IMP: Integrative Multi-species Prediction

Rattus norvegicus

85 known processes

Ywhaz

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

(Aliases: 14-3-3z)

Entrez: 25578
RGD: 3980
Ensembl: ENSRNOG00000008195
UniProtKB: P63102

Process Predictions
Disease Predictions

Ywhaz biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
histamine secretion involved in inflammatory response	GO:0002441	3	0.997
positive regulation of actin filament polymerization	GO:0030838	5	0.938
cellular macromolecule localization	GO:0070727	122	0.933
organelle organization	GO:0006996	266	0.892
mast cell degranulation	GO:0043303	10	0.863
vesicle mediated transport	GO:0016192	181	0.829
histamine secretion by mast cell	GO:0002553	3	0.798
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.795
histamine production involved in inflammatory response	GO:0002349	3	0.758
protein localization to organelle	GO:0033365	57	0.739
cellular component biogenesis	GO:0044085	368	0.724	Rat
intracellular transport	GO:0046907	185	0.718
protein complex subunit organization	GO:0071822	302	0.704	Rat
regulation of molecular function	GO:0065009	398	0.694
production of molecular mediator involved in inflammatory response	GO:0002532	5	0.684
rna metabolic process	GO:0016070	406	0.668	Rat
macromolecule localization	GO:0033036	252	0.651
neuron projection development	GO:0031175	273	0.638
regulation of ion transport	GO:0043269	245	0.609
cation transport	GO:0006812	382	0.603
secretion by cell	GO:0032940	248	0.602
arp2 3 complex mediated actin nucleation	GO:0034314	2	0.598
dendrite development	GO:0016358	72	0.595
single organism cellular localization	GO:1902580	102	0.592
leukocyte activation involved in immune response	GO:0002366	16	0.589
inorganic cation transmembrane transport	GO:0098662	202	0.543
myeloid cell activation involved in immune response	GO:0002275	13	0.537
cell cell signaling	GO:0007267	335	0.525
regulation of neurogenesis	GO:0050767	247	0.513
actin filament based process	GO:0030029	86	0.509
myeloid leukocyte mediated immunity	GO:0002444	12	0.506
cell cycle	GO:0007049	101	0.505
regulation of dendrite development	GO:0050773	59	0.499
regulation of organelle organization	GO:0033043	80	0.487
protein localization	GO:0008104	191	0.482
lysosome localization	GO:0032418	10	0.470
protein complex biogenesis	GO:0070271	263	0.469	Rat
intracellular protein transport	GO:0006886	79	0.465
macromolecular complex assembly	GO:0065003	273	0.463	Rat
regulation of neuron differentiation	GO:0045664	208	0.461
actin nucleation	GO:0045010	2	0.459
regulation of cell development	GO:0060284	263	0.452
establishment of protein localization	GO:0045184	141	0.452
neuron development	GO:0048666	286	0.447
regulation of rna metabolic process	GO:0051252	391	0.437	Rat
immune response	GO:0006955	104	0.435
nucleic acid templated transcription	GO:0097659	379	0.434	Rat
cellular component morphogenesis	GO:0032989	155	0.429
cell cycle process	GO:0022402	57	0.427
regulation of rna biosynthetic process	GO:2001141	381	0.419	Rat
divalent metal ion transport	GO:0070838	132	0.416
cell projection organization	GO:0030030	302	0.415
neuron differentiation	GO:0030182	368	0.409
cytoskeleton organization	GO:0007010	111	0.407
cellular component assembly	GO:0022607	360	0.406	Rat
intracellular signal transduction	GO:0035556	314	0.403
macromolecular complex subunit organization	GO:0043933	339	0.380	Rat
metal ion transport	GO:0030001	289	0.376
protein complex assembly	GO:0006461	263	0.366	Rat
regulation of transporter activity	GO:0032409	50	0.353
cellular response to endogenous stimulus	GO:0071495	377	0.352	Rat
regulation of catalytic activity	GO:0050790	304	0.352
regulation of nucleic acid templated transcription	GO:1903506	380	0.348	Rat
protein heterooligomerization	GO:0051291	89	0.348	Rat
single organism organelle organization	GO:1902589	180	0.344
actin cytoskeleton organization	GO:0030036	73	0.341
protein targeting	GO:0006605	61	0.340
regulation of cell projection organization	GO:0031344	175	0.335
rna biosynthetic process	GO:0032774	380	0.329	Rat
cellular metal ion homeostasis	GO:0006875	172	0.323
single organism intracellular transport	GO:1902582	166	0.323
organic substance catabolic process	GO:1901575	316	0.319
transmembrane transport	GO:0055085	412	0.316
regulation of multicellular organismal development	GO:2000026	376	0.314
regulation of nervous system development	GO:0051960	264	0.303
regulation of dendrite morphogenesis	GO:0048814	33	0.298
regulation of phosphate metabolic process	GO:0019220	349	0.296
regulation of anatomical structure size	GO:0090066	135	0.293
regulation of calcium ion transport	GO:0051924	77	0.278
endocytosis	GO:0006897	84	0.276
axon development	GO:0061564	96	0.274
nitrogen compound transport	GO:0071705	229	0.266
regulation of phosphorus metabolic process	GO:0051174	349	0.262
regulation of cell morphogenesis	GO:0022604	77	0.261
anatomical structure morphogenesis	GO:0009653	298	0.261
cell projection morphogenesis	GO:0048858	123	0.259
muscle contraction	GO:0006936	88	0.255
protein transport	GO:0015031	132	0.252
cation transmembrane transport	GO:0098655	263	0.250
regulation of phosphorylation	GO:0042325	248	0.248
exocytosis	GO:0006887	60	0.247
organelle localization	GO:0051640	55	0.242
anterior posterior pattern specification	GO:0009952	1	0.239
cellular nitrogen compound catabolic process	GO:0044270	163	0.236
regulation of transcription dna templated	GO:0006355	374	0.234	Rat
positive regulation of cell differentiation	GO:0045597	217	0.234
regulation of cell differentiation	GO:0045595	320	0.232
nucleoside triphosphate metabolic process	GO:0009141	144	0.231
purine containing compound metabolic process	GO:0072521	253	0.228
negative regulation of metabolic process	GO:0009892	331	0.224	Rat
regulation of metal ion transport	GO:0010959	118	0.223
cellular calcium ion homeostasis	GO:0006874	160	0.222
establishment or maintenance of cell polarity	GO:0007163	8	0.216
regulation of cellular component organization	GO:0051128	368	0.216
reproductive process	GO:0022414	372	0.215
positive regulation of response to stimulus	GO:0048584	285	0.214
regulation of neuron projection development	GO:0010975	161	0.213
mitochondrial transport	GO:0006839	19	0.211
establishment of chromosome localization	GO:0051303	1	0.210
cellular homeostasis	GO:0019725	252	0.205
transcription from rna polymerase ii promoter	GO:0006366	252	0.204
growth	GO:0040007	165	0.201
cell morphogenesis	GO:0000902	142	0.198
secretion	GO:0046903	307	0.197
cellular cation homeostasis	GO:0030003	180	0.197
divalent inorganic cation homeostasis	GO:0072507	165	0.197
regulation of hydrolase activity	GO:0051336	143	0.193
regulation of actin filament length	GO:0030832	12	0.192
regulation of protein metabolic process	GO:0051246	289	0.191
sensory organ development	GO:0007423	74	0.191
chromosome segregation	GO:0007059	2	0.191
calcium ion transport	GO:0006816	131	0.190
negative regulation of macromolecule metabolic process	GO:0010605	260	0.190	Rat
inorganic ion transmembrane transport	GO:0098660	229	0.189
cell part morphogenesis	GO:0032990	123	0.185
signal release	GO:0023061	145	0.182
circulatory system development	GO:0072359	134	0.180
neuron projection morphogenesis	GO:0048812	122	0.179
negative regulation of cellular metabolic process	GO:0031324	281	0.178	Rat
head development	GO:0060322	247	0.174
regulation of transmembrane transport	GO:0034762	122	0.174
cytoplasmic transport	GO:0016482	115	0.174
actin filament organization	GO:0007015	42	0.171
adult locomotory behavior	GO:0008344	4	0.169
positive regulation of signaling	GO:0023056	270	0.165
positive regulation of developmental process	GO:0051094	283	0.163
positive regulation of molecular function	GO:0044093	230	0.161
leukocyte activation	GO:0045321	76	0.160
synaptic transmission	GO:0007268	235	0.159
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.158	Rat
reproduction	GO:0000003	245	0.156
cellular response to peptide hormone stimulus	GO:0071375	120	0.156	Rat
calcium ion transmembrane transport	GO:0070588	70	0.156
catabolic process	GO:0009056	351	0.153
embryonic pattern specification	GO:0009880	1	0.148
regulation of anatomical structure morphogenesis	GO:0022603	141	0.145
ion transmembrane transport	GO:0034220	365	0.143
regulation of calcium ion transmembrane transporter activity	GO:1901019	17	0.142
multi organism reproductive process	GO:0044703	262	0.141
ras protein signal transduction	GO:0007265	29	0.140
spindle organization	GO:0007051	2	0.139
negative regulation of gene expression	GO:0010629	199	0.136	Rat
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.136
cellular response to peptide	GO:1901653	133	0.136	Rat
nucleobase containing small molecule metabolic process	GO:0055086	316	0.133
regulation of ion transmembrane transporter activity	GO:0032412	48	0.132
small gtpase mediated signal transduction	GO:0007264	36	0.132
cell activation	GO:0001775	97	0.132
biological adhesion	GO:0022610	110	0.131
response to wounding	GO:0009611	254	0.130
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.130
cellular response to insulin stimulus	GO:0032869	81	0.129	Rat
cation homeostasis	GO:0055080	195	0.129
cellular catabolic process	GO:0044248	295	0.127
regulation of transmembrane transporter activity	GO:0022898	49	0.127
cellular chemical homeostasis	GO:0055082	247	0.126
protein oligomerization	GO:0051259	191	0.125	Rat
brain development	GO:0007420	247	0.124
leukocyte mediated immunity	GO:0002443	28	0.121
positive regulation of phosphate metabolic process	GO:0045937	262	0.120
behavior	GO:0007610	205	0.120
mitotic spindle organization	GO:0007052	2	0.119
inflammatory response	GO:0006954	150	0.118
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.118
cellular protein complex assembly	GO:0043623	44	0.118
cellular ion homeostasis	GO:0006873	184	0.117
asymmetric stem cell division	GO:0098722	2	0.114
regulation of jnk cascade	GO:0046328	19	0.113
positive regulation of intracellular signal transduction	GO:1902533	138	0.113
positive regulation of cell development	GO:0010720	176	0.112
positive regulation of signal transduction	GO:0009967	175	0.111
response to metal ion	GO:0010038	253	0.111
embryo development	GO:0009790	49	0.110
ion homeostasis	GO:0050801	212	0.110
cell activation involved in immune response	GO:0002263	16	0.109
regulation of cellular protein metabolic process	GO:0032268	267	0.108
meiotic cell cycle process	GO:1903046	3	0.108
cellular protein localization	GO:0034613	122	0.104
nucleobase containing compound catabolic process	GO:0034655	152	0.104
nucleoside phosphate metabolic process	GO:0006753	283	0.102
defense response	GO:0006952	194	0.101
positive regulation of phosphorus metabolic process	GO:0010562	262	0.099
negative regulation of cellular biosynthetic process	GO:0031327	161	0.097	Rat
immune system process	GO:0002376	204	0.097
negative regulation of biosynthetic process	GO:0009890	168	0.096	Rat
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.096
smad protein complex assembly	GO:0007183	1	0.096
positive regulation of cellular component biogenesis	GO:0044089	55	0.096
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.095
divalent inorganic cation transport	GO:0072511	134	0.095
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.094
hormone transport	GO:0009914	121	0.093
chemical homeostasis	GO:0048878	292	0.093
central nervous system development	GO:0007417	311	0.092
positive regulation of neurogenesis	GO:0050769	165	0.092
calcium ion homeostasis	GO:0055074	162	0.091
positive regulation of cell communication	GO:0010647	271	0.090
programmed cell death	GO:0012501	392	0.089
sexual reproduction	GO:0019953	148	0.088
metal ion homeostasis	GO:0055065	186	0.088
nucleoside phosphate catabolic process	GO:1901292	140	0.087
transcription dna templated	GO:0006351	377	0.086	Rat
regulation of actin polymerization or depolymerization	GO:0008064	12	0.085
response to corticosteroid	GO:0031960	235	0.085
single organism reproductive process	GO:0044702	297	0.084
protein phosphorylation	GO:0006468	345	0.084
immune effector process	GO:0002252	53	0.083
regulation of protein phosphorylation	GO:0001932	183	0.083
actin filament polymerization	GO:0030041	11	0.083
centrosome organization	GO:0051297	1	0.083
somatic stem cell division	GO:0048103	2	0.083
regulation of cytoskeleton organization	GO:0051493	49	0.083
response to axon injury	GO:0048678	59	0.083
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.082
ribonucleoside metabolic process	GO:0009119	174	0.082
negative regulation of signaling	GO:0023057	157	0.082
mitochondrion organization	GO:0007005	35	0.082
positive regulation of phosphoprotein phosphatase activity	GO:0032516	3	0.081
dna metabolic process	GO:0006259	96	0.080
regulation of protein modification process	GO:0031399	194	0.080
regulation of stem cell differentiation	GO:2000736	2	0.079
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.077
positive regulation of lamellipodium assembly	GO:0010592	4	0.077
regulation of protein phosphatase type 2a activity	GO:0034047	2	0.077
mast cell mediated immunity	GO:0002448	10	0.077
positive regulation of cellular protein metabolic process	GO:0032270	167	0.077
single organism behavior	GO:0044708	130	0.076
regulation of protein polymerization	GO:0032271	19	0.076
positive regulation of cytoskeleton organization	GO:0051495	26	0.076
learning or memory	GO:0007611	90	0.075
barbed end actin filament capping	GO:0051016	1	0.074
positive regulation of protein dephosphorylation	GO:0035307	4	0.073
negative regulation of cellular component organization	GO:0051129	83	0.073
regulation of hormone levels	GO:0010817	187	0.073
positive regulation of gene expression	GO:0010628	244	0.072
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.072
apoptotic process	GO:0006915	381	0.071
nuclear transport	GO:0051169	49	0.070
myosin filament organization	GO:0031033	2	0.070
actin filament depolymerization	GO:0030042	3	0.070
reproductive structure development	GO:0048608	128	0.070
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.070
positive regulation of biosynthetic process	GO:0009891	319	0.069
negative regulation of cell development	GO:0010721	82	0.069
purine nucleotide catabolic process	GO:0006195	136	0.069
signal transduction by phosphorylation	GO:0023014	144	0.069
positive regulation of hydrolase activity	GO:0051345	86	0.068
regulation of cell cycle	GO:0051726	73	0.068
positive regulation of programmed cell death	GO:0043068	157	0.068
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.068	Rat
regulation of protein kinase activity	GO:0045859	105	0.068
positive regulation of transcription dna templated	GO:0045893	197	0.068
neurological system process	GO:0050877	219	0.067
regulation of actin cytoskeleton organization	GO:0032956	30	0.067
protein polymerization	GO:0051258	22	0.067
cellular response to nitrogen compound	GO:1901699	210	0.065	Rat
regulation of cellular localization	GO:0060341	263	0.065
establishment of organelle localization	GO:0051656	37	0.064
regulation of actin nucleation	GO:0051125	2	0.064
regulation of arp2 3 complex mediated actin nucleation	GO:0034315	2	0.063
regulation of ion transmembrane transport	GO:0034765	121	0.063
cytoskeleton dependent cytokinesis	GO:0061640	2	0.063
microtubule organizing center organization	GO:0031023	1	0.063
rna stabilization	GO:0043489	2	0.063
positive regulation of neuron differentiation	GO:0045666	126	0.062
developmental process involved in reproduction	GO:0003006	159	0.062
myeloid leukocyte activation	GO:0002274	36	0.062
homeostatic process	GO:0042592	331	0.062
sodium ion transmembrane transport	GO:0035725	67	0.062
regulation of intracellular signal transduction	GO:1902531	218	0.061
positive regulation of nucleoside metabolic process	GO:0045979	55	0.061
mast cell activation involved in immune response	GO:0002279	10	0.061
regulation of actin filament based process	GO:0032970	42	0.061
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.060
negative regulation of multicellular organismal process	GO:0051241	203	0.060
nucleoside catabolic process	GO:0009164	126	0.060
single organism catabolic process	GO:0044712	283	0.059
lysosomal transport	GO:0007041	8	0.059
purine nucleoside catabolic process	GO:0006152	124	0.058
response to inorganic substance	GO:0010035	377	0.058
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.058
atp metabolic process	GO:0046034	72	0.058
aromatic compound catabolic process	GO:0019439	168	0.058
regulation of calcium ion transmembrane transport	GO:1903169	18	0.057
regulation of signal transduction	GO:0009966	318	0.057
positive regulation of protein metabolic process	GO:0051247	178	0.057
regulation of ryanodine sensitive calcium release channel activity	GO:0060314	5	0.057
purine nucleoside monophosphate catabolic process	GO:0009128	55	0.056
cytosolic calcium ion homeostasis	GO:0051480	140	0.056
axis specification	GO:0009798	4	0.056
purine ribonucleoside metabolic process	GO:0046128	168	0.055
regulation of system process	GO:0044057	208	0.054
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.053
organic cyclic compound catabolic process	GO:1901361	175	0.053
cellular response to cytokine stimulus	GO:0071345	127	0.053
muscle system process	GO:0003012	115	0.053
positive regulation of catalytic activity	GO:0043085	184	0.053
skeletal muscle fiber adaptation	GO:0043503	1	0.052
negative regulation of nervous system development	GO:0051961	79	0.052
positive regulation of phosphorylation	GO:0042327	177	0.051
carbohydrate derivative metabolic process	GO:1901135	346	0.051
positive regulation of atp catabolic process	GO:1903291	6	0.051
cell morphogenesis involved in differentiation	GO:0000904	119	0.051
cell adhesion	GO:0007155	110	0.050
establishment of protein localization to organelle	GO:0072594	44	0.050
carbohydrate derivative catabolic process	GO:1901136	147	0.050
negative regulation of developmental process	GO:0051093	125	0.050
macromolecule catabolic process	GO:0009057	58	0.049
single organism cell adhesion	GO:0098602	46	0.049
regulated secretory pathway	GO:0045055	17	0.049
purine nucleotide metabolic process	GO:0006163	229	0.049
aging	GO:0007568	241	0.048
meiotic chromosome segregation	GO:0045132	1	0.048
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.047	Rat
microtubule based process	GO:0007017	36	0.047
response to oxidative stress	GO:0006979	186	0.047
actin polymerization or depolymerization	GO:0008154	14	0.047
mrna 3 end processing	GO:0031124	1	0.046
negative regulation of calcium ion transmembrane transport	GO:1903170	5	0.046
negative regulation of rna biosynthetic process	GO:1902679	118	0.046	Rat
establishment of cell polarity	GO:0030010	6	0.045
regulation of kinase activity	GO:0043549	117	0.045
single organism nuclear import	GO:1902593	35	0.044
embryonic axis specification	GO:0000578	1	0.044
negative regulation of transcription dna templated	GO:0045892	116	0.043	Rat
regulation of vascular smooth muscle contraction	GO:0003056	3	0.043
regulation of cellular component biogenesis	GO:0044087	86	0.043
multicellular organismal reproductive process	GO:0048609	233	0.043
regulation of smooth muscle contraction	GO:0006940	29	0.043
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.042
regulation of muscle contraction	GO:0006937	53	0.042
negative regulation of cell differentiation	GO:0045596	99	0.042
cell motility	GO:0048870	202	0.042
response to cytokine	GO:0034097	215	0.041
regulation of axonogenesis	GO:0050770	37	0.041
positive regulation of cellular component organization	GO:0051130	200	0.040
regulation of nucleotide metabolic process	GO:0006140	117	0.040
regulation of nucleoside metabolic process	GO:0009118	66	0.040
organophosphate catabolic process	GO:0046434	148	0.040
extracellular matrix organization	GO:0030198	13	0.040
chromosome localization	GO:0050000	1	0.039
response to radiation	GO:0009314	137	0.039
ribonucleotide metabolic process	GO:0009259	231	0.039
synaptic growth at neuromuscular junction	GO:0051124	1	0.039
organophosphate metabolic process	GO:0019637	370	0.039
cardiac ventricle development	GO:0003231	1	0.039
cellular response to hormone stimulus	GO:0032870	247	0.039	Rat
multicellular organism reproduction	GO:0032504	233	0.038
organelle fission	GO:0048285	25	0.038
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.038
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.038
glycosyl compound metabolic process	GO:1901657	182	0.037
purine ribonucleotide metabolic process	GO:0009150	227	0.037
response to purine containing compound	GO:0014074	126	0.037
carbohydrate derivative biosynthetic process	GO:1901137	124	0.036
positive regulation of organelle organization	GO:0010638	48	0.036
cellular response to abiotic stimulus	GO:0071214	85	0.036
protein localization to mitochondrion	GO:0070585	7	0.036
positive regulation of protein binding	GO:0032092	9	0.036
cell growth	GO:0016049	104	0.036
positive regulation of cellular biosynthetic process	GO:0031328	295	0.036
positive regulation of nervous system development	GO:0051962	178	0.036
locomotion	GO:0040011	237	0.036
proteolysis	GO:0006508	175	0.035
response to external biotic stimulus	GO:0043207	221	0.035
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.035
negative regulation of molecular function	GO:0044092	133	0.035
positive regulation of transferase activity	GO:0051347	81	0.035
regulation of cellular amine metabolic process	GO:0033238	8	0.035
protein catabolic process	GO:0030163	30	0.035
cellular protein catabolic process	GO:0044257	19	0.035
positive regulation of protein polymerization	GO:0032273	10	0.034
regulation of developmental growth	GO:0048638	45	0.034
response to gonadotropin	GO:0034698	34	0.034
cell projection assembly	GO:0030031	21	0.034
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	10	0.033
nucleotide metabolic process	GO:0009117	279	0.033
regulation of blood circulation	GO:1903522	110	0.033
regulation of blood vessel size	GO:0050880	89	0.033
negative regulation of cell communication	GO:0010648	158	0.033
regulation of sodium ion transmembrane transporter activity	GO:2000649	4	0.032
monovalent inorganic cation transport	GO:0015672	172	0.032
multicellular organismal homeostasis	GO:0048871	49	0.032
regulation of purine nucleotide metabolic process	GO:1900542	115	0.031
response to insulin	GO:0032868	133	0.031	Rat
organic hydroxy compound metabolic process	GO:1901615	115	0.031
leukocyte degranulation	GO:0043299	12	0.031
positive regulation of cell death	GO:0010942	184	0.030
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.030	Rat
tube development	GO:0035295	89	0.030
tissue development	GO:0009888	252	0.030
negative regulation of phosphate metabolic process	GO:0045936	80	0.030
mapk cascade	GO:0000165	140	0.030
synaptic vesicle localization	GO:0097479	24	0.030
positive regulation of protein modification process	GO:0031401	142	0.030
regulation of programmed cell death	GO:0043067	341	0.030
nucleoside metabolic process	GO:0009116	179	0.030
negative regulation of neurogenesis	GO:0050768	78	0.030
response to alkaloid	GO:0043279	132	0.029
cellular component movement	GO:0006928	248	0.029
gliogenesis	GO:0042063	93	0.029
histamine secretion	GO:0001821	8	0.029
negative regulation of cell division	GO:0051782	1	0.029
dephosphorylation	GO:0016311	98	0.029
positive regulation of cell projection organization	GO:0031346	111	0.029
heterocycle catabolic process	GO:0046700	167	0.029
negative regulation of nuclear division	GO:0051784	1	0.028
regulation of transferase activity	GO:0051338	123	0.027
calcium ion transport into cytosol	GO:0060402	38	0.027
positive regulation of rna biosynthetic process	GO:1902680	197	0.027
centrosome cycle	GO:0007098	1	0.027
regulation of ras protein signal transduction	GO:0046578	45	0.027
negative regulation of cellular protein metabolic process	GO:0032269	106	0.027
response to calcium ion	GO:0051592	59	0.027
regulation of secretion by cell	GO:1903530	208	0.026
smooth muscle contraction	GO:0006939	37	0.026
sensory perception	GO:0007600	101	0.026
positive regulation of protein kinase activity	GO:0045860	73	0.026
regulation of neural precursor cell proliferation	GO:2000177	16	0.026
organelle inheritance	GO:0048308	2	0.026
positive regulation of lipid kinase activity	GO:0090218	2	0.026
nucleoside monophosphate metabolic process	GO:0009123	93	0.025
ribonucleotide catabolic process	GO:0009261	136	0.025
negative regulation of synaptic transmission	GO:0050805	29	0.025
protein import into nucleus	GO:0006606	35	0.025
cellular amino acid metabolic process	GO:0006520	107	0.025
blood circulation	GO:0008015	183	0.024
organonitrogen compound catabolic process	GO:1901565	179	0.024
regulation of receptor activity	GO:0010469	29	0.024
negative regulation of rna metabolic process	GO:0051253	123	0.024	Rat
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.024
acrosome assembly	GO:0001675	3	0.024
cellular response to stress	GO:0033554	269	0.024
negative regulation of neuron differentiation	GO:0045665	62	0.024
regulation of endopeptidase activity	GO:0052548	51	0.024
regulation of cellular catabolic process	GO:0031329	101	0.024
protein modification by small protein conjugation or removal	GO:0070647	35	0.024
dendrite morphogenesis	GO:0048813	43	0.024
negative regulation of neuron projection development	GO:0010977	46	0.023
erbb signaling pathway	GO:0038127	23	0.023
development of primary sexual characteristics	GO:0045137	107	0.023
chemosensory behavior	GO:0007635	2	0.023
regulation of synaptic transmission	GO:0050804	141	0.023
adult behavior	GO:0030534	16	0.023
muscle organ development	GO:0007517	50	0.023
epithelium development	GO:0060429	96	0.022
single organism biosynthetic process	GO:0044711	342	0.022
purine nucleoside metabolic process	GO:0042278	169	0.022
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.022
response to other organism	GO:0051707	220	0.022
sodium ion transport	GO:0006814	82	0.022
regeneration	GO:0031099	163	0.022
positive regulation of monooxygenase activity	GO:0032770	5	0.022
heart morphogenesis	GO:0003007	3	0.022
response to peptide hormone	GO:0043434	278	0.022	Rat
cellular amine metabolic process	GO:0044106	38	0.021
response to interleukin 1	GO:0070555	55	0.021
cardiovascular system development	GO:0072358	134	0.021
protein dephosphorylation	GO:0006470	38	0.021
negative regulation of actin filament polymerization	GO:0030837	4	0.021
multicellular organism growth	GO:0035264	1	0.021
positive regulation of protein phosphorylation	GO:0001934	135	0.021
mitotic cell cycle process	GO:1903047	35	0.020
positive regulation of multicellular organismal process	GO:0051240	387	0.020
nucleotide catabolic process	GO:0009166	139	0.020
sequestering of calcium ion	GO:0051208	8	0.020
purine containing compound catabolic process	GO:0072523	138	0.020
negative regulation of protein metabolic process	GO:0051248	114	0.020
mitotic cell cycle	GO:0000278	49	0.020
nuclear division	GO:0000280	22	0.020
negative regulation of response to stimulus	GO:0048585	155	0.020
localization of cell	GO:0051674	202	0.020
positive regulation of neuron projection development	GO:0010976	99	0.020
dendritic spine development	GO:0060996	20	0.020
histamine transport	GO:0051608	9	0.020
glucose homeostasis	GO:0042593	75	0.020
positive regulation of nucleotide metabolic process	GO:0045981	91	0.020
endosome to lysosome transport	GO:0008333	6	0.020
posttranscriptional regulation of gene expression	GO:0010608	37	0.020
anion transport	GO:0006820	178	0.020
protein heterotrimerization	GO:0070208	2	0.019
regulation of response to wounding	GO:1903034	69	0.019
regulation of purine nucleotide catabolic process	GO:0033121	65	0.019
regulation of protein complex assembly	GO:0043254	33	0.019
protein localization to nucleus	GO:0034504	39	0.019

Ywhaz disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.130
nervous system disease	DOID:863	0.130
central nervous system disease	DOID:331	0.105
sensory system disease	DOID:0050155	0.064

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