Rattus norvegicus

310 known processes

Hnf4a

hepatocyte nuclear factor 4, alpha

(Aliases: Hnf4,Hnf4alpha)

Hnf4a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid metabolic processGO:00066292830.842
response to glucocorticoidGO:00513842230.386
Rat
carboxylic acid metabolic processGO:00197522890.326
cellular modified amino acid metabolic processGO:0006575610.289
vitamin d receptor signaling pathwayGO:007056110.287
organic acid biosynthetic processGO:0016053830.286
response to corticosteroidGO:00319602350.234
Rat
organic acid metabolic processGO:00060822920.233
response to inorganic substanceGO:00100353770.195
Rat
hepaticobiliary system developmentGO:0061008900.180
Rat
oxoacid metabolic processGO:00434362900.173
inorganic ion transmembrane transportGO:00986602290.169
vitamin a metabolic processGO:000677620.166
liver developmentGO:0001889900.162
Rat
negative regulation of pancreatic stellate cell proliferationGO:200023010.160
single organism biosynthetic processGO:00447113420.150
alpha amino acid metabolic processGO:1901605710.144
Human
cellular amino acid metabolic processGO:00065201070.144
Human
inflammatory responseGO:00069541500.140
Rat
pancreatic stellate cell proliferationGO:007234320.140
neuron projection developmentGO:00311752730.139
Rat
response to nutrientGO:00075842480.131
Rat
response to estradiolGO:00323551640.127
Rat
cellular lipid metabolic processGO:00442552080.125
regulation of system processGO:00440572080.121
response to oxidative stressGO:00069791860.120
defense responseGO:00069521940.118
Rat
carbohydrate derivative metabolic processGO:19011353460.115
response to extracellular stimulusGO:00099913800.112
Rat
t cell tolerance inductionGO:000251730.110
cellular response to hormone stimulusGO:00328702470.110
Rat
cellular response to stressGO:00335542690.109
Rat
mrna transcriptionGO:000929920.108
behavioral response to nicotineGO:003509520.105
circulatory system processGO:00030131830.105
carboxylic acid biosynthetic processGO:0046394830.103
tolerance induction dependent upon immune responseGO:000246120.101
response to peptideGO:19016522920.100
Rat
chemical homeostasisGO:00488782920.098
Human Mouse
single organism catabolic processGO:00447122830.098
Fly
regulation of hormone levelsGO:00108171870.096
Mouse
monocarboxylic acid metabolic processGO:00327871520.093
response to monosaccharideGO:00342841590.091
cellular response to organonitrogen compoundGO:00714171970.089
Rat
gland developmentGO:00487321550.089
Rat
cellular ketone metabolic processGO:0042180510.087
response to hypoxiaGO:00016662310.087
cellular component assemblyGO:00226073600.086
positive regulation of nucleobase containing compound metabolic processGO:00459353190.085
response to other organismGO:00517072200.085
positive regulation of macromolecule biosynthetic processGO:00105572470.084
cellular response to peptideGO:19016531330.081
Rat
positive regulation of transcription dna templatedGO:00458931970.080
response to xenobiotic stimulusGO:0009410230.079
Human
sterol homeostasisGO:005509230.077
Mouse
blood circulationGO:00080151830.076
regulation of transcription dna templatedGO:00063553740.074
protein complex subunit organizationGO:00718223020.074
response to cytokineGO:00340972150.073
positive regulation of rna metabolic processGO:00512542030.072
peptide transportGO:0015833970.069
Mouse
regulation of cellular ketone metabolic processGO:0010565270.069
protein complex biogenesisGO:00702712630.067
cellular response to endogenous stimulusGO:00714953770.065
Rat
fatty acid metabolic processGO:0006631990.065
regenerationGO:00310991630.064
Rat
regulation of nucleic acid templated transcriptionGO:19035063800.063
ion transmembrane transportGO:00342203650.062
response to external biotic stimulusGO:00432072210.062
rna biosynthetic processGO:00327743800.059
regulation of apoptotic processGO:00429813350.059
Rat
neuron developmentGO:00486662860.058
Rat
response to purine containing compoundGO:00140741260.057
macromolecular complex assemblyGO:00650032730.056
regulation of response to external stimulusGO:00321011060.056
digestive system developmentGO:0055123410.055
Mouse Rat
macromolecular complex subunit organizationGO:00439333390.054
transcription from rna polymerase ii promoterGO:00063662520.053
response to lipopolysaccharideGO:00324961910.052
response to peptide hormoneGO:00434342780.052
Rat
response to growth factorGO:00708481890.052
regulation of blood circulationGO:19035221100.051
regulation of pancreatic stellate cell proliferationGO:200022920.051
homeostatic processGO:00425923310.050
Human Mouse
intestinal absorptionGO:005089230.050
negative regulation of gene expressionGO:00106291990.050
Rat Worm
response to glucoseGO:00097491360.049
negative regulation of macromolecule metabolic processGO:00106052600.049
positive regulation of nucleic acid templated transcriptionGO:19035081970.048
digestive tract developmentGO:0048565390.047
Mouse Rat
negative regulation of transcription regulatory region dna bindingGO:200067820.047
negative regulation of muscle cell apoptotic processGO:0010656210.047
response to campGO:0051591910.047
positive regulation of phagocytosis engulfmentGO:006010040.047
cellular response to vitamin eGO:007130630.046
cellular component biogenesisGO:00440853680.046
response to oxygen levelsGO:00704822650.045
circadian regulation of gene expressionGO:003292230.043
positive regulation of biosynthetic processGO:00098913190.043
drug metabolic processGO:0017144110.043
cellular response to oxygen containing compoundGO:19017013860.042
Rat
purine containing compound metabolic processGO:00725212530.042
transmembrane transportGO:00550854120.042
ribose phosphate metabolic processGO:00196932350.042
cell projection organizationGO:00300303020.042
cellular response to nitrogen compoundGO:19016992100.041
Rat
isoprenoid metabolic processGO:0006720450.041
carbohydrate metabolic processGO:00059751300.039
response to ketoneGO:19016541820.039
positive regulation of tolerance inductionGO:000264510.038
negative regulation of telomerase activityGO:005197410.038
sulfur compound metabolic processGO:0006790700.038
secretionGO:00469033070.038
Mouse
regulation of neuron projection developmentGO:00109751610.038
Rat
inorganic cation transmembrane transportGO:00986622020.037
cellular response to steroid hormone stimulusGO:0071383930.037
cation transmembrane transportGO:00986552630.037
protein complex assemblyGO:00064612630.037
cellular catabolic processGO:00442482950.037
response to decreased oxygen levelsGO:00362932370.037
hormone metabolic processGO:0042445690.036
multicellular organismal signalingGO:0035637440.036
organophosphate metabolic processGO:00196373700.036
programmed cell deathGO:00125013920.036
Rat
response to fibroblast growth factorGO:0071774290.035
cell morphogenesis involved in neuron differentiationGO:00486671060.035
cellular amide metabolic processGO:0043603440.035
acyl coa metabolic processGO:0006637280.035
cellular component movementGO:00069282480.035
cellular response to alcoholGO:0097306870.035
regulation of phagocytosis engulfmentGO:006009940.035
cellular modified amino acid biosynthetic processGO:0042398180.034
transcription dna templatedGO:00063513770.034
locomotionGO:00400112370.034
catabolic processGO:00090563510.034
Fly
diterpenoid metabolic processGO:0016101330.034
response to woundingGO:00096112540.033
Human Rat
dendrite morphogenesisGO:0048813430.033
regulation of blood pressureGO:0008217830.033
positive regulation of gene expressionGO:00106282440.033
circulatory system developmentGO:00723591340.033
Rat
negative regulation of collagen biosynthetic processGO:003296640.033
neuron differentiationGO:00301823680.033
Rat
cellular response to corticosteroid stimulusGO:0071384690.032
cellular response to organic cyclic compoundGO:00714072020.032
insulin secretionGO:0030073690.031
Mouse
reactive oxygen species metabolic processGO:0072593370.031
regulation of cellular localizationGO:00603412630.030
positive regulation of epidermis developmentGO:004568410.030
negative regulation of macromolecule biosynthetic processGO:00105581480.030
Rat Worm
nucleoside metabolic processGO:00091161790.030
regulation of molecular functionGO:00650093980.030
regulation of protein phosphorylationGO:00019321830.030
negative regulation of nitrogen compound metabolic processGO:00511721610.030
Rat Worm
response to estrogenGO:00436272320.030
Rat
reproductive processGO:00224143720.029
Mouse Rat
response to nutrient levelsGO:00316673700.029
Rat
growthGO:00400071650.028
Human
amine metabolic processGO:0009308380.028
regulation of peptide hormone secretionGO:0090276800.028
Mouse
response to vitaminGO:00332731310.027
Rat
placenta developmentGO:0001890220.027
Rat
head developmentGO:00603222470.027
hormone secretionGO:00468791150.027
Mouse
glutamine family amino acid metabolic processGO:0009064150.027
brain developmentGO:00074202470.026
rna metabolic processGO:00160704060.026
response to biotic stimulusGO:00096072260.026
neurological system processGO:00508772190.026
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.026
microvillus assemblyGO:003003320.026
lipid biosynthetic processGO:00086101280.026
regulation of nervous system developmentGO:00519602640.025
Rat
antibiotic transportGO:004289120.025
drug transmembrane transportGO:0006855130.025
cellular response to growth factor stimulusGO:00713631620.025
regulation of cell proliferationGO:00421273590.025
response to foodGO:0032094270.025
regulation of body fluid levelsGO:0050878900.025
Human
thioester metabolic processGO:0035383280.025
positive regulation of nitrogen compound metabolic processGO:00511733340.025
regulation of tube sizeGO:0035150890.025
response to bacteriumGO:00096172000.025
regulation of telomerase activityGO:005197220.025
regulation of transforming growth factor beta3 productionGO:003291020.025
lipid localizationGO:0010876620.025
Worm
cellular response to glucocorticoid stimulusGO:0071385680.025
organonitrogen compound biosynthetic processGO:19015661670.024
regulation of membrane potentialGO:00423911100.024
single organism reproductive processGO:00447022970.024
Rat
cellular amine metabolic processGO:0044106380.024
cellular homeostasisGO:00197252520.024
localization of cellGO:00516742020.024
response to ethanolGO:00454711620.024
Rat
regulation of insulin secretionGO:0050796650.023
Mouse
multi organism reproductive processGO:00447032620.023
Rat
hormone transportGO:00099141210.023
Mouse
positive regulation of vasodilationGO:0045909290.023
monovalent inorganic cation transportGO:00156721720.022
ion homeostasisGO:00508012120.022
Mouse
smooth muscle cell proliferationGO:0048659770.022
response to hexoseGO:00097461440.022
cell part morphogenesisGO:00329901230.022
glucose homeostasisGO:0042593750.022
Mouse
vasodilationGO:0042311440.022
regulation of transcription from rna polymerase ii promoterGO:00063572340.021
positive regulation of hormone secretionGO:0046887650.021
regulation of secretionGO:00510462240.021
Mouse
positive regulation of developmental processGO:00510942830.021
regulation of multicellular organismal developmentGO:20000263760.021
Mouse Rat
tube developmentGO:0035295890.021
Mouse Rat
regulation of catalytic activityGO:00507903040.021
negative regulation of metabolic processGO:00098923310.021
positive regulation of molecular functionGO:00440932300.021
coenzyme metabolic processGO:0006732860.021
positive regulation of signalingGO:00230562700.021
response to acid chemicalGO:00011012220.021
Rat
response to insulinGO:00328681330.021
Rat
positive regulation of nervous system developmentGO:00519621780.021
organophosphate biosynthetic processGO:00904071430.021
steroid biosynthetic processGO:0006694480.021
anterior posterior pattern specificationGO:000995210.020
terpenoid metabolic processGO:0006721370.020
adenylate cyclase inhibiting opioid receptor signaling pathwayGO:003163520.020
regulation of neurogenesisGO:00507672470.020
Rat
exogenous drug catabolic processGO:004273810.019
tetrahydrofolate metabolic processGO:004665390.019
ribonucleoside metabolic processGO:00091191740.019
response to starvationGO:0042594590.019
regulation of tolerance inductionGO:000264320.019
striated muscle cell proliferationGO:001485590.019
regulation of cell motilityGO:20001451310.019
glycosyl compound metabolic processGO:19016571820.019
regulation of growthGO:00400081050.019
Human
positive regulation of blood circulationGO:1903524650.018
regulation of anatomical structure sizeGO:00900661350.018
immune responseGO:00069551040.018
acute inflammatory responseGO:0002526580.018
monosaccharide metabolic processGO:0005996610.018
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.018
dendrite developmentGO:0016358720.018
g protein coupled receptor signaling pathwayGO:00071862420.018
fatty acid oxidationGO:0019395290.018
monocarboxylic acid biosynthetic processGO:0072330480.018
small molecule biosynthetic processGO:00442831240.018
heart morphogenesisGO:000300730.018
positive regulation of cell developmentGO:00107201760.018
positive regulation of transferase activityGO:0051347810.018
carbohydrate derivative biosynthetic processGO:19011371240.018
neuronal action potentialGO:0019228350.017
neural crest cell migrationGO:000175510.017
positive regulation of cellular biosynthetic processGO:00313282950.017
negative regulation of collagen metabolic processGO:001071340.017
regulation of cell developmentGO:00602842630.017
Rat
regulation of protein metabolic processGO:00512462890.017
muscle cell proliferationGO:0033002840.017
regulation of peptide transportGO:0090087870.017
Mouse
steroid metabolic processGO:0008202730.017
neuron projection morphogenesisGO:00488121220.017
negative regulation of rna metabolic processGO:00512531230.017
Rat Worm
regulation of locomotionGO:00400121480.017
immune system processGO:00023762040.017
regulation of skeletal muscle tissue regenerationGO:004341620.017
cellular response to peptide hormone stimulusGO:00713751200.016
Rat
drug transportGO:0015893180.016
organ formationGO:004864530.016
reproductive structure developmentGO:00486081280.016
Rat
regulation of transcription regulatory region dna bindingGO:200067740.016
positive regulation of response to stimulusGO:00485842850.016
regulation of cellular component organizationGO:00511283680.016
cation transportGO:00068123820.016
carbohydrate homeostasisGO:0033500750.016
Mouse
peptidyl amino acid modificationGO:00181931260.016
negative regulation of nucleic acid templated transcriptionGO:19035071170.016
Rat Worm
central nervous system developmentGO:00074173110.015
positive regulation of neurogenesisGO:00507691650.015
reproductive system developmentGO:00614581280.015
Rat
positive regulation of cellular protein metabolic processGO:00322701670.015
cell cell signalingGO:00072673350.015
Mouse
alpha amino acid biosynthetic processGO:1901607230.015
gliogenesisGO:0042063930.015
protein heterooligomerizationGO:0051291890.015
positive regulation of fatty acid metabolic processGO:0045923140.015
intracellular signal transductionGO:00355563140.015
positive regulation of phosphorus metabolic processGO:00105622620.015
regulation of lipid metabolic processGO:0019216680.015
drug catabolic processGO:004273710.015
organic cyclic compound catabolic processGO:19013611750.015
synaptic transmissionGO:00072682350.015
positive regulation of rna biosynthetic processGO:19026801970.015
purine nucleoside metabolic processGO:00422781690.015
gastrulationGO:000736920.015
Mouse
positive regulation of cellular component organizationGO:00511302000.015
cardiac muscle tissue morphogenesisGO:005500810.015
forebrain developmentGO:0030900980.015
regulation of rna metabolic processGO:00512523910.015
innate immune responseGO:0045087350.015
positive regulation of fatty acid oxidationGO:004632160.015
complement receptor mediated signaling pathwayGO:000243020.015
cofactor biosynthetic processGO:0051188280.014
cardiac chamber developmentGO:000320510.014
endocytosisGO:0006897840.014
wound healingGO:00420601220.014
Human
regulation of vasodilationGO:0042312360.014
regulation of cellular amine metabolic processGO:003323880.014
regulation of kinase activityGO:00435491170.014
positive regulation of protein kinase activityGO:0045860730.014
regulation of cellular amino acid metabolic processGO:000652120.014
regulation of fat cell differentiationGO:004559830.014
reactive nitrogen species metabolic processGO:200105710.014
defense response to gram negative bacteriumGO:005082930.014
axon developmentGO:0061564960.014
Rat
embryonic pattern specificationGO:000988010.014
amide biosynthetic processGO:0043604100.014
nucleoside monophosphate catabolic processGO:0009125560.014
positive regulation of transportGO:00510502450.014
purine nucleotide metabolic processGO:00061632290.014
organonitrogen compound catabolic processGO:19015651790.014
dna metabolic processGO:0006259960.014
response to metforminGO:190155810.014
cardiac ventricle developmentGO:000323110.014
cellular response to prostaglandin stimulusGO:007137970.014
cellular response to ketoneGO:1901655510.013
oligopeptide transportGO:000685740.013
negative regulation of natural killer cell mediated cytotoxicityGO:004595340.013
aromatic compound catabolic processGO:00194391680.013
positive regulation of biomineral tissue developmentGO:007016940.013
response to carbohydrateGO:00097431830.013
lipid storageGO:001991510.013
Worm
secretion by cellGO:00329402480.013
Mouse
toxin transportGO:190199830.013
purinergic receptor signaling pathwayGO:0035587100.013
organophosphate catabolic processGO:00464341480.013
cell morphogenesis involved in differentiationGO:00009041190.013
female pregnancyGO:00075651220.013
Rat
positive regulation of interleukin 1 beta productionGO:003273160.013
ribonucleotide metabolic processGO:00092592310.013
chemosensory behaviorGO:000763520.013
cell projection morphogenesisGO:00488581230.013
response to ionizing radiationGO:0010212590.013
organic acid catabolic processGO:0016054490.013
regulation of cell growthGO:0001558850.013
Human
response to temperature stimulusGO:0009266940.013
heterocycle catabolic processGO:00467001670.013
activation of mapkk activityGO:0000186180.013
ribonucleoside catabolic processGO:00424541260.013
regulation of peptide secretionGO:0002791820.012
Mouse
activation of protein kinase activityGO:0032147470.012
response to mechanical stimulusGO:00096121340.012
lipid transportGO:0006869610.012
muscle organ morphogenesisGO:004864410.012
cofactor metabolic processGO:0051186950.012
negative regulation of cellular metabolic processGO:00313242810.012
negative regulation of growthGO:0045926370.012
Human
heart developmentGO:0007507720.012
Rat
divalent inorganic cation transportGO:00725111340.012
organic cation transportGO:0015695110.012
cellular amino acid biosynthetic processGO:0008652320.012
regulation of ion transportGO:00432692450.012
positive regulation of neuron projection developmentGO:0010976990.012
mesoderm developmentGO:000749820.012
negative regulation of mitotic cell cycle phase transitionGO:190199130.012
response to dexamethasoneGO:0071548490.012
purine containing compound catabolic processGO:00725231380.012
metal ion homeostasisGO:00550651860.012
neural crest cell differentiationGO:001403320.012
nucleotide metabolic processGO:00091172790.012
ribonucleoside triphosphate metabolic processGO:00091991410.012
visual perceptionGO:000760130.012
folic acid containing compound metabolic processGO:0006760100.011
neural crest cell developmentGO:001403220.011
muscle cell apoptotic processGO:0010657300.011
nucleobase containing compound catabolic processGO:00346551520.011
tissue homeostasisGO:0001894280.011
regulation of neuron deathGO:19012141150.011
cation homeostasisGO:00550801950.011
cellular chemical homeostasisGO:00550822470.011
negative regulation of multicellular organismal metabolic processGO:004425240.011
protein oligomerizationGO:00512591910.011
negative regulation of cellular amine metabolic processGO:003323930.011
negative regulation of transportGO:00510511360.011
cellular hormone metabolic processGO:0034754490.011
axon regenerationGO:0031103280.011
Rat
regulation of rna biosynthetic processGO:20011413810.011
neuron deathGO:00709971270.011
response to metal ionGO:00100382530.011
negative regulation of cell cycle phase transitionGO:190198840.011
regulation of cell migrationGO:00303341280.011
negative regulation of biosynthetic processGO:00098901680.011
Rat Worm
organelle organizationGO:00069962660.011
negative regulation of cellular amino acid metabolic processGO:004576300.011
muscle structure developmentGO:0061061870.011
Rat
regulation of fatty acid metabolic processGO:0019217180.011
ras protein signal transductionGO:0007265290.011
specification of organ identityGO:001009220.011
tissue developmentGO:00098882520.011
Rat
response to fatty acidGO:0070542650.011
developmental process involved in reproductionGO:00030061590.011
Mouse Rat
single organism organelle organizationGO:19025891800.011
response to toxic substanceGO:00096361330.011
vascular process in circulatory systemGO:0003018960.011
negative regulation of secretionGO:0051048820.010
oxidation reduction processGO:00551143040.010
Fly
transmission of nerve impulseGO:0019226420.010
nucleobase containing small molecule metabolic processGO:00550863160.010
cell communication involved in cardiac conductionGO:008606520.010
multicellular organism reproductionGO:00325042330.010
muscle organ developmentGO:0007517500.010
Rat
positive regulation of neuron differentiationGO:00456661260.010
response to cocaineGO:0042220390.010
cellular divalent inorganic cation homeostasisGO:00725031620.010
regulation of systemic arterial blood pressure by circulatory renin angiotensinGO:000199140.010
axis specificationGO:000979840.010
muscle tissue morphogenesisGO:006041510.010
cellular metal ion homeostasisGO:00068751720.010
proteoglycan metabolic processGO:000602930.010
positive regulation of cellular amino acid metabolic processGO:004576410.010
cellular response to carbohydrate stimulusGO:0071322720.010
positive regulation of insulin secretionGO:0032024360.010
proteolysisGO:00065081750.010
positive regulation of growthGO:0045927550.010

Hnf4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.058
Human
inherited metabolic disorderDOID:65500.058
nervous system diseaseDOID:86300.039
disease of anatomical entityDOID:700.039
cardiovascular system diseaseDOID:128700.022
metal metabolism disorderDOID:89600.021
cancerDOID:16200.019
disease of cellular proliferationDOID:1456600.019
gastrointestinal system cancerDOID:311900.019
organ system cancerDOID:005068600.019
connective tissue diseaseDOID:6500.018
musculoskeletal system diseaseDOID:1700.018
gastrointestinal system diseaseDOID:7700.016
hepatobiliary diseaseDOID:311800.016
liver diseaseDOID:40900.016
vascular diseaseDOID:17800.012
hepatocellular carcinomaDOID:68400.011
liver carcinomaDOID:68600.011
liver cancerDOID:357100.011
central nervous system diseaseDOID:33100.010
artery diseaseDOID:005082800.010