Rattus norvegicus

68 known processes

Sparc

secreted protein, acidic, cysteine-rich (osteonectin)

Sparc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to fluorideGO:190261730.601
response to radiationGO:00093141370.569
skeletal system developmentGO:0001501410.544
Zebrafish Mouse
response to estradiolGO:00323551640.494
response to estrogenGO:00436272320.482
head developmentGO:00603222470.432
cellular response to hormone stimulusGO:00328702470.431
response to reactive oxygen speciesGO:00003021200.419
response to growth factorGO:00708481890.350
Mouse
intermediate filament bundle assemblyGO:004511010.347
response to fibroblast growth factorGO:0071774290.321
carboxylic acid metabolic processGO:00197522890.285
digestive tract morphogenesisGO:004854680.269
tissue developmentGO:00098882520.256
Zebrafish
cellular response to nicotineGO:007131670.256
negative regulation of multicellular organismal processGO:00512412030.248
Human
response to glucocorticoidGO:00513842230.246
connective tissue developmentGO:0061448330.236
Zebrafish
response to epidermal growth factorGO:0070849180.234
endochondral bone morphogenesisGO:006035070.226
response to peptide hormoneGO:00434342780.224
extracellular fibril organizationGO:004320610.208
cellular response to transforming growth factor beta stimulusGO:0071560410.208
circulatory system developmentGO:00723591340.208
collagen fibril organizationGO:003019910.206
response to inorganic substanceGO:00100353770.195
wound healingGO:00420601220.192
cartilage development involved in endochondral bone morphogenesisGO:006035130.189
response to extracellular stimulusGO:00099913800.188
organic acid metabolic processGO:00060822920.186
tube developmentGO:0035295890.171
regulation of cell morphogenesis involved in differentiationGO:0010769720.170
oxoacid metabolic processGO:00434362900.156
regulation of cellular localizationGO:00603412630.146
cardiovascular system developmentGO:00723581340.146
response to oxidative stressGO:00069791860.145
lipid biosynthetic processGO:00086101280.145
skeletal system morphogenesisGO:0048705120.144
phototransduction visible lightGO:000760320.138
response to carbohydrateGO:00097431830.134
cellular ketone metabolic processGO:0042180510.134
proteolysisGO:00065081750.133
cellular response to abiotic stimulusGO:0071214850.132
agingGO:00075682410.130
response to nutrientGO:00075842480.130
regulation of anatomical structure morphogenesisGO:00226031410.129
Human
negative regulation of response to stimulusGO:00485851550.129
response to hydrogen peroxideGO:0042542890.127
response to peptideGO:19016522920.127
protein localization to membraneGO:0072657360.123
g protein coupled glutamate receptor signaling pathwayGO:000721680.119
macromolecular complex assemblyGO:00650032730.116
response to external biotic stimulusGO:00432072210.115
response to ketoneGO:19016541820.114
tooth eruptionGO:004469110.114
protein heterotrimerizationGO:007020820.113
cellular response to organic cyclic compoundGO:00714072020.113
lipid metabolic processGO:00066292830.113
developmental growthGO:00485891000.110
regenerationGO:00310991630.109
developmental growth involved in morphogenesisGO:0060560330.109
cellular response to fibroblast growth factor stimulusGO:0044344240.106
regulation of cellular component movementGO:00512701500.105
Human
positive regulation of signalingGO:00230562700.104
multi multicellular organism processGO:00447061380.103
cellular component movementGO:00069282480.103
Human
response to alkaloidGO:00432791320.103
peptide cross linkingGO:001814910.102
negative regulation of developmental processGO:00510931250.101
Human
cellular response to vitamin eGO:007130630.100
positive regulation of nitrogen compound metabolic processGO:00511733340.100
lens fiber cell differentiationGO:007030630.098
activation of phospholipase d activityGO:003158420.098
response to nutrient levelsGO:00316673700.097
negative regulation of neurogenesisGO:0050768780.093
bone developmentGO:0060348250.092
Mouse
positive regulation of stem cell differentiationGO:200073820.091
protein complex assemblyGO:00064612630.088
response to ionizing radiationGO:0010212590.087
cellular component assemblyGO:00226073600.087
epithelial cell differentiationGO:0030855710.085
positive regulation of multicellular organismal processGO:00512403870.085
Human
response to metal ionGO:00100382530.085
response to corticosteroidGO:00319602350.084
astrocyte developmentGO:001400240.083
cell motilityGO:00488702020.082
Human
protein oligomerizationGO:00512591910.081
cellular response to growth factor stimulusGO:00713631620.081
Mouse
reproductive processGO:00224143720.080
response to cytokineGO:00340972150.079
cellular response to endogenous stimulusGO:00714953770.078
growthGO:00400071650.078
cell adhesionGO:00071551100.074
neuron projection developmentGO:00311752730.072
positive regulation of developmental processGO:00510942830.072
membrane organizationGO:0061024940.072
regulation of nervous system developmentGO:00519602640.069
monovalent inorganic cation transportGO:00156721720.068
regulation of cellular protein metabolic processGO:00322682670.068
response to corticosteroneGO:0051412400.067
bone morphogenesisGO:0060349110.067
cellular response to thyroid hormone stimulusGO:009706750.066
brain developmentGO:00074202470.064
protein complex biogenesisGO:00702712630.064
cellular lipid metabolic processGO:00442552080.064
response to woundingGO:00096112540.061
regulation of cell developmentGO:00602842630.061
response to oxygen levelsGO:00704822650.061
female pregnancyGO:00075651220.061
embryonic skeletal system developmentGO:004870630.060
secretionGO:00469033070.059
positive regulation of cell proliferationGO:00082842490.059
cellular response to external stimulusGO:00714961180.059
regulation of cell differentiationGO:00455953200.058
odontogenesisGO:0042476320.058
secretion by cellGO:00329402480.058
positive regulation of cell differentiationGO:00455972170.057
response to transforming growth factor betaGO:0071559460.056
cellular component biogenesisGO:00440853680.055
response to nicotineGO:0035094510.054
organ morphogenesisGO:0009887750.054
Zebrafish
cellular protein localizationGO:00346131220.054
digestive system developmentGO:0055123410.054
positive regulation of cell developmentGO:00107201760.053
cellular macromolecule localizationGO:00707271220.052
response to morphineGO:0043278270.052
cellular amino acid metabolic processGO:00065201070.052
epithelium developmentGO:0060429960.052
Zebrafish
growth plate cartilage developmentGO:000341720.052
multicellular organism reproductionGO:00325042330.051
cellular amine metabolic processGO:0044106380.050
gastrulationGO:000736920.049
camp biosynthetic processGO:0006171470.049
schwann cell migrationGO:003613520.048
regulation of hormone levelsGO:00108171870.048
urogenital system developmentGO:0001655780.047
kidney developmentGO:0001822670.047
tissue regenerationGO:0042246360.047
synaptic transmissionGO:00072682350.047
cellular response to reactive oxygen speciesGO:0034614550.046
cellular response to epidermal growth factor stimulusGO:0071364120.045
forebrain developmentGO:0030900980.045
anatomical structure morphogenesisGO:00096532980.044
Human Zebrafish
regulation of cellular ketone metabolic processGO:0010565270.044
cellular response to extracellular stimulusGO:0031668730.044
cellular response to lipidGO:00713962010.044
central nervous system developmentGO:00074173110.043
single organism biosynthetic processGO:00447113420.043
response to acid chemicalGO:00011012220.043
cellular response to cytokine stimulusGO:00713451270.043
regulation of protein metabolic processGO:00512462890.042
cellular response to nutrientGO:0031670300.042
multi organism reproductive processGO:00447032620.042
muscle tissue developmentGO:0060537580.041
regulation of cell adhesionGO:0030155520.041
regulation of molecular functionGO:00650093980.041
positive regulation of cellular amino acid metabolic processGO:004576410.040
apoptotic processGO:00069153810.039
negative regulation of transportGO:00510511360.039
response to x rayGO:0010165150.039
glial cell differentiationGO:0010001650.039
muscle organ developmentGO:0007517500.039
reproductionGO:00000032450.039
membrane fusionGO:0061025260.039
reproductive system developmentGO:00614581280.039
regulation of secretionGO:00510462240.038
regulation of neurogenesisGO:00507672470.038
endochondral ossificationGO:000195820.038
ras protein signal transductionGO:0007265290.038
negative regulation of cell deathGO:00605482290.038
macromolecular complex subunit organizationGO:00439333390.037
macromolecule localizationGO:00330362520.037
maternal process involved in female pregnancyGO:0060135380.037
purine nucleotide biosynthetic processGO:0006164830.036
response to retinoic acidGO:0032526630.036
regulation of hydrolase activityGO:00513361430.036
single organism membrane organizationGO:0044802740.036
intracellular transportGO:00469071850.035
purine ribonucleotide biosynthetic processGO:0009152810.035
biological adhesionGO:00226101100.035
reproductive structure developmentGO:00486081280.034
amine metabolic processGO:0009308380.034
cell cell signalingGO:00072673350.034
cellular response to vitaminGO:0071295210.034
cation homeostasisGO:00550801950.033
positive regulation of cellular amine metabolic processGO:003324030.033
cell projection organizationGO:00300303020.033
positive regulation of protein metabolic processGO:00512471780.033
response to mineralocorticoidGO:0051385490.032
response to purine containing compoundGO:00140741260.032
developmental process involved in reproductionGO:00030061590.032
regulation of epithelial to mesenchymal transitionGO:001071720.032
regulation of programmed cell deathGO:00430673410.032
positive regulation of cell deathGO:00109421840.031
positive regulation of catalytic activityGO:00430851840.031
single organism intracellular transportGO:19025821660.031
protein targeting to plasma membraneGO:007266140.031
regulation of signal transductionGO:00099663180.031
programmed cell deathGO:00125013920.031
regulation of cellular amino acid metabolic processGO:000652120.030
protein complex subunit organizationGO:00718223020.030
regulation of intracellular signal transductionGO:19025312180.030
digestive tract developmentGO:0048565390.030
cellular chemical homeostasisGO:00550822470.030
gliogenesisGO:0042063930.029
positive regulation of cellular biosynthetic processGO:00313282950.029
multicellular organismal reproductive processGO:00486092330.029
cell part morphogenesisGO:00329901230.028
positive regulation of intracellular signal transductionGO:19025331380.028
response to campGO:0051591910.028
anatomical structure formation involved in morphogenesisGO:0048646830.028
Human Zebrafish
organelle organizationGO:00069962660.028
positive regulation of nucleobase containing compound metabolic processGO:00459353190.027
cellular catabolic processGO:00442482950.027
response to organophosphorusGO:00466831020.027
negative regulation of cell developmentGO:0010721820.027
regulation of embryonic developmentGO:004599520.027
negative regulation of cellular protein metabolic processGO:00322691060.027
positive regulation of response to stimulusGO:00485842850.027
glial cell developmentGO:0021782190.027
protein localizationGO:00081041910.027
positive regulation of cell communicationGO:00106472710.027
regulation of cell morphogenesisGO:0022604770.027
Human
regulation of phosphorus metabolic processGO:00511743490.026
regulation of secretion by cellGO:19035302080.026
dna strand renaturationGO:000073310.026
positive regulation of mapk cascadeGO:0043410920.026
cellular response to organonitrogen compoundGO:00714171970.026
cerebral cortex developmentGO:0021987180.026
negative regulation of cell proliferationGO:00082851190.026
Human
formation of primary germ layerGO:000170410.026
intermediate filament cytoskeleton organizationGO:004510430.026
regulation of catalytic activityGO:00507903040.026
regulation of schwann cell migrationGO:190014720.025
response to vitamin dGO:0033280340.025
response to hexoseGO:00097461440.025
regulation of apoptotic processGO:00429813350.025
dna metabolic processGO:0006259960.025
regulation of axonogenesisGO:0050770370.025
transcription from rna polymerase ii promoterGO:00063662520.025
intracellular signal transductionGO:00355563140.025
response to other organismGO:00517072200.024
neuron differentiationGO:00301823680.024
response to light stimulusGO:0009416520.024
positive regulation of molecular functionGO:00440932300.024
sodium ion transportGO:0006814820.024
ribonucleotide biosynthetic processGO:0009260850.024
tissue morphogenesisGO:0048729220.024
Zebrafish
negative regulation of neuron projection developmentGO:0010977460.024
cellular response to tumor necrosis factorGO:0071356460.023
positive regulation of lipid biosynthetic processGO:0046889250.023
aorta developmentGO:003590420.023
dna rewindingGO:003629210.023
monocarboxylic acid metabolic processGO:00327871520.023
single organism reproductive processGO:00447022970.023
response to interleukin 1GO:0070555550.023
regulation of small gtpase mediated signal transductionGO:0051056480.023
ribose phosphate biosynthetic processGO:0046390870.023
detection of visible lightGO:000958430.022
nitrogen compound transportGO:00717052290.022
positive regulation of cell morphogenesis involved in differentiationGO:0010770410.022
immune responseGO:00069551040.022
negative regulation of cell projection organizationGO:0031345500.022
peptide metabolic processGO:0006518320.022
localization of cellGO:00516742020.022
Human
response to mechanical stimulusGO:00096121340.021
organ regenerationGO:00311001010.021
blood vessel morphogenesisGO:0048514580.021
Human
positive regulation of gene expressionGO:00106282440.021
cellular response to fluorideGO:190261810.021
peptide transportGO:0015833970.021
response to tumor necrosis factorGO:0034612560.020
multicellular organism growthGO:003526410.020
bmp signaling pathwayGO:003050940.020
regulation of cell proliferationGO:00421273590.020
Human Mouse
regulation of neuron differentiationGO:00456642080.020
carbohydrate derivative metabolic processGO:19011353460.020
regulation of multicellular organismal developmentGO:20000263760.020
Human
regulation of cellular component organizationGO:00511283680.020
Human
positive regulation of signal transductionGO:00099671750.020
osteoblast differentiationGO:0001649260.020
response to thyroid hormoneGO:0097066170.020
negative regulation of neuron differentiationGO:0045665620.020
divalent inorganic cation homeostasisGO:00725071650.020
regulation of phosphate metabolic processGO:00192203490.020
response to decreased oxygen levelsGO:00362932370.019
negative regulation of response to external stimulusGO:0032102370.019
cellular hormone metabolic processGO:0034754490.019
cellular response to metal ionGO:0071248550.019
muscle structure developmentGO:0061061870.019
cellular response to corticosteroid stimulusGO:0071384690.019
signal releaseGO:00230611450.019
positive regulation of phosphorus metabolic processGO:00105622620.018
amide transportGO:00428861050.018
single organism organelle organizationGO:19025891800.018
organophosphate metabolic processGO:00196373700.018
negative regulation of molecular functionGO:00440921330.018
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.018
regulation of protein phosphorylationGO:00019321830.018
negative regulation of cellular component organizationGO:0051129830.018
regulation of proteolysisGO:0030162660.018
response to starvationGO:0042594590.018
organophosphate biosynthetic processGO:00904071430.018
unsaturated fatty acid biosynthetic processGO:0006636210.018
collagen catabolic processGO:003057420.018
locomotionGO:00400112370.018
Human
cellular response to glucocorticoid stimulusGO:0071385680.018
regulation of growthGO:00400081050.018
response to catecholamineGO:0071869160.018
male sex determinationGO:003023820.017
positive regulation of purine nucleotide biosynthetic processGO:1900373360.017
rna biosynthetic processGO:00327743800.017
intermediate filament based processGO:004510330.017
chemical homeostasisGO:00488782920.017
negative regulation of response to woundingGO:1903035230.017
regulation of synaptic transmissionGO:00508041410.017
positive regulation of lipid metabolic processGO:0045834330.017
hormone secretionGO:00468791150.017
glial cell proliferationGO:0014009170.017
renal system developmentGO:0072001670.017
positive regulation of cellular protein metabolic processGO:00322701670.017
response to increased oxygen levelsGO:0036296450.017
mapk cascadeGO:00001651400.017
negative regulation of gene expressionGO:00106291990.017
actin mediated cell contractionGO:0070252120.017
pallium developmentGO:0021543420.017
positive regulation of neuron projection developmentGO:0010976990.017
artery developmentGO:006084030.017
regulation of neuron projection developmentGO:00109751610.017
sulfur compound metabolic processGO:0006790700.016
adenosine receptor signaling pathwayGO:000197370.016
defense response to gram negative bacteriumGO:005082930.016
peptide secretionGO:0002790860.016
cellular response to peptideGO:19016531330.016
negative regulation of catalytic activityGO:00430861030.016
response to hyperoxiaGO:0055093450.016
ionotropic glutamate receptor signaling pathwayGO:0035235340.016
response to light intensityGO:000964290.016
axon extensionGO:0048675260.016
lens development in camera type eyeGO:0002088130.016
sensory perceptionGO:00076001010.016
multicellular organismal catabolic processGO:004424320.016
positive regulation of nervous system developmentGO:00519621780.016
positive regulation of phosphate metabolic processGO:00459372620.016
neuronal action potentialGO:0019228350.016
cellular response to mechanical stimulusGO:0071260480.016
ribose phosphate metabolic processGO:00196932350.015
salivary gland developmentGO:000743130.015
negative regulation of cellular metabolic processGO:00313242810.015
vasculature developmentGO:0001944700.015
Human
hormone transportGO:00099141210.015
icosanoid metabolic processGO:0006690380.015
negative regulation of cell communicationGO:00106481580.015
regulation of protein localizationGO:0032880810.015
neuron projection extensionGO:1990138260.015
negative regulation of wound healingGO:006104580.015
immune system processGO:00023762040.015
cellular response to stressGO:00335542690.015
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178270.015
cell activationGO:0001775970.015
sexual reproductionGO:00199531480.015
response to activityGO:0014823730.015
cell morphogenesis involved in differentiationGO:00009041190.015
positive regulation of protein phosphorylationGO:00019341350.015
ion homeostasisGO:00508012120.014
cellular component morphogenesisGO:00329891550.014
Human
striated muscle tissue developmentGO:0014706580.014
cellular response to nitrogen compoundGO:19016992100.014
ribonucleoside metabolic processGO:00091191740.014
positive regulation of macromolecule biosynthetic processGO:00105572470.014
response to amino acidGO:0043200750.014
ossificationGO:0001503700.014
glutamate receptor signaling pathwayGO:0007215430.014
response to vitaminGO:00332731310.014
response to glucoseGO:00097491360.014
positive regulation of dna metabolic processGO:0051054390.014
sensory organ developmentGO:0007423740.013
small gtpase mediated signal transductionGO:0007264360.013
regulation of transcription dna templatedGO:00063553740.013
visual perceptionGO:000760130.013
regulation of phosphorylationGO:00423252480.013
multicellular organismal metabolic processGO:0044236220.013
regulation of cell motilityGO:20001451310.013
Human
protein phosphorylationGO:00064683450.013
adenylate cyclase inhibiting g protein coupled receptor signaling pathwayGO:0007193190.013
nucleoside monophosphate metabolic processGO:0009123930.013
sperm motilityGO:003031750.013
regulation of transcription from rna polymerase ii promoterGO:00063572340.013
cellular response to peptide hormone stimulusGO:00713751200.013
response to transition metal nanoparticleGO:19902671220.013
regulation of sperm motilityGO:190131720.013
positive regulation of cellular component organizationGO:00511302000.013
rhythmic processGO:00485111560.013
regulation of developmental growthGO:0048638450.013
cartilage developmentGO:0051216220.013
Zebrafish
negative regulation of cell differentiationGO:0045596990.013
regulation of canonical wnt signaling pathwayGO:006082840.013
positive regulation of neuron differentiationGO:00456661260.013
positive regulation of apoptotic processGO:00430651540.013
negative regulation of rna biosynthetic processGO:19026791180.013
gamete generationGO:00072761240.013
regulation of lipid biosynthetic processGO:0046890380.013
negative regulation of apoptotic processGO:00430661810.013
heart morphogenesisGO:000300730.013
response to monoamineGO:0071867170.013
cortical actin cytoskeleton organizationGO:003086620.012
g protein coupled receptor signaling pathwayGO:00071862420.012
telencephalon developmentGO:0021537620.012
regulation of establishment of planar polarityGO:009017520.012
cellular response to nutrient levelsGO:0031669600.012
positive regulation of map kinase activityGO:0043406460.012
neuron developmentGO:00486662860.012
regulation of cell projection organizationGO:00313441750.012
positive regulation of cyclic nucleotide metabolic processGO:0030801370.012
chondrocyte differentiationGO:0002062100.012
establishment of protein localizationGO:00451841410.012
negative regulation of macromolecule metabolic processGO:00106052600.012
multicellular organismal macromolecule metabolic processGO:0044259210.012
positive regulation of prostaglandin biosynthetic processGO:003139450.012
transforming growth factor beta receptor signaling pathwayGO:0007179180.012
cell cycle processGO:0022402570.012
cellular response to acid chemicalGO:0071229750.012
positive regulation of neurogenesisGO:00507691650.012
organic substance catabolic processGO:19015753160.012
wnt signaling pathwayGO:0016055170.012
regulation of hormone secretionGO:00468831060.012
skeletal muscle organ developmentGO:0060538330.012
cellular response to oxygen containing compoundGO:19017013860.012
positive regulation of programmed cell deathGO:00430681570.012
regulation of nucleic acid templated transcriptionGO:19035063800.012
defense response to fungusGO:005083210.012
negative regulation of nervous system developmentGO:0051961790.011
regulation of protein modification processGO:00313991940.011
negative regulation of secretion by cellGO:1903531720.011
muscle organ morphogenesisGO:004864410.011
cytoplasmic transportGO:00164821150.011
regulation of nucleocytoplasmic transportGO:0046822280.011
sensory perception of bitter tasteGO:005091340.011
negative regulation of protein metabolic processGO:00512481140.011
negative regulation of endopeptidase activityGO:0010951360.011
dna duplex unwindingGO:003250830.011
regulation of transferase activityGO:00513381230.011
negative regulation of signalingGO:00230571570.011
negative regulation of cellular amide metabolic processGO:003424910.011
regulation of lipid metabolic processGO:0019216680.011
regulation of cell growthGO:0001558850.011
nucleoside metabolic processGO:00091161790.011
behaviorGO:00076102050.011
spermatogenesisGO:0007283990.011
negative regulation of nucleobase containing compound metabolic processGO:00459341530.011
positive regulation of cyclic nucleotide biosynthetic processGO:0030804340.011
neurological system processGO:00508772190.011
sensory perception of light stimulusGO:005095330.011
purine nucleoside monophosphate biosynthetic processGO:0009127200.011
endochondral bone growthGO:000341630.011
heterocycle catabolic processGO:00467001670.011
regulation of immune responseGO:0050776550.011
regulation of catabolic processGO:00098941130.010
positive regulation of epithelial to mesenchymal transitionGO:001071820.010
insulin secretionGO:0030073690.010
nucleoside phosphate metabolic processGO:00067532830.010
signal transduction by phosphorylationGO:00230141440.010
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.010
response to molecule of bacterial originGO:00022371940.010
morphogenesis of a polarized epitheliumGO:000173810.010
cellular amide metabolic processGO:0043603440.010
protein homooligomerizationGO:0051260910.010
nucleoside phosphate biosynthetic processGO:19012931020.010
regulation of response to woundingGO:1903034690.010
cyclic purine nucleotide metabolic processGO:0052652620.010
appendage morphogenesisGO:003510740.010
positive regulation of protein kinase activityGO:0045860730.010
positive regulation of lipid kinase activityGO:009021820.010

Sparc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.881
musculoskeletal system diseaseDOID:1700.881
connective tissue diseaseDOID:6500.547
ehlers danlos syndromeDOID:1335900.169
collagen diseaseDOID:85400.169
bone diseaseDOID:008000100.160
bone development diseaseDOID:008000600.128
osteogenesis imperfectaDOID:1234700.103
osteochondrodysplasiaDOID:225600.103
nervous system diseaseDOID:86300.028
sensory system diseaseDOID:005015500.028
eye and adnexa diseaseDOID:149200.028
eye diseaseDOID:561400.019
retinal diseaseDOID:567900.017
age related macular degenerationDOID:1087100.015
degeneration of macula and posterior poleDOID:200700.015
macular degenerationDOID:444800.015
retinal degenerationDOID:846600.015
blood protein diseaseDOID:62000.013
hematopoietic system diseaseDOID:7400.013
immune system diseaseDOID:291400.013
b cell deficiencyDOID:211500.013
agammaglobulinemiaDOID:258300.013
primary immunodeficiency diseaseDOID:61200.013