IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Otx2

orthodenticle homeobox 2

Entrez: 305858
Ensembl: ENSRNOG00000013406
RGD: 1305705
UniProtKB: F2Z3S7

Process Predictions
Disease Predictions

Otx2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organophosphate metabolic process	GO:0019637	370	0.210
regulation of phosphorus metabolic process	GO:0051174	349	0.080
cellular lipid metabolic process	GO:0044255	208	0.062
lipid metabolic process	GO:0006629	283	0.062
g protein coupled receptor signaling pathway	GO:0007186	242	0.058
purine nucleotide metabolic process	GO:0006163	229	0.057
regulation of molecular function	GO:0065009	398	0.050
carbohydrate derivative metabolic process	GO:1901135	346	0.049
transmembrane transport	GO:0055085	412	0.049
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.042	Fly
positive regulation of gene expression	GO:0010628	244	0.039	Human Mouse Worm Fly
single organism biosynthetic process	GO:0044711	342	0.038
neuron differentiation	GO:0030182	368	0.038	Human Mouse Worm Fly
negative regulation of transport	GO:0051051	136	0.038
regulation of catecholamine secretion	GO:0050433	32	0.038
catabolic process	GO:0009056	351	0.038
reproductive process	GO:0022414	372	0.037
head development	GO:0060322	247	0.037	Zebrafish Mouse Fly
nucleotide metabolic process	GO:0009117	279	0.036
rna biosynthetic process	GO:0032774	380	0.033	Human Mouse Worm Fly
nucleobase containing small molecule metabolic process	GO:0055086	316	0.032
ribose phosphate metabolic process	GO:0019693	235	0.032
rhythmic process	GO:0048511	156	0.032
intracellular signal transduction	GO:0035556	314	0.031
blood circulation	GO:0008015	183	0.030
purine containing compound metabolic process	GO:0072521	253	0.029
regulation of nucleic acid templated transcription	GO:1903506	380	0.029	Human Mouse Worm Fly
single organism catabolic process	GO:0044712	283	0.028
regulation of hormone levels	GO:0010817	187	0.028
organophosphate biosynthetic process	GO:0090407	143	0.027
central nervous system development	GO:0007417	311	0.027	Zebrafish Mouse Fly
cellular component biogenesis	GO:0044085	368	0.027	Human
regulation of rna biosynthetic process	GO:2001141	381	0.027	Human Mouse Worm Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.026	Human Mouse Worm Fly
developmental process involved in reproduction	GO:0003006	159	0.026
cellular amine metabolic process	GO:0044106	38	0.026
organic substance catabolic process	GO:1901575	316	0.026
carbohydrate derivative catabolic process	GO:1901136	147	0.026
negative regulation of rna metabolic process	GO:0051253	123	0.025	Fly
positive regulation of intracellular signal transduction	GO:1902533	138	0.025
regulation of sodium ion transmembrane transporter activity	GO:2000649	4	0.025
cellular ion homeostasis	GO:0006873	184	0.025
cellular calcium ion homeostasis	GO:0006874	160	0.025
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.025	Fly
neuron development	GO:0048666	286	0.025	Human Fly
organonitrogen compound biosynthetic process	GO:1901566	167	0.024
purine ribonucleotide metabolic process	GO:0009150	227	0.024
hormone transport	GO:0009914	121	0.024
cellular catabolic process	GO:0044248	295	0.024
single organism reproductive process	GO:0044702	297	0.023
tissue development	GO:0009888	252	0.023	Zebrafish Mouse Fly
multicellular organismal reproductive process	GO:0048609	233	0.023
glycerolipid metabolic process	GO:0046486	67	0.023
apoptotic process	GO:0006915	381	0.023
amine metabolic process	GO:0009308	38	0.023
organonitrogen compound catabolic process	GO:1901565	179	0.022
transcription from rna polymerase ii promoter	GO:0006366	252	0.022	Human Mouse Worm Fly
phototransduction visible light	GO:0007603	2	0.022
negative regulation of cellular metabolic process	GO:0031324	281	0.022	Fly
positive regulation of cell proliferation	GO:0008284	249	0.022
positive regulation of rna metabolic process	GO:0051254	203	0.022	Human Mouse Worm Fly
regulation of ion transmembrane transport	GO:0034765	121	0.021
inorganic ion transmembrane transport	GO:0098660	229	0.021
growth	GO:0040007	165	0.021
ribonucleotide metabolic process	GO:0009259	231	0.021
negative regulation of cellular biosynthetic process	GO:0031327	161	0.021	Fly
cellular response to oxygen containing compound	GO:1901701	386	0.021	Zebrafish
response to monosaccharide	GO:0034284	159	0.021
regulation of phosphorylation	GO:0042325	248	0.021
positive regulation of cell death	GO:0010942	184	0.021
organic hydroxy compound metabolic process	GO:1901615	115	0.021
regulation of phosphate metabolic process	GO:0019220	349	0.021
brain development	GO:0007420	247	0.020	Zebrafish Mouse Fly
inorganic cation transmembrane transport	GO:0098662	202	0.020
ribonucleotide biosynthetic process	GO:0009260	85	0.020
eye morphogenesis	GO:0048592	4	0.020	Mouse Fly
circulatory system process	GO:0003013	183	0.020
cellular homeostasis	GO:0019725	252	0.020
regulation of programmed cell death	GO:0043067	341	0.020
regulation of nucleotide metabolic process	GO:0006140	117	0.019
hormone secretion	GO:0046879	115	0.019
organ morphogenesis	GO:0009887	75	0.019	Mouse Fly
sex differentiation	GO:0007548	113	0.019
regulation of purine nucleotide metabolic process	GO:1900542	115	0.019
organophosphate catabolic process	GO:0046434	148	0.019
regulation of transporter activity	GO:0032409	50	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.019	Human Mouse Worm Fly
nucleoside phosphate metabolic process	GO:0006753	283	0.019
single organism carbohydrate metabolic process	GO:0044723	118	0.019
negative regulation of macromolecule metabolic process	GO:0010605	260	0.019	Fly
sodium ion transmembrane transport	GO:0035725	67	0.018
gland development	GO:0048732	155	0.018
regulation of intracellular signal transduction	GO:1902531	218	0.018
purine nucleotide catabolic process	GO:0006195	136	0.018
behavior	GO:0007610	205	0.018	Worm
cellular chemical homeostasis	GO:0055082	247	0.018
nucleobase containing compound catabolic process	GO:0034655	152	0.018
alcohol metabolic process	GO:0006066	77	0.018
camp metabolic process	GO:0046058	63	0.018
rna metabolic process	GO:0016070	406	0.018	Human Mouse Worm Fly
response to nutrient levels	GO:0031667	370	0.017
response to peptide	GO:1901652	292	0.017
axis specification	GO:0009798	4	0.017	Mouse
heterocycle catabolic process	GO:0046700	167	0.017
response to extracellular stimulus	GO:0009991	380	0.017
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.017	Fly
negative regulation of gene expression	GO:0010629	199	0.017	Fly
cellular ketone metabolic process	GO:0042180	51	0.017
male sex differentiation	GO:0046661	64	0.016
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.016	Fly
regulation of signal transduction	GO:0009966	318	0.016
positive regulation of molecular function	GO:0044093	230	0.016
cellular metal ion homeostasis	GO:0006875	172	0.016
response to metal ion	GO:0010038	253	0.016
organ formation	GO:0048645	3	0.016
response to ethanol	GO:0045471	162	0.016
development of primary sexual characteristics	GO:0045137	107	0.016
purine ribonucleotide biosynthetic process	GO:0009152	81	0.016
cellular response to organonitrogen compound	GO:0071417	197	0.016
carbohydrate derivative biosynthetic process	GO:1901137	124	0.016
reproductive system development	GO:0061458	128	0.016
response to radiation	GO:0009314	137	0.016
positive regulation of rna biosynthetic process	GO:1902680	197	0.016	Human Mouse Worm Fly
organelle organization	GO:0006996	266	0.016	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.016	Human Mouse Worm Fly
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.016
regulation of cyclic nucleotide biosynthetic process	GO:0030802	45	0.016
purine ribonucleoside metabolic process	GO:0046128	168	0.016
negative regulation of transcription dna templated	GO:0045892	116	0.016	Fly
cellular response to peptide hormone stimulus	GO:0071375	120	0.016
purine ribonucleotide catabolic process	GO:0009154	136	0.016
regulation of rna metabolic process	GO:0051252	391	0.015	Human Mouse Worm Fly
positive regulation of cellular amine metabolic process	GO:0033240	3	0.015
secretion by cell	GO:0032940	248	0.015
positive regulation of phosphate metabolic process	GO:0045937	262	0.015
reproductive structure development	GO:0048608	128	0.015
gonad development	GO:0008406	104	0.015
phospholipid metabolic process	GO:0006644	61	0.015
response to ketone	GO:1901654	182	0.015
metal ion transport	GO:0030001	289	0.015
oxidation reduction process	GO:0055114	304	0.015
macromolecular complex subunit organization	GO:0043933	339	0.015	Human
purine containing compound biosynthetic process	GO:0072522	85	0.015
regulation of peptide transport	GO:0090087	87	0.015
organic hydroxy compound biosynthetic process	GO:1901617	51	0.015
regulation of erk1 and erk2 cascade	GO:0070372	41	0.015
calcium ion transmembrane transport	GO:0070588	70	0.015
forebrain development	GO:0030900	98	0.015	Mouse
carboxylic acid metabolic process	GO:0019752	289	0.015
chemical homeostasis	GO:0048878	292	0.014
response to camp	GO:0051591	91	0.014
nucleoside phosphate catabolic process	GO:1901292	140	0.014
negative regulation of metabolic process	GO:0009892	331	0.014	Fly
regulation of secretion	GO:0051046	224	0.014
regulation of cellular amino acid metabolic process	GO:0006521	2	0.014
single organism behavior	GO:0044708	130	0.014	Worm
regulation of cellular ketone metabolic process	GO:0010565	27	0.014
cellular carbohydrate metabolic process	GO:0044262	72	0.014
heart morphogenesis	GO:0003007	3	0.014
regulation of metal ion transport	GO:0010959	118	0.014
retina morphogenesis in camera type eye	GO:0060042	1	0.014
multi organism reproductive process	GO:0044703	262	0.014
nucleoside phosphate biosynthetic process	GO:1901293	102	0.014
positive regulation of cell communication	GO:0010647	271	0.014
ribonucleoside metabolic process	GO:0009119	174	0.014
negative regulation of molecular function	GO:0044092	133	0.014
cation transmembrane transport	GO:0098655	263	0.014
positive regulation of cellular biosynthetic process	GO:0031328	295	0.014	Human Mouse Worm Fly
cytosolic calcium ion homeostasis	GO:0051480	140	0.014
protein complex subunit organization	GO:0071822	302	0.014	Human
cellular response to hormone stimulus	GO:0032870	247	0.014
nucleic acid templated transcription	GO:0097659	379	0.013	Human Mouse Worm Fly
ovulation cycle process	GO:0022602	50	0.013
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.013	Fly
cellular nitrogen compound catabolic process	GO:0044270	163	0.013
guanosine containing compound metabolic process	GO:1901068	74	0.013
response to glucocorticoid	GO:0051384	223	0.013
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.013	Fly
regulation of transcription dna templated	GO:0006355	374	0.013	Human Mouse Worm Fly
purine containing compound catabolic process	GO:0072523	138	0.013
sodium ion transport	GO:0006814	82	0.013
negative regulation of biosynthetic process	GO:0009890	168	0.013	Fly
embryonic appendage morphogenesis	GO:0035113	4	0.013
nucleoside metabolic process	GO:0009116	179	0.013
positive regulation of phosphorus metabolic process	GO:0010562	262	0.013
regulation of multicellular organismal development	GO:2000026	376	0.013	Mouse Fly
monovalent inorganic cation transport	GO:0015672	172	0.013
oxoacid metabolic process	GO:0043436	290	0.012
embryonic limb morphogenesis	GO:0030326	4	0.012
regulation of cellular amine metabolic process	GO:0033238	8	0.012
calcium ion homeostasis	GO:0055074	162	0.012
regulation of secretion by cell	GO:1903530	208	0.012
positive regulation of nucleotide metabolic process	GO:0045981	91	0.012
sensory organ development	GO:0007423	74	0.012	Zebrafish Mouse Fly
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.012
cyclic nucleotide metabolic process	GO:0009187	80	0.012
cellular response to lipid	GO:0071396	201	0.012
aromatic compound catabolic process	GO:0019439	168	0.012
vesicle mediated transport	GO:0016192	181	0.012
sensory perception	GO:0007600	101	0.012	Worm
cation transport	GO:0006812	382	0.012
camp biosynthetic process	GO:0006171	47	0.012
regeneration	GO:0031099	163	0.012
positive regulation of apoptotic process	GO:0043065	154	0.012
response to wounding	GO:0009611	254	0.012
adult locomotory behavior	GO:0008344	4	0.012
developmental growth	GO:0048589	100	0.012
cyclic nucleotide biosynthetic process	GO:0009190	63	0.012
regulation of protein metabolic process	GO:0051246	289	0.012
organic acid metabolic process	GO:0006082	292	0.012
sequestering of metal ion	GO:0051238	9	0.012
peptide transport	GO:0015833	97	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
regulation of vesicle mediated transport	GO:0060627	81	0.011
regulation of apoptotic process	GO:0042981	335	0.011
regulation of peptide secretion	GO:0002791	82	0.011
limb morphogenesis	GO:0035108	4	0.011
nucleotide catabolic process	GO:0009166	139	0.011
regulation of neuron death	GO:1901214	115	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.011	Human Mouse Worm Fly
cell cell signaling	GO:0007267	335	0.011
response to reactive oxygen species	GO:0000302	120	0.011
hormone metabolic process	GO:0042445	69	0.011
positive regulation of protein metabolic process	GO:0051247	178	0.011
regulation of protein phosphorylation	GO:0001932	183	0.011
response to organophosphorus	GO:0046683	102	0.011
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	27	0.011
peptide hormone secretion	GO:0030072	84	0.011
gliogenesis	GO:0042063	93	0.011
endocrine system development	GO:0035270	30	0.011
reproduction	GO:0000003	245	0.011
embryonic axis specification	GO:0000578	1	0.011	Mouse
intracellular transport	GO:0046907	185	0.011
positive regulation of catalytic activity	GO:0043085	184	0.011
cellular component movement	GO:0006928	248	0.011	Human
purine nucleoside metabolic process	GO:0042278	169	0.011
amide transport	GO:0042886	105	0.011
ribonucleoside catabolic process	GO:0042454	126	0.011
positive regulation of biosynthetic process	GO:0009891	319	0.011	Human Mouse Worm Fly
cell migration	GO:0016477	197	0.011
response to purine containing compound	GO:0014074	126	0.011
neuromuscular process	GO:0050905	2	0.011
regulation of insulin secretion	GO:0050796	65	0.011
negative regulation of secretion	GO:0051048	82	0.011
programmed cell death	GO:0012501	392	0.011
regulation of neurogenesis	GO:0050767	247	0.010	Fly
response to peptide hormone	GO:0043434	278	0.010
negative regulation of signaling	GO:0023057	157	0.010
regulation of cell differentiation	GO:0045595	320	0.010	Fly
response to light stimulus	GO:0009416	52	0.010
neural crest cell development	GO:0014032	2	0.010
gastrulation	GO:0007369	2	0.010	Mouse
heart development	GO:0007507	72	0.010
gtp metabolic process	GO:0046039	72	0.010
sequestering of calcium ion	GO:0051208	8	0.010
carbohydrate metabolic process	GO:0005975	130	0.010
cellular response to nitrogen compound	GO:1901699	210	0.010
cell fate determination	GO:0001709	2	0.010	Mouse
small gtpase mediated signal transduction	GO:0007264	36	0.010
nucleotide biosynthetic process	GO:0009165	98	0.010
development of primary female sexual characteristics	GO:0046545	56	0.010
regulation of gtp catabolic process	GO:0033124	58	0.010
regulation of protein modification process	GO:0031399	194	0.010
gtp catabolic process	GO:0006184	71	0.010
regulation of cell development	GO:0060284	263	0.010	Fly

Otx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
eye disease	DOID:5614	0.079	Human
nervous system disease	DOID:863	0.079	Human
eye and adnexa disease	DOID:1492	0.079	Human
disease of anatomical entity	DOID:7	0.079	Human
sensory system disease	DOID:0050155	0.079	Human
retinal disease	DOID:5679	0.079
retinal degeneration	DOID:8466	0.069
retinitis pigmentosa	DOID:10584	0.046
disease of metabolism	DOID:0014667	0.017
cone rod dystrophy	DOID:0050572	0.015
central nervous system disease	DOID:331	0.012

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