Rattus norvegicus

92 known processes

Map2k3

mitogen activated protein kinase kinase 3

Map2k3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
apoptotic processGO:00069153810.126
Rat
regulation of apoptotic processGO:00429813350.116
Rat
programmed cell deathGO:00125013920.108
Rat
negative regulation of apoptotic processGO:00430661810.088
organic acid metabolic processGO:00060822920.085
protein complex assemblyGO:00064612630.080
negative regulation of programmed cell deathGO:00430691830.079
regulation of rna metabolic processGO:00512523910.074
Human
cellular amino acid metabolic processGO:00065201070.070
regulation of transcription dna templatedGO:00063553740.068
Human
regulation of programmed cell deathGO:00430673410.066
Rat
intracellular signal transductionGO:00355563140.065
Mouse Rat
regulation of nucleic acid templated transcriptionGO:19035063800.063
Human
negative regulation of cell deathGO:00605482290.063
regulation of phosphorus metabolic processGO:00511743490.058
protein phosphorylationGO:00064683450.055
response to oxygen levelsGO:00704822650.054
regulation of signal transductionGO:00099663180.054
Mouse Rat
agingGO:00075682410.053
protein complex subunit organizationGO:00718223020.051
rna biosynthetic processGO:00327743800.048
Human
carbohydrate metabolic processGO:00059751300.048
carboxylic acid metabolic processGO:00197522890.048
regulation of protein modification processGO:00313991940.046
oxidation reduction processGO:00551143040.046
response to inorganic substanceGO:00100353770.046
macromolecular complex assemblyGO:00650032730.045
cation transmembrane transportGO:00986552630.044
protein heterooligomerizationGO:0051291890.043
oxoacid metabolic processGO:00434362900.042
cellular ketone metabolic processGO:0042180510.042
tissue developmentGO:00098882520.042
Rat
positive regulation of developmental processGO:00510942830.041
circulatory system processGO:00030131830.040
Mouse
regulation of cellular ketone metabolic processGO:0010565270.040
reproductive processGO:00224143720.040
Rat
transcription from rna polymerase ii promoterGO:00063662520.038
ion transmembrane transportGO:00342203650.038
regulation of rna biosynthetic processGO:20011413810.038
Human
multicellular organism growthGO:003526410.037
positive regulation of cellular biosynthetic processGO:00313282950.036
Human Rat
macromolecule localizationGO:00330362520.035
Rat
transcription dna templatedGO:00063513770.035
Human
cellular component assemblyGO:00226073600.034
protein oligomerizationGO:00512591910.034
regulation of cellular amino acid metabolic processGO:000652120.034
regulation of molecular functionGO:00650093980.032
Human Mouse Rat
cellular response to stressGO:00335542690.032
Rat
response to woundingGO:00096112540.032
negative regulation of metabolic processGO:00098923310.032
carbohydrate derivative metabolic processGO:19011353460.031
rna metabolic processGO:00160704060.031
Human
inorganic ion transmembrane transportGO:00986602290.031
inorganic cation transmembrane transportGO:00986622020.031
nucleic acid templated transcriptionGO:00976593790.031
Human
positive regulation of gene expressionGO:00106282440.030
Human
regulation of catalytic activityGO:00507903040.030
Human Mouse Rat
positive regulation of biosynthetic processGO:00098913190.029
negative regulation of cellular metabolic processGO:00313242810.029
regulation of cellular amine metabolic processGO:003323880.029
positive regulation of nitrogen compound metabolic processGO:00511733340.029
Human Rat
mapk cascadeGO:00001651400.028
Mouse Rat
protein complex biogenesisGO:00702712630.028
response to decreased oxygen levelsGO:00362932370.028
regulation of phosphorylationGO:00423252480.028
amine metabolic processGO:0009308380.027
regulation of transcription from rna polymerase ii promoterGO:00063572340.027
positive regulation of rna metabolic processGO:00512542030.027
Human
central nervous system developmentGO:00074173110.027
transmembrane transportGO:00550854120.026
cellular component biogenesisGO:00440853680.026
nucleobase containing small molecule metabolic processGO:00550863160.026
cellular amine metabolic processGO:0044106380.026
single organism reproductive processGO:00447022970.025
Rat
macromolecular complex subunit organizationGO:00439333390.025
cellular protein localizationGO:00346131220.025
negative regulation of phosphorus metabolic processGO:0010563800.025
single organism biosynthetic processGO:00447113420.024
cellular response to organonitrogen compoundGO:00714171970.024
negative regulation of nucleobase containing compound metabolic processGO:00459341530.024
positive regulation of nucleobase containing compound metabolic processGO:00459353190.024
Human Rat
heart processGO:0003015570.024
Mouse
positive regulation of cell differentiationGO:00455972170.024
positive regulation of catalytic activityGO:00430851840.024
Human Mouse Rat
response to metal ionGO:00100382530.023
response to oxidative stressGO:00069791860.023
response to estrogenGO:00436272320.023
negative regulation of nitrogen compound metabolic processGO:00511721610.023
response to biotic stimulusGO:00096072260.023
positive regulation of molecular functionGO:00440932300.023
Human Mouse Rat
response to hypoxiaGO:00016662310.023
regulation of intracellular signal transductionGO:19025312180.023
Mouse Rat
regulation of cell differentiationGO:00455953200.022
cellular response to oxygen containing compoundGO:19017013860.022
single organism intracellular transportGO:19025821660.022
single organism carbohydrate metabolic processGO:00447231180.022
response to growth factorGO:00708481890.022
tube developmentGO:0035295890.022
cellular response to organic cyclic compoundGO:00714072020.022
reactive oxygen species metabolic processGO:0072593370.022
gastrulationGO:000736920.021
response to extracellular stimulusGO:00099913800.021
brain developmentGO:00074202470.021
response to reactive oxygen speciesGO:00003021200.021
behaviorGO:00076102050.021
negative regulation of macromolecule metabolic processGO:00106052600.021
positive regulation of cellular protein metabolic processGO:00322701670.021
metal ion transportGO:00300012890.021
cofactor metabolic processGO:0051186950.021
organelle organizationGO:00069962660.021
regulation of protein phosphorylationGO:00019321830.021
cell cycle checkpointGO:000007520.021
protein localizationGO:00081041910.021
cellular response to cytokine stimulusGO:00713451270.021
regulation of phosphate metabolic processGO:00192203490.020
monovalent inorganic cation transportGO:00156721720.020
regulation of multicellular organismal developmentGO:20000263760.020
intracellular transportGO:00469071850.020
positive regulation of phosphorylationGO:00423271770.020
anatomical structure morphogenesisGO:00096532980.020
secretion by cellGO:00329402480.020
single organism cellular localizationGO:19025801020.020
neuron differentiationGO:00301823680.020
positive regulation of transcription dna templatedGO:00458931970.020
Human
head developmentGO:00603222470.020
nucleotide metabolic processGO:00091172790.020
cellular glucan metabolic processGO:0006073230.020
positive regulation of multicellular organismal processGO:00512403870.020
response to cytokineGO:00340972150.020
regulation of mapk cascadeGO:00434081160.020
Mouse Rat
glycogen metabolic processGO:0005977230.019
regulation of cellular protein metabolic processGO:00322682670.019
blood circulationGO:00080151830.019
Mouse
defense responseGO:00069521940.019
Mouse
regulation of cellular localizationGO:00603412630.019
nucleoside phosphate metabolic processGO:00067532830.019
organophosphate metabolic processGO:00196373700.019
muscle system processGO:00030121150.019
Mouse Rat
response to hydrogen peroxideGO:0042542890.019
regulation of ion transportGO:00432692450.019
Rat
positive regulation of cellular amine metabolic processGO:003324030.019
signal transduction by phosphorylationGO:00230141440.019
Mouse Rat
positive regulation of cellular amino acid metabolic processGO:004576410.019
positive regulation of rna biosynthetic processGO:19026801970.019
Human
negative regulation of biosynthetic processGO:00098901680.018
neuron developmentGO:00486662860.018
regulation of cell developmentGO:00602842630.018
locomotionGO:00400112370.018
cellular response to nitrogen compoundGO:19016992100.018
negative regulation of molecular functionGO:00440921330.018
membrane organizationGO:0061024940.018
regulation of cell proliferationGO:00421273590.018
organonitrogen compound biosynthetic processGO:19015661670.017
regulation of kinase activityGO:00435491170.017
Human Mouse Rat
regulation of nervous system developmentGO:00519602640.017
single organism organelle organizationGO:19025891800.017
regulation of secretion by cellGO:19035302080.017
nucleoside metabolic processGO:00091161790.017
regulation of cytokine productionGO:0001817560.017
Mouse
response to peptideGO:19016522920.017
negative regulation of signalingGO:00230571570.017
multi organism reproductive processGO:00447032620.017
regulation of blood circulationGO:19035221100.017
cellular response to endogenous stimulusGO:00714953770.017
regulation of secretionGO:00510462240.017
Rat
negative regulation of response to stimulusGO:00485851550.016
establishment of protein localizationGO:00451841410.016
positive regulation of cellular component organizationGO:00511302000.016
positive regulation of cell deathGO:00109421840.016
Rat
small molecule biosynthetic processGO:00442831240.016
nitrogen compound transportGO:00717052290.016
regulation of protein metabolic processGO:00512462890.016
response to bacteriumGO:00096172000.016
response to ethanolGO:00454711620.016
tumor necrosis factor mediated signaling pathwayGO:003320940.016
glycosyl compound metabolic processGO:19016571820.016
cellular macromolecule localizationGO:00707271220.016
carboxylic acid transportGO:00469421150.016
Rat
negative regulation of gene expressionGO:00106291990.016
negative regulation of rna biosynthetic processGO:19026791180.016
response to molecule of bacterial originGO:00022371940.016
single organism membrane organizationGO:0044802740.016
heart developmentGO:0007507720.015
regulation of proteasomal protein catabolic processGO:006113640.015
negative regulation of phosphate metabolic processGO:0045936800.015
lipid biosynthetic processGO:00086101280.015
neuron projection developmentGO:00311752730.015
secretionGO:00469033070.015
Rat
response to acid chemicalGO:00011012220.015
purine nucleotide metabolic processGO:00061632290.015
ribose phosphate metabolic processGO:00196932350.015
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.015
heart contractionGO:0060047570.015
Mouse
cellular chemical homeostasisGO:00550822470.015
protein targetingGO:0006605610.015
cation transportGO:00068123820.015
positive regulation of protein metabolic processGO:00512471780.015
organophosphate biosynthetic processGO:00904071430.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.014
cellular polysaccharide metabolic processGO:0044264230.014
purine ribonucleoside metabolic processGO:00461281680.014
positive regulation of protein modification processGO:00314011420.014
negative regulation of catalytic activityGO:00430861030.014
positive regulation of phosphorus metabolic processGO:00105622620.014
regulation of response to external stimulusGO:00321011060.014
negative regulation of nucleic acid templated transcriptionGO:19035071170.014
positive regulation of phosphate metabolic processGO:00459372620.014
kidney developmentGO:0001822670.014
lipid metabolic processGO:00066292830.014
coenzyme metabolic processGO:0006732860.014
cellular carbohydrate metabolic processGO:0044262720.014
wound healingGO:00420601220.014
carboxylic acid biosynthetic processGO:0046394830.014
single organism catabolic processGO:00447122830.014
muscle contractionGO:0006936880.014
Mouse
response to external biotic stimulusGO:00432072210.014
regulation of cell projection organizationGO:00313441750.014
muscle tissue developmentGO:0060537580.014
Rat
regulation of neurogenesisGO:00507672470.014
intracellular protein transportGO:0006886790.013
protein transportGO:00150311320.013
dna integrity checkpointGO:003157020.013
purine nucleoside metabolic processGO:00422781690.013
ion homeostasisGO:00508012120.013
response to radiationGO:00093141370.013
anion transportGO:00068201780.013
Rat
positive regulation of cell proliferationGO:00082842490.013
homeostatic processGO:00425923310.013
negative regulation of macromolecule biosynthetic processGO:00105581480.013
dephosphorylationGO:0016311980.013
organic acid transportGO:00158491160.013
Rat
cell projection organizationGO:00300303020.013
lipid storageGO:001991510.013
circulatory system developmentGO:00723591340.013
regulation of protein localizationGO:0032880810.013
regulation of cell morphogenesis involved in differentiationGO:0010769720.013
regulation of neuron differentiationGO:00456642080.013
peptidyl amino acid modificationGO:00181931260.013
reproductionGO:00000032450.013
Rat
regulation of cellular component organizationGO:00511283680.013
chemical homeostasisGO:00488782920.013
regulation of transferase activityGO:00513381230.012
Human Mouse Rat
cation homeostasisGO:00550801950.012
purine ribonucleoside monophosphate metabolic processGO:0009167840.012
protein localization to nucleusGO:0034504390.012
cellular lipid metabolic processGO:00442552080.012
g protein coupled receptor signaling pathwayGO:00071862420.012
purine containing compound metabolic processGO:00725212530.012
amide transportGO:00428861050.012
positive regulation of neurogenesisGO:00507691650.012
multicellular organism reproductionGO:00325042330.012
Rat
signal releaseGO:00230611450.012
negative regulation of cell communicationGO:00106481580.012
organic hydroxy compound metabolic processGO:19016151150.012
negative regulation of multicellular organismal processGO:00512412030.012
regulation of muscle system processGO:0090257790.012
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.012
renal system developmentGO:0072001670.012
cellular response to peptideGO:19016531330.012
heart morphogenesisGO:000300730.012
positive regulation of cell developmentGO:00107201760.012
regulation of anatomical structure morphogenesisGO:00226031410.012
respiratory gaseous exchangeGO:000758540.012
multicellular organismal reproductive processGO:00486092330.012
Rat
positive regulation of nervous system developmentGO:00519621780.012
response to nutrientGO:00075842480.012
response to vitaminGO:00332731310.012
negative regulation of rna metabolic processGO:00512531230.012
divalent inorganic cation homeostasisGO:00725071650.012
anterior posterior pattern specificationGO:000995210.012
embryonic pattern specificationGO:000988010.012
respiratory system processGO:000301630.012
response to glucocorticoidGO:00513842230.012
negative regulation of transcription dna templatedGO:00458921160.012
cytoplasmic transportGO:00164821150.012
regulation of system processGO:00440572080.012
response to other organismGO:00517072200.012
negative regulation of protein metabolic processGO:00512481140.011
reproductive system developmentGO:00614581280.011
positive regulation of signalingGO:00230562700.011
Mouse Rat
ribonucleoside metabolic processGO:00091191740.011
regulation of neuron projection developmentGO:00109751610.011
regulation of hormone levelsGO:00108171870.011
axis specificationGO:000979840.011
protein localization to organelleGO:0033365570.011
catabolic processGO:00090563510.011
lipid localizationGO:0010876620.011
Rat
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.011
striated muscle contractionGO:0006941440.011
Mouse
anion transmembrane transportGO:0098656770.011
reproductive structure developmentGO:00486081280.011
regulation of cell migrationGO:00303341280.011
regulation of hydrolase activityGO:00513361430.011
muscle organ morphogenesisGO:004864410.011
organic anion transportGO:00157111320.011
Rat
cell cell signalingGO:00072673350.011
cellular homeostasisGO:00197252520.011
regulation of cell motilityGO:20001451310.011
small gtpase mediated signal transductionGO:0007264360.011
sodium ion transportGO:0006814820.011
metal ion homeostasisGO:00550651860.011
cellular component movementGO:00069282480.011
cellular divalent inorganic cation homeostasisGO:00725031620.011
regulation of cellular component movementGO:00512701500.011
epithelium developmentGO:0060429960.011
ras protein signal transductionGO:0007265290.010
developmental process involved in reproductionGO:00030061590.010
positive regulation of protein phosphorylationGO:00019341350.010
cytokine productionGO:0001816610.010
Mouse
cellular response to oxidative stressGO:0034599760.010
positive regulation of signal transductionGO:00099671750.010
Mouse Rat
peptidyl tyrosine modificationGO:0018212720.010
positive regulation of immunoglobulin productionGO:000263940.010
regenerationGO:00310991630.010
alcohol metabolic processGO:0006066770.010
positive regulation of nucleic acid templated transcriptionGO:19035081970.010
Human
regulation of response to woundingGO:1903034690.010

Map2k3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.049
muscle tissue diseaseDOID:6600.049
musculoskeletal system diseaseDOID:1700.049
muscular diseaseDOID:008000000.049
myopathyDOID:42300.049
muscular dystrophyDOID:988400.049
nervous system diseaseDOID:86300.035
cardiovascular system diseaseDOID:128700.028
cardiomyopathyDOID:005070000.014
heart diseaseDOID:11400.014
intrinsic cardiomyopathyDOID:006003600.012
central nervous system diseaseDOID:33100.012
disease of metabolismDOID:001466700.012
charcot marie tooth diseaseDOID:1059500.011
neuropathyDOID:87000.011
neuromuscular diseaseDOID:44000.011
skin diseaseDOID:3700.010
integumentary system diseaseDOID:1600.010