IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Aipl1

aryl hydrocarbon receptor-interacting protein-like 1

Entrez: 59110
RGD: 70906
UniProtKB: Q9JLG9

Process Predictions
Disease Predictions

Aipl1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
lipid metabolic process	GO:0006629	283	0.197
response to other organism	GO:0051707	220	0.191
metal ion transport	GO:0030001	289	0.176
rna biosynthetic process	GO:0032774	380	0.136
response to cytokine	GO:0034097	215	0.135
transmembrane transport	GO:0055085	412	0.129
regulation of multicellular organismal development	GO:2000026	376	0.118
response to external biotic stimulus	GO:0043207	221	0.113
response to radiation	GO:0009314	137	0.101
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.099
regulation of phosphate metabolic process	GO:0019220	349	0.097
l glutamate import	GO:0051938	2	0.076
cation transport	GO:0006812	382	0.075
neuron differentiation	GO:0030182	368	0.073
rna metabolic process	GO:0016070	406	0.072
response to toxic substance	GO:0009636	133	0.070
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.069
regulation of signal transduction	GO:0009966	318	0.068
regulation of cell proliferation	GO:0042127	359	0.067
rhythmic process	GO:0048511	156	0.065
homeostatic process	GO:0042592	331	0.063
regulation of cellular protein metabolic process	GO:0032268	267	0.063
regulation of rna metabolic process	GO:0051252	391	0.062
regulation of nucleic acid templated transcription	GO:1903506	380	0.062
positive regulation of biosynthetic process	GO:0009891	319	0.062
regulation of hormone levels	GO:0010817	187	0.062
protein phosphorylation	GO:0006468	345	0.060
regulation of transcription dna templated	GO:0006355	374	0.058
phosphatidylinositol dephosphorylation	GO:0046856	4	0.057
single organism biosynthetic process	GO:0044711	342	0.057
cation transmembrane transport	GO:0098655	263	0.055
macromolecule localization	GO:0033036	252	0.055
regulation of molecular function	GO:0065009	398	0.055
regulation of nervous system development	GO:0051960	264	0.055
positive regulation of transport	GO:0051050	245	0.054
response to inorganic substance	GO:0010035	377	0.054
positive regulation of cellular biosynthetic process	GO:0031328	295	0.054
cellular response to endogenous stimulus	GO:0071495	377	0.053
regulation of hormone secretion	GO:0046883	106	0.052
neuron projection morphogenesis	GO:0048812	122	0.051
response to oxygen levels	GO:0070482	265	0.051
intracellular signal transduction	GO:0035556	314	0.051
regulation of rna biosynthetic process	GO:2001141	381	0.050
response to growth factor	GO:0070848	189	0.050
single organism reproductive process	GO:0044702	297	0.050
cellular response to lipid	GO:0071396	201	0.050
response to molecule of bacterial origin	GO:0002237	194	0.050
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.049
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.048
reproduction	GO:0000003	245	0.048
positive regulation of phosphate metabolic process	GO:0045937	262	0.047
purine containing compound metabolic process	GO:0072521	253	0.047
ribonucleotide metabolic process	GO:0009259	231	0.047
regulation of catalytic activity	GO:0050790	304	0.047
lipid biosynthetic process	GO:0008610	128	0.046
multicellular organism reproduction	GO:0032504	233	0.046
response to estrogen	GO:0043627	232	0.045
regulation of lipid metabolic process	GO:0019216	68	0.044
response to extracellular stimulus	GO:0009991	380	0.042
cellular response to growth factor stimulus	GO:0071363	162	0.042
purine nucleotide metabolic process	GO:0006163	229	0.042
response to hypoxia	GO:0001666	231	0.041
calcium ion transport	GO:0006816	131	0.041
transcription from rna polymerase ii promoter	GO:0006366	252	0.041
positive regulation of phosphorus metabolic process	GO:0010562	262	0.040
response to lipopolysaccharide	GO:0032496	191	0.040
positive regulation of cell communication	GO:0010647	271	0.039
apoptotic process	GO:0006915	381	0.038
cellular lipid metabolic process	GO:0044255	208	0.038
inorganic cation transmembrane transport	GO:0098662	202	0.037
transcription dna templated	GO:0006351	377	0.036
negative regulation of rna biosynthetic process	GO:1902679	118	0.036
organophosphate metabolic process	GO:0019637	370	0.036
regulation of phosphorus metabolic process	GO:0051174	349	0.035
positive regulation of protein metabolic process	GO:0051247	178	0.035
cell cell signaling	GO:0007267	335	0.034
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.034
nucleic acid templated transcription	GO:0097659	379	0.033
response to wounding	GO:0009611	254	0.033
detection of visible light	GO:0009584	3	0.033
positive regulation of cell proliferation	GO:0008284	249	0.032
negative regulation of cell death	GO:0060548	229	0.032
striated muscle contraction	GO:0006941	44	0.032
chemical homeostasis	GO:0048878	292	0.032
positive regulation of developmental process	GO:0051094	283	0.032
divalent metal ion transport	GO:0070838	132	0.032
response to bacterium	GO:0009617	200	0.032
positive regulation of catalytic activity	GO:0043085	184	0.032
potassium ion transport	GO:0006813	97	0.031
positive regulation of molecular function	GO:0044093	230	0.031
response to decreased oxygen levels	GO:0036293	237	0.031
regulation of ion transport	GO:0043269	245	0.031
hormone metabolic process	GO:0042445	69	0.031
sensory perception of pain	GO:0019233	73	0.030
negative regulation of apoptotic process	GO:0043066	181	0.030
reproductive process	GO:0022414	372	0.030
response to nutrient levels	GO:0031667	370	0.030
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.030
positive regulation of signal transduction	GO:0009967	175	0.029
cellular response to stress	GO:0033554	269	0.029
negative regulation of gene expression	GO:0010629	199	0.029
response to metal ion	GO:0010038	253	0.029
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.029
ribose phosphate metabolic process	GO:0019693	235	0.029
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.029
nucleobase containing small molecule metabolic process	GO:0055086	316	0.029
regulation of phosphorylation	GO:0042325	248	0.029
response to carbohydrate	GO:0009743	183	0.029
positive regulation of nervous system development	GO:0051962	178	0.029
regulation of peptide secretion	GO:0002791	82	0.028
cellular protein localization	GO:0034613	122	0.028
positive regulation of response to stimulus	GO:0048584	285	0.027
ion transmembrane transport	GO:0034220	365	0.027
dna metabolic process	GO:0006259	96	0.027
macromolecular complex assembly	GO:0065003	273	0.027
nucleotide metabolic process	GO:0009117	279	0.027
oxoacid metabolic process	GO:0043436	290	0.027
carbohydrate derivative metabolic process	GO:1901135	346	0.026
taxis	GO:0042330	67	0.026
peptidyl tyrosine modification	GO:0018212	72	0.026
response to monosaccharide	GO:0034284	159	0.026
anatomical structure morphogenesis	GO:0009653	298	0.026
inorganic ion transmembrane transport	GO:0098660	229	0.026
regulation of neuron differentiation	GO:0045664	208	0.026
phototransduction visible light	GO:0007603	2	0.025
anion transport	GO:0006820	178	0.025
positive regulation of gene expression	GO:0010628	244	0.025
response to transforming growth factor beta	GO:0071559	46	0.025
negative regulation of multicellular organismal process	GO:0051241	203	0.025
response to corticosteroid	GO:0031960	235	0.025
monocarboxylic acid metabolic process	GO:0032787	152	0.025
muscle tissue development	GO:0060537	58	0.024
negative regulation of cell proliferation	GO:0008285	119	0.024
positive regulation of phosphorylation	GO:0042327	177	0.024
blood circulation	GO:0008015	183	0.024
positive regulation of transcription dna templated	GO:0045893	197	0.024
negative regulation of neuron differentiation	GO:0045665	62	0.024
cellular response to oxygen containing compound	GO:1901701	386	0.024
modified amino acid transport	GO:0072337	12	0.024
protein complex biogenesis	GO:0070271	263	0.024
purine ribonucleotide metabolic process	GO:0009150	227	0.024
regulation of cellular localization	GO:0060341	263	0.023
regulation of protein metabolic process	GO:0051246	289	0.023
monovalent inorganic cation transport	GO:0015672	172	0.023
cellular response to organonitrogen compound	GO:0071417	197	0.023
regulation of cellular ketone metabolic process	GO:0010565	27	0.022
negative regulation of developmental process	GO:0051093	125	0.022
female sex differentiation	GO:0046660	59	0.022
multicellular organismal reproductive process	GO:0048609	233	0.022
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.022
regulation of intracellular signal transduction	GO:1902531	218	0.022
nucleoside phosphate metabolic process	GO:0006753	283	0.021
insulin secretion	GO:0030073	69	0.021
regulation of neurogenesis	GO:0050767	247	0.021
negative regulation of metabolic process	GO:0009892	331	0.021
organic substance catabolic process	GO:1901575	316	0.021
sensory perception of light stimulus	GO:0050953	3	0.021
positive regulation of intracellular signal transduction	GO:1902533	138	0.021
neurotransmitter transport	GO:0006836	42	0.021
negative regulation of transcription dna templated	GO:0045892	116	0.021
regulation of establishment of planar polarity	GO:0090175	2	0.021
negative regulation of ion transmembrane transporter activity	GO:0032413	12	0.020
positive regulation of signaling	GO:0023056	270	0.020
response to light stimulus	GO:0009416	52	0.020
cellular response to nitrogen compound	GO:1901699	210	0.020
cellular component biogenesis	GO:0044085	368	0.020
glycerolipid metabolic process	GO:0046486	67	0.020
response to transition metal nanoparticle	GO:1990267	122	0.020
response to biotic stimulus	GO:0009607	226	0.020
learning or memory	GO:0007611	90	0.020
programmed cell death	GO:0012501	392	0.019
fatty acid metabolic process	GO:0006631	99	0.019
response to acid chemical	GO:0001101	222	0.019
choline transport	GO:0015871	4	0.019
neuron development	GO:0048666	286	0.019
regulation of peptide hormone secretion	GO:0090276	80	0.019
response to calcium ion	GO:0051592	59	0.019
amine metabolic process	GO:0009308	38	0.019
negative regulation of macromolecule metabolic process	GO:0010605	260	0.019
vesicle mediated transport	GO:0016192	181	0.019
regulation of cell development	GO:0060284	263	0.019
response to hexose	GO:0009746	144	0.018
organic hydroxy compound metabolic process	GO:1901615	115	0.018
positive regulation of rna biosynthetic process	GO:1902680	197	0.018
regulation of system process	GO:0044057	208	0.018
positive regulation of multicellular organismal process	GO:0051240	387	0.018
sodium ion transmembrane transport	GO:0035725	67	0.018
neuromuscular synaptic transmission	GO:0007274	2	0.018
hormone secretion	GO:0046879	115	0.018
response to retinoic acid	GO:0032526	63	0.018
response to cgmp	GO:0070305	3	0.018
intracellular transport	GO:0046907	185	0.018
organonitrogen compound biosynthetic process	GO:1901566	167	0.018
response to camp	GO:0051591	91	0.018
regulation of nucleotide metabolic process	GO:0006140	117	0.018
oligopeptide transport	GO:0006857	4	0.017
circulatory system process	GO:0003013	183	0.017
amide transport	GO:0042886	105	0.017
response to reactive oxygen species	GO:0000302	120	0.017
synaptic transmission	GO:0007268	235	0.017
lipid modification	GO:0030258	52	0.017
peptidyl amino acid modification	GO:0018193	126	0.017
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.017
regulation of protein phosphorylation	GO:0001932	183	0.017
negative regulation of cellular metabolic process	GO:0031324	281	0.017
carbohydrate derivative biosynthetic process	GO:1901137	124	0.017
carboxylic acid metabolic process	GO:0019752	289	0.017
maintenance of location	GO:0051235	17	0.017
regulation of chemotaxis	GO:0050920	29	0.017
hormone transport	GO:0009914	121	0.017
negative regulation of transport	GO:0051051	136	0.017
protein oligomerization	GO:0051259	191	0.017
response to oxidative stress	GO:0006979	186	0.017
protein localization	GO:0008104	191	0.017
cytosolic calcium ion homeostasis	GO:0051480	140	0.017
behavior	GO:0007610	205	0.016
cell projection organization	GO:0030030	302	0.016
regulation of sodium ion transmembrane transporter activity	GO:2000649	4	0.016
multi organism reproductive process	GO:0044703	262	0.016
regulation of vesicle mediated transport	GO:0060627	81	0.016
cellular homeostasis	GO:0019725	252	0.016
regulation of muscle tissue development	GO:1901861	25	0.016
negative regulation of cellular biosynthetic process	GO:0031327	161	0.016
regulation of blood vessel size	GO:0050880	89	0.016
regulation of cell differentiation	GO:0045595	320	0.016
positive regulation of cell differentiation	GO:0045597	217	0.016
sodium ion transport	GO:0006814	82	0.016
developmental process involved in reproduction	GO:0003006	159	0.016
neurological system process	GO:0050877	219	0.016
negative regulation of secretion	GO:0051048	82	0.016
regulation of insulin secretion	GO:0050796	65	0.015
proteolysis	GO:0006508	175	0.015
regulation of programmed cell death	GO:0043067	341	0.015
lipid storage	GO:0019915	1	0.015
response to ethanol	GO:0045471	162	0.015
positive regulation of neurogenesis	GO:0050769	165	0.015
ion homeostasis	GO:0050801	212	0.015
circadian rhythm	GO:0007623	88	0.015
regulation of membrane potential	GO:0042391	110	0.015
negative regulation of cell differentiation	GO:0045596	99	0.015
action potential	GO:0001508	54	0.015
lipid localization	GO:0010876	62	0.015
negative regulation of nervous system development	GO:0051961	79	0.015
urogenital system development	GO:0001655	78	0.015
cellular response to oxidative stress	GO:0034599	76	0.014
cellular ketone metabolic process	GO:0042180	51	0.014
negative regulation of programmed cell death	GO:0043069	183	0.014
multi multicellular organism process	GO:0044706	138	0.014
response to glucocorticoid	GO:0051384	223	0.014
cellular amine metabolic process	GO:0044106	38	0.014
response to blue light	GO:0009637	1	0.014
positive regulation of transferase activity	GO:0051347	81	0.014
sequestering of calcium ion	GO:0051208	8	0.014
desensitization of g protein coupled receptor protein signaling pathway by arrestin	GO:0002032	1	0.014
regulation of bmp signaling pathway	GO:0030510	2	0.014
carbohydrate derivative catabolic process	GO:1901136	147	0.014
cellular response to hexose stimulus	GO:0071331	65	0.014
neuronal action potential	GO:0019228	35	0.014
central nervous system development	GO:0007417	311	0.013
regulation of purine nucleotide metabolic process	GO:1900542	115	0.013
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.013
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.013
sensory perception	GO:0007600	101	0.013
negative regulation of rna metabolic process	GO:0051253	123	0.013
glucose homeostasis	GO:0042593	75	0.013
muscle cell apoptotic process	GO:0010657	30	0.013
cofactor metabolic process	GO:0051186	95	0.013
glycosyl compound metabolic process	GO:1901657	182	0.013
amino acid transport	GO:0006865	70	0.013
regulation of lipid biosynthetic process	GO:0046890	38	0.013
secretion by cell	GO:0032940	248	0.013
ensheathment of neurons	GO:0007272	40	0.013
intestinal absorption	GO:0050892	3	0.013
regulation of cellular amino acid metabolic process	GO:0006521	2	0.013
cellular response to abiotic stimulus	GO:0071214	85	0.013
cellular macromolecule localization	GO:0070727	122	0.013
phototransduction	GO:0007602	3	0.013
regulation of secretion	GO:0051046	224	0.013
phospholipid metabolic process	GO:0006644	61	0.013
nucleobase containing compound catabolic process	GO:0034655	152	0.013
multicellular organismal signaling	GO:0035637	44	0.013
regulation of cellular component organization	GO:0051128	368	0.013
cellular response to organic cyclic compound	GO:0071407	202	0.012
regulation of apoptotic process	GO:0042981	335	0.012
protein complex assembly	GO:0006461	263	0.012
cellular chemical homeostasis	GO:0055082	247	0.012
positive regulation of protein modification process	GO:0031401	142	0.012
response to glucose	GO:0009749	136	0.012
cgmp biosynthetic process	GO:0006182	15	0.012
transmission of nerve impulse	GO:0019226	42	0.012
purine ribonucleoside catabolic process	GO:0046130	124	0.012
negative regulation of transporter activity	GO:0032410	13	0.012
carboxylic acid biosynthetic process	GO:0046394	83	0.012
establishment of protein localization	GO:0045184	141	0.012
response to peptide	GO:1901652	292	0.012
regulation of cell cycle	GO:0051726	73	0.012
multicellular organismal response to stress	GO:0033555	25	0.012
kidney development	GO:0001822	67	0.012
activation of protein kinase activity	GO:0032147	47	0.012
purine containing compound biosynthetic process	GO:0072522	85	0.012
bmp signaling pathway	GO:0030509	4	0.012
cell cycle	GO:0007049	101	0.012
organic acid transport	GO:0015849	116	0.012
ribonucleotide biosynthetic process	GO:0009260	85	0.011
regulation of neurotransmitter levels	GO:0001505	42	0.011
organic acid metabolic process	GO:0006082	292	0.011
sexual reproduction	GO:0019953	148	0.011
response to zinc ion	GO:0010043	39	0.011
nucleotide biosynthetic process	GO:0009165	98	0.011
positive regulation of endocytosis	GO:0045807	28	0.011
visual perception	GO:0007601	3	0.011
catabolic process	GO:0009056	351	0.011
positive regulation of cellular component organization	GO:0051130	200	0.011
calcium ion transmembrane transport	GO:0070588	70	0.011
response to fatty acid	GO:0070542	65	0.011
positive regulation of cell development	GO:0010720	176	0.011
divalent inorganic cation transport	GO:0072511	134	0.011
organonitrogen compound catabolic process	GO:1901565	179	0.011
cellular component assembly	GO:0022607	360	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.011
spermatogenesis	GO:0007283	99	0.011
regulation of cell migration	GO:0030334	128	0.011
smooth muscle cell proliferation	GO:0048659	77	0.011
positive regulation of gamma aminobutyric acid secretion	GO:0014054	4	0.011
dephosphorylation	GO:0016311	98	0.011
carbohydrate homeostasis	GO:0033500	75	0.011
cellular response to glucose stimulus	GO:0071333	65	0.011
tube development	GO:0035295	89	0.011
regulation of metal ion transport	GO:0010959	118	0.011
response to amine	GO:0014075	46	0.011
peptide transport	GO:0015833	97	0.010
positive regulation of kinase activity	GO:0033674	77	0.010
tissue development	GO:0009888	252	0.010
negative regulation of secretion by cell	GO:1903531	72	0.010
cellular response to carbohydrate stimulus	GO:0071322	72	0.010
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.010
negative regulation of cell communication	GO:0010648	158	0.010
detection of calcium ion	GO:0005513	1	0.010
regulation of muscle cell apoptotic process	GO:0010660	26	0.010
adult locomotory behavior	GO:0008344	4	0.010
regulation of locomotion	GO:0040012	148	0.010
fatty acid biosynthetic process	GO:0006633	33	0.010
steroid metabolic process	GO:0008202	73	0.010
regulation of gtp catabolic process	GO:0033124	58	0.010
heterocycle catabolic process	GO:0046700	167	0.010
response to nicotine	GO:0035094	51	0.010
calcium ion homeostasis	GO:0055074	162	0.010
drug transport	GO:0015893	18	0.010
cellular potassium ion transport	GO:0071804	72	0.010
neuron neuron synaptic transmission	GO:0007270	60	0.010
positive regulation of protein phosphorylation	GO:0001934	135	0.010
renal system development	GO:0072001	67	0.010
gamete generation	GO:0007276	124	0.010

Aipl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
eye disease	DOID:5614	0.380
eye and adnexa disease	DOID:1492	0.380
retinitis pigmentosa	DOID:10584	0.380
disease of anatomical entity	DOID:7	0.380
sensory system disease	DOID:0050155	0.380
retinal degeneration	DOID:8466	0.380
retinal disease	DOID:5679	0.380
nervous system disease	DOID:863	0.380
night blindness	DOID:8499	0.363
cone rod dystrophy	DOID:0050572	0.079
musculoskeletal system disease	DOID:17	0.024
congenital stationary night blindness	DOID:0050534	0.021
connective tissue disease	DOID:65	0.013

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network