Rattus norvegicus

278 known processes

Sirt1

sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

(Aliases: Sir2)

Sirt1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organic acid metabolic processGO:00060822920.056
carboxylic acid metabolic processGO:00197522890.052
oxoacid metabolic processGO:00434362900.049
regulation of cellular ketone metabolic processGO:0010565270.047
positive regulation of nitrogen compound metabolic processGO:00511733340.044
rna metabolic processGO:00160704060.044
response to extracellular stimulusGO:00099913800.042
response to nutrient levelsGO:00316673700.041
cellular ketone metabolic processGO:0042180510.041
regulation of transcription from rna polymerase ii promoterGO:00063572340.040
positive regulation of cellular biosynthetic processGO:00313282950.040
positive regulation of nucleobase containing compound metabolic processGO:00459353190.040
regulation of transcription dna templatedGO:00063553740.039
transcription dna templatedGO:00063513770.037
positive regulation of rna biosynthetic processGO:19026801970.037
regulation of rna metabolic processGO:00512523910.037
oxidation reduction processGO:00551143040.036
regulation of nucleic acid templated transcriptionGO:19035063800.036
nucleic acid templated transcriptionGO:00976593790.035
cellular amino acid metabolic processGO:00065201070.035
rna biosynthetic processGO:00327743800.035
positive regulation of macromolecule biosynthetic processGO:00105572470.034
cellular response to oxygen containing compoundGO:19017013860.034
cellular amine metabolic processGO:0044106380.034
cellular response to endogenous stimulusGO:00714953770.034
regulation of rna biosynthetic processGO:20011413810.033
regulation of phosphate metabolic processGO:00192203490.033
response to inorganic substanceGO:00100353770.033
regulation of cellular amino acid metabolic processGO:000652120.032
single organism biosynthetic processGO:00447113420.032
catabolic processGO:00090563510.031
carbohydrate derivative metabolic processGO:19011353460.030
positive regulation of rna metabolic processGO:00512542030.030
regulation of cellular amine metabolic processGO:003323880.029
single organism catabolic processGO:00447122830.029
positive regulation of gene expressionGO:00106282440.028
transcription from rna polymerase ii promoterGO:00063662520.028
negative regulation of metabolic processGO:00098923310.028
regulation of molecular functionGO:00650093980.028
cellular response to nitrogen compoundGO:19016992100.028
regulation of programmed cell deathGO:00430673410.027
organophosphate metabolic processGO:00196373700.027
regulation of phosphorus metabolic processGO:00511743490.027
nucleobase containing small molecule metabolic processGO:00550863160.027
response to glucocorticoidGO:00513842230.026
response to oxygen levelsGO:00704822650.026
response to acid chemicalGO:00011012220.026
positive regulation of biosynthetic processGO:00098913190.026
organic substance catabolic processGO:19015753160.026
purine containing compound metabolic processGO:00725212530.026
positive regulation of transcription dna templatedGO:00458931970.026
regulation of cellular component organizationGO:00511283680.025
regulation of apoptotic processGO:00429813350.025
response to nutrientGO:00075842480.025
transmembrane transportGO:00550854120.025
regulation of cell proliferationGO:00421273590.025
positive regulation of nucleic acid templated transcriptionGO:19035081970.025
amine metabolic processGO:0009308380.025
lipid metabolic processGO:00066292830.025
response to corticosteroidGO:00319602350.024
positive regulation of molecular functionGO:00440932300.024
positive regulation of phosphate metabolic processGO:00459372620.024
regulation of signal transductionGO:00099663180.023
apoptotic processGO:00069153810.023
carbohydrate metabolic processGO:00059751300.023
monocarboxylic acid metabolic processGO:00327871520.023
secretionGO:00469033070.023
cellular response to stressGO:00335542690.023
nucleoside phosphate metabolic processGO:00067532830.023
cellular component assemblyGO:00226073600.022
positive regulation of cell proliferationGO:00082842490.022
positive regulation of phosphorus metabolic processGO:00105622620.022
response to decreased oxygen levelsGO:00362932370.022
ion transmembrane transportGO:00342203650.022
response to hypoxiaGO:00016662310.021
regulation of protein metabolic processGO:00512462890.021
cellular response to hormone stimulusGO:00328702470.021
ribose phosphate metabolic processGO:00196932350.021
regulation of nervous system developmentGO:00519602640.021
cellular response to lipidGO:00713962010.021
purine nucleotide metabolic processGO:00061632290.021
cellular component biogenesisGO:00440853680.021
regulation of homeostatic processGO:00328441010.021
single organism carbohydrate metabolic processGO:00447231180.020
intracellular signal transductionGO:00355563140.020
ribonucleotide metabolic processGO:00092592310.020
single organism reproductive processGO:00447022970.020
purine ribonucleotide metabolic processGO:00091502270.020
regulation of secretionGO:00510462240.019
purine nucleoside metabolic processGO:00422781690.019
positive regulation of developmental processGO:00510942830.019
homeostatic processGO:00425923310.019
neuron differentiationGO:00301823680.019
regulation of neurogenesisGO:00507672470.019
ribonucleoside metabolic processGO:00091191740.019
protein phosphorylationGO:00064683450.019
negative regulation of cell deathGO:00605482290.019
response to oxidative stressGO:00069791860.019
cell projection organizationGO:00300303020.019
negative regulation of cellular metabolic processGO:00313242810.019
purine ribonucleoside metabolic processGO:00461281680.019
cellular carbohydrate metabolic processGO:0044262720.018
cellular catabolic processGO:00442482950.018
regulation of ion transportGO:00432692450.018
positive regulation of cellular amine metabolic processGO:003324030.018
regulation of secretion by cellGO:19035302080.018
response to cytokineGO:00340972150.018
negative regulation of macromolecule metabolic processGO:00106052600.018
ion homeostasisGO:00508012120.018
glycosyl compound metabolic processGO:19016571820.018
programmed cell deathGO:00125013920.018
chemical homeostasisGO:00488782920.018
cellular homeostasisGO:00197252520.017
macromolecular complex assemblyGO:00650032730.017
multi organism reproductive processGO:00447032620.017
positive regulation of cellular component organizationGO:00511302000.017
cell cell signalingGO:00072673350.017
regulation of cell developmentGO:00602842630.017
positive regulation of cellular amino acid metabolic processGO:004576410.017
nucleoside metabolic processGO:00091161790.017
regulation of hormone levelsGO:00108171870.017
response to peptide hormoneGO:00434342780.017
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.017
response to vitaminGO:00332731310.017
regulation of cell differentiationGO:00455953200.017
positive regulation of signalingGO:00230562700.017
nucleotide metabolic processGO:00091172790.017
cellular chemical homeostasisGO:00550822470.017
regulation of membrane potentialGO:00423911100.017
rhythmic processGO:00485111560.017
positive regulation of cell communicationGO:00106472710.017
protein complex biogenesisGO:00702712630.017
response to carbohydrateGO:00097431830.016
regulation of cellular localizationGO:00603412630.016
positive regulation of cellular protein metabolic processGO:00322701670.016
neuron projection developmentGO:00311752730.016
response to hexoseGO:00097461440.016
response to ethanolGO:00454711620.016
regulation of catalytic activityGO:00507903040.016
organelle organizationGO:00069962660.016
positive regulation of multicellular organismal processGO:00512403870.016
protein complex subunit organizationGO:00718223020.016
response to monosaccharideGO:00342841590.016
negative regulation of transportGO:00510511360.016
neurological system processGO:00508772190.016
defense responseGO:00069521940.016
cation transportGO:00068123820.016
regulation of neuron deathGO:19012141150.016
regulation of multicellular organismal developmentGO:20000263760.015
positive regulation of catalytic activityGO:00430851840.015
regulation of neuron projection developmentGO:00109751610.015
organophosphate biosynthetic processGO:00904071430.015
tissue developmentGO:00098882520.015
protein complex assemblyGO:00064612630.015
negative regulation of programmed cell deathGO:00430691830.015
central nervous system developmentGO:00074173110.015
establishment of tissue polarityGO:000716420.015
localization of cellGO:00516742020.015
nitrogen compound transportGO:00717052290.015
reproductive processGO:00224143720.015
cellular component movementGO:00069282480.015
macromolecule localizationGO:00330362520.015
purine nucleotide biosynthetic processGO:0006164830.015
organonitrogen compound biosynthetic processGO:19015661670.015
circulatory system processGO:00030131830.015
macromolecular complex subunit organizationGO:00439333390.015
positive regulation of phosphorylationGO:00423271770.015
gastrulationGO:000736920.014
carbohydrate derivative biosynthetic processGO:19011371240.014
nucleoside phosphate biosynthetic processGO:19012931020.014
response to glucoseGO:00097491360.014
negative regulation of gene expressionGO:00106291990.014
small gtpase mediated signal transductionGO:0007264360.014
regulation of protein modification processGO:00313991940.014
regenerationGO:00310991630.014
nucleoside triphosphate metabolic processGO:00091411440.014
positive regulation of protein metabolic processGO:00512471780.014
cell migrationGO:00164771970.014
regulation of cell projection organizationGO:00313441750.014
cell motilityGO:00488702020.014
transmission of nerve impulseGO:0019226420.014
reproductionGO:00000032450.014
positive regulation of homeostatic processGO:0032846490.014
positive regulation of response to stimulusGO:00485842850.014
regulation of cellular protein metabolic processGO:00322682670.014
regulation of cell motilityGO:20001451310.014
intracellular transportGO:00469071850.014
purine nucleoside triphosphate metabolic processGO:00091441410.014
multicellular organismal reproductive processGO:00486092330.014
response to peptideGO:19016522920.014
regulation of phosphorylationGO:00423252480.014
ras protein signal transductionGO:0007265290.014
positive regulation of apoptotic processGO:00430651540.014
negative regulation of molecular functionGO:00440921330.014
negative regulation of apoptotic processGO:00430661810.014
anterior posterior pattern specificationGO:000995210.014
head developmentGO:00603222470.014
positive regulation of cell deathGO:00109421840.014
regulation of nucleotide metabolic processGO:00061401170.014
g protein coupled receptor signaling pathwayGO:00071862420.014
response to growth factorGO:00708481890.013
anatomical structure morphogenesisGO:00096532980.013
blood circulationGO:00080151830.013
lipid storageGO:001991510.013
positive regulation of transportGO:00510502450.013
response to estrogenGO:00436272320.013
regulation of protein phosphorylationGO:00019321830.013
monosaccharide metabolic processGO:0005996610.013
cellular divalent inorganic cation homeostasisGO:00725031620.013
inflammatory responseGO:00069541500.013
nucleoside monophosphate metabolic processGO:0009123930.013
nucleotide biosynthetic processGO:0009165980.013
neuron developmentGO:00486662860.013
brain developmentGO:00074202470.013
purine ribonucleoside triphosphate metabolic processGO:00092051400.013
cellular lipid metabolic processGO:00442552080.013
calcium ion homeostasisGO:00550741620.013
response to purine containing compoundGO:00140741260.013
metal ion homeostasisGO:00550651860.013
negative regulation of multicellular organismal processGO:00512412030.013
coenzyme metabolic processGO:0006732860.013
axis specificationGO:000979840.013
positive regulation of programmed cell deathGO:00430681570.013
response to estradiolGO:00323551640.013
ribonucleoside triphosphate metabolic processGO:00091991410.013
divalent inorganic cation homeostasisGO:00725071650.013
cellular response to organic cyclic compoundGO:00714072020.013
cell type specific apoptotic processGO:00972851340.013
response to metal ionGO:00100382530.013
purine containing compound biosynthetic processGO:0072522850.013
cation homeostasisGO:00550801950.013
cellular hormone metabolic processGO:0034754490.013
response to woundingGO:00096112540.013
cellular cation homeostasisGO:00300031800.012
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.012
response to insulinGO:00328681330.012
maintenance of locationGO:0051235170.012
secretion by cellGO:00329402480.012
regulation of intracellular signal transductionGO:19025312180.012
positive regulation of nervous system developmentGO:00519621780.012
cellular ion homeostasisGO:00068731840.012
protein localizationGO:00081041910.012
regulation of purine nucleotide metabolic processGO:19005421150.012
protein oligomerizationGO:00512591910.012
single organism intracellular transportGO:19025821660.012
negative regulation of nitrogen compound metabolic processGO:00511721610.012
hormone secretionGO:00468791150.012
sex differentiationGO:00075481130.012
cellular metal ion homeostasisGO:00068751720.012
metal ion transportGO:00300012890.012
negative regulation of biosynthetic processGO:00098901680.012
proteolysisGO:00065081750.012
circadian rhythmGO:0007623880.012
response to ketoneGO:19016541820.012
heart morphogenesisGO:000300730.012
negative regulation of signalingGO:00230571570.012
chromosome segregationGO:000705920.012
cellular calcium ion homeostasisGO:00068741600.012
organic cyclic compound catabolic processGO:19013611750.012
ribonucleoside monophosphate metabolic processGO:0009161880.012
peptidyl amino acid modificationGO:00181931260.012
cellular response to growth factor stimulusGO:00713631620.012
amide transportGO:00428861050.012
negative regulation of innate immune responseGO:004582440.011
lipid modificationGO:0030258520.011
cellular response to cytokine stimulusGO:00713451270.011
regulation of catabolic processGO:00098941130.011
positive regulation of purine nucleotide metabolic processGO:1900544910.011
multicellular organismal signalingGO:0035637440.011
agingGO:00075682410.011
dna metabolic processGO:0006259960.011
locomotionGO:00400112370.011
negative regulation of macromolecule biosynthetic processGO:00105581480.011
neuronal action potentialGO:0019228350.011
regulation of transferase activityGO:00513381230.011
negative regulation of nucleobase containing compound metabolic processGO:00459341530.011
peptide transportGO:0015833970.011
cytoplasmic transportGO:00164821150.011
gland developmentGO:00487321550.011
response to other organismGO:00517072200.011
regulation of peptide secretionGO:0002791820.011
multicellular organism reproductionGO:00325042330.011
cytosolic calcium ion homeostasisGO:00514801400.011
fatty acid metabolic processGO:0006631990.011
ribose phosphate biosynthetic processGO:0046390870.011
peptide secretionGO:0002790860.011
regulation of cell migrationGO:00303341280.011
organonitrogen compound catabolic processGO:19015651790.011
regulation of carbohydrate metabolic processGO:0006109410.011
reproductive system developmentGO:00614581280.011
negative regulation of cell communicationGO:00106481580.011
negative regulation of protein metabolic processGO:00512481140.011
cellular response to oxidative stressGO:0034599760.011
eye morphogenesisGO:004859240.011
cation transmembrane transportGO:00986552630.011
negative regulation of rna metabolic processGO:00512531230.011
response to external biotic stimulusGO:00432072210.011
establishment of protein localizationGO:00451841410.011
regulation of body fluid levelsGO:0050878900.011
negative regulation of cell developmentGO:0010721820.010
response to amino acidGO:0043200750.010
negative regulation of developmental processGO:00510931250.010
cholesterol homeostasisGO:004263230.010
response to activityGO:0014823730.010
positive regulation of cell differentiationGO:00455972170.010
cellular response to peptideGO:19016531330.010
nucleobase containing compound catabolic processGO:00346551520.010
synaptic transmissionGO:00072682350.010
regulation of neuron differentiationGO:00456642080.010
positive regulation of neuron differentiationGO:00456661260.010
purine ribonucleotide biosynthetic processGO:0009152810.010
regulation of ion transmembrane transportGO:00347651210.010
peptide hormone secretionGO:0030072840.010
purine nucleoside monophosphate metabolic processGO:0009126840.010
ribonucleotide biosynthetic processGO:0009260850.010
regulation of kinase activityGO:00435491170.010
hormone transportGO:00099141210.010
regulation of cellular catabolic processGO:00313291010.010
response to fatty acidGO:0070542650.010
embryonic pattern specificationGO:000988010.010
negative regulation of response to stimulusGO:00485851550.010
cellular nitrogen compound catabolic processGO:00442701630.010
alpha amino acid metabolic processGO:1901605710.010
small molecule biosynthetic processGO:00442831240.010

Sirt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.022
nervous system diseaseDOID:86300.022
disease of metabolismDOID:001466700.016
sensory system diseaseDOID:005015500.013
musculoskeletal system diseaseDOID:1700.011
central nervous system diseaseDOID:33100.010