Rattus norvegicus

133 known processes

Map4k4

mitogen-activated protein kinase kinase kinase kinase 4

Map4k4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of programmed cell deathGO:00430673410.208
regulation of apoptotic processGO:00429813350.161
locomotionGO:00400112370.148
regulation of cellular localizationGO:00603412630.120
cellular response to endogenous stimulusGO:00714953770.118
cardiovascular system developmentGO:00723581340.110
regulation of molecular functionGO:00650093980.099
positive regulation of macromolecule biosynthetic processGO:00105572470.095
cellular response to stressGO:00335542690.095
vesicle mediated transportGO:00161921810.093
regulation of rna metabolic processGO:00512523910.092
response to inorganic substanceGO:00100353770.088
positive regulation of multicellular organismal processGO:00512403870.088
negative regulation of signalingGO:00230571570.087
nucleic acid templated transcriptionGO:00976593790.086
establishment of protein localizationGO:00451841410.084
apoptotic processGO:00069153810.084
organic acid metabolic processGO:00060822920.080
macromolecule localizationGO:00330362520.080
regulation of transcription dna templatedGO:00063553740.077
positive regulation of cell migrationGO:0030335960.077
positive regulation of nitrogen compound metabolic processGO:00511733340.077
embryonic skeletal system morphogenesisGO:004870430.075
cation transportGO:00068123820.074
response to cytokineGO:00340972150.073
regulation of secretionGO:00510462240.071
neuron developmentGO:00486662860.071
regulation of cell proliferationGO:00421273590.070
neuron projection developmentGO:00311752730.070
cellular response to oxygen containing compoundGO:19017013860.070
positive regulation of cellular component movementGO:00512721020.069
localization of cellGO:00516742020.069
cell motilityGO:00488702020.068
protein transportGO:00150311320.068
axon developmentGO:0061564960.068
regulation of catalytic activityGO:00507903040.068
nitrogen compound transportGO:00717052290.066
response to molecule of bacterial originGO:00022371940.065
rna metabolic processGO:00160704060.065
programmed cell deathGO:00125013920.065
taxisGO:0042330670.065
secretionGO:00469033070.063
reproductive processGO:00224143720.062
positive regulation of programmed cell deathGO:00430681570.061
positive regulation of cell motilityGO:2000147970.061
regulation of cell cycleGO:0051726730.061
positive regulation of cell deathGO:00109421840.059
positive regulation of cell communicationGO:00106472710.057
axonogenesisGO:0007409710.056
neuron differentiationGO:00301823680.055
regulation of cellular component organizationGO:00511283680.055
multicellular organism reproductionGO:00325042330.055
oxoacid metabolic processGO:00434362900.054
cation transmembrane transportGO:00986552630.054
ion transmembrane transportGO:00342203650.054
protein localizationGO:00081041910.053
rna biosynthetic processGO:00327743800.052
negative regulation of gene expressionGO:00106291990.052
central nervous system developmentGO:00074173110.052
positive regulation of nervous system developmentGO:00519621780.050
cellular response to cytokine stimulusGO:00713451270.050
cellular component assemblyGO:00226073600.050
choline transportGO:001587140.050
positive regulation of biosynthetic processGO:00098913190.049
cellular protein localizationGO:00346131220.049
single organism intracellular transportGO:19025821660.049
positive regulation of cell differentiationGO:00455972170.049
head developmentGO:00603222470.049
positive regulation of rna biosynthetic processGO:19026801970.049
regulation of multicellular organismal developmentGO:20000263760.048
positive regulation of signalingGO:00230562700.048
motor neuron axon guidanceGO:000804510.048
regulation of secretion by cellGO:19035302080.047
actin crosslink formationGO:005176430.047
reproductionGO:00000032450.047
response to woundingGO:00096112540.047
cellular component movementGO:00069282480.047
response to external biotic stimulusGO:00432072210.046
response to other organismGO:00517072200.046
mesoderm developmentGO:000749820.046
regulation of neuron differentiationGO:00456642080.046
cellular component biogenesisGO:00440853680.046
chemotaxisGO:0006935660.046
vasculature developmentGO:0001944700.045
regulation of nervous system developmentGO:00519602640.045
cellular macromolecule localizationGO:00707271220.045
tissue developmentGO:00098882520.045
response to lipopolysaccharideGO:00324961910.044
secretion by cellGO:00329402480.044
response to bacteriumGO:00096172000.043
carboxylic acid metabolic processGO:00197522890.043
regulation of mesenchymal cell proliferationGO:001046440.043
immune system processGO:00023762040.043
blood vessel developmentGO:0001568690.042
response to biotic stimulusGO:00096072260.042
regulation of cell migrationGO:00303341280.042
intracellular signal transductionGO:00355563140.041
regulation of kinase activityGO:00435491170.041
cell cycleGO:00070491010.041
negative regulation of metabolic processGO:00098923310.041
brain developmentGO:00074202470.040
cellular response to growth factor stimulusGO:00713631620.040
transcription from rna polymerase ii promoterGO:00063662520.040
organelle organizationGO:00069962660.040
embryonic skeletal system developmentGO:004870630.040
regulation of neurogenesisGO:00507672470.040
regulation of nucleic acid templated transcriptionGO:19035063800.039
positive regulation of apoptotic processGO:00430651540.039
cellular amino acid metabolic processGO:00065201070.038
protein phosphorylationGO:00064683450.038
regulation of locomotionGO:00400121480.038
organonitrogen compound biosynthetic processGO:19015661670.038
response to growth factorGO:00708481890.037
negative regulation of multicellular organismal processGO:00512412030.037
positive regulation of transportGO:00510502450.037
intracellular transportGO:00469071850.037
regulation of rna biosynthetic processGO:20011413810.037
positive regulation of signal transductionGO:00099671750.036
regulation of immune system processGO:00026821230.036
macromolecular complex assemblyGO:00650032730.035
response to oxidative stressGO:00069791860.035
ras protein signal transductionGO:0007265290.035
somatic diversification of immune receptors via germline recombination within a single locusGO:000256220.035
circulatory system developmentGO:00723591340.035
sexual reproductionGO:00199531480.034
positive regulation of cellular protein metabolic processGO:00322701670.034
positive regulation of neuron differentiationGO:00456661260.034
cell projection organizationGO:00300303020.034
single organism reproductive processGO:00447022970.034
endocytosisGO:0006897840.034
cell part morphogenesisGO:00329901230.034
negative regulation of apoptotic processGO:00430661810.034
muscle structure developmentGO:0061061870.034
negative regulation of macromolecule biosynthetic processGO:00105581480.034
homeostatic processGO:00425923310.034
anterior posterior pattern specificationGO:000995210.034
growthGO:00400071650.033
regulation of signal transductionGO:00099663180.033
cell migrationGO:00164771970.033
positive regulation of gene expressionGO:00106282440.033
positive regulation of intracellular signal transductionGO:19025331380.032
agingGO:00075682410.032
transmembrane transportGO:00550854120.032
cellular response to lipidGO:00713962010.032
positive regulation of cell developmentGO:00107201760.032
regulation of cell projection organizationGO:00313441750.032
regulation of cell growthGO:0001558850.032
b cell differentiationGO:003018320.031
response to oxygen levelsGO:00704822650.031
positive regulation of protein metabolic processGO:00512471780.031
transcription dna templatedGO:00063513770.031
positive regulation of cell projection organizationGO:00313461110.031
positive regulation of cellular biosynthetic processGO:00313282950.031
intracellular protein transportGO:0006886790.031
negative regulation of rna biosynthetic processGO:19026791180.031
response to alkaloidGO:00432791320.030
negative regulation of developmental processGO:00510931250.030
neurological system processGO:00508772190.030
positive regulation of response to stimulusGO:00485842850.030
response to hypoxiaGO:00016662310.030
negative regulation of cell deathGO:00605482290.030
positive regulation of nucleobase containing compound metabolic processGO:00459353190.029
response to ketoneGO:19016541820.029
response to metal ionGO:00100382530.029
embryonic cranial skeleton morphogenesisGO:004870120.029
nuclear transportGO:0051169490.029
positive regulation of cellular amine metabolic processGO:003324030.029
regulation of protein metabolic processGO:00512462890.029
response to hydrogen peroxideGO:0042542890.029
regulation of transcription from rna polymerase ii promoterGO:00063572340.028
protein complex biogenesisGO:00702712630.028
hair follicle developmentGO:000194220.028
coronary vasculature morphogenesisGO:006097730.028
negative regulation of molecular functionGO:00440921330.028
positive regulation of blood coagulationGO:003019440.028
activation of cysteine type endopeptidase activityGO:009720240.027
anatomical structure morphogenesisGO:00096532980.027
proteolysisGO:00065081750.027
response to estradiolGO:00323551640.027
response to extracellular stimulusGO:00099913800.027
negative regulation of macromolecule metabolic processGO:00106052600.027
positive regulation of cellular component organizationGO:00511302000.027
regenerationGO:00310991630.027
positive regulation of secretionGO:00510471400.027
response to nutrient levelsGO:00316673700.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.026
regulation of cell motilityGO:20001451310.026
regulation of cellular protein metabolic processGO:00322682670.026
negative regulation of response to stimulusGO:00485851550.026
angiogenesisGO:0001525530.025
single organism organelle organizationGO:19025891800.025
positive regulation of neurogenesisGO:00507691650.025
negative regulation of transcription dna templatedGO:00458921160.025
glandular epithelial cell differentiationGO:000206740.025
single organism biosynthetic processGO:00447113420.025
cell chemotaxisGO:0060326310.025
positive regulation of secretion by cellGO:19035321280.025
developmental growthGO:00485891000.025
regulation of intracellular signal transductionGO:19025312180.025
cell cycle processGO:0022402570.025
dna metabolic processGO:0006259960.025
anion transportGO:00068201780.024
positive regulation of mapk cascadeGO:0043410920.024
regulation of phosphorus metabolic processGO:00511743490.024
hematopoietic progenitor cell differentiationGO:000224420.024
sensory organ developmentGO:0007423740.024
positive regulation of catalytic activityGO:00430851840.023
multicellular organismal reproductive processGO:00486092330.023
small gtpase mediated signal transductionGO:0007264360.023
positive regulation of cellular amino acid metabolic processGO:004576410.023
regulation of nucleocytoplasmic transportGO:0046822280.023
positive regulation of cell proliferationGO:00082842490.023
developmental process involved in reproductionGO:00030061590.023
positive regulation of developmental processGO:00510942830.023
positive regulation of phosphorylationGO:00423271770.022
regulation of cell developmentGO:00602842630.022
cell adhesionGO:00071551100.022
regulation of protein localizationGO:0032880810.022
regulation of smoothened signaling pathwayGO:000858920.022
negative regulation of cellular metabolic processGO:00313242810.022
cellular amine metabolic processGO:0044106380.022
epiboly involved in wound healingGO:009050520.022
synaptic growth at neuromuscular junctionGO:005112410.022
gastrulationGO:000736920.022
regulation of protein transportGO:0051223680.022
cellular response to nitrogen compoundGO:19016992100.022
amine metabolic processGO:0009308380.022
synaptic transmissionGO:00072682350.022
multi organism reproductive processGO:00447032620.021
regulation of neuron projection developmentGO:00109751610.021
regulation of cellular amino acid metabolic processGO:000652120.021
positive regulation of transcription dna templatedGO:00458931970.021
neuron projection morphogenesisGO:00488121220.021
response to ammonium ionGO:0060359710.021
organic substance catabolic processGO:19015753160.021
response to insulinGO:00328681330.021
regulation of synaptic growth at neuromuscular junctionGO:000858210.020
cellular ketone metabolic processGO:0042180510.020
positive regulation of neuron projection developmentGO:0010976990.020
regulation of behaviorGO:0050795610.020
sulfur compound metabolic processGO:0006790700.020
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.020
response to nicotineGO:0035094510.020
regulation of protein kinase activityGO:00458591050.020
positive regulation of rna metabolic processGO:00512542030.020
membrane organizationGO:0061024940.020
positive regulation of molecular functionGO:00440932300.020
cytoskeleton organizationGO:00070101110.020
embryonic pattern specificationGO:000988010.020
mechanoreceptor differentiationGO:004249020.020
cellular response to organic cyclic compoundGO:00714072020.020
positive regulation of endothelial cell migrationGO:001059540.020
somatic stem cell divisionGO:004810320.020
regulation of cell differentiationGO:00455953200.020
positive regulation of ion transportGO:0043270940.020
chemical homeostasisGO:00488782920.020
skin morphogenesisGO:004358920.019
lipid metabolic processGO:00066292830.019
positive regulation of phosphate metabolic processGO:00459372620.019
neuron projection guidanceGO:0097485240.019
protein complex subunit organizationGO:00718223020.019
cellular homeostasisGO:00197252520.019
negative regulation of programmed cell deathGO:00430691830.019
cytoplasmic transportGO:00164821150.019
regulation of cellular ketone metabolic processGO:0010565270.019
regulation of ion transportGO:00432692450.019
rhythmic processGO:00485111560.019
hindlimb morphogenesisGO:003513720.019
response to nutrientGO:00075842480.019
carbohydrate derivative biosynthetic processGO:19011371240.019
molting cycle processGO:002240420.019
lymphocyte migrationGO:007267630.019
regulation of establishment of protein localizationGO:0070201690.019
regulation of cellular amine metabolic processGO:003323880.019
protein localization to organelleGO:0033365570.019
heart valve morphogenesisGO:000317910.019
response to radiationGO:00093141370.019
regulation of stem cell differentiationGO:200073620.019
negative regulation of transportGO:00510511360.019
reproductive structure developmentGO:00486081280.018
positive regulation of phosphorus metabolic processGO:00105622620.018
gamete generationGO:00072761240.018
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.018
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.018
cellular response to ketoneGO:1901655510.018
mitotic cell cycleGO:0000278490.018
negative regulation of cell communicationGO:00106481580.018
gonad developmentGO:00084061040.018
regulation of alternative mrna splicing via spliceosomeGO:000038120.018
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.017
vasculogenesisGO:000157030.017
cellular response to organonitrogen compoundGO:00714171970.017
axis specificationGO:000979840.017
regulation of cellular component movementGO:00512701500.017
positive regulation of protein export from nucleusGO:004682730.017
organic anion transportGO:00157111320.017
negative regulation of biosynthetic processGO:00098901680.017
positive regulation of intracellular transportGO:0032388390.017
behaviorGO:00076102050.017
regulation of transferase activityGO:00513381230.017
hair cycle processGO:002240520.017
regulation of hormone secretionGO:00468831060.017
regulation of vasculature developmentGO:1901342440.017
chromosome segregationGO:000705920.016
potassium ion transportGO:0006813970.016
divalent metal ion transportGO:00708381320.016
positive regulation of protein modification processGO:00314011420.016
regulation of mapk cascadeGO:00434081160.016
negative regulation of osteoblast differentiationGO:004566820.016
sequestering of metal ionGO:005123890.016
regulation of system processGO:00440572080.016
cytokine mediated signaling pathwayGO:0019221430.016
gliogenesisGO:0042063930.016
purine containing compound metabolic processGO:00725212530.016
mitotic cell cycle phase transitionGO:0044772200.016
artery developmentGO:006084030.016
ossificationGO:0001503700.016
macromolecular complex subunit organizationGO:00439333390.016
cell morphogenesis involved in neuron differentiationGO:00486671060.016
regulation of chemotaxisGO:0050920290.016
cellular response to external stimulusGO:00714961180.016
reproductive system developmentGO:00614581280.016
striated muscle cell developmentGO:0055002260.016
bmp signaling pathwayGO:003050940.016
organonitrogen compound catabolic processGO:19015651790.016
sex differentiationGO:00075481130.016
positive regulation of growthGO:0045927550.015
skeletal muscle cell differentiationGO:003591420.015
protein complex assemblyGO:00064612630.015
spindle organizationGO:000705120.015
signal releaseGO:00230611450.015
rho protein signal transductionGO:0007266110.015
positive regulation of locomotionGO:00400171020.015
regulation of protein modification processGO:00313991940.015
mitotic cell cycle processGO:1903047350.015
positive regulation of protein transportGO:0051222410.015
cell type specific apoptotic processGO:00972851340.015
calcium ion homeostasisGO:00550741620.015
negative regulation of rna metabolic processGO:00512531230.015
cell cycle checkpointGO:000007520.015
regulation of phosphate metabolic processGO:00192203490.015
wound healing spreading of cellsGO:004431920.015
metal ion homeostasisGO:00550651860.014
cellular response to alcoholGO:0097306870.014
muscle system processGO:00030121150.014
cell cycle g1 s phase transitionGO:0044843130.014
calcium ion transportGO:00068161310.014
cell projection morphogenesisGO:00488581230.014
regulation of endocrine processGO:0044060210.014
cellular response to hormone stimulusGO:00328702470.014
neuron fate commitmentGO:004866340.014
negative regulation of catalytic activityGO:00430861030.014
somatic diversification of immune receptorsGO:000220020.014
response to amineGO:0014075460.014
regulation of neuron deathGO:19012141150.014
positive regulation of intracellular protein transportGO:0090316200.014
liver developmentGO:0001889900.014
response to ethanolGO:00454711620.014
spinal cord developmentGO:0021510270.014
regulation of vesicle mediated transportGO:0060627810.014
response to gamma radiationGO:0010332240.014
stem cell divisionGO:001714540.014
negative regulation of neuron differentiationGO:0045665620.014
negative regulation of nitrogen compound metabolic processGO:00511721610.014
eye morphogenesisGO:004859240.014
divalent inorganic cation transportGO:00725111340.014
heart morphogenesisGO:000300730.014
anion transmembrane transportGO:0098656770.014
catabolic processGO:00090563510.014
amino acid transportGO:0006865700.014
cell morphogenesisGO:00009021420.014
female gonad developmentGO:0008585530.014
organic acid transportGO:00158491160.014
response to axon injuryGO:0048678590.013
regulation of intracellular transportGO:0032386650.013
regulation of peptidase activityGO:0052547550.013
actin filament based processGO:0030029860.013
negative regulation of signal transductionGO:0009968830.013
regulation of anatomical structure sizeGO:00900661350.013
regulation of hydrolase activityGO:00513361430.013
cellular divalent inorganic cation homeostasisGO:00725031620.013
activation of cysteine type endopeptidase activity involved in apoptotic processGO:000691940.013
response to transforming growth factor betaGO:0071559460.013
blood vessel morphogenesisGO:0048514580.013
negative regulation of nucleobase containing compound metabolic processGO:00459341530.013
development of primary female sexual characteristicsGO:0046545560.013
response to mechanical stimulusGO:00096121340.013
gland developmentGO:00487321550.013
response to vitaminGO:00332731310.013
sensory perceptionGO:00076001010.013
response to acid chemicalGO:00011012220.013
positive regulation of mitochondrion organizationGO:001082240.013
blood circulationGO:00080151830.013
regulation of developmental growthGO:0048638450.013
regulation of synaptic transmissionGO:00508041410.013
single organism nuclear importGO:1902593350.013
immune system developmentGO:0002520410.013
sulfur compound biosynthetic processGO:0044272190.013
establishment of organelle localizationGO:0051656370.013
response to reactive oxygen speciesGO:00003021200.013
regulation of endothelial cell differentiationGO:004560140.013
response to decreased oxygen levelsGO:00362932370.013
response to dexamethasoneGO:0071548490.013
regulation of growthGO:00400081050.013
carbohydrate derivative metabolic processGO:19011353460.013
single organism behaviorGO:00447081300.013
spermatogenesisGO:0007283990.013
wound healingGO:00420601220.012
regulation of response to stressGO:00801341260.012
glycosaminoglycan biosynthetic processGO:000602440.012
cytosolic calcium ion homeostasisGO:00514801400.012
growth involved in heart morphogenesisGO:000324110.012
regulation of bmp signaling pathwayGO:003051020.012
multicellular organism growthGO:003526410.012
enzyme linked receptor protein signaling pathwayGO:00071671160.012
morphogenesis of an epithelial sheetGO:000201120.012
negative regulation of nucleic acid templated transcriptionGO:19035071170.012
eye developmentGO:0001654500.012
response to corticosteroidGO:00319602350.012
connective tissue developmentGO:0061448330.012
female pregnancyGO:00075651220.012
antigen receptor mediated signaling pathwayGO:005085110.012
lipid biosynthetic processGO:00086101280.012
single organism cellular localizationGO:19025801020.012
organ regenerationGO:00311001010.012
response to light stimulusGO:0009416520.012
mesenchymal cell proliferationGO:001046340.012
regulation of cell cycle processGO:0010564310.012
cellular catabolic processGO:00442482950.012
single organism membrane organizationGO:0044802740.012
metal ion transportGO:00300012890.012
leukocyte migrationGO:0050900380.012
regulation of proteolysisGO:0030162660.012
lipid transportGO:0006869610.012
nucleoside phosphate metabolic processGO:00067532830.011
regulation of erk1 and erk2 cascadeGO:0070372410.011
nucleocytoplasmic transportGO:0006913480.011
hair cell differentiationGO:003531520.011
protein processingGO:0016485680.011
negative regulation of secretion by cellGO:1903531720.011
negative regulation of protein metabolic processGO:00512481140.011
response to carbohydrateGO:00097431830.011
epithelial cell differentiationGO:0030855710.011
cellular lipid metabolic processGO:00442552080.011
epithelial cell proliferationGO:0050673540.011
divalent inorganic cation homeostasisGO:00725071650.011
ion homeostasisGO:00508012120.011
leukocyte chemotaxisGO:0030595220.011
somatic cell dna recombinationGO:001644420.011
mitotic spindle organizationGO:000705220.011
positive regulation of immunoglobulin productionGO:000263940.011
renal filtrationGO:0097205100.011
regulation of protein phosphorylationGO:00019321830.011
negative regulation of cellular biosynthetic processGO:00313271610.011
molting cycleGO:004230330.011
organic hydroxy compound transportGO:0015850770.011
g1 s transition of mitotic cell cycleGO:0000082120.011
rna localizationGO:000640340.011
ribose phosphate metabolic processGO:00196932350.011
cellular calcium ion homeostasisGO:00068741600.011
regulation of neuron apoptotic processGO:0043523830.011
aminoglycan biosynthetic processGO:000602340.011
cell growthGO:00160491040.011
regulation of cell maturationGO:190342930.011
positive regulation of protein kinase activityGO:0045860730.011
cognitionGO:0050890920.011
organ formationGO:004864530.011
positive regulation of protein phosphorylationGO:00019341350.011
muscle cell differentiationGO:0042692520.011
oxidation reduction processGO:00551143040.011
anatomical structure maturationGO:007169520.011
regulation of organ formationGO:000315620.010
regulation of intracellular protein transportGO:0033157340.010
dephosphorylationGO:0016311980.010
regulation of protein export from nucleusGO:004682540.010
organophosphate metabolic processGO:00196373700.010
regulation of endopeptidase activityGO:0052548510.010
response to mineralocorticoidGO:0051385490.010
response to activityGO:0014823730.010
negative regulation of cell developmentGO:0010721820.010
muscle cell developmentGO:0055001260.010
alpha amino acid metabolic processGO:1901605710.010
inorganic cation transmembrane transportGO:00986622020.010
dendrite developmentGO:0016358720.010
peptide transportGO:0015833970.010
ventral spinal cord developmentGO:002151730.010
male gamete generationGO:0048232990.010
response to toxic substanceGO:00096361330.010
cell differentiation involved in kidney developmentGO:006100540.010
heart formationGO:006091410.010

Map4k4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.013
nervous system diseaseDOID:86300.013
sensory system diseaseDOID:005015500.013
eye diseaseDOID:561400.013
eye and adnexa diseaseDOID:149200.013