Rattus norvegicus

0 known processes

Otx2

orthodenticle homeobox 2

Otx2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organophosphate metabolic processGO:00196373700.210
regulation of phosphorus metabolic processGO:00511743490.080
cellular lipid metabolic processGO:00442552080.062
lipid metabolic processGO:00066292830.062
g protein coupled receptor signaling pathwayGO:00071862420.058
purine nucleotide metabolic processGO:00061632290.057
regulation of molecular functionGO:00650093980.050
carbohydrate derivative metabolic processGO:19011353460.049
transmembrane transportGO:00550854120.049
negative regulation of nitrogen compound metabolic processGO:00511721610.042
Fly
positive regulation of gene expressionGO:00106282440.039
Human Mouse Worm Fly
single organism biosynthetic processGO:00447113420.038
neuron differentiationGO:00301823680.038
Human Mouse Worm Fly
negative regulation of transportGO:00510511360.038
regulation of catecholamine secretionGO:0050433320.038
catabolic processGO:00090563510.038
reproductive processGO:00224143720.037
head developmentGO:00603222470.037
Zebrafish Mouse Fly
nucleotide metabolic processGO:00091172790.036
rna biosynthetic processGO:00327743800.033
Human Mouse Worm Fly
nucleobase containing small molecule metabolic processGO:00550863160.032
ribose phosphate metabolic processGO:00196932350.032
rhythmic processGO:00485111560.032
intracellular signal transductionGO:00355563140.031
blood circulationGO:00080151830.030
purine containing compound metabolic processGO:00725212530.029
regulation of nucleic acid templated transcriptionGO:19035063800.029
Human Mouse Worm Fly
single organism catabolic processGO:00447122830.028
regulation of hormone levelsGO:00108171870.028
organophosphate biosynthetic processGO:00904071430.027
central nervous system developmentGO:00074173110.027
Zebrafish Mouse Fly
cellular component biogenesisGO:00440853680.027
Human
regulation of rna biosynthetic processGO:20011413810.027
Human Mouse Worm Fly
regulation of transcription from rna polymerase ii promoterGO:00063572340.026
Human Mouse Worm Fly
developmental process involved in reproductionGO:00030061590.026
cellular amine metabolic processGO:0044106380.026
organic substance catabolic processGO:19015753160.026
carbohydrate derivative catabolic processGO:19011361470.026
negative regulation of rna metabolic processGO:00512531230.025
Fly
positive regulation of intracellular signal transductionGO:19025331380.025
regulation of sodium ion transmembrane transporter activityGO:200064940.025
cellular ion homeostasisGO:00068731840.025
cellular calcium ion homeostasisGO:00068741600.025
negative regulation of nucleobase containing compound metabolic processGO:00459341530.025
Fly
neuron developmentGO:00486662860.025
Human Fly
organonitrogen compound biosynthetic processGO:19015661670.024
purine ribonucleotide metabolic processGO:00091502270.024
hormone transportGO:00099141210.024
cellular catabolic processGO:00442482950.024
single organism reproductive processGO:00447022970.023
tissue developmentGO:00098882520.023
Zebrafish Mouse Fly
multicellular organismal reproductive processGO:00486092330.023
glycerolipid metabolic processGO:0046486670.023
apoptotic processGO:00069153810.023
amine metabolic processGO:0009308380.023
organonitrogen compound catabolic processGO:19015651790.022
transcription from rna polymerase ii promoterGO:00063662520.022
Human Mouse Worm Fly
phototransduction visible lightGO:000760320.022
negative regulation of cellular metabolic processGO:00313242810.022
Fly
positive regulation of cell proliferationGO:00082842490.022
positive regulation of rna metabolic processGO:00512542030.022
Human Mouse Worm Fly
regulation of ion transmembrane transportGO:00347651210.021
inorganic ion transmembrane transportGO:00986602290.021
growthGO:00400071650.021
ribonucleotide metabolic processGO:00092592310.021
negative regulation of cellular biosynthetic processGO:00313271610.021
Fly
cellular response to oxygen containing compoundGO:19017013860.021
Zebrafish
response to monosaccharideGO:00342841590.021
regulation of phosphorylationGO:00423252480.021
positive regulation of cell deathGO:00109421840.021
organic hydroxy compound metabolic processGO:19016151150.021
regulation of phosphate metabolic processGO:00192203490.021
brain developmentGO:00074202470.020
Zebrafish Mouse Fly
inorganic cation transmembrane transportGO:00986622020.020
ribonucleotide biosynthetic processGO:0009260850.020
eye morphogenesisGO:004859240.020
Mouse Fly
circulatory system processGO:00030131830.020
cellular homeostasisGO:00197252520.020
regulation of programmed cell deathGO:00430673410.020
regulation of nucleotide metabolic processGO:00061401170.019
hormone secretionGO:00468791150.019
organ morphogenesisGO:0009887750.019
Mouse Fly
sex differentiationGO:00075481130.019
regulation of purine nucleotide metabolic processGO:19005421150.019
organophosphate catabolic processGO:00464341480.019
regulation of transporter activityGO:0032409500.019
positive regulation of nucleobase containing compound metabolic processGO:00459353190.019
Human Mouse Worm Fly
nucleoside phosphate metabolic processGO:00067532830.019
single organism carbohydrate metabolic processGO:00447231180.019
negative regulation of macromolecule metabolic processGO:00106052600.019
Fly
sodium ion transmembrane transportGO:0035725670.018
gland developmentGO:00487321550.018
regulation of intracellular signal transductionGO:19025312180.018
purine nucleotide catabolic processGO:00061951360.018
behaviorGO:00076102050.018
Worm
cellular chemical homeostasisGO:00550822470.018
nucleobase containing compound catabolic processGO:00346551520.018
alcohol metabolic processGO:0006066770.018
camp metabolic processGO:0046058630.018
rna metabolic processGO:00160704060.018
Human Mouse Worm Fly
response to nutrient levelsGO:00316673700.017
response to peptideGO:19016522920.017
axis specificationGO:000979840.017
Mouse
heterocycle catabolic processGO:00467001670.017
response to extracellular stimulusGO:00099913800.017
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.017
Fly
negative regulation of gene expressionGO:00106291990.017
Fly
cellular ketone metabolic processGO:0042180510.017
male sex differentiationGO:0046661640.016
negative regulation of macromolecule biosynthetic processGO:00105581480.016
Fly
regulation of signal transductionGO:00099663180.016
positive regulation of molecular functionGO:00440932300.016
cellular metal ion homeostasisGO:00068751720.016
response to metal ionGO:00100382530.016
organ formationGO:004864530.016
response to ethanolGO:00454711620.016
development of primary sexual characteristicsGO:00451371070.016
purine ribonucleotide biosynthetic processGO:0009152810.016
cellular response to organonitrogen compoundGO:00714171970.016
carbohydrate derivative biosynthetic processGO:19011371240.016
reproductive system developmentGO:00614581280.016
response to radiationGO:00093141370.016
positive regulation of rna biosynthetic processGO:19026801970.016
Human Mouse Worm Fly
organelle organizationGO:00069962660.016
Fly
positive regulation of nitrogen compound metabolic processGO:00511733340.016
Human Mouse Worm Fly
ribonucleoside triphosphate metabolic processGO:00091991410.016
regulation of cyclic nucleotide biosynthetic processGO:0030802450.016
purine ribonucleoside metabolic processGO:00461281680.016
negative regulation of transcription dna templatedGO:00458921160.016
Fly
cellular response to peptide hormone stimulusGO:00713751200.016
purine ribonucleotide catabolic processGO:00091541360.016
regulation of rna metabolic processGO:00512523910.015
Human Mouse Worm Fly
positive regulation of cellular amine metabolic processGO:003324030.015
secretion by cellGO:00329402480.015
positive regulation of phosphate metabolic processGO:00459372620.015
reproductive structure developmentGO:00486081280.015
gonad developmentGO:00084061040.015
phospholipid metabolic processGO:0006644610.015
response to ketoneGO:19016541820.015
metal ion transportGO:00300012890.015
oxidation reduction processGO:00551143040.015
macromolecular complex subunit organizationGO:00439333390.015
Human
purine containing compound biosynthetic processGO:0072522850.015
regulation of peptide transportGO:0090087870.015
organic hydroxy compound biosynthetic processGO:1901617510.015
regulation of erk1 and erk2 cascadeGO:0070372410.015
calcium ion transmembrane transportGO:0070588700.015
forebrain developmentGO:0030900980.015
Mouse
carboxylic acid metabolic processGO:00197522890.015
chemical homeostasisGO:00488782920.014
response to campGO:0051591910.014
nucleoside phosphate catabolic processGO:19012921400.014
negative regulation of metabolic processGO:00098923310.014
Fly
regulation of secretionGO:00510462240.014
regulation of cellular amino acid metabolic processGO:000652120.014
single organism behaviorGO:00447081300.014
Worm
regulation of cellular ketone metabolic processGO:0010565270.014
cellular carbohydrate metabolic processGO:0044262720.014
heart morphogenesisGO:000300730.014
regulation of metal ion transportGO:00109591180.014
retina morphogenesis in camera type eyeGO:006004210.014
multi organism reproductive processGO:00447032620.014
nucleoside phosphate biosynthetic processGO:19012931020.014
positive regulation of cell communicationGO:00106472710.014
ribonucleoside metabolic processGO:00091191740.014
negative regulation of molecular functionGO:00440921330.014
cation transmembrane transportGO:00986552630.014
positive regulation of cellular biosynthetic processGO:00313282950.014
Human Mouse Worm Fly
cytosolic calcium ion homeostasisGO:00514801400.014
protein complex subunit organizationGO:00718223020.014
Human
cellular response to hormone stimulusGO:00328702470.014
nucleic acid templated transcriptionGO:00976593790.013
Human Mouse Worm Fly
ovulation cycle processGO:0022602500.013
negative regulation of nucleic acid templated transcriptionGO:19035071170.013
Fly
cellular nitrogen compound catabolic processGO:00442701630.013
guanosine containing compound metabolic processGO:1901068740.013
response to glucocorticoidGO:00513842230.013
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.013
Fly
regulation of transcription dna templatedGO:00063553740.013
Human Mouse Worm Fly
purine containing compound catabolic processGO:00725231380.013
sodium ion transportGO:0006814820.013
negative regulation of biosynthetic processGO:00098901680.013
Fly
embryonic appendage morphogenesisGO:003511340.013
nucleoside metabolic processGO:00091161790.013
positive regulation of phosphorus metabolic processGO:00105622620.013
regulation of multicellular organismal developmentGO:20000263760.013
Mouse Fly
monovalent inorganic cation transportGO:00156721720.013
oxoacid metabolic processGO:00434362900.012
embryonic limb morphogenesisGO:003032640.012
regulation of cellular amine metabolic processGO:003323880.012
calcium ion homeostasisGO:00550741620.012
regulation of secretion by cellGO:19035302080.012
positive regulation of nucleotide metabolic processGO:0045981910.012
sensory organ developmentGO:0007423740.012
Zebrafish Mouse Fly
cell cell signaling involved in cell fate commitmentGO:004516820.012
cyclic nucleotide metabolic processGO:0009187800.012
cellular response to lipidGO:00713962010.012
aromatic compound catabolic processGO:00194391680.012
vesicle mediated transportGO:00161921810.012
sensory perceptionGO:00076001010.012
Worm
cation transportGO:00068123820.012
camp biosynthetic processGO:0006171470.012
regenerationGO:00310991630.012
positive regulation of apoptotic processGO:00430651540.012
response to woundingGO:00096112540.012
adult locomotory behaviorGO:000834440.012
developmental growthGO:00485891000.012
cyclic nucleotide biosynthetic processGO:0009190630.012
regulation of protein metabolic processGO:00512462890.012
organic acid metabolic processGO:00060822920.012
sequestering of metal ionGO:005123890.012
peptide transportGO:0015833970.011
camera type eye morphogenesisGO:004859320.011
regulation of vesicle mediated transportGO:0060627810.011
regulation of apoptotic processGO:00429813350.011
regulation of peptide secretionGO:0002791820.011
limb morphogenesisGO:003510840.011
nucleotide catabolic processGO:00091661390.011
regulation of neuron deathGO:19012141150.011
positive regulation of macromolecule biosynthetic processGO:00105572470.011
Human Mouse Worm Fly
cell cell signalingGO:00072673350.011
response to reactive oxygen speciesGO:00003021200.011
hormone metabolic processGO:0042445690.011
positive regulation of protein metabolic processGO:00512471780.011
regulation of protein phosphorylationGO:00019321830.011
response to organophosphorusGO:00466831020.011
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200270.011
peptide hormone secretionGO:0030072840.011
gliogenesisGO:0042063930.011
endocrine system developmentGO:0035270300.011
reproductionGO:00000032450.011
embryonic axis specificationGO:000057810.011
Mouse
intracellular transportGO:00469071850.011
positive regulation of catalytic activityGO:00430851840.011
cellular component movementGO:00069282480.011
Human
purine nucleoside metabolic processGO:00422781690.011
amide transportGO:00428861050.011
ribonucleoside catabolic processGO:00424541260.011
positive regulation of biosynthetic processGO:00098913190.011
Human Mouse Worm Fly
cell migrationGO:00164771970.011
response to purine containing compoundGO:00140741260.011
neuromuscular processGO:005090520.011
regulation of insulin secretionGO:0050796650.011
negative regulation of secretionGO:0051048820.011
programmed cell deathGO:00125013920.011
regulation of neurogenesisGO:00507672470.010
Fly
response to peptide hormoneGO:00434342780.010
negative regulation of signalingGO:00230571570.010
regulation of cell differentiationGO:00455953200.010
Fly
response to light stimulusGO:0009416520.010
neural crest cell developmentGO:001403220.010
gastrulationGO:000736920.010
Mouse
heart developmentGO:0007507720.010
gtp metabolic processGO:0046039720.010
sequestering of calcium ionGO:005120880.010
carbohydrate metabolic processGO:00059751300.010
cellular response to nitrogen compoundGO:19016992100.010
cell fate determinationGO:000170920.010
Mouse
small gtpase mediated signal transductionGO:0007264360.010
nucleotide biosynthetic processGO:0009165980.010
development of primary female sexual characteristicsGO:0046545560.010
regulation of gtp catabolic processGO:0033124580.010
regulation of protein modification processGO:00313991940.010
gtp catabolic processGO:0006184710.010
regulation of cell developmentGO:00602842630.010
Fly

Otx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
eye diseaseDOID:561400.079
Human
nervous system diseaseDOID:86300.079
Human
eye and adnexa diseaseDOID:149200.079
Human
disease of anatomical entityDOID:700.079
Human
sensory system diseaseDOID:005015500.079
Human
retinal diseaseDOID:567900.079
retinal degenerationDOID:846600.069
retinitis pigmentosaDOID:1058400.046
disease of metabolismDOID:001466700.017
cone rod dystrophyDOID:005057200.015
central nervous system diseaseDOID:33100.012