IMP: Integrative Multi-species Prediction

Rattus norvegicus

22 known processes

Cuzd1

CUB and zona pellucida-like domains 1

(Aliases: UO-44,Utczp,Uo,ERG1,Itmap1)

RGD: 619771
Entrez: 117179
Ensembl: ENSRNOG00000029945
UniProtKB: Q9QZT0

Process Predictions
Disease Predictions

Cuzd1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
single organism biosynthetic process	GO:0044711	342	0.493
regulation of cellular component organization	GO:0051128	368	0.370
response to cytokine	GO:0034097	215	0.339
ion transmembrane transport	GO:0034220	365	0.257
response to extracellular stimulus	GO:0009991	380	0.215
response to peptide	GO:1901652	292	0.197
response to external biotic stimulus	GO:0043207	221	0.196
positive regulation of multicellular organismal process	GO:0051240	387	0.190
organic acid metabolic process	GO:0006082	292	0.176
response to peptide hormone	GO:0043434	278	0.175
steroid biosynthetic process	GO:0006694	48	0.173
response to toxic substance	GO:0009636	133	0.154
rhythmic process	GO:0048511	156	0.145
regulation of multicellular organismal development	GO:2000026	376	0.142
carboxylic acid metabolic process	GO:0019752	289	0.141
cellular response to endogenous stimulus	GO:0071495	377	0.133
small molecule biosynthetic process	GO:0044283	124	0.133
response to nutrient	GO:0007584	248	0.123
monocarboxylic acid metabolic process	GO:0032787	152	0.121
wound healing	GO:0042060	122	0.120
regulation of cell development	GO:0060284	263	0.108
response to hexose	GO:0009746	144	0.105
response to estradiol	GO:0032355	164	0.099
organic hydroxy compound metabolic process	GO:1901615	115	0.095
response to oxygen levels	GO:0070482	265	0.095
cation transport	GO:0006812	382	0.090
response to estrogen	GO:0043627	232	0.090
organonitrogen compound biosynthetic process	GO:1901566	167	0.089
response to bacterium	GO:0009617	200	0.089
lipid biosynthetic process	GO:0008610	128	0.085
homeostatic process	GO:0042592	331	0.085
positive regulation of cell development	GO:0010720	176	0.083
positive regulation of cell proliferation	GO:0008284	249	0.081
response to glucose	GO:0009749	136	0.080
response to corticosteroid	GO:0031960	235	0.079
synapse assembly	GO:0007416	29	0.074
reproductive process	GO:0022414	372	0.073
hormone metabolic process	GO:0042445	69	0.072
proteolysis	GO:0006508	175	0.071
regeneration	GO:0031099	163	0.071
oxoacid metabolic process	GO:0043436	290	0.068
catabolic process	GO:0009056	351	0.066
transmembrane transport	GO:0055085	412	0.065
metal ion transport	GO:0030001	289	0.064
intracellular signal transduction	GO:0035556	314	0.064
regulation of neurogenesis	GO:0050767	247	0.064
response to camp	GO:0051591	91	0.061
response to hypoxia	GO:0001666	231	0.061
single organism reproductive process	GO:0044702	297	0.060
alcohol metabolic process	GO:0006066	77	0.060
cellular lipid metabolic process	GO:0044255	208	0.059
organophosphate metabolic process	GO:0019637	370	0.058
response to nutrient levels	GO:0031667	370	0.058
response to lipopolysaccharide	GO:0032496	191	0.058
positive regulation of cell death	GO:0010942	184	0.057
response to monosaccharide	GO:0034284	159	0.056
cellular amino acid metabolic process	GO:0006520	107	0.055
regulation of signal transduction	GO:0009966	318	0.055
response to transition metal nanoparticle	GO:1990267	122	0.055
hormone biosynthetic process	GO:0042446	25	0.054
response to organophosphorus	GO:0046683	102	0.053
multicellular organismal reproductive process	GO:0048609	233	0.052
cellular response to oxygen containing compound	GO:1901701	386	0.052
reproduction	GO:0000003	245	0.052
regulation of cell differentiation	GO:0045595	320	0.052
growth	GO:0040007	165	0.052
regulation of nervous system development	GO:0051960	264	0.051
female pregnancy	GO:0007565	122	0.050
carbohydrate metabolic process	GO:0005975	130	0.050
secretion by cell	GO:0032940	248	0.050
anion transport	GO:0006820	178	0.049
regulation of jak stat cascade	GO:0046425	21	0.048
rna biosynthetic process	GO:0032774	380	0.048
amine metabolic process	GO:0009308	38	0.046
cellular response to hormone stimulus	GO:0032870	247	0.046
cell cell signaling	GO:0007267	335	0.046
response to biotic stimulus	GO:0009607	226	0.046
positive regulation of phosphate metabolic process	GO:0045937	262	0.045
neuron differentiation	GO:0030182	368	0.045
positive regulation of response to stimulus	GO:0048584	285	0.045
positive regulation of phosphorus metabolic process	GO:0010562	262	0.045
hepaticobiliary system development	GO:0061008	90	0.044
lipid metabolic process	GO:0006629	283	0.043
response to ketone	GO:1901654	182	0.043
steroid metabolic process	GO:0008202	73	0.042
programmed cell death	GO:0012501	392	0.042
regulation of cell proliferation	GO:0042127	359	0.041
cellular component assembly	GO:0022607	360	0.041
multicellular organism reproduction	GO:0032504	233	0.041
gland development	GO:0048732	155	0.041
pyruvate metabolic process	GO:0006090	27	0.041
cellular ketone metabolic process	GO:0042180	51	0.040
inorganic cation transmembrane transport	GO:0098662	202	0.040
rna metabolic process	GO:0016070	406	0.040
positive regulation of cellular biosynthetic process	GO:0031328	295	0.040
regulation of epithelial cell proliferation	GO:0050678	49	0.039
carboxylic acid biosynthetic process	GO:0046394	83	0.038
organic substance catabolic process	GO:1901575	316	0.038
protein oligomerization	GO:0051259	191	0.038
response to molecule of bacterial origin	GO:0002237	194	0.037
carbohydrate derivative metabolic process	GO:1901135	346	0.037
organ regeneration	GO:0031100	101	0.036
organic hydroxy compound biosynthetic process	GO:1901617	51	0.036
response to metal ion	GO:0010038	253	0.036
positive regulation of secretion by cell	GO:1903532	128	0.036
synaptic transmission glycinergic	GO:0060012	2	0.036
regulation of cellular ketone metabolic process	GO:0010565	27	0.036
sodium ion transport	GO:0006814	82	0.036
regulation of growth	GO:0040008	105	0.035
positive regulation of programmed cell death	GO:0043068	157	0.035
regulation of cell projection organization	GO:0031344	175	0.034
cellular amine metabolic process	GO:0044106	38	0.034
response to histamine	GO:0034776	3	0.034
cellular response to cytokine stimulus	GO:0071345	127	0.034
neuron development	GO:0048666	286	0.033
positive regulation of phosphorylation	GO:0042327	177	0.033
response to purine containing compound	GO:0014074	126	0.033
anatomical structure morphogenesis	GO:0009653	298	0.032
brain development	GO:0007420	247	0.032
regulation of phosphate metabolic process	GO:0019220	349	0.031
monosaccharide metabolic process	GO:0005996	61	0.030
synapse organization	GO:0050808	46	0.030
monocarboxylic acid biosynthetic process	GO:0072330	48	0.030
monovalent inorganic cation transport	GO:0015672	172	0.030
negative regulation of programmed cell death	GO:0043069	183	0.030
cellular hormone metabolic process	GO:0034754	49	0.030
regulation of lipid metabolic process	GO:0019216	68	0.030
protein complex assembly	GO:0006461	263	0.030
response to ethanol	GO:0045471	162	0.030
fatty acid metabolic process	GO:0006631	99	0.029
ossification	GO:0001503	70	0.029
organ morphogenesis	GO:0009887	75	0.029
positive regulation of neurogenesis	GO:0050769	165	0.029
protein phosphorylation	GO:0006468	345	0.029
macromolecular complex subunit organization	GO:0043933	339	0.028
response to growth factor	GO:0070848	189	0.028
positive regulation of cellular component organization	GO:0051130	200	0.028
regulation of catalytic activity	GO:0050790	304	0.028
regulation of phosphorylation	GO:0042325	248	0.028
epithelial cell proliferation	GO:0050673	54	0.028
protein complex subunit organization	GO:0071822	302	0.028
response to wounding	GO:0009611	254	0.028
response to carbohydrate	GO:0009743	183	0.028
regulation of protein metabolic process	GO:0051246	289	0.027
blood circulation	GO:0008015	183	0.027
regulation of hormone secretion	GO:0046883	106	0.027
response to other organism	GO:0051707	220	0.027
tissue development	GO:0009888	252	0.027
negative regulation of cellular metabolic process	GO:0031324	281	0.027
positive regulation of nervous system development	GO:0051962	178	0.026
positive regulation of epithelial cell proliferation	GO:0050679	32	0.026
jak stat cascade	GO:0007259	26	0.026
neuron projection development	GO:0031175	273	0.026
intracellular transport	GO:0046907	185	0.026
sodium ion transmembrane transport	GO:0035725	67	0.025
regulation of programmed cell death	GO:0043067	341	0.025
cellular chemical homeostasis	GO:0055082	247	0.025
regulation of immunoglobulin production	GO:0002637	4	0.025
cellular response to histamine	GO:0071420	3	0.025
metal ion homeostasis	GO:0055065	186	0.025
negative regulation of transcription dna templated	GO:0045892	116	0.025
regulation of system process	GO:0044057	208	0.024
positive regulation of intracellular signal transduction	GO:1902533	138	0.024
negative regulation of cellular component organization	GO:0051129	83	0.024
cellular calcium ion homeostasis	GO:0006874	160	0.024
response to insulin	GO:0032868	133	0.024
positive regulation of secretion	GO:0051047	140	0.024
regulation of lipid biosynthetic process	GO:0046890	38	0.023
chemical homeostasis	GO:0048878	292	0.023
regulation of hormone levels	GO:0010817	187	0.023
response to decreased oxygen levels	GO:0036293	237	0.023
serotonin receptor signaling pathway	GO:0007210	10	0.023
response to inorganic substance	GO:0010035	377	0.022
regulation of secretion by cell	GO:1903530	208	0.022
response to activity	GO:0014823	73	0.022
regulation of phosphorus metabolic process	GO:0051174	349	0.022
organophosphate biosynthetic process	GO:0090407	143	0.022
carbohydrate derivative biosynthetic process	GO:1901137	124	0.022
cation transmembrane transport	GO:0098655	263	0.022
regulation of phosphatidylinositol dephosphorylation	GO:0060304	1	0.022
circadian rhythm	GO:0007623	88	0.022
inorganic ion transmembrane transport	GO:0098660	229	0.022
transcription dna templated	GO:0006351	377	0.022
macromolecular complex assembly	GO:0065003	273	0.022
ion homeostasis	GO:0050801	212	0.022
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.022
calcium ion transport	GO:0006816	131	0.021
cellular homeostasis	GO:0019725	252	0.021
cellular response to growth factor stimulus	GO:0071363	162	0.021
epithelial cell differentiation	GO:0030855	71	0.021
cellular response to peptide hormone stimulus	GO:0071375	120	0.021
peptidyl amino acid modification	GO:0018193	126	0.021
cellular component biogenesis	GO:0044085	368	0.021
regulation of protein phosphorylation	GO:0001932	183	0.021
regulation of cellular amino acid metabolic process	GO:0006521	2	0.020
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.020
regulation of apoptotic process	GO:0042981	335	0.020
positive regulation of protein metabolic process	GO:0051247	178	0.020
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.020
cellular response to lipid	GO:0071396	201	0.020
regulation of intracellular signal transduction	GO:1902531	218	0.019
androgen metabolic process	GO:0008209	14	0.019
apoptotic process	GO:0006915	381	0.019
response to zinc ion	GO:0010043	39	0.019
negative regulation of developmental process	GO:0051093	125	0.019
single organism intracellular transport	GO:1902582	166	0.019
divalent metal ion transport	GO:0070838	132	0.019
cellular catabolic process	GO:0044248	295	0.019
phospholipid metabolic process	GO:0006644	61	0.019
liver development	GO:0001889	90	0.019
divalent inorganic cation transport	GO:0072511	134	0.019
defense response	GO:0006952	194	0.019
g protein coupled receptor signaling pathway	GO:0007186	242	0.018
ovulation cycle	GO:0042698	67	0.018
progesterone metabolic process	GO:0042448	8	0.018
organic acid biosynthetic process	GO:0016053	83	0.018
detection of calcium ion	GO:0005513	1	0.018
response to tumor necrosis factor	GO:0034612	56	0.018
positive regulation of jak stat cascade	GO:0046427	19	0.018
positive regulation of biosynthetic process	GO:0009891	319	0.018
nucleobase containing small molecule metabolic process	GO:0055086	316	0.018
cell cycle	GO:0007049	101	0.018
regulation of protein modification process	GO:0031399	194	0.018
response to calcium ion	GO:0051592	59	0.018
protein heterooligomerization	GO:0051291	89	0.018
vesicle mediated transport	GO:0016192	181	0.018
neuron neuron synaptic transmission	GO:0007270	60	0.018
regulation of rna metabolic process	GO:0051252	391	0.017
positive regulation of catalytic activity	GO:0043085	184	0.017
glucose metabolic process	GO:0006006	52	0.017
response to fatty acid	GO:0070542	65	0.017
camp metabolic process	GO:0046058	63	0.017
response to hyperoxia	GO:0055093	45	0.017
reproductive system development	GO:0061458	128	0.017
nucleoside phosphate biosynthetic process	GO:1901293	102	0.017
circulatory system process	GO:0003013	183	0.017
regulation of sodium ion transport	GO:0002028	21	0.017
secretion	GO:0046903	307	0.017
protein homooligomerization	GO:0051260	91	0.017
small molecule catabolic process	GO:0044282	59	0.016
cellular metal ion homeostasis	GO:0006875	172	0.016
cellular response to stress	GO:0033554	269	0.016
negative regulation of rna biosynthetic process	GO:1902679	118	0.016
regulation of neuron projection development	GO:0010975	161	0.016
tube development	GO:0035295	89	0.016
response to radiation	GO:0009314	137	0.016
single organism carbohydrate metabolic process	GO:0044723	118	0.016
multi multicellular organism process	GO:0044706	138	0.016
nucleic acid templated transcription	GO:0097659	379	0.016
tissue regeneration	GO:0042246	36	0.016
male sex differentiation	GO:0046661	64	0.016
response to progesterone	GO:0032570	48	0.016
establishment of protein localization	GO:0045184	141	0.016
response to temperature stimulus	GO:0009266	94	0.016
single organism carbohydrate catabolic process	GO:0044724	40	0.015
positive regulation of cellular amine metabolic process	GO:0033240	3	0.015
regulation of secretion	GO:0051046	224	0.015
cellular response to nitrogen compound	GO:1901699	210	0.015
protein transport	GO:0015031	132	0.015
respiratory system development	GO:0060541	45	0.015
response to fungicide	GO:0060992	20	0.015
gonad development	GO:0008406	104	0.015
inflammatory response	GO:0006954	150	0.015
striated muscle tissue development	GO:0014706	58	0.015
positive regulation of hydrolase activity	GO:0051345	86	0.015
positive regulation of developmental process	GO:0051094	283	0.015
regulation of immune response	GO:0050776	55	0.015
hexose metabolic process	GO:0019318	58	0.015
peptidyl tyrosine phosphorylation	GO:0018108	72	0.015
regulation of anatomical structure morphogenesis	GO:0022603	141	0.015
response to mechanical stimulus	GO:0009612	134	0.014
cell projection organization	GO:0030030	302	0.014
regulation of peptide secretion	GO:0002791	82	0.014
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.014
regulation of molecular function	GO:0065009	398	0.014
muscle cell differentiation	GO:0042692	52	0.014
response to electrical stimulus	GO:0051602	56	0.014
regulation of cell morphogenesis	GO:0022604	77	0.014
positive regulation of apoptotic process	GO:0043065	154	0.014
nitrogen compound transport	GO:0071705	229	0.014
regulation of cellular protein metabolic process	GO:0032268	267	0.014
cation homeostasis	GO:0055080	195	0.014
transmission of nerve impulse	GO:0019226	42	0.014
response to amphetamine	GO:0001975	25	0.014
purine nucleotide biosynthetic process	GO:0006164	83	0.014
carboxylic acid transport	GO:0046942	115	0.014
cellular response to insulin stimulus	GO:0032869	81	0.013
response to mineralocorticoid	GO:0051385	49	0.013
pancreas development	GO:0031016	19	0.013
negative regulation of macromolecule metabolic process	GO:0010605	260	0.013
membrane hyperpolarization	GO:0060081	11	0.013
organic anion transport	GO:0015711	132	0.013
negative regulation of cell differentiation	GO:0045596	99	0.013
purine ribonucleotide metabolic process	GO:0009150	227	0.013
hormone secretion	GO:0046879	115	0.013
regulation of cellular localization	GO:0060341	263	0.013
calcium ion homeostasis	GO:0055074	162	0.013
adenylate cyclase inhibiting serotonin receptor signaling pathway	GO:0007198	1	0.013
reproductive structure development	GO:0048608	128	0.013
head development	GO:0060322	247	0.013
glycerophospholipid metabolic process	GO:0006650	47	0.013
developmental growth	GO:0048589	100	0.013
cellular response to organonitrogen compound	GO:0071417	197	0.013
multi organism reproductive process	GO:0044703	262	0.013
positive regulation of transport	GO:0051050	245	0.013
phosphatidylinositol dephosphorylation	GO:0046856	4	0.013
positive regulation of neuron differentiation	GO:0045666	126	0.013
regulation of tube size	GO:0035150	89	0.013
protein catabolic process	GO:0030163	30	0.013
cellular protein complex assembly	GO:0043623	44	0.013
transcription from rna polymerase ii promoter	GO:0006366	252	0.013
developmental process involved in reproduction	GO:0003006	159	0.013
regulation of systemic arterial blood pressure by norepinephrine epinephrine	GO:0001993	2	0.012
negative regulation of cellular biosynthetic process	GO:0031327	161	0.012
regulation of peptide hormone secretion	GO:0090276	80	0.012
response to amino acid	GO:0043200	75	0.012
diaphragm contraction	GO:0002086	2	0.012
organelle localization	GO:0051640	55	0.012
cellular response to glucose stimulus	GO:0071333	65	0.012
central nervous system development	GO:0007417	311	0.012
cytoplasmic transport	GO:0016482	115	0.012
positive regulation of gene expression	GO:0010628	244	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.012
macromolecule catabolic process	GO:0009057	58	0.012
positive regulation of molecular function	GO:0044093	230	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.012
cellular response to hexose stimulus	GO:0071331	65	0.012
organonitrogen compound catabolic process	GO:1901565	179	0.012
positive regulation of cellular protein metabolic process	GO:0032270	167	0.012
response to glucocorticoid	GO:0051384	223	0.012
tongue morphogenesis	GO:0043587	3	0.012
positive regulation of protein modification process	GO:0031401	142	0.012
carbohydrate homeostasis	GO:0033500	75	0.012
regulation of membrane potential	GO:0042391	110	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.012
glycolytic process	GO:0006096	17	0.012
aging	GO:0007568	241	0.012
response to cold	GO:0009409	29	0.012
regulation of peptidase activity	GO:0052547	55	0.012
salivary gland development	GO:0007431	3	0.012
regulation of organ formation	GO:0003156	2	0.012
multicellular organismal water homeostasis	GO:0050891	4	0.012
peptidyl tyrosine modification	GO:0018212	72	0.012
icosanoid metabolic process	GO:0006690	38	0.011
regulation of body fluid levels	GO:0050878	90	0.011
regulation of anatomical structure size	GO:0090066	135	0.011
fatty acid derivative metabolic process	GO:1901568	38	0.011
cytokine production	GO:0001816	61	0.011
synaptic transmission	GO:0007268	235	0.011
aromatic compound catabolic process	GO:0019439	168	0.011
purine containing compound biosynthetic process	GO:0072522	85	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.011
regulation of stem cell differentiation	GO:2000736	2	0.011
regulation of cell cycle	GO:0051726	73	0.011
regulation of blood vessel size	GO:0050880	89	0.011
extracellular matrix constituent secretion	GO:0070278	4	0.011
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.011
hippocampus development	GO:0021766	30	0.011
single organism catabolic process	GO:0044712	283	0.011
divalent inorganic cation homeostasis	GO:0072507	165	0.011
autophagic cell death	GO:0048102	4	0.011
cellular response to metal ion	GO:0071248	55	0.011
glucose homeostasis	GO:0042593	75	0.011
negative regulation of cell death	GO:0060548	229	0.011
negative regulation of signaling	GO:0023057	157	0.011
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.011
signal transduction by phosphorylation	GO:0023014	144	0.011
cellular glucose homeostasis	GO:0001678	66	0.011
male gamete generation	GO:0048232	99	0.011
female gonad development	GO:0008585	53	0.011
negative regulation of molecular function	GO:0044092	133	0.011
carbohydrate catabolic process	GO:0016052	40	0.011
protein localization	GO:0008104	191	0.011
negative regulation of protein metabolic process	GO:0051248	114	0.011
regulation of cellular amine metabolic process	GO:0033238	8	0.011
neuronal action potential	GO:0019228	35	0.011
regulation of cell growth	GO:0001558	85	0.011
leydig cell differentiation	GO:0033327	8	0.010
protein polymerization	GO:0051258	22	0.010
cellular response to monosaccharide stimulus	GO:0071326	67	0.010
positive regulation of the force of heart contraction by epinephrine norepinephrine	GO:0001997	2	0.010
regulation of muscle organ development	GO:0048634	26	0.010
negative regulation of transport	GO:0051051	136	0.010
development of primary male sexual characteristics	GO:0046546	59	0.010
multicellular organism growth	GO:0035264	1	0.010
cellular biogenic amine metabolic process	GO:0006576	30	0.010
circadian sleep wake cycle sleep	GO:0050802	21	0.010
negative regulation of metabolic process	GO:0009892	331	0.010
exocytosis	GO:0006887	60	0.010
cardiac muscle tissue growth	GO:0055017	20	0.010

Cuzd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.013
	disease of anatomical entity	DOID:7	0	0.013

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