IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Slc44a4

solute carrier family 44, member 4

(Aliases: Ng22)

RGD: 1303167
Entrez: 294255
Ensembl: ENSRNOG00000000878
UniProtKB: Q6MG71

Process Predictions
Disease Predictions

Slc44a4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
sodium ion transport	GO:0006814	82	0.209
sodium ion transmembrane transport	GO:0035725	67	0.112
nucleic acid templated transcription	GO:0097659	379	0.107
organic acid metabolic process	GO:0006082	292	0.092
vesicle mediated transport	GO:0016192	181	0.088
response to metal ion	GO:0010038	253	0.086
response to inorganic substance	GO:0010035	377	0.078
organelle assembly	GO:0070925	22	0.073
rna biosynthetic process	GO:0032774	380	0.069
carboxylic acid metabolic process	GO:0019752	289	0.066
response to peptide hormone	GO:0043434	278	0.065
catabolic process	GO:0009056	351	0.062
neuron development	GO:0048666	286	0.058
cellular component assembly	GO:0022607	360	0.058
reproductive process	GO:0022414	372	0.057
regulation of rna biosynthetic process	GO:2001141	381	0.057
oxoacid metabolic process	GO:0043436	290	0.056
cellular component biogenesis	GO:0044085	368	0.054
endocytosis	GO:0006897	84	0.052
nucleobase containing small molecule metabolic process	GO:0055086	316	0.049
response to camp	GO:0051591	91	0.046
cellular amino acid metabolic process	GO:0006520	107	0.046
organelle organization	GO:0006996	266	0.044
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.043
response to cytokine	GO:0034097	215	0.043
cellular response to oxygen containing compound	GO:1901701	386	0.042
regulation of transcription dna templated	GO:0006355	374	0.041
female pregnancy	GO:0007565	122	0.041
cation transport	GO:0006812	382	0.040	Human
regulation of cellular component organization	GO:0051128	368	0.040	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.040
transcription dna templated	GO:0006351	377	0.039
multi organism reproductive process	GO:0044703	262	0.039
anatomical structure morphogenesis	GO:0009653	298	0.038
transmembrane transport	GO:0055085	412	0.037
gland development	GO:0048732	155	0.036
regulation of rna metabolic process	GO:0051252	391	0.036
response to hexose	GO:0009746	144	0.036
carboxylic acid biosynthetic process	GO:0046394	83	0.035
single organism organelle organization	GO:1902589	180	0.034
negative regulation of transcription dna templated	GO:0045892	116	0.034
response to molecule of fungal origin	GO:0002238	3	0.034
response to biotic stimulus	GO:0009607	226	0.034
positive regulation of transcription dna templated	GO:0045893	197	0.034
macromolecular complex assembly	GO:0065003	273	0.033
cellular response to oxidative stress	GO:0034599	76	0.032
single organism catabolic process	GO:0044712	283	0.032
response to mineralocorticoid	GO:0051385	49	0.031
positive regulation of hepatocyte differentiation	GO:0070368	2	0.031
small molecule biosynthetic process	GO:0044283	124	0.031
negative regulation of cell proliferation	GO:0008285	119	0.031
carbohydrate derivative metabolic process	GO:1901135	346	0.031
response to nutrient	GO:0007584	248	0.031
carbohydrate derivative catabolic process	GO:1901136	147	0.031
metal ion transport	GO:0030001	289	0.030
lipid metabolic process	GO:0006629	283	0.030
cell projection organization	GO:0030030	302	0.030
programmed cell death	GO:0012501	392	0.029
regulation of nucleic acid templated transcription	GO:1903506	380	0.029
monovalent inorganic cation transport	GO:0015672	172	0.028
response to wounding	GO:0009611	254	0.028
aging	GO:0007568	241	0.028
response to glucocorticoid	GO:0051384	223	0.028
vitamin transport	GO:0051180	14	0.028
positive regulation of biosynthetic process	GO:0009891	319	0.027
response to oxidative stress	GO:0006979	186	0.027
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.027
response to estradiol	GO:0032355	164	0.027
response to extracellular stimulus	GO:0009991	380	0.026
cellular response to stress	GO:0033554	269	0.026
organic acid biosynthetic process	GO:0016053	83	0.026
response to peptide	GO:1901652	292	0.026
positive regulation of multicellular organismal process	GO:0051240	387	0.026
response to toxic substance	GO:0009636	133	0.026
regulation of programmed cell death	GO:0043067	341	0.026
organic cyclic compound catabolic process	GO:1901361	175	0.025
cytoskeleton organization	GO:0007010	111	0.025
response to tumor necrosis factor	GO:0034612	56	0.025
response to corticosteroid	GO:0031960	235	0.025
regulation of system process	GO:0044057	208	0.025
cellular response to hormone stimulus	GO:0032870	247	0.024
establishment of protein localization	GO:0045184	141	0.024
regulation of cellular amino acid metabolic process	GO:0006521	2	0.024
transcription from rna polymerase ii promoter	GO:0006366	252	0.024
nucleoside metabolic process	GO:0009116	179	0.024
cellular amine metabolic process	GO:0044106	38	0.024
regeneration	GO:0031099	163	0.024
multi multicellular organism process	GO:0044706	138	0.024
response to retinoic acid	GO:0032526	63	0.024
response to decreased oxygen levels	GO:0036293	237	0.023
organonitrogen compound catabolic process	GO:1901565	179	0.023
transmission of nerve impulse	GO:0019226	42	0.023
regulation of cellular ketone metabolic process	GO:0010565	27	0.023
negative regulation of multicellular organismal process	GO:0051241	203	0.022
regulation of body fluid levels	GO:0050878	90	0.022
positive regulation of cellular biosynthetic process	GO:0031328	295	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.022
ribose phosphate metabolic process	GO:0019693	235	0.022
response to monosaccharide	GO:0034284	159	0.022
purine containing compound metabolic process	GO:0072521	253	0.022
organophosphate metabolic process	GO:0019637	370	0.022
positive regulation of rna biosynthetic process	GO:1902680	197	0.021
amine metabolic process	GO:0009308	38	0.021
sexual reproduction	GO:0019953	148	0.021
protein localization	GO:0008104	191	0.021
response to bacterium	GO:0009617	200	0.021
regulation of phosphorus metabolic process	GO:0051174	349	0.021
apoptotic process	GO:0006915	381	0.021
reproductive structure development	GO:0048608	128	0.020
neuronal action potential	GO:0019228	35	0.020
membrane organization	GO:0061024	94	0.020
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.020
ribonucleoside metabolic process	GO:0009119	174	0.020
negative regulation of protein metabolic process	GO:0051248	114	0.020
myelination	GO:0042552	39	0.020
negative regulation of cell development	GO:0010721	82	0.020
purine nucleotide catabolic process	GO:0006195	136	0.020
negative regulation of rna metabolic process	GO:0051253	123	0.020
cofactor metabolic process	GO:0051186	95	0.020
coenzyme metabolic process	GO:0006732	86	0.020
protein oligomerization	GO:0051259	191	0.019
nucleobase containing compound catabolic process	GO:0034655	152	0.019
positive regulation of cell communication	GO:0010647	271	0.019
nucleotide catabolic process	GO:0009166	139	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.019
cellular catabolic process	GO:0044248	295	0.019
cell morphogenesis	GO:0000902	142	0.019
rna metabolic process	GO:0016070	406	0.019
response to nutrient levels	GO:0031667	370	0.019
response to ketone	GO:1901654	182	0.019
nucleoside triphosphate catabolic process	GO:0009143	123	0.019
nucleoside phosphate metabolic process	GO:0006753	283	0.019
gamete generation	GO:0007276	124	0.019
tumor necrosis factor mediated signaling pathway	GO:0033209	4	0.018
nucleoside phosphate catabolic process	GO:1901292	140	0.018
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.018
negative regulation of cellular metabolic process	GO:0031324	281	0.018
monocarboxylic acid metabolic process	GO:0032787	152	0.018
macromolecular complex subunit organization	GO:0043933	339	0.018
response to organophosphorus	GO:0046683	102	0.018
response to hydrogen peroxide	GO:0042542	89	0.018
reactive oxygen species metabolic process	GO:0072593	37	0.018
ensheathment of neurons	GO:0007272	40	0.018
negative regulation of macromolecule metabolic process	GO:0010605	260	0.018
purine ribonucleoside metabolic process	GO:0046128	168	0.017
response to calcium ion	GO:0051592	59	0.017
purine containing compound catabolic process	GO:0072523	138	0.017
positive regulation of cellular amine metabolic process	GO:0033240	3	0.017
peptidyl amino acid modification	GO:0018193	126	0.017
organic hydroxy compound transport	GO:0015850	77	0.017
protein complex subunit organization	GO:0071822	302	0.017
multicellular organismal signaling	GO:0035637	44	0.017
response to hypoxia	GO:0001666	231	0.017
dna metabolic process	GO:0006259	96	0.017
purine nucleoside metabolic process	GO:0042278	169	0.017
behavioral response to nicotine	GO:0035095	2	0.017
purine nucleotide metabolic process	GO:0006163	229	0.017
cardiac chamber development	GO:0003205	1	0.016
ribonucleotide catabolic process	GO:0009261	136	0.016
purine ribonucleotide metabolic process	GO:0009150	227	0.016
single organism reproductive process	GO:0044702	297	0.016
sulfur compound metabolic process	GO:0006790	70	0.016
response to cadmium ion	GO:0046686	35	0.016
positive regulation of developmental process	GO:0051094	283	0.016
single organism intracellular transport	GO:1902582	166	0.016
cell growth	GO:0016049	104	0.016	Human
protein phosphorylation	GO:0006468	345	0.016
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.016
neurological system process	GO:0050877	219	0.016
protein complex biogenesis	GO:0070271	263	0.016
regulation of catalytic activity	GO:0050790	304	0.016
negative regulation of gene expression	GO:0010629	199	0.016
cellular modified amino acid metabolic process	GO:0006575	61	0.016
negative regulation of metabolic process	GO:0009892	331	0.015
regulation of cellular amine metabolic process	GO:0033238	8	0.015
glycosyl compound metabolic process	GO:1901657	182	0.015
purine nucleoside catabolic process	GO:0006152	124	0.015
ribonucleotide metabolic process	GO:0009259	231	0.015
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.015
negative regulation of cell differentiation	GO:0045596	99	0.015
response to acid chemical	GO:0001101	222	0.015
organic substance catabolic process	GO:1901575	316	0.015
circulatory system process	GO:0003013	183	0.015
protein complex assembly	GO:0006461	263	0.015
embryonic placenta development	GO:0001892	1	0.015
spermatogenesis	GO:0007283	99	0.015
heterocycle catabolic process	GO:0046700	167	0.015
monocarboxylic acid biosynthetic process	GO:0072330	48	0.015
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.015
reproduction	GO:0000003	245	0.015
negative regulation of nervous system development	GO:0051961	79	0.015
negative regulation of biosynthetic process	GO:0009890	168	0.015
axon ensheathment	GO:0008366	40	0.015
terpenoid metabolic process	GO:0006721	37	0.015
anion transport	GO:0006820	178	0.015
fatty acid metabolic process	GO:0006631	99	0.015
gastrulation	GO:0007369	2	0.015
regulation of glomerular filtration	GO:0003093	9	0.015
negative regulation of cellular protein metabolic process	GO:0032269	106	0.015
response to estrogen	GO:0043627	232	0.015
chemical homeostasis	GO:0048878	292	0.015
tissue development	GO:0009888	252	0.015
regulation of purine nucleotide metabolic process	GO:1900542	115	0.014
response to insulin	GO:0032868	133	0.014
reactive oxygen species biosynthetic process	GO:1903409	8	0.014
cellular nitrogen compound catabolic process	GO:0044270	163	0.014
neutral lipid metabolic process	GO:0006638	21	0.014
homeostatic process	GO:0042592	331	0.014
negative regulation of neuron differentiation	GO:0045665	62	0.014
cellular component morphogenesis	GO:0032989	155	0.014
hepaticobiliary system development	GO:0061008	90	0.014
embryo development	GO:0009790	49	0.014
divalent inorganic cation transport	GO:0072511	134	0.014
positive regulation of cell development	GO:0010720	176	0.014
regulation of phosphorylation	GO:0042325	248	0.014
appendage morphogenesis	GO:0035107	4	0.014
bmp signaling pathway	GO:0030509	4	0.014
positive regulation of gene expression	GO:0010628	244	0.014
embryonic skeletal system development	GO:0048706	3	0.014
oxidation reduction process	GO:0055114	304	0.014
response to vitamin	GO:0033273	131	0.014
axis specification	GO:0009798	4	0.014
positive regulation of cellular component organization	GO:0051130	200	0.014
regulation of molecular function	GO:0065009	398	0.013
organophosphate catabolic process	GO:0046434	148	0.013
positive regulation of signaling	GO:0023056	270	0.013
nucleotide metabolic process	GO:0009117	279	0.013
response to interleukin 1	GO:0070555	55	0.013
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.013
epithelial cell differentiation	GO:0030855	71	0.013
regulation of cell growth	GO:0001558	85	0.013	Human
organic hydroxy compound biosynthetic process	GO:1901617	51	0.013
negative regulation of growth	GO:0045926	37	0.013
insecticide metabolic process	GO:0017143	4	0.013
aromatic compound catabolic process	GO:0019439	168	0.013
epithelium development	GO:0060429	96	0.013
positive regulation of cell differentiation	GO:0045597	217	0.013
negative regulation of molecular function	GO:0044092	133	0.013
spindle organization	GO:0007051	2	0.013
embryonic pattern specification	GO:0009880	1	0.013
ras protein signal transduction	GO:0007265	29	0.013
intestinal absorption	GO:0050892	3	0.013
cellular ketone metabolic process	GO:0042180	51	0.013
cellular response to endogenous stimulus	GO:0071495	377	0.013
regulation of cellular protein metabolic process	GO:0032268	267	0.013
chemosensory behavior	GO:0007635	2	0.013
muscle structure development	GO:0061061	87	0.013
multicellular organismal water homeostasis	GO:0050891	4	0.013
oligopeptide transport	GO:0006857	4	0.012
regulation of stem cell differentiation	GO:2000736	2	0.012
carbohydrate metabolic process	GO:0005975	130	0.012
unsaturated fatty acid biosynthetic process	GO:0006636	21	0.012
cellular response to abiotic stimulus	GO:0071214	85	0.012
fatty acid derivative metabolic process	GO:1901568	38	0.012
lipid storage	GO:0019915	1	0.012
placenta development	GO:0001890	22	0.012
thyroid gland development	GO:0030878	1	0.012
single organismal cell cell adhesion	GO:0016337	42	0.012
ribonucleoside catabolic process	GO:0042454	126	0.012
heart morphogenesis	GO:0003007	3	0.012
neuron projection development	GO:0031175	273	0.012
negative regulation of developmental process	GO:0051093	125	0.012
leydig cell differentiation	GO:0033327	8	0.012
cellular response to hexose stimulus	GO:0071331	65	0.012
mitotic spindle organization	GO:0007052	2	0.012
regulation of blood circulation	GO:1903522	110	0.012
cytoplasmic transport	GO:0016482	115	0.012
negative regulation of cellular biosynthetic process	GO:0031327	161	0.012
glycosyl compound catabolic process	GO:1901658	126	0.012
regulation of cell development	GO:0060284	263	0.012
glucose homeostasis	GO:0042593	75	0.012
lipid localization	GO:0010876	62	0.012
regulation of canonical wnt signaling pathway	GO:0060828	4	0.012
positive regulation of reactive oxygen species metabolic process	GO:2000379	16	0.012
wound healing	GO:0042060	122	0.012
alpha amino acid metabolic process	GO:1901605	71	0.012
carbohydrate homeostasis	GO:0033500	75	0.012
regulation of endocytosis	GO:0030100	42	0.012
macromolecule localization	GO:0033036	252	0.012
establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	1	0.012
mesoderm development	GO:0007498	2	0.012
camera type eye morphogenesis	GO:0048593	2	0.012
potassium ion transport	GO:0006813	97	0.012
muscle tissue morphogenesis	GO:0060415	1	0.012
steroid biosynthetic process	GO:0006694	48	0.012
proteolysis	GO:0006508	175	0.012
positive regulation of cell growth	GO:0030307	44	0.012	Human
positive regulation of cell proliferation	GO:0008284	249	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.011
microtubule organizing center organization	GO:0031023	1	0.011
negative regulation of programmed cell death	GO:0043069	183	0.011
positive regulation of phosphate metabolic process	GO:0045937	262	0.011
embryonic limb morphogenesis	GO:0030326	4	0.011
response to vitamin a	GO:0033189	36	0.011
regulation of cell differentiation	GO:0045595	320	0.011
defense response to gram negative bacterium	GO:0050829	3	0.011
purine ribonucleotide catabolic process	GO:0009154	136	0.011
single organism biosynthetic process	GO:0044711	342	0.011	Human
phosphatidylethanolamine metabolic process	GO:0046337	1	0.011
response to glucose	GO:0009749	136	0.011
molting cycle process	GO:0022404	2	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.011
multicellular organismal reproductive process	GO:0048609	233	0.011
growth	GO:0040007	165	0.011	Human
organic hydroxy compound metabolic process	GO:1901615	115	0.011
positive regulation of ion transport	GO:0043270	94	0.011
kidney development	GO:0001822	67	0.011
positive regulation of transport	GO:0051050	245	0.011
muscle cell differentiation	GO:0042692	52	0.011
isoquinoline alkaloid metabolic process	GO:0033076	2	0.011
nitrogen compound transport	GO:0071705	229	0.011	Human
cellular amide metabolic process	GO:0043603	44	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
fatty acid biosynthetic process	GO:0006633	33	0.011
cellular component movement	GO:0006928	248	0.011
regulation of growth	GO:0040008	105	0.011	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.011
synaptic transmission	GO:0007268	235	0.011	Human
response to transition metal nanoparticle	GO:1990267	122	0.011
cilium morphogenesis	GO:0060271	2	0.011
regulation of synaptic transmission	GO:0050804	141	0.011
actin filament based process	GO:0030029	86	0.011
response to growth factor	GO:0070848	189	0.011
organonitrogen compound biosynthetic process	GO:1901566	167	0.011
cardiac ventricle development	GO:0003231	1	0.011
blood circulation	GO:0008015	183	0.011
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.011
regulation of kinase activity	GO:0043549	117	0.011
glutathione transport	GO:0034635	2	0.011
nucleoside catabolic process	GO:0009164	126	0.011
regulation of metal ion transport	GO:0010959	118	0.011
mesonephric tubule development	GO:0072164	14	0.011
positive regulation of apoptotic process	GO:0043065	154	0.011
tripeptide transport	GO:0042939	2	0.010
cell communication by chemical coupling	GO:0010643	2	0.010
cell adhesion	GO:0007155	110	0.010
hormone secretion	GO:0046879	115	0.010
sulfur compound biosynthetic process	GO:0044272	19	0.010
glomerular filtration	GO:0003094	10	0.010
regulation of apoptotic process	GO:0042981	335	0.010
embryonic appendage morphogenesis	GO:0035113	4	0.010
reproductive system development	GO:0061458	128	0.010
cellular component assembly involved in morphogenesis	GO:0010927	17	0.010
cellular response to alkaloid	GO:0071312	25	0.010
positive regulation of protein phosphorylation	GO:0001934	135	0.010
response to reactive oxygen species	GO:0000302	120	0.010
cellular response to metal ion	GO:0071248	55	0.010
icosanoid metabolic process	GO:0006690	38	0.010
cation homeostasis	GO:0055080	195	0.010
single organism membrane organization	GO:0044802	74	0.010
circadian regulation of gene expression	GO:0032922	3	0.010
bile acid secretion	GO:0032782	5	0.010
prostate gland epithelium morphogenesis	GO:0060740	2	0.010

Slc44a4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
lower respiratory tract disease	DOID:0050161	0.018
respiratory system disease	DOID:1579	0.018
disease of anatomical entity	DOID:7	0.018
cardiovascular system disease	DOID:1287	0.016
vascular disease	DOID:178	0.016
bone disease	DOID:0080001	0.016
connective tissue disease	DOID:65	0.016
musculoskeletal system disease	DOID:17	0.016
nervous system disease	DOID:863	0.016
disease of metabolism	DOID:0014667	0.016
gastrointestinal system disease	DOID:77	0.011

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