response to cytokine stimulusGO:00713451270.021
ribose phosphate metabolic processGO:00196932350.021
negative regulation of cellular component organizationGO:0051129830.021
Mouse
guanosine containing compound catabolic processGO:1901069710.021
organelle organizationGO:00069962660.021
Human Yeast Mouse Fly
regulation of coenzyme metabolic processGO:005119610.021
monocarboxylic acid metabolic processGO:00327871520.021
negative regulation of multicellular organismal processGO:00512412030.021
mitotic spindle organizationGO:000705220.020
purine nucleotide metabolic processGO:00061632290.020
protein modification by small protein conjugationGO:0032446310.020
vascular process in circulatory systemGO:0003018960.020
cellular divalent inorganic cation homeostasisGO:00725031620.020
nucleotide metabolic processGO:00091172790.020
multicellular organism reproductionGO:00325042330.019
Mouse
single organism membrane organizationGO:0044802740.019
cell growthGO:00160491040.019
aromatic compound catabolic processGO:00194391680.019
protein oligomerizationGO:00512591910.019
cellular response to insulin stimulusGO:0032869810.019
organic cyclic compound catabolic processGO:19013611750.019
macromolecular complex subunit organizationGO:00439333390.019
Human Yeast Mouse Fly
negative regulation of cell deathGO:00605482290.019
response to growth factorGO:00708481890.019
Human
negative regulation of macromolecule biosynthetic processGO:00105581480.019
Human Yeast Mouse
ras protein signal transductionGO:0007265290.019
carbohydrate homeostasisGO:0033500750.019
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.019
protein homooligomerizationGO:0051260910.019
regulation of cellular ketone metabolic processGO:0010565270.019
regulation of apoptotic processGO:00429813350.019
regulation of anatomical structure sizeGO:00900661350.019
regulation of growthGO:00400081050.019
response to metal ionGO:00100382530.019
rna metabolic processGO:00160704060.018
Human Yeast Mouse
purine nucleoside metabolic processGO:00422781690.018
eye developmentGO:0001654500.018
nucleobase containing compound catabolic processGO:00346551520.018
negative regulation of signal transductionGO:0009968830.018
Rat
blood circulationGO:00080151830.018
ribonucleotide catabolic processGO:00092611360.018
nucleic acid templated transcriptionGO:00976593790.018
Human Yeast Mouse
positive regulation of cellular amino acid metabolic processGO:004576410.018
peptide secretionGO:0002790860.018
Rat
multicellular organismal reproductive processGO:00486092330.018
Mouse
eye morphogenesisGO:004859240.018
spindle organizationGO:000705120.018
positive regulation of cell developmentGO:00107201760.018
Mouse
cellular response to peptide hormone stimulusGO:00713751200.018
regulation of protein metabolic processGO:00512462890.018
Human Mouse
circulatory system processGO:00030131830.018
purine ribonucleotide catabolic processGO:00091541360.018
negative regulation of gene expressionGO:00106291990.018
Human Yeast Mouse
organophosphate catabolic processGO:00464341480.018
regulation of nucleic acid templated transcriptionGO:19035063800.018
Human Yeast Mouse
neurological system processGO:00508772190.018
positive regulation of phosphorylationGO:00423271770.017
small molecule biosynthetic processGO:00442831240.017
regulation of protein localizationGO:0032880810.017
Mouse
positive regulation of protein metabolic processGO:00512471780.017
Human Mouse
glucose homeostasisGO:0042593750.017
cognitionGO:0050890920.017
phospholipid metabolic processGO:0006644610.017
neuron neuron synaptic transmissionGO:0007270600.017
cellular nitrogen compound catabolic processGO:00442701630.017
positive regulation of ion transportGO:0043270940.017
regulation of cellular amino acid metabolic processGO:000652120.017
regulation of transcription dna templatedGO:00063553740.017
Human Yeast Mouse
phosphatidic acid biosynthetic processGO:000665410.017
purine containing compound metabolic processGO:00725212530.017
cellular modified amino acid metabolic processGO:0006575610.017
regulation of anatomical structure morphogenesisGO:00226031410.016
regulation of neurogenesisGO:00507672470.016
cardiovascular system developmentGO:00723581340.016
salivary gland developmentGO:000743130.016
fatty acid metabolic processGO:0006631990.016
purine nucleotide catabolic processGO:00061951360.016
regulation of ion transportGO:00432692450.016
response to heatGO:0009408600.016
lipid storageGO:001991510.016
small gtpase mediated signal transductionGO:0007264360.016
monosaccharide transportGO:0015749310.016
phospholipid biosynthetic processGO:0008654290.016
negative regulation of catalytic activityGO:00430861030.016
response to cytokineGO:00340972150.016
regulation of insulin secretionGO:0050796650.016
Rat
purine ribonucleotide metabolic processGO:00091502270.016
cellular response to reactive oxygen speciesGO:0034614550.015
negative regulation of phosphorus metabolic processGO:0010563800.015
Mouse Rat
regulation of lipid metabolic processGO:0019216680.015
macroautophagyGO:001623640.015
regulation of neuron projection developmentGO:00109751610.015
regulation of response to woundingGO:1903034690.015
gtp metabolic processGO:0046039720.015
cellular ketone metabolic processGO:0042180510.015
response to bacteriumGO:00096172000.015
Human Mouse
glycogen metabolic processGO:0005977230.015
negative regulation of biosynthetic processGO:00098901680.015
Human Yeast Mouse
positive regulation of cellular catabolic processGO:0031331710.015
Human Mouse
regulation of response to external stimulusGO:00321011060.015
Human Mouse
response to woundingGO:00096112540.015
regulation of cellular localizationGO:00603412630.015
Mouse Rat
response to ethanolGO:00454711620.015
negative regulation of programmed cell deathGO:00430691830.015
ribonucleoside metabolic processGO:00091191740.015
nucleoside triphosphate catabolic processGO:00091431230.015
positive regulation of gene expressionGO:00106282440.015
Yeast Mouse
regulation of cellular amine metabolic processGO:003323880.014
synaptic transmission glutamatergicGO:0035249330.014
divalent metal ion transportGO:00708381320.014
inflammatory responseGO:00069541500.014
secretion by cellGO:00329402480.014
Rat
regulation of immune system processGO:00026821230.014
regulation of cellular component biogenesisGO:0044087860.014
Mouse
developmental process involved in reproductionGO:00030061590.014
Mouse
gtp catabolic processGO:0006184710.014
regulation of secretionGO:00510462240.014
Rat
ribonucleoside triphosphate catabolic processGO:00092031220.014
ribonucleotide metabolic processGO:00092592310.014
cellular component assemblyGO:00226073600.014
Mouse
positive regulation of macromolecule biosynthetic processGO:00105572470.014
Yeast Mouse
transmission of nerve impulseGO:0019226420.014
response to ammonium ionGO:0060359710.014
regulation of protein kinase activityGO:00458591050.014
cytosolic calcium ion homeostasisGO:00514801400.014
positive regulation of peptide secretionGO:0002793520.014
Rat
purine containing compound catabolic processGO:00725231380.014
immune system processGO:00023762040.014
regulation of hydrolase activityGO:00513361430.014
negative regulation of intracellular signal transductionGO:1902532380.014
Rat
vesicle mediated transportGO:00161921810.014
rna localizationGO:000640340.014
response to acid chemicalGO:00011012220.013
response to biotic stimulusGO:00096072260.013
Human Mouse
cellular response to hexose stimulusGO:0071331650.013
positive regulation of programmed cell deathGO:00430681570.013
Mouse
regulation of synaptic transmissionGO:00508041410.013
axis specificationGO:000979840.013
defense response to gram negative bacteriumGO:005082930.013
tissue developmentGO:00098882520.013
Human
intracellular protein transportGO:0006886790.013
positive regulation of response to stimulusGO:00485842850.013
circadian rhythmGO:0007623880.013
cellular cation homeostasisGO:00300031800.013
cellular metal ion homeostasisGO:00068751720.013
peptide metabolic processGO:0006518320.013
purine nucleoside triphosphate metabolic processGO:00091441410.013
response to cgmpGO:007030530.013
negative regulation of cellular protein metabolic processGO:00322691060.013
Mouse
positive regulation of developmental processGO:00510942830.013
Mouse
centrosome localizationGO:005164210.013
regulation of proteasomal ubiquitin dependent protein catabolic processGO:003243430.013
Human Mouse
wound healingGO:00420601220.013
response to external biotic stimulusGO:00432072210.013
Human Mouse
negative regulation of synaptic transmissionGO:0050805290.013
single organism carbohydrate metabolic processGO:00447231180.013
positive regulation of intracellular signal transductionGO:19025331380.013
intracellular transportGO:00469071850.013
amide transportGO:00428861050.013
Rat
neuron differentiationGO:00301823680.013
Fly
negative regulation of growthGO:0045926370.013
regulation of tube sizeGO:0035150890.012
ribonucleoside catabolic processGO:00424541260.012
positive regulation of protein transportGO:0051222410.012
multicellular organismal signalingGO:0035637440.012
negative regulation of rna metabolic processGO:00512531230.012
Human Yeast Mouse
microtubule cytoskeleton organizationGO:0000226250.012
Mouse
cellular glucan metabolic processGO:0006073230.012
purine nucleoside catabolic processGO:00061521240.012
metal ion homeostasisGO:00550651860.012
positive regulation of nervous system developmentGO:00519621780.012
response to monosaccharideGO:00342841590.012
mapk cascadeGO:00001651400.012
Rat
antigen processing and presentationGO:001988220.012
protein heterooligomerizationGO:0051291890.012
guanosine containing compound metabolic processGO:1901068740.012
cellular polysaccharide metabolic processGO:0044264230.012
positive regulation of neuron differentiationGO:00456661260.012
regulation of endocytosisGO:0030100420.012
peptidyl serine phosphorylationGO:0018105330.012
cell junction maintenanceGO:003433110.012
negative regulation of phosphate metabolic processGO:0045936800.012
Mouse Rat
regulation of transcription from rna polymerase ii promoterGO:00063572340.012
Human Mouse
embryonic pattern specificationGO:000988010.012
regulation of organelle organizationGO:0033043800.012
Mouse
rna biosynthetic processGO:00327743800.012
Human Yeast Mouse
regulation of neuron differentiationGO:00456642080.012
negative regulation of rna splicingGO:003311930.012
action potentialGO:0001508540.012
nucleoside metabolic processGO:00091161790.012
phosphatidylethanolamine metabolic processGO:004633710.012
cellular biogenic amine metabolic processGO:0006576300.012
urinary tract smooth muscle contractionGO:001484840.012
negative regulation of cellular biosynthetic processGO:00313271610.012
Human Yeast Mouse
response to organophosphorusGO:00466831020.011
cytokine mediated signaling pathwayGO:0019221430.011
positive regulation of cell projection organizationGO:00313461110.011
positive regulation of cytosolic calcium ion concentrationGO:00072041220.011
sensory organ developmentGO:0007423740.011
spermatogenesisGO:0007283990.011
purine ribonucleoside triphosphate catabolic processGO:00092071220.011
single organism cellular localizationGO:19025801020.011
cellular response to nutrient levelsGO:0031669600.011
Mouse
microtubule organizing center organizationGO:003102310.011
positive regulation of hydrolase activityGO:0051345860.011
cellular ion homeostasisGO:00068731840.011
response to starvationGO:0042594590.011
Mouse
nucleoside phosphate catabolic processGO:19012921400.011
glycerophospholipid metabolic processGO:0006650470.011
cellular response to alcoholGO:0097306870.011
cell cycle checkpointGO:000007520.011
organ formationGO:004864530.011
regulation of establishment of protein localizationGO:0070201690.011
calcium ion transportGO:00068161310.011
cellular response to nitrogen compoundGO:19016992100.011
Mouse
regulation of blood vessel sizeGO:0050880890.011
anatomical structure formation involved in morphogenesisGO:0048646830.011
membrane organizationGO:0061024940.011
maintenance of locationGO:0051235170.011
Mouse
developmental growthGO:00485891000.011
organic hydroxy compound metabolic processGO:19016151150.011
response to hexoseGO:00097461440.011
positive regulation of neurogenesisGO:00507691650.011
positive regulation of cell proliferationGO:00082842490.011
anion transmembrane transportGO:0098656770.011
regulation of synapse structure and activityGO:0050803210.011
organelle localizationGO:0051640550.011
cation transmembrane transportGO:00986552630.011
regulation of intracellular protein transportGO:0033157340.011
cellular response to carbohydrate stimulusGO:0071322720.011
glycosyl compound catabolic processGO:19016581260.010
cellular carbohydrate metabolic processGO:0044262720.010
positive regulation of hormone secretionGO:0046887650.010
Rat
single organism intracellular transportGO:19025821660.010
morphogenesis of a polarized epitheliumGO:000173810.010
epithelium developmentGO:0060429960.010
ribonucleoside triphosphate metabolic processGO:00091991410.010
establishment of vesicle localizationGO:0051650310.010
establishment of tissue polarityGO:000716420.010
purine ribonucleoside catabolic processGO:00461301240.010
negative regulation of transportGO:00510511360.010
asymmetric protein localizationGO:000810520.010
regulation of intracellular transportGO:0032386650.010
response to glucoseGO:00097491360.010

Sirt2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.042
nervous system diseaseDOID:86300.042
disease of metabolismDOID:001466700.020
sensory system diseaseDOID:005015500.019
muscular diseaseDOID:008000000.014
muscle tissue diseaseDOID:6600.014
musculoskeletal system diseaseDOID:1700.014
eye and adnexa diseaseDOID:149200.012
retinal diseaseDOID:567900.011
eye diseaseDOID:561400.011