IMP: Integrative Multi-species Prediction

Rattus norvegicus

84 known processes

Serpinf2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Entrez: 287527
RGD: 1306692
Ensembl: ENSRNOG00000003233
UniProtKB: Q68FT8

Process Predictions
Disease Predictions

Serpinf2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ion transmembrane transport	GO:0034220	365	0.217
response to inorganic substance	GO:0010035	377	0.194	Rat
regeneration	GO:0031099	163	0.187
cellular amino acid metabolic process	GO:0006520	107	0.179
regulation of molecular function	GO:0065009	398	0.178
wound healing	GO:0042060	122	0.156
oxoacid metabolic process	GO:0043436	290	0.138
negative regulation of multicellular organismal process	GO:0051241	203	0.126
organic acid metabolic process	GO:0006082	292	0.118
response to extracellular stimulus	GO:0009991	380	0.116
catabolic process	GO:0009056	351	0.110
cation transport	GO:0006812	382	0.103
coagulation	GO:0050817	28	0.095
carboxylic acid metabolic process	GO:0019752	289	0.092
intracellular signal transduction	GO:0035556	314	0.090	Human
immune system process	GO:0002376	204	0.089
regulation of protein metabolic process	GO:0051246	289	0.086
response to camp	GO:0051591	91	0.086
metal ion transport	GO:0030001	289	0.085
transmembrane transport	GO:0055085	412	0.082
plasminogen activation	GO:0031639	2	0.081	Human
rhythmic process	GO:0048511	156	0.078	Rat
positive regulation of blood coagulation	GO:0030194	4	0.077
response to wounding	GO:0009611	254	0.076
regulation of phosphate metabolic process	GO:0019220	349	0.071	Human
gland development	GO:0048732	155	0.070
negative regulation of macromolecule metabolic process	GO:0010605	260	0.069
apoptotic process	GO:0006915	381	0.069
regulation of body fluid levels	GO:0050878	90	0.066
response to nutrient levels	GO:0031667	370	0.065
regulation of anatomical structure morphogenesis	GO:0022603	141	0.064
organic substance catabolic process	GO:1901575	316	0.064
negative regulation of molecular function	GO:0044092	133	0.063
cellular amide metabolic process	GO:0043603	44	0.063
hemostasis	GO:0007599	26	0.063
response to estrogen	GO:0043627	232	0.060
proteolysis	GO:0006508	175	0.060
response to peptide	GO:1901652	292	0.059
developmental growth	GO:0048589	100	0.058
regulation of programmed cell death	GO:0043067	341	0.054
response to organophosphorus	GO:0046683	102	0.054
negative regulation of wound healing	GO:0061045	8	0.054
protein processing	GO:0016485	68	0.053	Human
response to peptide hormone	GO:0043434	278	0.051
regulation of signal transduction	GO:0009966	318	0.050	Human
blood coagulation	GO:0007596	26	0.050
organophosphate metabolic process	GO:0019637	370	0.049
metal ion homeostasis	GO:0055065	186	0.046
regulation of cellular amine metabolic process	GO:0033238	8	0.046
regulation of protein modification process	GO:0031399	194	0.045
response to cytokine	GO:0034097	215	0.044
response to metal ion	GO:0010038	253	0.043	Rat
negative regulation of developmental process	GO:0051093	125	0.043
cellular amine metabolic process	GO:0044106	38	0.043
inorganic cation transmembrane transport	GO:0098662	202	0.043
fibrinolysis	GO:0042730	2	0.043
response to estradiol	GO:0032355	164	0.041
regulation of apoptotic process	GO:0042981	335	0.041
negative regulation of cell differentiation	GO:0045596	99	0.040
cellular catabolic process	GO:0044248	295	0.040
regulation of intracellular signal transduction	GO:1902531	218	0.040	Human
cellular component assembly	GO:0022607	360	0.040	Human
response to purine containing compound	GO:0014074	126	0.039
amine metabolic process	GO:0009308	38	0.039
regulation of cellular protein metabolic process	GO:0032268	267	0.038
liver development	GO:0001889	90	0.038
cellular ketone metabolic process	GO:0042180	51	0.038
regulation of cell development	GO:0060284	263	0.038	Rat
secretion	GO:0046903	307	0.037
homeostatic process	GO:0042592	331	0.037	Rat
growth	GO:0040007	165	0.037
carboxylic acid transport	GO:0046942	115	0.037
reproduction	GO:0000003	245	0.037	Rat
protein maturation	GO:0051604	68	0.036	Human
organic anion transport	GO:0015711	132	0.036
regulation of hydrolase activity	GO:0051336	143	0.036
locomotion	GO:0040011	237	0.036	Rat
regulation of cellular amino acid metabolic process	GO:0006521	2	0.036
response to mechanical stimulus	GO:0009612	134	0.036
nucleobase containing small molecule metabolic process	GO:0055086	316	0.035
carboxylic acid biosynthetic process	GO:0046394	83	0.035
negative regulation of response to wounding	GO:1903035	23	0.035
tissue regeneration	GO:0042246	36	0.034
blood circulation	GO:0008015	183	0.034	Mouse
carbohydrate derivative metabolic process	GO:1901135	346	0.034
response to external biotic stimulus	GO:0043207	221	0.034
cellular response to nitrogen compound	GO:1901699	210	0.034
regulation of blood vessel size	GO:0050880	89	0.034	Mouse
cofactor metabolic process	GO:0051186	95	0.033
macromolecular complex subunit organization	GO:0043933	339	0.032	Human Mouse
regulation of response to stress	GO:0080134	126	0.032
nucleoside phosphate metabolic process	GO:0006753	283	0.031
ribonucleotide metabolic process	GO:0009259	231	0.031
regulation of protein processing	GO:0070613	50	0.031
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.031
ribonucleoside metabolic process	GO:0009119	174	0.031
circadian rhythm	GO:0007623	88	0.031
regulation of cell proliferation	GO:0042127	359	0.031	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.031
cell migration	GO:0016477	197	0.030	Rat
regulation of phosphorus metabolic process	GO:0051174	349	0.030	Human
anatomical structure morphogenesis	GO:0009653	298	0.030	Mouse
positive regulation of coagulation	GO:0050820	5	0.029
positive regulation of hemostasis	GO:1900048	4	0.029
regulation of neuron differentiation	GO:0045664	208	0.029	Rat
inflammatory response	GO:0006954	150	0.029	Rat
negative regulation of cellular metabolic process	GO:0031324	281	0.028
hepatocyte proliferation	GO:0072574	3	0.028
cellular response to organonitrogen compound	GO:0071417	197	0.028
nucleotide metabolic process	GO:0009117	279	0.028
cellular response to abiotic stimulus	GO:0071214	85	0.027
regulation of hemostasis	GO:1900046	9	0.027
regulation of cell growth	GO:0001558	85	0.027
organ regeneration	GO:0031100	101	0.026
negative regulation of biomineral tissue development	GO:0070168	2	0.026
anion transport	GO:0006820	178	0.026
immune response	GO:0006955	104	0.026
nitrogen compound transport	GO:0071705	229	0.026
regulation of blood coagulation	GO:0030193	9	0.026
response to decreased oxygen levels	GO:0036293	237	0.026
regulation of protein maturation	GO:1903317	50	0.025
cellular response to endogenous stimulus	GO:0071495	377	0.025	Rat
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.025
cellular response to cytokine stimulus	GO:0071345	127	0.025
organic acid transport	GO:0015849	116	0.025
organelle organization	GO:0006996	266	0.024	Human
organic cyclic compound catabolic process	GO:1901361	175	0.024
regulation of coagulation	GO:0050818	11	0.024
purine nucleotide metabolic process	GO:0006163	229	0.024
negative regulation of metabolic process	GO:0009892	331	0.024
cellular cation homeostasis	GO:0030003	180	0.024
regulation of ion transport	GO:0043269	245	0.024
cell morphogenesis involved in differentiation	GO:0000904	119	0.024
cellular nitrogen compound catabolic process	GO:0044270	163	0.024
regulation of cellular component organization	GO:0051128	368	0.024	Human Rat
cellular response to oxygen containing compound	GO:1901701	386	0.023	Rat
positive regulation of response to stimulus	GO:0048584	285	0.023
regulation of cell projection organization	GO:0031344	175	0.023	Rat
divalent inorganic cation transport	GO:0072511	134	0.023
hepaticobiliary system development	GO:0061008	90	0.023
regulation of immune response	GO:0050776	55	0.022
purine containing compound metabolic process	GO:0072521	253	0.022
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.022
single organism biosynthetic process	GO:0044711	342	0.022	Human Mouse
negative regulation of catalytic activity	GO:0043086	103	0.022
aging	GO:0007568	241	0.022	Rat
cation transmembrane transport	GO:0098655	263	0.022
negative regulation of protein metabolic process	GO:0051248	114	0.022
negative regulation of endopeptidase activity	GO:0010951	36	0.022
positive regulation of cellular amine metabolic process	GO:0033240	3	0.022
regulation of calcium ion transport	GO:0051924	77	0.022
neuron projection development	GO:0031175	273	0.022	Rat
regulation of rna biosynthetic process	GO:2001141	381	0.021	Human Mouse
macromolecular complex assembly	GO:0065003	273	0.021
sterol homeostasis	GO:0055092	3	0.021
regulation of cell projection size	GO:0032536	1	0.021
nucleoside phosphate catabolic process	GO:1901292	140	0.021
lipid metabolic process	GO:0006629	283	0.021
positive regulation of signaling	GO:0023056	270	0.021	Human
positive regulation of neuron projection development	GO:0010976	99	0.021	Rat
glycosyl compound metabolic process	GO:1901657	182	0.021
alpha amino acid metabolic process	GO:1901605	71	0.021
tonic smooth muscle contraction	GO:0014820	4	0.021
negative regulation of peptidase activity	GO:0010466	38	0.021
regulation of neuron projection development	GO:0010975	161	0.020	Rat
regulation of synaptic plasticity	GO:0048167	70	0.020
regulation of cellular localization	GO:0060341	263	0.020
cellular chemical homeostasis	GO:0055082	247	0.020	Rat
positive regulation of catalytic activity	GO:0043085	184	0.020
cellular response to steroid hormone stimulus	GO:0071383	93	0.020	Rat
regulation of protein phosphorylation	GO:0001932	183	0.020
positive regulation of protein metabolic process	GO:0051247	178	0.020
organonitrogen compound catabolic process	GO:1901565	179	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.020
cellular homeostasis	GO:0019725	252	0.020	Rat
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.019
cellular lipid metabolic process	GO:0044255	208	0.019
positive regulation of phosphorylation	GO:0042327	177	0.019	Human
response to oxygen levels	GO:0070482	265	0.019
defense response	GO:0006952	194	0.019	Rat
cholesterol homeostasis	GO:0042632	3	0.019
macromolecule localization	GO:0033036	252	0.019
epithelial cell proliferation involved in liver morphogenesis	GO:0072575	3	0.019
nucleoside phosphate biosynthetic process	GO:1901293	102	0.019
anion transmembrane transport	GO:0098656	77	0.019
positive regulation of cell projection organization	GO:0031346	111	0.019	Rat
negative regulation of response to stimulus	GO:0048585	155	0.019
regulation of cell differentiation	GO:0045595	320	0.019	Human Mouse Rat
reactive oxygen species biosynthetic process	GO:1903409	8	0.019
cellular response to mechanical stimulus	GO:0071260	48	0.018
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.018
regulation of fibrinolysis	GO:0051917	2	0.018
positive regulation of apoptotic process	GO:0043065	154	0.018
positive regulation of multicellular organismal process	GO:0051240	387	0.018
response to corticosteroid	GO:0031960	235	0.018	Rat
cellular response to lipid	GO:0071396	201	0.018	Rat
ribonucleoside catabolic process	GO:0042454	126	0.018
heterocycle catabolic process	GO:0046700	167	0.018
protein complex assembly	GO:0006461	263	0.018
cofactor biosynthetic process	GO:0051188	28	0.017
regulation of catalytic activity	GO:0050790	304	0.017
regulation of cellular ketone metabolic process	GO:0010565	27	0.017
immunoglobulin mediated immune response	GO:0016064	4	0.017
liver morphogenesis	GO:0072576	3	0.017
purine ribonucleotide catabolic process	GO:0009154	136	0.017
response to nutrient	GO:0007584	248	0.017
positive regulation of molecular function	GO:0044093	230	0.017
circulatory system process	GO:0003013	183	0.017	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.017	Human Mouse
transcription dna templated	GO:0006351	377	0.017	Human Mouse
purine nucleoside metabolic process	GO:0042278	169	0.017
negative regulation of fibrinolysis	GO:0051918	2	0.017
circulatory system development	GO:0072359	134	0.017	Mouse
positive regulation of phosphate metabolic process	GO:0045937	262	0.016	Human
pyridine nucleotide biosynthetic process	GO:0019363	2	0.016
protein phosphorylation	GO:0006468	345	0.016
amine transport	GO:0015837	57	0.016
regulation of rna metabolic process	GO:0051252	391	0.016	Human Mouse
brain development	GO:0007420	247	0.016
cell adhesion	GO:0007155	110	0.016
negative regulation of programmed cell death	GO:0043069	183	0.016
mapk cascade	GO:0000165	140	0.016	Human
negative regulation of blood coagulation	GO:0030195	6	0.016
purine ribonucleotide metabolic process	GO:0009150	227	0.016
protein complex subunit organization	GO:0071822	302	0.016	Human Mouse
dicarboxylic acid metabolic process	GO:0043648	42	0.016
negative regulation of coagulation	GO:0050819	7	0.016
transmission of nerve impulse	GO:0019226	42	0.016
regulation of cellular component movement	GO:0051270	150	0.016	Rat
reproductive process	GO:0022414	372	0.016	Rat
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.016
positive regulation of ion transport	GO:0043270	94	0.016
nucleobase containing compound catabolic process	GO:0034655	152	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.015	Human Mouse
regulation of growth	GO:0040008	105	0.015
regulation of multicellular organismal development	GO:2000026	376	0.015	Rat
response to retinoic acid	GO:0032526	63	0.015	Rat
purine containing compound catabolic process	GO:0072523	138	0.015
protein activation cascade	GO:0072376	12	0.015
positive regulation of phosphorus metabolic process	GO:0010562	262	0.015	Human
nucleoside metabolic process	GO:0009116	179	0.015
tissue development	GO:0009888	252	0.015	Rat
organonitrogen compound biosynthetic process	GO:1901566	167	0.015
multi organism reproductive process	GO:0044703	262	0.015
negative regulation of response to external stimulus	GO:0032102	37	0.015
regulation of synaptic transmission	GO:0050804	141	0.015
protein oligomerization	GO:0051259	191	0.015
fatty acid transmembrane transport	GO:1902001	3	0.015
response to vitamin k	GO:0032571	4	0.015
negative regulation of gene expression	GO:0010629	199	0.015
regulation of mapk cascade	GO:0043408	116	0.015	Human
negative regulation of cellular protein metabolic process	GO:0032269	106	0.015
regulation of anatomical structure size	GO:0090066	135	0.015	Mouse
nucleoside monophosphate metabolic process	GO:0009123	93	0.015
negative regulation of cellular amide metabolic process	GO:0034249	1	0.015
cellular modified amino acid metabolic process	GO:0006575	61	0.015
multicellular organism reproduction	GO:0032504	233	0.015	Rat
programmed cell death	GO:0012501	392	0.015
response to bacterium	GO:0009617	200	0.014
regulation of phosphorylation	GO:0042325	248	0.014	Human
carbohydrate derivative catabolic process	GO:1901136	147	0.014
acute inflammatory response	GO:0002526	58	0.014
cellular response to glucocorticoid stimulus	GO:0071385	68	0.014	Rat
regulation of neurogenesis	GO:0050767	247	0.014	Rat
cell morphogenesis	GO:0000902	142	0.014
regulation of secretion	GO:0051046	224	0.014
response to reactive oxygen species	GO:0000302	120	0.014
purine ribonucleoside metabolic process	GO:0046128	168	0.014
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.014
rna biosynthetic process	GO:0032774	380	0.014	Human Mouse
regulation of system process	GO:0044057	208	0.014
organophosphate biosynthetic process	GO:0090407	143	0.014
positive regulation of signal transduction	GO:0009967	175	0.014	Human
positive regulation of cellular protein metabolic process	GO:0032270	167	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.014
multicellular organismal signaling	GO:0035637	44	0.014
positive regulation of cellular biosynthetic process	GO:0031328	295	0.014	Human Mouse
negative regulation of hydrolase activity	GO:0051346	52	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.014
positive regulation of mapk cascade	GO:0043410	92	0.014	Human
organophosphate catabolic process	GO:0046434	148	0.014
glycosyl compound catabolic process	GO:1901658	126	0.013
reactive nitrogen species metabolic process	GO:2001057	1	0.013
ribose phosphate metabolic process	GO:0019693	235	0.013
positive regulation of secretion by cell	GO:1903532	128	0.013
rna metabolic process	GO:0016070	406	0.013	Human Mouse
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.013
cellular response to hormone stimulus	GO:0032870	247	0.013	Rat
positive regulation of reactive oxygen species metabolic process	GO:2000379	16	0.013
negative regulation of hemostasis	GO:1900047	6	0.013
response to hypoxia	GO:0001666	231	0.013
muscle cell differentiation	GO:0042692	52	0.013
regulation of immune system process	GO:0002682	123	0.013
positive regulation of protein modification process	GO:0031401	142	0.013
cell activation	GO:0001775	97	0.013
aromatic compound catabolic process	GO:0019439	168	0.013
macromolecule catabolic process	GO:0009057	58	0.013
regulation of response to wounding	GO:1903034	69	0.013
epithelial cell proliferation	GO:0050673	54	0.013
ion homeostasis	GO:0050801	212	0.013
multi multicellular organism process	GO:0044706	138	0.013
response to glucose	GO:0009749	136	0.013	Rat
cellular response to stress	GO:0033554	269	0.013	Human
negative regulation of apoptotic process	GO:0043066	181	0.013
cellular response to insulin stimulus	GO:0032869	81	0.013
pancreatic a cell differentiation	GO:0003310	1	0.012
vesicle mediated transport	GO:0016192	181	0.012
regulation of nervous system development	GO:0051960	264	0.012	Rat
positive regulation of extracellular matrix organization	GO:1903055	4	0.012
regulation of peptidase activity	GO:0052547	55	0.012
regulation of b cell mediated immunity	GO:0002712	2	0.012
negative regulation of cell death	GO:0060548	229	0.012	Rat
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.012
regulation of hormone levels	GO:0010817	187	0.012
response to vitamin	GO:0033273	131	0.012
regulation of response to external stimulus	GO:0032101	106	0.012
angiogenesis	GO:0001525	53	0.012
regulation of cell migration	GO:0030334	128	0.012	Rat
single organism catabolic process	GO:0044712	283	0.012
regulation of immunoglobulin mediated immune response	GO:0002889	2	0.012
regulation of immunoglobulin production	GO:0002637	4	0.012
cell cell signaling	GO:0007267	335	0.012
organic hydroxy compound transport	GO:0015850	77	0.012
glucose homeostasis	GO:0042593	75	0.012	Rat
negative regulation of cell development	GO:0010721	82	0.012
purine nucleoside catabolic process	GO:0006152	124	0.012
negative regulation of proteolysis	GO:0045861	41	0.012
negative regulation of nervous system development	GO:0051961	79	0.012
positive regulation of cellular component organization	GO:0051130	200	0.012	Human Rat
regulation of transcription dna templated	GO:0006355	374	0.012	Human Mouse
positive regulation of nitric oxide biosynthetic process	GO:0045429	14	0.012
monovalent inorganic cation transport	GO:0015672	172	0.012
regulation of serine type endopeptidase activity	GO:1900003	1	0.011
response to acid chemical	GO:0001101	222	0.011	Rat
synaptic transmission	GO:0007268	235	0.011
fertilization	GO:0009566	3	0.011
b cell mediated immunity	GO:0019724	4	0.011
nucleotide catabolic process	GO:0009166	139	0.011
catecholamine transport	GO:0051937	37	0.011
renal system process	GO:0003014	40	0.011	Mouse
positive regulation of neuron differentiation	GO:0045666	126	0.011	Rat
nucleotide biosynthetic process	GO:0009165	98	0.011
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.011
cytolysis	GO:0019835	4	0.011
defense response to gram negative bacterium	GO:0050829	3	0.011
cellular response to growth factor stimulus	GO:0071363	162	0.011
small molecule catabolic process	GO:0044282	59	0.011
divalent metal ion transport	GO:0070838	132	0.011
axis specification	GO:0009798	4	0.011
response to ammonium ion	GO:0060359	71	0.011
response to alkaloid	GO:0043279	132	0.011
gamete generation	GO:0007276	124	0.011
organic acid biosynthetic process	GO:0016053	83	0.011
cell projection organization	GO:0030030	302	0.011	Rat
cellular ion homeostasis	GO:0006873	184	0.011
central nervous system development	GO:0007417	311	0.011
response to other organism	GO:0051707	220	0.011
chemical homeostasis	GO:0048878	292	0.011	Rat
embryonic pattern specification	GO:0009880	1	0.011
reactive oxygen species metabolic process	GO:0072593	37	0.011
response to muscle activity involved in regulation of muscle adaptation	GO:0014873	2	0.011
positive regulation of cell proliferation	GO:0008284	249	0.011	Mouse
regulation of kinase activity	GO:0043549	117	0.011
extracellular matrix constituent secretion	GO:0070278	4	0.010
cellular response to external stimulus	GO:0071496	118	0.010
coenzyme metabolic process	GO:0006732	86	0.010
regulation of wound healing	GO:0061041	14	0.010
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.010
positive regulation of cell growth	GO:0030307	44	0.010
ribonucleotide catabolic process	GO:0009261	136	0.010
sterol catabolic process	GO:0016127	1	0.010
cellular response to camp	GO:0071320	26	0.010
multicellular organismal reproductive process	GO:0048609	233	0.010	Rat
regulation of cell morphogenesis	GO:0022604	77	0.010
spermatogenesis	GO:0007283	99	0.010
regulation of metal ion transport	GO:0010959	118	0.010
regulation of muscle system process	GO:0090257	79	0.010
muscle tissue development	GO:0060537	58	0.010
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.010

Serpinf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.036
cardiovascular system disease	DOID:1287	0.035
vascular disease	DOID:178	0.035
disease of anatomical entity	DOID:7	0.035
artery disease	DOID:0050828	0.035
cerebrovascular disease	DOID:6713	0.035
nervous system disease	DOID:863	0.025
inherited metabolic disorder	DOID:655	0.020
disease of cellular proliferation	DOID:14566	0.010
organ system cancer	DOID:0050686	0.010
cancer	DOID:162	0.010

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