Rattus norvegicus

24 known processes

Penk

proenkephalin

(Aliases: Penk-rs,Penk2,Enk,Penk1,MGC93514)

Penk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of rna metabolic processGO:00512523910.132
regulation of transcription dna templatedGO:00063553740.113
oxoacid metabolic processGO:00434362900.108
organic acid metabolic processGO:00060822920.105
cellular component movementGO:00069282480.100
single organism biosynthetic processGO:00447113420.089
cellular calcium ion homeostasisGO:00068741600.088
rna metabolic processGO:00160704060.082
cellular metal ion homeostasisGO:00068751720.080
carboxylic acid metabolic processGO:00197522890.069
chemical homeostasisGO:00488782920.068
cation transportGO:00068123820.066
regulation of programmed cell deathGO:00430673410.063
protein complex subunit organizationGO:00718223020.062
nucleic acid templated transcriptionGO:00976593790.059
positive regulation of cell proliferationGO:00082842490.058
rna biosynthetic processGO:00327743800.057
central nervous system developmentGO:00074173110.057
cellular ion homeostasisGO:00068731840.056
cellular amino acid metabolic processGO:00065201070.056
learning or memoryGO:0007611900.055
reproductive processGO:00224143720.054
response to mechanical stimulusGO:00096121340.054
positive regulation of signal transductionGO:00099671750.054
homeostatic processGO:00425923310.053
divalent inorganic cation homeostasisGO:00725071650.053
regulation of cell differentiationGO:00455953200.053
cell migrationGO:00164771970.053
regulation of signal transductionGO:00099663180.053
ion homeostasisGO:00508012120.052
cellular chemical homeostasisGO:00550822470.051
transcription dna templatedGO:00063513770.050
regulation of synaptic transmissionGO:00508041410.050
reproductionGO:00000032450.050
cellular component morphogenesisGO:00329891550.049
positive regulation of cell communicationGO:00106472710.048
rhythmic processGO:00485111560.048
protein complex assemblyGO:00064612630.048
metal ion transportGO:00300012890.046
brain developmentGO:00074202470.045
g protein coupled receptor signaling pathwayGO:00071862420.045
cellular homeostasisGO:00197252520.045
cellular component biogenesisGO:00440853680.045
response to decreased oxygen levelsGO:00362932370.045
amine metabolic processGO:0009308380.044
cytosolic calcium ion homeostasisGO:00514801400.044
metal ion homeostasisGO:00550651860.044
positive regulation of signalingGO:00230562700.043
anatomical structure morphogenesisGO:00096532980.043
monocarboxylic acid metabolic processGO:00327871520.042
regulation of molecular functionGO:00650093980.041
small molecule biosynthetic processGO:00442831240.041
macromolecular complex subunit organizationGO:00439333390.040
cation homeostasisGO:00550801950.040
negative regulation of metabolic processGO:00098923310.039
transcription from rna polymerase ii promoterGO:00063662520.039
cellular cation homeostasisGO:00300031800.039
locomotionGO:00400112370.038
calcium ion homeostasisGO:00550741620.038
response to nutrient levelsGO:00316673700.038
purine containing compound metabolic processGO:00725212530.038
cellular divalent inorganic cation homeostasisGO:00725031620.037
regulation of behaviorGO:0050795610.037
cellular amine metabolic processGO:0044106380.037
single organism reproductive processGO:00447022970.036
response to peptide hormoneGO:00434342780.036
multi organism reproductive processGO:00447032620.036
regulation of cellular component organizationGO:00511283680.036
regulation of cell proliferationGO:00421273590.036
regulation of rna biosynthetic processGO:20011413810.036
positive regulation of nitrogen compound metabolic processGO:00511733340.036
protein localizationGO:00081041910.035
organelle organizationGO:00069962660.035
lipid metabolic processGO:00066292830.034
regulation of cell developmentGO:00602842630.034
cellular component assemblyGO:00226073600.034
regulation of phosphate metabolic processGO:00192203490.034
positive regulation of nucleobase containing compound metabolic processGO:00459353190.033
apoptotic processGO:00069153810.033
positive regulation of cytosolic calcium ion concentrationGO:00072041220.033
negative regulation of multicellular organismal processGO:00512412030.032
positive regulation of phosphate metabolic processGO:00459372620.032
cellular lipid metabolic processGO:00442552080.032
head developmentGO:00603222470.032
taxisGO:0042330670.032
response to carbohydrateGO:00097431830.031
intracellular signal transductionGO:00355563140.031
negative regulation of developmental processGO:00510931250.031
cellular ketone metabolic processGO:0042180510.031
regulation of nervous system developmentGO:00519602640.031
carbohydrate derivative metabolic processGO:19011353460.031
response to temperature stimulusGO:0009266940.031
blood circulationGO:00080151830.031
nucleobase containing small molecule metabolic processGO:00550863160.030
cognitionGO:0050890920.030
positive regulation of developmental processGO:00510942830.030
lipid biosynthetic processGO:00086101280.030
regulation of intracellular signal transductionGO:19025312180.030
single organism catabolic processGO:00447122830.030
multicellular organismal reproductive processGO:00486092330.030
negative regulation of nitrogen compound metabolic processGO:00511721610.029
regulation of hydrolase activityGO:00513361430.028
purine ribonucleoside metabolic processGO:00461281680.028
cellular response to endogenous stimulusGO:00714953770.028
positive regulation of cell differentiationGO:00455972170.028
neurological system processGO:00508772190.028
regulation of phosphorus metabolic processGO:00511743490.028
muscle system processGO:00030121150.028
positive regulation of phosphorus metabolic processGO:00105622620.027
regulation of metal ion transportGO:00109591180.027
positive regulation of nervous system developmentGO:00519621780.027
protein complex biogenesisGO:00702712630.027
positive regulation of gene expressionGO:00106282440.027
macromolecular complex assemblyGO:00650032730.026
ras protein signal transductionGO:0007265290.026
positive regulation of cellular biosynthetic processGO:00313282950.026
neuron projection developmentGO:00311752730.026
cell motilityGO:00488702020.026
neuron differentiationGO:00301823680.026
circulatory system processGO:00030131830.025
gliogenesisGO:0042063930.025
small gtpase mediated signal transductionGO:0007264360.025
positive regulation of multicellular organismal processGO:00512403870.025
purine nucleotide metabolic processGO:00061632290.025
behaviorGO:00076102050.025
multicellular organism reproductionGO:00325042330.025
regulation of ion transportGO:00432692450.025
regulation of cellular ketone metabolic processGO:0010565270.025
programmed cell deathGO:00125013920.025
response to peptideGO:19016522920.025
regulation of cellular amine metabolic processGO:003323880.025
organic hydroxy compound metabolic processGO:19016151150.025
response to oxygen levelsGO:00704822650.025
cellular catabolic processGO:00442482950.025
positive regulation of cell developmentGO:00107201760.024
cellular response to organonitrogen compoundGO:00714171970.024
sexual reproductionGO:00199531480.024
organic acid biosynthetic processGO:0016053830.024
negative regulation of gene expressionGO:00106291990.024
secretionGO:00469033070.024
negative regulation of cellular metabolic processGO:00313242810.024
regulation of locomotionGO:00400121480.023
kidney developmentGO:0001822670.023
response to hypoxiaGO:00016662310.023
organonitrogen compound biosynthetic processGO:19015661670.023
regulation of cellular amino acid metabolic processGO:000652120.023
neuron developmentGO:00486662860.023
positive regulation of cell deathGO:00109421840.023
secretion by cellGO:00329402480.023
monovalent inorganic cation transportGO:00156721720.023
positive regulation of rna metabolic processGO:00512542030.023
response to inorganic substanceGO:00100353770.022
regulation of nucleic acid templated transcriptionGO:19035063800.022
response to alkaloidGO:00432791320.022
cell projection organizationGO:00300303020.022
positive regulation of biosynthetic processGO:00098913190.022
protein phosphorylationGO:00064683450.022
regulation of purine nucleotide metabolic processGO:19005421150.022
organophosphate catabolic processGO:00464341480.022
response to growth factorGO:00708481890.022
organic substance catabolic processGO:19015753160.022
cellular response to growth factor stimulusGO:00713631620.021
cell morphogenesis involved in neuron differentiationGO:00486671060.021
carboxylic acid biosynthetic processGO:0046394830.021
regulation of secretion by cellGO:19035302080.021
neuron projection morphogenesisGO:00488121220.021
fatty acid metabolic processGO:0006631990.021
negative regulation of macromolecule metabolic processGO:00106052600.021
regulation of transcription from rna polymerase ii promoterGO:00063572340.021
positive regulation of cell migrationGO:0030335960.021
catabolic processGO:00090563510.020
regulation of cellular component movementGO:00512701500.020
organophosphate biosynthetic processGO:00904071430.020
positive regulation of cellular component organizationGO:00511302000.020
ribonucleoside metabolic processGO:00091191740.020
nucleotide metabolic processGO:00091172790.020
response to monosaccharideGO:00342841590.020
intracellular transportGO:00469071850.020
divalent inorganic cation transportGO:00725111340.020
positive regulation of transportGO:00510502450.020
negative regulation of cell differentiationGO:0045596990.020
ribose phosphate metabolic processGO:00196932350.020
regulation of multicellular organismal developmentGO:20000263760.019
synaptic transmissionGO:00072682350.019
response to ethanolGO:00454711620.019
glial cell differentiationGO:0010001650.019
purine ribonucleotide metabolic processGO:00091502270.019
organophosphate metabolic processGO:00196373700.019
regulation of cellular protein metabolic processGO:00322682670.019
positive regulation of nucleic acid templated transcriptionGO:19035081970.019
response to other organismGO:00517072200.019
cell growthGO:00160491040.019
negative regulation of nucleobase containing compound metabolic processGO:00459341530.019
positive regulation of response to stimulusGO:00485842850.019
regulation of phosphorylationGO:00423252480.019
heart processGO:0003015570.019
nucleoside metabolic processGO:00091161790.018
axis specificationGO:000979840.018
response to amineGO:0014075460.018
regulation of response to external stimulusGO:00321011060.018
macromolecule localizationGO:00330362520.018
regulation of neurogenesisGO:00507672470.018
positive regulation of rna biosynthetic processGO:19026801970.018
regulation of hormone levelsGO:00108171870.018
positive regulation of synaptic transmissionGO:0050806620.018
regulation of cell migrationGO:00303341280.018
transmembrane transportGO:00550854120.018
positive regulation of cellular amino acid metabolic processGO:004576410.018
positive regulation of programmed cell deathGO:00430681570.017
regulation of secretionGO:00510462240.017
positive regulation of transcription dna templatedGO:00458931970.017
cell chemotaxisGO:0060326310.017
renal system developmentGO:0072001670.017
nucleoside phosphate metabolic processGO:00067532830.017
regulation of protein metabolic processGO:00512462890.017
negative regulation of rna metabolic processGO:00512531230.017
regulation of cell projection organizationGO:00313441750.017
purine ribonucleoside triphosphate metabolic processGO:00092051400.017
positive regulation of macromolecule biosynthetic processGO:00105572470.017
positive regulation of ion transportGO:0043270940.017
regulation of catalytic activityGO:00507903040.017
negative regulation of rna biosynthetic processGO:19026791180.017
positive regulation of neurogenesisGO:00507691650.017
regulation of apoptotic processGO:00429813350.017
regulation of cell motilityGO:20001451310.017
negative regulation of transcription dna templatedGO:00458921160.017
nucleobase containing compound catabolic processGO:00346551520.016
gamete generationGO:00072761240.016
response to vitaminGO:00332731310.016
sequestering of calcium ionGO:005120880.016
response to molecule of bacterial originGO:00022371940.016
regulation of blood pressureGO:0008217830.016
negative regulation of biosynthetic processGO:00098901680.016
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.016
response to biotic stimulusGO:00096072260.016
circadian rhythmGO:0007623880.016
negative regulation of signalingGO:00230571570.016
protein transportGO:00150311320.016
response to nutrientGO:00075842480.016
agingGO:00075682410.016
heart contractionGO:0060047570.016
positive regulation of cellular component movementGO:00512721020.016
cellular response to hormone stimulusGO:00328702470.016
nucleoside phosphate catabolic processGO:19012921400.016
oxidation reduction processGO:00551143040.016
peptidyl amino acid modificationGO:00181931260.016
negative regulation of cell communicationGO:00106481580.016
positive regulation of molecular functionGO:00440932300.016
localization of cellGO:00516742020.016
single organism intracellular transportGO:19025821660.016
divalent metal ion transportGO:00708381320.016
positive regulation of neuron projection developmentGO:0010976990.016
response to cytokineGO:00340972150.015
defense responseGO:00069521940.015
regulation of blood vessel sizeGO:0050880890.015
response to extracellular stimulusGO:00099913800.015
regulation of nucleotide metabolic processGO:00061401170.015
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.015
ribonucleoside catabolic processGO:00424541260.015
regulation of anatomical structure morphogenesisGO:00226031410.015
positive regulation of cellular amine metabolic processGO:003324030.015
muscle contractionGO:0006936880.015
response to purine containing compoundGO:00140741260.015
cytoplasmic transportGO:00164821150.015
memoryGO:0007613540.015
negative regulation of transportGO:00510511360.015
response to glucoseGO:00097491360.015
protein oligomerizationGO:00512591910.014
nucleotide catabolic processGO:00091661390.014
purine ribonucleoside catabolic processGO:00461301240.014
cell cell signalingGO:00072673350.014
response to lipopolysaccharideGO:00324961910.014
circulatory system developmentGO:00723591340.014
organonitrogen compound catabolic processGO:19015651790.014
purine nucleoside triphosphate metabolic processGO:00091441410.014
cell morphogenesis involved in differentiationGO:00009041190.014
ribonucleotide metabolic processGO:00092592310.014
regulation of canonical wnt signaling pathwayGO:006082840.014
regulation of cellular localizationGO:00603412630.014
alcohol metabolic processGO:0006066770.014
cell morphogenesisGO:00009021420.014
response to hexoseGO:00097461440.014
calcium ion transportGO:00068161310.014
regulation of neuron projection developmentGO:00109751610.014
organic hydroxy compound biosynthetic processGO:1901617510.014
positive regulation of mapk cascadeGO:0043410920.014
carbohydrate derivative catabolic processGO:19011361470.014
smooth muscle contractionGO:0006939370.014
regulation of cell morphogenesisGO:0022604770.014
positive regulation of protein modification processGO:00314011420.014
actin filament based processGO:0030029860.014
cellular response to nitrogen compoundGO:19016992100.014
regulation of cell growthGO:0001558850.014
positive regulation of phosphorylationGO:00423271770.014
positive regulation of intracellular signal transductionGO:19025331380.014
salivary gland morphogenesisGO:000743510.013
regulation of fat cell differentiationGO:004559830.013
response to acid chemicalGO:00011012220.013
cell projection morphogenesisGO:00488581230.013
regulation of body fluid levelsGO:0050878900.013
cell part morphogenesisGO:00329901230.013
positive regulation of cell motilityGO:2000147970.013
cellular response to organic cyclic compoundGO:00714072020.013
cellular response to stressGO:00335542690.013
chemotaxisGO:0006935660.013
positive regulation of cell projection organizationGO:00313461110.013
positive regulation of apoptotic processGO:00430651540.013
regulation of blood circulationGO:19035221100.013
positive regulation of protein metabolic processGO:00512471780.013
actin cytoskeleton organizationGO:0030036730.013
positive regulation of nucleotide metabolic processGO:0045981910.013
regulation of dendrite developmentGO:0050773590.013
renal system processGO:0003014400.013
proteolysisGO:00065081750.013
chemosensory behaviorGO:000763520.013
vesicle mediated transportGO:00161921810.013
heart morphogenesisGO:000300730.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.012
regulation of respiratory gaseous exchangeGO:004357620.012
enzyme linked receptor protein signaling pathwayGO:00071671160.012
response to woundingGO:00096112540.012
regulation of neuron differentiationGO:00456642080.012
single organism behaviorGO:00447081300.012
axonogenesisGO:0007409710.012
neuron deathGO:00709971270.012
anion transportGO:00068201780.012
response to metal ionGO:00100382530.012
spermatogenesisGO:0007283990.012
positive regulation of secretionGO:00510471400.012
positive regulation of response to external stimulusGO:0032103510.012
regulation of cell morphogenesis involved in differentiationGO:0010769720.012
negative regulation of cell deathGO:00605482290.012
lipid catabolic processGO:0016042460.012
nucleoside triphosphate metabolic processGO:00091411440.012
organic cyclic compound catabolic processGO:19013611750.012
purine ribonucleoside triphosphate catabolic processGO:00092071220.012
ribonucleoside triphosphate metabolic processGO:00091991410.012
regulation of hormone secretionGO:00468831060.012
aromatic compound catabolic processGO:00194391680.012
relaxation of muscleGO:009007540.012
adult locomotory behaviorGO:000834440.012
ribonucleoside triphosphate catabolic processGO:00092031220.012
cellular response to external stimulusGO:00714961180.012
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.012
negative regulation of response to stimulusGO:00485851550.012
regulation of synaptic plasticityGO:0048167700.012
membrane organizationGO:0061024940.012
cellular response to peptideGO:19016531330.011
nucleoside phosphate biosynthetic processGO:19012931020.011
ion transmembrane transportGO:00342203650.011
gtp catabolic processGO:0006184710.011
purine containing compound biosynthetic processGO:0072522850.011
rho protein signal transductionGO:0007266110.011
positive regulation of neuron differentiationGO:00456661260.011
feeding behaviorGO:0007631530.011
negative regulation of neurogenesisGO:0050768780.011
positive regulation of immune system processGO:0002684900.011
purine containing compound catabolic processGO:00725231380.011
epithelium developmentGO:0060429960.011
carbohydrate metabolic processGO:00059751300.011
ribose phosphate biosynthetic processGO:0046390870.011
single organism organelle organizationGO:19025891800.011
cellular response to oxygen containing compoundGO:19017013860.011
male gamete generationGO:0048232990.011
cellular carbohydrate metabolic processGO:0044262720.011
neuronal action potentialGO:0019228350.011
smooth muscle cell migrationGO:0014909360.011
regulation of calcium ion transportGO:0051924770.011
purine nucleoside catabolic processGO:00061521240.011
vascular process in circulatory systemGO:0003018960.011
inflammatory responseGO:00069541500.011
neural crest cell developmentGO:001403220.011
axon developmentGO:0061564960.011
negative regulation of protein metabolic processGO:00512481140.011
response to amphetamineGO:0001975250.011
negative regulation of macromolecule biosynthetic processGO:00105581480.011
biological adhesionGO:00226101100.011
cytoskeleton organizationGO:00070101110.011
regulation of mapk cascadeGO:00434081160.011
negative regulation of programmed cell deathGO:00430691830.011
neuron neuron synaptic transmissionGO:0007270600.011
developmental process involved in reproductionGO:00030061590.011
positive regulation of blood circulationGO:1903524650.011
regulation of ion homeostasisGO:2000021630.010
positive regulation of secretion by cellGO:19035321280.010
purine nucleoside triphosphate catabolic processGO:00091461220.010
glycosyl compound metabolic processGO:19016571820.010
purine nucleoside metabolic processGO:00422781690.010
cardiovascular system developmentGO:00723581340.010
cellular response to molecule of bacterial originGO:0071219560.010
glycosyl compound catabolic processGO:19016581260.010
anterior posterior pattern specificationGO:000995210.010
negative regulation of nucleic acid templated transcriptionGO:19035071170.010
regulation of neurological system processGO:0031644430.010
embryonic pattern specificationGO:000988010.010
action potentialGO:0001508540.010
steroid metabolic processGO:0008202730.010
regulation of system processGO:00440572080.010
alcohol biosynthetic processGO:0046165380.010
response to external biotic stimulusGO:00432072210.010

Penk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.016
nervous system diseaseDOID:86300.016
musculoskeletal system diseaseDOID:1700.010