Rattus norvegicus

166 known processes

Map2k6

mitogen-activated protein kinase kinase 6

(Aliases: MGC93287,Mkk6)

Map2k6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
rna biosynthetic processGO:00327743800.154
nucleic acid templated transcriptionGO:00976593790.106
oxoacid metabolic processGO:00434362900.094
regulation of transcription dna templatedGO:00063553740.093
regulation of cellular component organizationGO:00511283680.093
positive regulation of nitrogen compound metabolic processGO:00511733340.091
Rat
regulation of rna biosynthetic processGO:20011413810.088
programmed cell deathGO:00125013920.087
negative regulation of macromolecule metabolic processGO:00106052600.084
regulation of rna metabolic processGO:00512523910.082
apoptotic processGO:00069153810.078
regulation of nucleic acid templated transcriptionGO:19035063800.076
regulation of cell developmentGO:00602842630.074
negative regulation of cellular metabolic processGO:00313242810.073
carboxylic acid metabolic processGO:00197522890.073
negative regulation of metabolic processGO:00098923310.072
single organism biosynthetic processGO:00447113420.072
regulation of signal transductionGO:00099663180.071
cellular amino acid metabolic processGO:00065201070.069
transcription dna templatedGO:00063513770.063
protein complex biogenesisGO:00702712630.063
rna metabolic processGO:00160704060.060
organic acid metabolic processGO:00060822920.059
positive regulation of signalingGO:00230562700.058
intracellular signal transductionGO:00355563140.057
negative regulation of gene expressionGO:00106291990.057
cellular component movementGO:00069282480.056
positive regulation of cell communicationGO:00106472710.055
regulation of intracellular signal transductionGO:19025312180.054
cellular component assemblyGO:00226073600.053
organic substance catabolic processGO:19015753160.053
growthGO:00400071650.051
Rat
regulation of multicellular organismal developmentGO:20000263760.051
negative regulation of biosynthetic processGO:00098901680.050
regulation of cell differentiationGO:00455953200.048
positive regulation of rna biosynthetic processGO:19026801970.048
cell growthGO:00160491040.047
Rat
regulation of neurogenesisGO:00507672470.047
protein phosphorylationGO:00064683450.047
neuron projection developmentGO:00311752730.046
regulation of phosphate metabolic processGO:00192203490.046
catabolic processGO:00090563510.045
cell migrationGO:00164771970.044
response to metal ionGO:00100382530.044
regulation of molecular functionGO:00650093980.044
response to nutrientGO:00075842480.043
positive regulation of phosphate metabolic processGO:00459372620.043
negative regulation of macromolecule biosynthetic processGO:00105581480.043
regulation of cellular localizationGO:00603412630.043
positive regulation of biosynthetic processGO:00098913190.043
neuron differentiationGO:00301823680.042
positive regulation of response to stimulusGO:00485842850.042
homeostatic processGO:00425923310.042
neuron developmentGO:00486662860.042
single organism carbohydrate metabolic processGO:00447231180.042
positive regulation of cellular biosynthetic processGO:00313282950.041
Rat
regulation of cellular protein metabolic processGO:00322682670.041
regulation of cell proliferationGO:00421273590.041
regulation of apoptotic processGO:00429813350.041
regulation of programmed cell deathGO:00430673410.040
regulation of cellular ketone metabolic processGO:0010565270.040
negative regulation of cell deathGO:00605482290.040
cellular ketone metabolic processGO:0042180510.039
response to extracellular stimulusGO:00099913800.039
protein oligomerizationGO:00512591910.039
positive regulation of signal transductionGO:00099671750.038
reproductive processGO:00224143720.038
positive regulation of multicellular organismal processGO:00512403870.037
negative regulation of programmed cell deathGO:00430691830.037
positive regulation of phosphorus metabolic processGO:00105622620.037
secretionGO:00469033070.037
cell cell signalingGO:00072673350.037
protein autophosphorylationGO:0046777660.037
macromolecular complex subunit organizationGO:00439333390.036
response to nutrient levelsGO:00316673700.036
transcription from rna polymerase ii promoterGO:00063662520.036
regulation of neuron differentiationGO:00456642080.036
negative regulation of cellular biosynthetic processGO:00313271610.036
macromolecule localizationGO:00330362520.035
protein complex assemblyGO:00064612630.035
nucleobase containing small molecule metabolic processGO:00550863160.035
cellular component biogenesisGO:00440853680.035
carbohydrate metabolic processGO:00059751300.035
positive regulation of macromolecule biosynthetic processGO:00105572470.035
regulation of catalytic activityGO:00507903040.035
organelle organizationGO:00069962660.034
cellular catabolic processGO:00442482950.034
single organism intracellular transportGO:19025821660.034
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.034
cellular amine metabolic processGO:0044106380.033
positive regulation of intracellular signal transductionGO:19025331380.033
cellular response to stressGO:00335542690.033
Rat
negative regulation of cell proliferationGO:00082851190.033
negative regulation of apoptotic processGO:00430661810.033
central nervous system developmentGO:00074173110.032
carbohydrate derivative metabolic processGO:19011353460.032
cation transportGO:00068123820.032
regulation of cellular amino acid metabolic processGO:000652120.032
establishment of protein localizationGO:00451841410.032
response to acid chemicalGO:00011012220.032
locomotionGO:00400112370.032
negative regulation of rna metabolic processGO:00512531230.032
regulation of ion transportGO:00432692450.032
cellular homeostasisGO:00197252520.031
regulation of nervous system developmentGO:00519602640.031
cellular chemical homeostasisGO:00550822470.031
cell type specific apoptotic processGO:00972851340.030
Rat
chemical homeostasisGO:00488782920.030
anatomical structure morphogenesisGO:00096532980.030
macromolecular complex assemblyGO:00650032730.030
positive regulation of phosphorylationGO:00423271770.030
positive regulation of cell differentiationGO:00455972170.030
regulation of transcription from rna polymerase ii promoterGO:00063572340.030
single organism organelle organizationGO:19025891800.029
positive regulation of developmental processGO:00510942830.029
regulation of phosphorylationGO:00423252480.029
regulation of mapk cascadeGO:00434081160.029
dna metabolic processGO:0006259960.028
Rat
secretion by cellGO:00329402480.028
single organism reproductive processGO:00447022970.028
amine metabolic processGO:0009308380.028
regulation of protein metabolic processGO:00512462890.028
anion transportGO:00068201780.028
positive regulation of nervous system developmentGO:00519621780.028
intracellular transportGO:00469071850.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.027
organophosphate metabolic processGO:00196373700.027
positive regulation of cell developmentGO:00107201760.027
positive regulation of rna metabolic processGO:00512542030.027
negative regulation of nucleobase containing compound metabolic processGO:00459341530.027
monosaccharide metabolic processGO:0005996610.027
single organism catabolic processGO:00447122830.027
response to carbohydrateGO:00097431830.026
brain developmentGO:00074202470.026
enzyme linked receptor protein signaling pathwayGO:00071671160.026
positive regulation of cellular component organizationGO:00511302000.026
negative regulation of rna biosynthetic processGO:19026791180.026
positive regulation of transcription dna templatedGO:00458931970.025
regulation of phosphorus metabolic processGO:00511743490.025
multicellular organism reproductionGO:00325042330.025
behaviorGO:00076102050.025
protein transportGO:00150311320.025
positive regulation of molecular functionGO:00440932300.025
regulation of anatomical structure morphogenesisGO:00226031410.024
multi organism reproductive processGO:00447032620.024
cellular response to endogenous stimulusGO:00714953770.024
cell motilityGO:00488702020.024
multicellular organismal reproductive processGO:00486092330.024
negative regulation of transportGO:00510511360.024
cell morphogenesis involved in differentiationGO:00009041190.024
metal ion transportGO:00300012890.024
lipid biosynthetic processGO:00086101280.024
neurological system processGO:00508772190.024
regulation of catabolic processGO:00098941130.024
cell projection organizationGO:00300303020.024
reproductionGO:00000032450.024
cellular response to oxygen containing compoundGO:19017013860.024
chromosome segregationGO:000705920.024
purine containing compound metabolic processGO:00725212530.023
regulation of membrane potentialGO:00423911100.023
positive regulation of cellular amine metabolic processGO:003324030.023
transmembrane transportGO:00550854120.023
signal transduction by phosphorylationGO:00230141440.023
cell cycleGO:00070491010.022
alpha amino acid metabolic processGO:1901605710.022
small gtpase mediated signal transductionGO:0007264360.022
regulation of cellular amine metabolic processGO:003323880.022
cellular carbohydrate metabolic processGO:0044262720.022
purine ribonucleoside catabolic processGO:00461301240.022
lipid metabolic processGO:00066292830.022
tissue developmentGO:00098882520.022
Rat
response to oxygen levelsGO:00704822650.022
cellular response to hormone stimulusGO:00328702470.022
positive regulation of neurogenesisGO:00507691650.022
protein complex subunit organizationGO:00718223020.022
agingGO:00075682410.021
nucleotide metabolic processGO:00091172790.021
positive regulation of gene expressionGO:00106282440.021
developmental process involved in reproductionGO:00030061590.021
calcium ion transportGO:00068161310.021
positive regulation of cellular amino acid metabolic processGO:004576410.021
organonitrogen compound catabolic processGO:19015651790.021
negative regulation of cell communicationGO:00106481580.021
regulation of protein modification processGO:00313991940.020
localization of cellGO:00516742020.020
gland developmentGO:00487321550.020
negative regulation of molecular functionGO:00440921330.020
positive regulation of cell deathGO:00109421840.020
regenerationGO:00310991630.020
regulation of nucleotide metabolic processGO:00061401170.020
response to peptide hormoneGO:00434342780.020
negative regulation of signalingGO:00230571570.020
positive regulation of cell proliferationGO:00082842490.020
regulation of neuron projection developmentGO:00109751610.020
regulation of metal ion transportGO:00109591180.020
neuronal action potentialGO:0019228350.020
ribonucleotide metabolic processGO:00092592310.020
circulatory system developmentGO:00723591340.020
Rat
protein localizationGO:00081041910.020
regulation of cellular component movementGO:00512701500.019
regulation of cell motilityGO:20001451310.019
divalent metal ion transportGO:00708381320.019
regulation of cell cycleGO:0051726730.019
peptidyl amino acid modificationGO:00181931260.019
positive regulation of apoptotic processGO:00430651540.019
negative regulation of transcription dna templatedGO:00458921160.019
negative regulation of protein metabolic processGO:00512481140.019
head developmentGO:00603222470.019
regulation of cell growthGO:0001558850.019
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.019
cellular response to nitrogen compoundGO:19016992100.019
nucleoside phosphate metabolic processGO:00067532830.019
regulation of secretion by cellGO:19035302080.019
cell adhesionGO:00071551100.019
ribonucleoside catabolic processGO:00424541260.019
ras protein signal transductionGO:0007265290.019
positive regulation of protein metabolic processGO:00512471780.019
ion homeostasisGO:00508012120.019
response to hypoxiaGO:00016662310.019
regulation of cell projection organizationGO:00313441750.019
positive regulation of cellular protein metabolic processGO:00322701670.019
cellular nitrogen compound catabolic processGO:00442701630.019
negative regulation of nitrogen compound metabolic processGO:00511721610.019
axis specificationGO:000979840.018
purine ribonucleotide catabolic processGO:00091541360.018
response to woundingGO:00096112540.018
positive regulation of programmed cell deathGO:00430681570.018
ribonucleoside metabolic processGO:00091191740.018
regulation of neuron deathGO:19012141150.018
Rat
positive regulation of protein phosphorylationGO:00019341350.018
purine ribonucleoside metabolic processGO:00461281680.018
gamete generationGO:00072761240.018
sexual reproductionGO:00199531480.018
response to peptideGO:19016522920.018
cellular component morphogenesisGO:00329891550.018
cellular cation homeostasisGO:00300031800.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.018
neuron deathGO:00709971270.018
Rat
cellular macromolecule localizationGO:00707271220.017
peptidyl tyrosine phosphorylationGO:0018108720.017
purine nucleotide metabolic processGO:00061632290.017
regulation of secretionGO:00510462240.017
response to decreased oxygen levelsGO:00362932370.017
positive regulation of neuron projection developmentGO:0010976990.017
nitrogen compound transportGO:00717052290.017
negative regulation of multicellular organismal processGO:00512412030.017
organic cyclic compound catabolic processGO:19013611750.017
nucleoside metabolic processGO:00091161790.017
regulation of lipid metabolic processGO:0019216680.017
guanosine containing compound metabolic processGO:1901068740.017
regulation of protein phosphorylationGO:00019321830.017
purine nucleoside triphosphate metabolic processGO:00091441410.017
single organism cellular localizationGO:19025801020.017
cellular protein localizationGO:00346131220.017
multicellular organismal signalingGO:0035637440.016
response to purine containing compoundGO:00140741260.016
neuron apoptotic processGO:0051402880.016
Rat
transmission of nerve impulseGO:0019226420.016
response to glucoseGO:00097491360.016
regulation of organelle organizationGO:0033043800.016
regulation of cell migrationGO:00303341280.016
gastrulationGO:000736920.016
ribose phosphate metabolic processGO:00196932350.016
positive regulation of protein modification processGO:00314011420.016
cardiovascular system developmentGO:00723581340.016
Rat
response to monosaccharideGO:00342841590.016
response to oxidative stressGO:00069791860.016
urogenital system developmentGO:0001655780.016
multicellular organism growthGO:003526410.016
regulation of homeostatic processGO:00328441010.016
positive regulation of cell projection organizationGO:00313461110.016
sex differentiationGO:00075481130.016
regulation of transmembrane transportGO:00347621220.016
cellular calcium ion homeostasisGO:00068741600.016
sulfur compound metabolic processGO:0006790700.016
organophosphate biosynthetic processGO:00904071430.016
positive regulation of neuron differentiationGO:00456661260.016
proteolysisGO:00065081750.015
divalent inorganic cation transportGO:00725111340.015
positive regulation of purine nucleotide metabolic processGO:1900544910.015
positive regulation of ion transportGO:0043270940.015
metal ion homeostasisGO:00550651860.015
negative regulation of cellular protein metabolic processGO:00322691060.015
response to fatty acidGO:0070542650.015
ribonucleotide catabolic processGO:00092611360.015
small molecule biosynthetic processGO:00442831240.015
cellular metal ion homeostasisGO:00068751720.015
organic hydroxy compound metabolic processGO:19016151150.015
negative regulation of developmental processGO:00510931250.015
glucose metabolic processGO:0006006520.015
regulation of anatomical structure sizeGO:00900661350.015
mapk cascadeGO:00001651400.015
developmental growthGO:00485891000.015
Rat
regulation of hydrolase activityGO:00513361430.015
mesoderm developmentGO:000749820.015
regulation of locomotionGO:00400121480.015
negative regulation of cellular component organizationGO:0051129830.015
cellular lipid metabolic processGO:00442552080.015
positive regulation of cellular component movementGO:00512721020.015
nucleotide catabolic processGO:00091661390.015
learning or memoryGO:0007611900.014
divalent inorganic cation homeostasisGO:00725071650.014
cellular response to lipidGO:00713962010.014
Rat
response to radiationGO:00093141370.014
glycosyl compound metabolic processGO:19016571820.014
regulation of transferase activityGO:00513381230.014
inorganic ion transmembrane transportGO:00986602290.014
cellular response to peptide hormone stimulusGO:00713751200.014
cognitionGO:0050890920.014
purine ribonucleotide metabolic processGO:00091502270.014
cellular response to growth factor stimulusGO:00713631620.014
nucleobase containing compound catabolic processGO:00346551520.014
organophosphate catabolic processGO:00464341480.014
regulation of cellular catabolic processGO:00313291010.014
regulation of kinase activityGO:00435491170.014
response to hexoseGO:00097461440.014
cellular ion homeostasisGO:00068731840.014
positive regulation of cytosolic calcium ion concentrationGO:00072041220.014
response to growth factorGO:00708481890.014
cation homeostasisGO:00550801950.014
regulation of proteasomal protein catabolic processGO:006113640.014
g protein coupled receptor signaling pathwayGO:00071862420.014
cofactor metabolic processGO:0051186950.014
peptidyl tyrosine modificationGO:0018212720.014
oxidation reduction processGO:00551143040.014
negative regulation of nucleic acid templated transcriptionGO:19035071170.014
response to inorganic substanceGO:00100353770.014
maintenance of locationGO:0051235170.014
nucleoside phosphate catabolic processGO:19012921400.013
regulation of chromosome segregationGO:005198310.013
cellular response to organic cyclic compoundGO:00714072020.013
cell cycle checkpointGO:000007520.013
mitotic cell cycleGO:0000278490.013
regulation of growthGO:00400081050.013
response to external biotic stimulusGO:00432072210.013
Rat
response to lipopolysaccharideGO:00324961910.013
Rat
positive regulation of nucleobase containing compound metabolic processGO:00459353190.013
Rat
taxisGO:0042330670.013
cytoplasmic transportGO:00164821150.013
spermatogenesisGO:0007283990.013
regulation of hormone levelsGO:00108171870.013
purine nucleoside metabolic processGO:00422781690.013
purine ribonucleoside triphosphate catabolic processGO:00092071220.013
cellular response to peptideGO:19016531330.013
mitotic cell cycle processGO:1903047350.013
regulation of calcium ion transportGO:0051924770.013
cellular divalent inorganic cation homeostasisGO:00725031620.013
regulation of dna metabolic processGO:0051052600.013
Rat
cellular response to insulin stimulusGO:0032869810.013
phospholipid metabolic processGO:0006644610.013
response to mechanical stimulusGO:00096121340.013
response to ketoneGO:19016541820.013
cell projection morphogenesisGO:00488581230.013
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.013
regulation of reactive oxygen species metabolic processGO:2000377260.013
cellular response to organonitrogen compoundGO:00714171970.013
single organism behaviorGO:00447081300.013
carbohydrate derivative catabolic processGO:19011361470.012
intracellular protein transportGO:0006886790.012
positive regulation of locomotionGO:00400171020.012
carbohydrate biosynthetic processGO:0016051420.012
gonad developmentGO:00084061040.012
salivary gland morphogenesisGO:000743510.012
insulin like growth factor receptor signaling pathwayGO:004800930.012
positive regulation of mapk cascadeGO:0043410920.012
negative regulation of cell cycle phase transitionGO:190198840.012
positive regulation of transportGO:00510502450.012
purine ribonucleoside triphosphate metabolic processGO:00092051400.012
organonitrogen compound biosynthetic processGO:19015661670.012
actin cytoskeleton organizationGO:0030036730.012
cell morphogenesisGO:00009021420.012
neuron projection morphogenesisGO:00488121220.012
regulation of purine nucleotide metabolic processGO:19005421150.012
actin filament based processGO:0030029860.012
regulation of canonical wnt signaling pathwayGO:006082840.012
kidney developmentGO:0001822670.012
salivary gland developmentGO:000743130.012
positive regulation of nucleotide metabolic processGO:0045981910.012
embryonic pattern specificationGO:000988010.012
cell part morphogenesisGO:00329901230.012
action potentialGO:0001508540.012
calcium ion homeostasisGO:00550741620.012
muscle system processGO:00030121150.012
Mouse Rat
eye morphogenesisGO:004859240.012
response to amineGO:0014075460.012
cellular response to abiotic stimulusGO:0071214850.012
heart morphogenesisGO:000300730.012
sensory perceptionGO:00076001010.012
sister chromatid segregationGO:000081910.012
reproductive structure developmentGO:00486081280.012
negative regulation of response to stimulusGO:00485851550.012
nucleoside triphosphate metabolic processGO:00091411440.012
response to molecule of bacterial originGO:00022371940.011
Rat
peptide transportGO:0015833970.011
dephosphorylationGO:0016311980.011
ensheathment of neuronsGO:0007272400.011
glycosyl compound catabolic processGO:19016581260.011
defense responseGO:00069521940.011
multi multicellular organism processGO:00447061380.011
purine nucleoside catabolic processGO:00061521240.011
response to temperature stimulusGO:0009266940.011
hexose metabolic processGO:0019318580.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
inorganic cation transmembrane transportGO:00986622020.011
synaptic transmissionGO:00072682350.011
organic anion transportGO:00157111320.011
male gamete generationGO:0048232990.011
response to reactive oxygen speciesGO:00003021200.011
protein targetingGO:0006605610.011
glycogen metabolic processGO:0005977230.011
carboxylic acid biosynthetic processGO:0046394830.011
positive regulation of secretion by cellGO:19035321280.011
regulation of mitotic sister chromatid segregationGO:003304710.011
guanosine containing compound catabolic processGO:1901069710.011
negative regulation of catalytic activityGO:00430861030.011
purine containing compound catabolic processGO:00725231380.011
positive regulation of catalytic activityGO:00430851840.011
response to ethanolGO:00454711620.011
regulation of protein kinase activityGO:00458591050.011
regulation of cell morphogenesisGO:0022604770.011
nucleoside catabolic processGO:00091641260.011
response to bacteriumGO:00096172000.011
Rat
carbohydrate derivative biosynthetic processGO:19011371240.011
ribonucleoside triphosphate catabolic processGO:00092031220.011
mitotic spindle organizationGO:000705220.011
positive regulation of cell motilityGO:2000147970.011
negative regulation of mitotic cell cycle phase transitionGO:190199130.011
rhythmic processGO:00485111560.011
development of primary sexual characteristicsGO:00451371070.011
negative regulation of signal transductionGO:0009968830.011
blood circulationGO:00080151830.011
Mouse
cell cycle processGO:0022402570.011
polysaccharide metabolic processGO:0005976250.011
positive regulation of nucleoside metabolic processGO:0045979550.011
negative regulation of cell differentiationGO:0045596990.011
ion transmembrane transportGO:00342203650.011
motor neuron axon guidanceGO:000804510.011
purine nucleoside triphosphate catabolic processGO:00091461220.011
mitotic sister chromatid separationGO:005130610.011
endocytosisGO:0006897840.011
organic acid transportGO:00158491160.010
vesicle mediated transportGO:00161921810.010
organic acid biosynthetic processGO:0016053830.010
response to cytokineGO:00340972150.010
carboxylic acid transportGO:00469421150.010
alcohol metabolic processGO:0006066770.010
cellular response to external stimulusGO:00714961180.010
muscle contractionGO:0006936880.010
Mouse
cytoskeleton dependent cytokinesisGO:006164020.010
nucleoside triphosphate catabolic processGO:00091431230.010
regulation of neuron apoptotic processGO:0043523830.010
Rat
cellular response to acid chemicalGO:0071229750.010
purine nucleotide catabolic processGO:00061951360.010
response to campGO:0051591910.010

Map2k6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.027
disease of anatomical entityDOID:700.027
central nervous system diseaseDOID:33100.016
vascular diseaseDOID:17800.012
cardiovascular system diseaseDOID:128700.012
disease of metabolismDOID:001466700.012
inherited metabolic disorderDOID:65500.012
cancerDOID:16200.010
organ system cancerDOID:005068600.010
disease of cellular proliferationDOID:1456600.010