IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Pdzd4

PDZ domain containing 4

(Aliases: RGD1561214)

Ensembl: ENSRNOG00000037282
RGD: 1561214
Entrez: 293856
UniProtKB: D3ZLI9

Process Predictions
Disease Predictions

Pdzd4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
macromolecular complex subunit organization	GO:0043933	339	0.120
synaptic vesicle docking involved in exocytosis	GO:0016081	2	0.099
intracellular signal transduction	GO:0035556	314	0.095
neuron projection development	GO:0031175	273	0.079
catabolic process	GO:0009056	351	0.074
protein complex assembly	GO:0006461	263	0.069
neuron differentiation	GO:0030182	368	0.066
cellular component assembly	GO:0022607	360	0.064
organic acid metabolic process	GO:0006082	292	0.064
programmed cell death	GO:0012501	392	0.064
neuron development	GO:0048666	286	0.052
apoptotic process	GO:0006915	381	0.052
cellular catabolic process	GO:0044248	295	0.050
regulation of molecular function	GO:0065009	398	0.050
regulation of catalytic activity	GO:0050790	304	0.049
synaptic transmission	GO:0007268	235	0.048
reproductive process	GO:0022414	372	0.048
positive regulation of neuron projection development	GO:0010976	99	0.047
single organism catabolic process	GO:0044712	283	0.047
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.047
regulation of nervous system development	GO:0051960	264	0.046
protein complex biogenesis	GO:0070271	263	0.046
protein phosphorylation	GO:0006468	345	0.045
locomotion	GO:0040011	237	0.044
protein complex subunit organization	GO:0071822	302	0.044
regulation of phosphorus metabolic process	GO:0051174	349	0.043
organic substance catabolic process	GO:1901575	316	0.043
positive regulation of apoptotic process	GO:0043065	154	0.042
macromolecular complex assembly	GO:0065003	273	0.041
positive regulation of cell differentiation	GO:0045597	217	0.041
positive regulation of cell death	GO:0010942	184	0.040
cell projection organization	GO:0030030	302	0.040
regulation of anatomical structure morphogenesis	GO:0022603	141	0.040
multicellular organismal reproductive process	GO:0048609	233	0.039
positive regulation of programmed cell death	GO:0043068	157	0.038
positive regulation of neurogenesis	GO:0050769	165	0.037
regulation of transcription dna templated	GO:0006355	374	0.037
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.037
regulation of signal transduction	GO:0009966	318	0.036
protein modification by small protein conjugation or removal	GO:0070647	35	0.036
response to nutrient levels	GO:0031667	370	0.036
vesicle mediated transport	GO:0016192	181	0.036
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.035
positive regulation of cell development	GO:0010720	176	0.035
secretion	GO:0046903	307	0.034
response to extracellular stimulus	GO:0009991	380	0.034
sexual reproduction	GO:0019953	148	0.034
regulation of rna metabolic process	GO:0051252	391	0.034
cytoskeleton organization	GO:0007010	111	0.033
cellular component biogenesis	GO:0044085	368	0.033
reproduction	GO:0000003	245	0.033
transcription dna templated	GO:0006351	377	0.033
single organism organelle organization	GO:1902589	180	0.032
positive regulation of neuron differentiation	GO:0045666	126	0.032
anatomical structure morphogenesis	GO:0009653	298	0.032
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.032
transcription from rna polymerase ii promoter	GO:0006366	252	0.031
axis specification	GO:0009798	4	0.031
neuron projection morphogenesis	GO:0048812	122	0.031
rna biosynthetic process	GO:0032774	380	0.031
vesicle docking involved in exocytosis	GO:0006904	4	0.030
carbohydrate derivative metabolic process	GO:1901135	346	0.029
cellular response to insulin stimulus	GO:0032869	81	0.029
cell morphogenesis	GO:0000902	142	0.029
proteolysis	GO:0006508	175	0.029
rna metabolic process	GO:0016070	406	0.028
regulation of apoptotic process	GO:0042981	335	0.028
gamete generation	GO:0007276	124	0.028
carboxylic acid metabolic process	GO:0019752	289	0.028
head development	GO:0060322	247	0.028
positive regulation of catalytic activity	GO:0043085	184	0.028
signal transduction by phosphorylation	GO:0023014	144	0.027
negative regulation of macromolecule metabolic process	GO:0010605	260	0.027
cellular amino acid metabolic process	GO:0006520	107	0.027
central nervous system development	GO:0007417	311	0.027
actin filament based process	GO:0030029	86	0.026
oxoacid metabolic process	GO:0043436	290	0.026
regulation of neuron projection development	GO:0010975	161	0.026
actin crosslink formation	GO:0051764	3	0.026
positive regulation of biosynthetic process	GO:0009891	319	0.026
cell adhesion	GO:0007155	110	0.026
nucleobase containing small molecule metabolic process	GO:0055086	316	0.026
multicellular organism reproduction	GO:0032504	233	0.026
regulation of neurogenesis	GO:0050767	247	0.025
regulation of cell development	GO:0060284	263	0.025
positive regulation of signaling	GO:0023056	270	0.025
response to oxidative stress	GO:0006979	186	0.025
response to hypoxia	GO:0001666	231	0.025
regulation of cell differentiation	GO:0045595	320	0.025
response to peptide	GO:1901652	292	0.024
regulation of phosphorylation	GO:0042325	248	0.024
cell part morphogenesis	GO:0032990	123	0.024
multi organism reproductive process	GO:0044703	262	0.024
anterior posterior pattern specification	GO:0009952	1	0.024
regulation of programmed cell death	GO:0043067	341	0.023
chromosome segregation	GO:0007059	2	0.023
positive regulation of nervous system development	GO:0051962	178	0.023
regulation of cellular component organization	GO:0051128	368	0.023
cellular protein localization	GO:0034613	122	0.023
regulation of cellular protein metabolic process	GO:0032268	267	0.023
regulation of neuron death	GO:1901214	115	0.023
negative regulation of apoptotic process	GO:0043066	181	0.023
regulation of vesicle mediated transport	GO:0060627	81	0.022
secretion by cell	GO:0032940	248	0.022
organelle organization	GO:0006996	266	0.022
regulation of kinase activity	GO:0043549	117	0.022
cellular component movement	GO:0006928	248	0.022
regulation of rna biosynthetic process	GO:2001141	381	0.022
nucleic acid templated transcription	GO:0097659	379	0.022
actin filament bundle assembly	GO:0051017	19	0.022
neuron death	GO:0070997	127	0.022
response to temperature stimulus	GO:0009266	94	0.022
regulation of phosphate metabolic process	GO:0019220	349	0.022
response to nutrient	GO:0007584	248	0.021
regulation of protein phosphorylation	GO:0001932	183	0.021
positive regulation of developmental process	GO:0051094	283	0.021
regulation of protein modification process	GO:0031399	194	0.021
positive regulation of cellular biosynthetic process	GO:0031328	295	0.020
response to decreased oxygen levels	GO:0036293	237	0.020
regulation of transferase activity	GO:0051338	123	0.020
negative regulation of metabolic process	GO:0009892	331	0.020
anion transport	GO:0006820	178	0.020
positive regulation of molecular function	GO:0044093	230	0.020
cellular component morphogenesis	GO:0032989	155	0.020
response to peptide hormone	GO:0043434	278	0.020
uracil metabolic process	GO:0019860	3	0.020
regulation of multicellular organismal development	GO:2000026	376	0.019
cellular nitrogen compound catabolic process	GO:0044270	163	0.019
negative regulation of cell communication	GO:0010648	158	0.019
response to inorganic substance	GO:0010035	377	0.019
cell morphogenesis involved in differentiation	GO:0000904	119	0.019
cellular response to endogenous stimulus	GO:0071495	377	0.019
chemosensory behavior	GO:0007635	2	0.019
dendrite development	GO:0016358	72	0.019
negative regulation of signaling	GO:0023057	157	0.019
protein oligomerization	GO:0051259	191	0.019
embryonic pattern specification	GO:0009880	1	0.019
positive regulation of cell communication	GO:0010647	271	0.019
regulation of cellular amino acid metabolic process	GO:0006521	2	0.019
single organism reproductive process	GO:0044702	297	0.019
pyrimidine nucleobase catabolic process	GO:0006208	3	0.018
organic hydroxy compound metabolic process	GO:1901615	115	0.018
axon development	GO:0061564	96	0.018
positive regulation of protein metabolic process	GO:0051247	178	0.018
growth	GO:0040007	165	0.018
response to glucocorticoid	GO:0051384	223	0.018
regulation of nucleic acid templated transcription	GO:1903506	380	0.018
cell type specific apoptotic process	GO:0097285	134	0.018
regulation of alternative mrna splicing via spliceosome	GO:0000381	2	0.018
behavior	GO:0007610	205	0.018
response to amino acid	GO:0043200	75	0.018
positive regulation of gene expression	GO:0010628	244	0.018
regulation of neuron differentiation	GO:0045664	208	0.018
response to amphetamine	GO:0001975	25	0.017
positive regulation of signal transduction	GO:0009967	175	0.017
regulation of cell projection organization	GO:0031344	175	0.017
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.017
purine containing compound metabolic process	GO:0072521	253	0.017
regulation of cellular amine metabolic process	GO:0033238	8	0.017
cellular amine metabolic process	GO:0044106	38	0.017
negative regulation of cellular metabolic process	GO:0031324	281	0.017
organonitrogen compound catabolic process	GO:1901565	179	0.017
response to oxygen levels	GO:0070482	265	0.017
organic cyclic compound catabolic process	GO:1901361	175	0.017
actin cytoskeleton organization	GO:0030036	73	0.017
regulation of cell maturation	GO:1903429	3	0.017
microvillus assembly	GO:0030033	2	0.017
localization of cell	GO:0051674	202	0.017
cellular response to peptide	GO:1901653	133	0.017
positive regulation of rna metabolic process	GO:0051254	203	0.016
positive regulation of cell projection organization	GO:0031346	111	0.016
response to insulin	GO:0032868	133	0.016
response to metal ion	GO:0010038	253	0.016
dna integrity checkpoint	GO:0031570	2	0.016
amine metabolic process	GO:0009308	38	0.016
cytoskeleton dependent cytokinesis	GO:0061640	2	0.016
positive regulation of transcription dna templated	GO:0045893	197	0.016
response to amine	GO:0014075	46	0.016
regulation of mapk cascade	GO:0043408	116	0.016
actin filament organization	GO:0007015	42	0.015
regulation of neuron apoptotic process	GO:0043523	83	0.015
nucleotide metabolic process	GO:0009117	279	0.015
response to transition metal nanoparticle	GO:1990267	122	0.015
microtubule organizing center organization	GO:0031023	1	0.015
establishment of planar polarity	GO:0001736	1	0.015
response to vitamin	GO:0033273	131	0.015
cellular macromolecule localization	GO:0070727	122	0.015
rhythmic process	GO:0048511	156	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.015
cation transport	GO:0006812	382	0.015
cellular ketone metabolic process	GO:0042180	51	0.015
positive regulation of cellular component organization	GO:0051130	200	0.015
ribonucleoside metabolic process	GO:0009119	174	0.014
heterocycle catabolic process	GO:0046700	167	0.014
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.014
response to acid chemical	GO:0001101	222	0.014
biological adhesion	GO:0022610	110	0.014
positive regulation of protein phosphorylation	GO:0001934	135	0.014
g protein coupled receptor signaling pathway	GO:0007186	242	0.014
ribonucleotide metabolic process	GO:0009259	231	0.014
dicarboxylic acid transport	GO:0006835	34	0.014
embryonic axis specification	GO:0000578	1	0.014
regulation of embryonic development	GO:0045995	2	0.014
protein transport	GO:0015031	132	0.014
cellular response to hormone stimulus	GO:0032870	247	0.014
thymine catabolic process	GO:0006210	2	0.014
regulation of protein kinase activity	GO:0045859	105	0.014
regulation of amino acid transport	GO:0051955	25	0.014
ion homeostasis	GO:0050801	212	0.014
regulation of cellular component biogenesis	GO:0044087	86	0.014
gland development	GO:0048732	155	0.014
response to cytokine	GO:0034097	215	0.014
regulation of secretion by cell	GO:1903530	208	0.014
cellular chemical homeostasis	GO:0055082	247	0.014
protein autophosphorylation	GO:0046777	66	0.014
establishment of vesicle localization	GO:0051650	31	0.013
ras protein signal transduction	GO:0007265	29	0.013
regulation of intracellular signal transduction	GO:1902531	218	0.013
regulation of cellular localization	GO:0060341	263	0.013
positive regulation of phosphate metabolic process	GO:0045937	262	0.013
synaptic vesicle priming	GO:0016082	4	0.013
ribose phosphate metabolic process	GO:0019693	235	0.013
negative regulation of molecular function	GO:0044092	133	0.013
cellular response to stress	GO:0033554	269	0.013
mapk cascade	GO:0000165	140	0.013
neuron apoptotic process	GO:0051402	88	0.013
positive regulation of secretion	GO:0051047	140	0.013
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.013
cell substrate adhesion	GO:0031589	29	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.013
male gamete generation	GO:0048232	99	0.012
negative regulation of cellular protein metabolic process	GO:0032269	106	0.012
spindle organization	GO:0007051	2	0.012
endocytosis	GO:0006897	84	0.012
cellular ion homeostasis	GO:0006873	184	0.012
cellular response to nitrogen compound	GO:1901699	210	0.012
multicellular organism growth	GO:0035264	1	0.012
regulation of anatomical structure size	GO:0090066	135	0.012
cellular homeostasis	GO:0019725	252	0.012
carbohydrate derivative catabolic process	GO:1901136	147	0.012
defecation	GO:0030421	1	0.012
positive regulation of phosphorylation	GO:0042327	177	0.012
negative regulation of protein metabolic process	GO:0051248	114	0.012
regulation of mrna splicing via spliceosome	GO:0048024	3	0.012
rna localization	GO:0006403	4	0.012
regulation of ion transport	GO:0043269	245	0.012
negative regulation of catalytic activity	GO:0043086	103	0.012
positive regulation of multicellular organismal process	GO:0051240	387	0.012
blood vessel morphogenesis	GO:0048514	58	0.012
response to ethanol	GO:0045471	162	0.012
positive regulation of intracellular signal transduction	GO:1902533	138	0.012
regulation of secretion	GO:0051046	224	0.012
nucleobase containing compound catabolic process	GO:0034655	152	0.012
positive regulation of protein modification process	GO:0031401	142	0.012
negative regulation of cell proliferation	GO:0008285	119	0.011
alternative mrna splicing via spliceosome	GO:0000380	4	0.011
response to monosaccharide	GO:0034284	159	0.011
purine ribonucleotide metabolic process	GO:0009150	227	0.011
detection of chemical stimulus involved in sensory perception of bitter taste	GO:0001580	4	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
cellular response to oxygen containing compound	GO:1901701	386	0.011
negative regulation of cellular component organization	GO:0051129	83	0.011
aging	GO:0007568	241	0.011
olfactory behavior	GO:0042048	2	0.011
cytokinetic process	GO:0032506	1	0.011
purine ribonucleoside catabolic process	GO:0046130	124	0.011
sodium ion transport	GO:0006814	82	0.011
response to glucose	GO:0009749	136	0.011
positive regulation of protein kinase activity	GO:0045860	73	0.011
positive regulation of synaptic transmission	GO:0050806	62	0.011
transmembrane transport	GO:0055085	412	0.011
purine nucleotide catabolic process	GO:0006195	136	0.011
regulation of cell morphogenesis	GO:0022604	77	0.011
cell motility	GO:0048870	202	0.010
positive regulation of response to stimulus	GO:0048584	285	0.010
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.010
response to hexose	GO:0009746	144	0.010
glycosyl compound metabolic process	GO:1901657	182	0.010
response to activity	GO:0014823	73	0.010
macromolecule localization	GO:0033036	252	0.010
meiotic cell cycle process	GO:1903046	3	0.010
mitotic cell cycle	GO:0000278	49	0.010
mechanoreceptor differentiation	GO:0042490	2	0.010
activation of phospholipase d activity	GO:0031584	2	0.010
chemical homeostasis	GO:0048878	292	0.010
thymine metabolic process	GO:0019859	2	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.010
single organism cellular localization	GO:1902580	102	0.010

Pdzd4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.014
central nervous system disease	DOID:331	0.014
nervous system disease	DOID:863	0.014

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network