Rattus norvegicus

83 known processes

Map2k2

mitogen activated protein kinase kinase 2

(Aliases: Prkmk2)

Map2k2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
macromolecular complex subunit organizationGO:00439333390.284
Yeast Rat
positive regulation of signal transductionGO:00099671750.277
protein complex biogenesisGO:00702712630.252
Rat
positive regulation of cell communicationGO:00106472710.201
regulation of molecular functionGO:00650093980.154
cellular component assemblyGO:00226073600.147
Rat
regulation of cellular component organizationGO:00511283680.132
Yeast
response to woundingGO:00096112540.125
Rat
single organism organelle organizationGO:19025891800.124
Yeast Rat
intracellular signal transductionGO:00355563140.119
organonitrogen compound biosynthetic processGO:19015661670.115
positive regulation of ruffle assemblyGO:190002910.108
positive regulation of cellular component biogenesisGO:0044089550.107
regulation of phosphate metabolic processGO:00192203490.106
positive regulation of response to stimulusGO:00485842850.103
regulation of phosphorus metabolic processGO:00511743490.099
neuron differentiationGO:00301823680.098
Rat
reproductionGO:00000032450.097
Yeast Worm Fly
peptide biosynthetic processGO:004304330.095
regulation of transcription from rna polymerase ii promoterGO:00063572340.094
Rat
programmed cell deathGO:00125013920.090
Worm
positive regulation of intracellular signal transductionGO:19025331380.087
positive regulation of cellular amine metabolic processGO:003324030.086
protein complex assemblyGO:00064612630.083
Rat
cellular response to stressGO:00335542690.082
Yeast
negative regulation of phosphorus metabolic processGO:0010563800.081
rna biosynthetic processGO:00327743800.077
Rat
mitotic cell cycleGO:0000278490.077
Rat
mitotic cell cycle processGO:1903047350.076
Rat
positive regulation of signalingGO:00230562700.075
oxidation reduction processGO:00551143040.071
cytoskeleton organizationGO:00070101110.071
Yeast
neurological system processGO:00508772190.069
cell cycleGO:00070491010.069
Rat
positive regulation of cellular component organizationGO:00511302000.068
negative regulation of response to stimulusGO:00485851550.067
negative regulation of macromolecule metabolic processGO:00106052600.067
response to mineralocorticoidGO:0051385490.063
regulation of immune responseGO:0050776550.062
regulation of catalytic activityGO:00507903040.059
regulation of signal transductionGO:00099663180.058
heart contractionGO:0060047570.058
response to ketoneGO:19016541820.056
negative regulation of cellular metabolic processGO:00313242810.056
organelle organizationGO:00069962660.055
Yeast Rat
metal ion transportGO:00300012890.055
cellular amide metabolic processGO:0043603440.055
negative regulation of phosphate metabolic processGO:0045936800.054
regulation of multicellular organismal developmentGO:20000263760.054
response to estradiolGO:00323551640.054
regulation of apoptotic processGO:00429813350.054
spindle organizationGO:000705120.053
regulation of cell migrationGO:00303341280.052
Rat
multi organism reproductive processGO:00447032620.052
Yeast Fly
catabolic processGO:00090563510.052
Yeast Rat Worm
regulation of intracellular signal transductionGO:19025312180.052
regulation of cell proliferationGO:00421273590.051
organic substance catabolic processGO:19015753160.051
Rat Worm
negative regulation of metabolic processGO:00098923310.051
cation transportGO:00068123820.051
regulation of cellular amine metabolic processGO:003323880.050
peptide metabolic processGO:0006518320.050
single organism cellular localizationGO:19025801020.049
Yeast Rat
regulation of nucleotide catabolic processGO:0030811650.049
Rat
positive regulation of nervous system developmentGO:00519621780.049
multicellular organism growthGO:003526410.047
response to extracellular stimulusGO:00099913800.047
locomotionGO:00400112370.047
Mouse Rat Fly
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.046
Rat
deoxyribonucleoside monophosphate metabolic processGO:000916260.046
positive regulation of monooxygenase activityGO:003277050.045
single organism catabolic processGO:00447122830.045
Yeast Rat
response to corticosteroneGO:0051412400.045
neuron deathGO:00709971270.045
head developmentGO:00603222470.044
reproductive processGO:00224143720.044
Yeast Worm Fly
positive regulation of oxidoreductase activityGO:005135370.044
positive regulation of cellular component movementGO:00512721020.043
Mouse Rat
positive regulation of cellular biosynthetic processGO:00313282950.042
Rat
positive regulation of cell proliferationGO:00082842490.041
single organism reproductive processGO:00447022970.041
Worm Fly
regulation of neurogenesisGO:00507672470.041
mitotic spindle organizationGO:000705220.041
immune responseGO:00069551040.041
carbohydrate derivative metabolic processGO:19011353460.041
Rat
multicellular organism reproductionGO:00325042330.041
Fly
cellular amine metabolic processGO:0044106380.040
organic acid metabolic processGO:00060822920.040
neuron apoptotic processGO:0051402880.039
organic cyclic compound catabolic processGO:19013611750.039
Rat
regulation of nervous system developmentGO:00519602640.039
regulation of nucleoside metabolic processGO:0009118660.039
Rat
multicellular organismal reproductive processGO:00486092330.038
Fly
negative regulation of nitrogen compound metabolic processGO:00511721610.038
cellular catabolic processGO:00442482950.038
Yeast Rat
regulation of neuron differentiationGO:00456642080.038
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123950.038
axis specificationGO:000979840.037
Fly
protein phosphorylationGO:00064683450.037
response to starvationGO:0042594590.037
apoptotic processGO:00069153810.037
Worm
positive regulation of rna metabolic processGO:00512542030.037
Rat
protein oligomerizationGO:00512591910.037
Rat
cellular amino acid metabolic processGO:00065201070.036
gamete generationGO:00072761240.036
Fly
heart processGO:0003015570.036
nucleobase containing compound catabolic processGO:00346551520.036
Rat
small molecule catabolic processGO:0044282590.036
positive regulation of organelle organizationGO:0010638480.036
regulation of purine nucleotide metabolic processGO:19005421150.035
Rat
purine nucleoside metabolic processGO:00422781690.035
Rat
regulation of system processGO:00440572080.035
Rat
rna metabolic processGO:00160704060.035
Rat
nucleobase containing small molecule metabolic processGO:00550863160.034
Rat
positive regulation of gene expressionGO:00106282440.034
Rat
nucleotide metabolic processGO:00091172790.034
Rat
cellular glucan metabolic processGO:0006073230.034
brain developmentGO:00074202470.033
response to estrogenGO:00436272320.033
negative regulation of cellular protein metabolic processGO:00322691060.032
positive regulation of cell migrationGO:0030335960.032
Rat
blood circulationGO:00080151830.032
Rat
regulation of cell projection organizationGO:00313441750.032
regulation of protein metabolic processGO:00512462890.032
central nervous system developmentGO:00074173110.031
deoxyribose phosphate metabolic processGO:001969290.030
divalent metal ion transportGO:00708381320.030
regulation of gtpase activityGO:0043087570.030
Rat
behaviorGO:00076102050.030
amine metabolic processGO:0009308380.030
sexual reproductionGO:00199531480.029
Yeast Fly
regulation of apoptotic signaling pathwayGO:2001233130.029
response to nutrient levelsGO:00316673700.029
response to glucocorticoidGO:00513842230.029
Rat
immune system processGO:00023762040.029
Fly
positive regulation of developmental processGO:00510942830.029
negative regulation of molecular functionGO:00440921330.029
transcription dna templatedGO:00063513770.028
Rat
regulation of mrna splicing via spliceosomeGO:004802430.028
cellular response to nutrient levelsGO:0031669600.028
positive regulation of cytoskeleton organizationGO:0051495260.028
regulation of nucleic acid templated transcriptionGO:19035063800.028
Rat
macroautophagyGO:001623640.028
regulation of programmed cell deathGO:00430673410.028
protein heterooligomerizationGO:0051291890.028
Rat
regulation of neurotransmitter levelsGO:0001505420.028
heterocycle catabolic processGO:00467001670.028
Rat
deoxyribonucleotide biosynthetic processGO:000926360.028
regulation of response to woundingGO:1903034690.028
regulation of catabolic processGO:00098941130.027
Rat
cellular ketone metabolic processGO:0042180510.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.027
Rat
regulation of phosphorylationGO:00423252480.027
response to corticosteroidGO:00319602350.027
Rat
response to temperature stimulusGO:0009266940.027
Yeast
positive regulation of synaptic transmissionGO:0050806620.027
cellular protein complex assemblyGO:0043623440.027
positive regulation of erk1 and erk2 cascadeGO:0070374290.027
Fly
regulation of rna metabolic processGO:00512523910.026
Rat
regulation of kinase activityGO:00435491170.026
positive regulation of cell motilityGO:2000147970.026
Mouse Rat
regulation of cellular amino acid metabolic processGO:000652120.026
regulation of blood circulationGO:19035221100.026
Rat
2 deoxyribonucleotide biosynthetic processGO:000926560.026
oxoacid metabolic processGO:00434362900.026
regulation of response to stressGO:00801341260.026
Yeast
developmental growthGO:00485891000.025
regulation of cell cycleGO:0051726730.025
aromatic compound catabolic processGO:00194391680.025
Rat
transcription from rna polymerase ii promoterGO:00063662520.025
Rat
agingGO:00075682410.025
Worm
regulation of protein kinase activityGO:00458591050.025
positive regulation of hydrolase activityGO:0051345860.024
Rat
regulation of neuron deathGO:19012141150.024
cell motilityGO:00488702020.024
Mouse Rat Fly
positive regulation of neuron differentiationGO:00456661260.024
regulation of ion transportGO:00432692450.024
response to acid chemicalGO:00011012220.024
microtubule cytoskeleton organizationGO:0000226250.024
regulation of purine nucleotide catabolic processGO:0033121650.024
Rat
regulation of nitric oxide synthase activityGO:005099980.024
cell cell signalingGO:00072673350.023
positive regulation of membrane potentialGO:0045838160.023
nucleic acid templated transcriptionGO:00976593790.023
Rat
intraspecies interaction between organismsGO:0051703150.023
positive regulation of phosphate metabolic processGO:00459372620.023
single organism biosynthetic processGO:00447113420.022
regulation of cyclic nucleotide metabolic processGO:0030799510.022
regulation of cellular ketone metabolic processGO:0010565270.022
regulation of response to external stimulusGO:00321011060.022
sensory perceptionGO:00076001010.022
regulation of neuron apoptotic processGO:0043523830.022
stress activated protein kinase signaling cascadeGO:0031098370.022
positive regulation of cell differentiationGO:00455972170.022
regulation of immune system processGO:00026821230.022
gastrulationGO:000736920.022
ribose phosphate biosynthetic processGO:0046390870.022
g protein coupled receptor signaling pathwayGO:00071862420.022
Yeast
positive regulation of nitrogen compound metabolic processGO:00511733340.021
Rat
multi multicellular organism processGO:00447061380.021
positive regulation of rna biosynthetic processGO:19026801970.021
Rat
epithelial cell proliferationGO:0050673540.021
defense responseGO:00069521940.021
intracellular protein transportGO:0006886790.021
Yeast
regulation of growthGO:00400081050.021
ribonucleotide metabolic processGO:00092592310.021
Rat
positive regulation of cellular protein metabolic processGO:00322701670.021
protein complex subunit organizationGO:00718223020.021
Yeast Rat
response to activityGO:0014823730.021
regulation of heart contractionGO:0008016480.021
secondary metabolite catabolic processGO:009048710.021
carbohydrate derivative biosynthetic processGO:19011371240.021
regulation of transcription dna templatedGO:00063553740.020
Rat
macromolecular complex assemblyGO:00650032730.020
Rat
reactive nitrogen species metabolic processGO:200105710.020
regulation of microtubule polymerization or depolymerizationGO:0031110120.020
hair follicle developmentGO:000194220.020
negative regulation of cell cycle phase transitionGO:190198840.020
glycosyl compound metabolic processGO:19016571820.020
Rat
regulation of cellular component biogenesisGO:0044087860.019
homeostatic processGO:00425923310.019
positive regulation of macromolecule biosynthetic processGO:00105572470.019
Rat
regulation of protein modification processGO:00313991940.019
intracellular transportGO:00469071850.019
Yeast Rat
regulation of organelle organizationGO:0033043800.019
calcium ion transportGO:00068161310.019
negative regulation of neuron deathGO:1901215690.019
positive regulation of kinase activityGO:0033674770.019
negative regulation of protein phosphorylationGO:0001933440.019
regulation of cellular component movementGO:00512701500.019
Mouse Rat
cell migrationGO:00164771970.019
Rat Fly
negative regulation of response to nutrient levelsGO:003210870.019
purine ribonucleotide biosynthetic processGO:0009152810.018
regulation of cellular catabolic processGO:00313291010.018
Rat
pentose metabolic processGO:001932180.018
negative regulation of gene expressionGO:00106291990.018
negative regulation of protein modification processGO:0031400520.018
organonitrogen compound catabolic processGO:19015651790.018
Rat
regulation of epithelial cell proliferationGO:0050678490.018
nucleoside phosphate metabolic processGO:00067532830.018
Rat
regulation of hydrolase activityGO:00513361430.018
Rat
developmental process involved in reproductionGO:00030061590.018
Worm Fly
circulatory system processGO:00030131830.018
Rat
positive regulation of nucleobase containing compound metabolic processGO:00459353190.018
Rat
regulation of cellular response to stressGO:0080135490.018
Yeast
receptor localization to synapseGO:009712020.018
apoptotic signaling pathwayGO:0097190270.017
regulation of cell developmentGO:00602842630.017
sequestering of metal ionGO:005123890.017
single organism carbohydrate metabolic processGO:00447231180.017
response to vitaminGO:00332731310.017
ribose phosphate metabolic processGO:00196932350.017
Rat
positive regulation of locomotionGO:00400171020.017
Mouse Rat
negative regulation of mitotic cell cycle phase transitionGO:190199130.017
positive regulation of cyclic nucleotide metabolic processGO:0030801370.017
amide biosynthetic processGO:0043604100.016
circulatory system developmentGO:00723591340.016
positive regulation of transcription dna templatedGO:00458931970.016
Rat
positive regulation of cell deathGO:00109421840.016
regulation of anatomical structure sizeGO:00900661350.016
Rat
regulation of monooxygenase activityGO:003276880.016
adenylate cyclase activating g protein coupled receptor signaling pathwayGO:0007189240.016
nucleoside phosphate catabolic processGO:19012921400.016
Rat
positive regulation of biosynthetic processGO:00098913190.016
Rat
cell projection organizationGO:00300303020.015
Rat
cell type specific apoptotic processGO:00972851340.015
purine nucleotide metabolic processGO:00061632290.015
Rat
positive regulation of gtpase activityGO:0043547470.015
Rat
negative regulation of rna splicingGO:003311930.015
purine nucleotide biosynthetic processGO:0006164830.015
calcium ion homeostasisGO:00550741620.015
negative regulation of cell deathGO:00605482290.015
cellular component biogenesisGO:00440853680.015
Rat
negative regulation of signalingGO:00230571570.015
regulation of protein complex assemblyGO:0043254330.015
regulation of cell differentiationGO:00455953200.015
positive regulation of ion transportGO:0043270940.015
divalent inorganic cation transportGO:00725111340.015
regulation of map kinase activityGO:0043405530.015
growthGO:00400071650.015
Yeast
organophosphate catabolic processGO:00464341480.015
Rat
reactive oxygen species biosynthetic processGO:190340980.015
nucleotide catabolic processGO:00091661390.014
Rat
regulation of vesicle mediated transportGO:0060627810.014
regulation of cellular protein metabolic processGO:00322682670.014
axon developmentGO:0061564960.014
negative regulation of signal transductionGO:0009968830.014
lipid modificationGO:0030258520.014
single organism nuclear importGO:1902593350.014
Yeast
microtubule based processGO:0007017360.014
Rat
regulation of cytoskeleton organizationGO:0051493490.014
cellular response to extracellular stimulusGO:0031668730.014
monosaccharide metabolic processGO:0005996610.014
negative regulation of protein metabolic processGO:00512481140.014
positive regulation of cell developmentGO:00107201760.014
positive regulation of neurogenesisGO:00507691650.014
response to decreased oxygen levelsGO:00362932370.014
positive regulation of cyclase activityGO:0031281150.014
regulation of rna biosynthetic processGO:20011413810.014
Rat
negative regulation of innate immune responseGO:004582440.013
protein localizationGO:00081041910.013
Yeast
camp metabolic processGO:0046058630.013
negative regulation of neuron apoptotic processGO:0043524450.013
negative regulation of cell communicationGO:00106481580.013
female pregnancyGO:00075651220.013
positive regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124120.013
negative regulation of nucleobase containing compound metabolic processGO:00459341530.013
transmembrane transportGO:00550854120.013
actin filament based processGO:0030029860.013
Yeast
regulation of transferase activityGO:00513381230.013
nucleotide biosynthetic processGO:0009165980.013
purine containing compound biosynthetic processGO:0072522850.013
purine containing compound metabolic processGO:00725212530.013
Rat
positive regulation of cell projection organizationGO:00313461110.013
regulation of cell motilityGO:20001451310.013
Mouse Rat
response to inorganic substanceGO:00100353770.012
positive regulation of catalytic activityGO:00430851840.012
regulation of cyclase activityGO:0031279210.012
positive regulation of neuron projection developmentGO:0010976990.012
ion homeostasisGO:00508012120.012
cell morphogenesis involved in neuron differentiationGO:00486671060.012
negative regulation of purine nucleotide metabolic processGO:1900543230.012
cell growthGO:00160491040.012
Yeast
negative regulation of phosphorylationGO:0042326570.012
regulation of synaptic transmissionGO:00508041410.012
response to ethanolGO:00454711620.012
feeding behaviorGO:0007631530.012
response to toxic substanceGO:00096361330.012
purine ribonucleoside triphosphate catabolic processGO:00092071220.012
Rat
organophosphate metabolic processGO:00196373700.012
Rat
response to fatty acidGO:0070542650.012
hair cycle processGO:002240520.012
purine nucleoside triphosphate catabolic processGO:00091461220.012
Rat
triglyceride homeostasisGO:007032820.012
macromolecule localizationGO:00330362520.012
Yeast
regulation of ras protein signal transductionGO:0046578450.012
Rat Fly
nucleoside phosphate biosynthetic processGO:19012931020.012
regulation of blood vessel endothelial cell migrationGO:004353540.012
eye developmentGO:0001654500.012
positive regulation of protein metabolic processGO:00512471780.012
regulation of cell cycle processGO:0010564310.011
negative regulation of ras gtpase activityGO:003426120.011
regulation of mapk cascadeGO:00434081160.011
adult locomotory behaviorGO:000834440.011
response to external biotic stimulusGO:00432072210.011
regulation of dna metabolic processGO:0051052600.011
glycosaminoglycan biosynthetic processGO:000602440.011
cellular nitrogen compound catabolic processGO:00442701630.011
Rat
cyclic nucleotide biosynthetic processGO:0009190630.011
sensory organ developmentGO:0007423740.011
guanosine containing compound catabolic processGO:1901069710.011
Rat
establishment of protein localizationGO:00451841410.011
Yeast
nadp metabolic processGO:0006739130.011
cation homeostasisGO:00550801950.011
synaptic transmissionGO:00072682350.011
transformation of host cell by virusGO:001908740.011
response to electrical stimulusGO:0051602560.011
sulfur compound biosynthetic processGO:0044272190.011
cellular carbohydrate metabolic processGO:0044262720.011
regulation of smooth muscle cell proliferationGO:0048660750.011
cell adhesionGO:00071551100.011
Rat
acetate ester metabolic processGO:190061940.011
response to hydrogen peroxideGO:0042542890.011
positive regulation of response to woundingGO:1903036340.011
negative regulation of apoptotic processGO:00430661810.011
response to peptideGO:19016522920.011
protein targeting to nucleusGO:0044744350.011
Yeast
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.011
neuron developmentGO:00486662860.010
Rat
visual perceptionGO:000760130.010
response to heatGO:0009408600.010
Yeast
carbohydrate derivative catabolic processGO:19011361470.010
Rat
secretion by cellGO:00329402480.010
potassium ion transportGO:0006813970.010
purine ribonucleoside metabolic processGO:00461281680.010
Rat
metal ion homeostasisGO:00550651860.010
nuclear transportGO:0051169490.010
Yeast
gtp catabolic processGO:0006184710.010
Rat
positive regulation of cellular catabolic processGO:0031331710.010
Rat
phenol containing compound metabolic processGO:0018958300.010
cellular response to alcoholGO:0097306870.010
neuronal action potentialGO:0019228350.010
purine ribonucleotide catabolic processGO:00091541360.010
Rat
negative regulation of catalytic activityGO:00430861030.010
positive regulation of epithelial cell proliferationGO:0050679320.010

Map2k2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
endocrine gland cancerDOID:17000.127
cancerDOID:16200.127
organ system cancerDOID:005068600.127
disease of cellular proliferationDOID:1456600.127
thyroid cancerDOID:178100.010
thyroid carcinomaDOID:396300.010