Rattus norvegicus

201 known processes

Map2k4

mitogen activated protein kinase kinase 4

(Aliases: MKK4)

Map2k4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
rna biosynthetic processGO:00327743800.139
intracellular signal transductionGO:00355563140.126
protein autophosphorylationGO:0046777660.126
positive regulation of nucleobase containing compound metabolic processGO:00459353190.122
rna metabolic processGO:00160704060.111
regulation of rna biosynthetic processGO:20011413810.110
mapk cascadeGO:00001651400.109
transcription dna templatedGO:00063513770.100
regulation of rna metabolic processGO:00512523910.100
regulation of jun kinase activityGO:0043506100.095
nucleic acid templated transcriptionGO:00976593790.093
regulation of phosphorylationGO:00423252480.088
regulation of intracellular signal transductionGO:19025312180.083
single organism biosynthetic processGO:00447113420.075
programmed cell deathGO:00125013920.073
positive regulation of phosphate metabolic processGO:00459372620.069
positive regulation of signalingGO:00230562700.069
regulation of cellular component organizationGO:00511283680.067
Worm
metal ion transportGO:00300012890.066
regulation of nucleic acid templated transcriptionGO:19035063800.066
single organism organelle organizationGO:19025891800.065
negative regulation of biosynthetic processGO:00098901680.061
regulation of protein phosphorylationGO:00019321830.060
cellular component morphogenesisGO:00329891550.060
Fly
regulation of cell morphogenesisGO:0022604770.060
positive regulation of cell communicationGO:00106472710.059
positive regulation of ion transportGO:0043270940.058
Rat
regulation of ion transportGO:00432692450.058
Rat
lipid transportGO:0006869610.058
Rat
negative regulation of metabolic processGO:00098923310.058
cell growthGO:00160491040.057
macromolecular complex assemblyGO:00650032730.057
regulation of transcription dna templatedGO:00063553740.057
protein phosphorylationGO:00064683450.057
oxoacid metabolic processGO:00434362900.056
positive regulation of macromolecule biosynthetic processGO:00105572470.056
regulation of cellular ketone metabolic processGO:0010565270.055
macromolecular complex subunit organizationGO:00439333390.055
positive regulation of nitrogen compound metabolic processGO:00511733340.054
organophosphate metabolic processGO:00196373700.053
lipid biosynthetic processGO:00086101280.053
regulation of signal transductionGO:00099663180.052
regulation of stress activated mapk cascadeGO:0032872230.051
nucleoside phosphate metabolic processGO:00067532830.051
positive regulation of transcription dna templatedGO:00458931970.049
growthGO:00400071650.049
positive regulation of signal transductionGO:00099671750.044
signal transduction by phosphorylationGO:00230141440.044
lipid metabolic processGO:00066292830.044
catabolic processGO:00090563510.044
negative regulation of signal transductionGO:0009968830.043
regulation of phosphate metabolic processGO:00192203490.043
cellular catabolic processGO:00442482950.043
protein complex subunit organizationGO:00718223020.042
regulation of protein metabolic processGO:00512462890.042
regulation of protein complex assemblyGO:0043254330.042
apoptotic processGO:00069153810.042
positive regulation of phosphorus metabolic processGO:00105622620.042
positive regulation of response to stimulusGO:00485842850.041
single organism intracellular transportGO:19025821660.041
cellular amino acid metabolic processGO:00065201070.041
protein complex assemblyGO:00064612630.041
positive regulation of intracellular signal transductionGO:19025331380.041
negative regulation of nucleic acid templated transcriptionGO:19035071170.040
positive regulation of programmed cell deathGO:00430681570.040
cell morphogenesisGO:00009021420.040
Fly
regulation of anion transportGO:0044070430.040
Rat
lipid localizationGO:0010876620.039
Rat
cellular component biogenesisGO:00440853680.039
organic acid biosynthetic processGO:0016053830.039
positive regulation of biosynthetic processGO:00098913190.039
regulation of mapk cascadeGO:00434081160.038
negative regulation of rna biosynthetic processGO:19026791180.038
cellular response to oxygen containing compoundGO:19017013860.037
cellular ketone metabolic processGO:0042180510.037
negative regulation of nitrogen compound metabolic processGO:00511721610.037
regulation of anatomical structure morphogenesisGO:00226031410.037
cellular response to lipidGO:00713962010.037
Rat
positive regulation of multicellular organismal processGO:00512403870.037
cell projection organizationGO:00300303020.037
Fly
organic anion transportGO:00157111320.037
Rat
negative regulation of nucleobase containing compound metabolic processGO:00459341530.037
positive regulation of phosphorylationGO:00423271770.037
organic substance catabolic processGO:19015753160.037
organelle organizationGO:00069962660.036
cellular response to stressGO:00335542690.036
ion homeostasisGO:00508012120.036
regulation of cellular protein metabolic processGO:00322682670.036
apoptotic mitochondrial changesGO:0008637100.036
cation transportGO:00068123820.036
negative regulation of cellular metabolic processGO:00313242810.035
negative regulation of macromolecule metabolic processGO:00106052600.035
cellular response to growth factor stimulusGO:00713631620.035
dna metabolic processGO:0006259960.035
anatomical structure morphogenesisGO:00096532980.035
Fly
cellular response to abiotic stimulusGO:0071214850.035
Human
cellular response to endogenous stimulusGO:00714953770.034
single organism catabolic processGO:00447122830.034
organ morphogenesisGO:0009887750.034
protein complex biogenesisGO:00702712630.034
negative regulation of cellular biosynthetic processGO:00313271610.034
regulation of cell developmentGO:00602842630.033
immune system processGO:00023762040.033
positive regulation of protein modification processGO:00314011420.033
monovalent inorganic cation transportGO:00156721720.033
regulation of kinase activityGO:00435491170.033
agingGO:00075682410.033
defense responseGO:00069521940.033
Worm
organic acid metabolic processGO:00060822920.032
establishment of protein localizationGO:00451841410.032
negative regulation of gene expressionGO:00106291990.032
inflammatory responseGO:00069541500.032
negative regulation of transcription dna templatedGO:00458921160.032
positive regulation of rna metabolic processGO:00512542030.032
negative regulation of macromolecule biosynthetic processGO:00105581480.032
positive regulation of cellular biosynthetic processGO:00313282950.031
regulation of microtubule polymerizationGO:003111380.031
cell morphogenesis involved in differentiationGO:00009041190.031
transcription from rna polymerase ii promoterGO:00063662520.031
negative regulation of signalingGO:00230571570.030
purine containing compound metabolic processGO:00725212530.029
small molecule biosynthetic processGO:00442831240.029
regulation of map kinase activityGO:0043405530.029
positive regulation of developmental processGO:00510942830.029
positive regulation of gene expressionGO:00106282440.029
positive regulation of protein metabolic processGO:00512471780.029
regulation of cell migrationGO:00303341280.029
regulation of stress activated protein kinase signaling cascadeGO:0070302230.029
neuron projection developmentGO:00311752730.028
Fly
cellular macromolecule localizationGO:00707271220.028
carbohydrate derivative metabolic processGO:19011353460.028
positive regulation of cellular protein metabolic processGO:00322701670.027
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.027
multicellular organismal reproductive processGO:00486092330.027
Rat
localization of cellGO:00516742020.027
cellular response to nitrogen compoundGO:19016992100.027
negative regulation of rna metabolic processGO:00512531230.027
cellular response to mechanical stimulusGO:0071260480.026
Human
cellular response to external stimulusGO:00714961180.026
Human
intracellular protein transportGO:0006886790.026
monocarboxylic acid transportGO:0015718520.026
Rat
positive regulation of cell deathGO:00109421840.026
regulation of cell morphogenesis involved in differentiationGO:0010769720.026
peptidyl amino acid modificationGO:00181931260.026
positive regulation of molecular functionGO:00440932300.026
positive regulation of cellular component organizationGO:00511302000.025
epiboly involved in wound healingGO:009050520.025
cellular component movementGO:00069282480.025
organonitrogen compound catabolic processGO:19015651790.025
regulation of programmed cell deathGO:00430673410.025
amine metabolic processGO:0009308380.025
response to radiationGO:00093141370.025
stress activated protein kinase signaling cascadeGO:0031098370.025
regulation of phosphorus metabolic processGO:00511743490.024
positive regulation of rna biosynthetic processGO:19026801970.024
cellular lipid metabolic processGO:00442552080.024
chemical homeostasisGO:00488782920.024
positive regulation of protein phosphorylationGO:00019341350.024
organic acid transportGO:00158491160.024
Rat
nucleobase containing small molecule metabolic processGO:00550863160.024
neuron developmentGO:00486662860.024
Fly
carboxylic acid metabolic processGO:00197522890.024
regulation of cell differentiationGO:00455953200.024
cell migrationGO:00164771970.024
prostaglandin secretionGO:003231060.024
Rat
carboxylic acid transportGO:00469421150.023
Rat
protein localizationGO:00081041910.023
regulation of secretionGO:00510462240.023
Rat
regulation of cellular component movementGO:00512701500.023
cellular chemical homeostasisGO:00550822470.023
regulation of protein kinase activityGO:00458591050.023
small gtpase mediated signal transductionGO:0007264360.023
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.023
reproductive processGO:00224143720.023
Rat
multi organism reproductive processGO:00447032620.023
cell projection morphogenesisGO:00488581230.022
Fly
response to extracellular stimulusGO:00099913800.022
regulation of cell projection organizationGO:00313441750.022
positive regulation of transportGO:00510502450.022
Rat
nucleotide metabolic processGO:00091172790.022
synaptic growth at neuromuscular junctionGO:005112410.022
ribonucleotide metabolic processGO:00092592310.022
neuron differentiationGO:00301823680.022
Fly
regulation of lipid biosynthetic processGO:0046890380.022
protein oligomerizationGO:00512591910.022
prostaglandin transportGO:001573280.022
Rat
establishment of vesicle localizationGO:0051650310.021
regulation of jnk cascadeGO:0046328190.021
response to nutrient levelsGO:00316673700.021
ras protein signal transductionGO:0007265290.021
release of cytochrome c from mitochondriaGO:000183680.021
regulation of molecular functionGO:00650093980.021
membrane organizationGO:0061024940.021
positive regulation of cell developmentGO:00107201760.021
transmembrane transportGO:00550854120.021
cellular amine metabolic processGO:0044106380.021
regulation of cellular amino acid metabolic processGO:000652120.021
regulation of cellular component biogenesisGO:0044087860.021
regulation of catalytic activityGO:00507903040.020
regulation of protein modification processGO:00313991940.020
purine nucleotide metabolic processGO:00061632290.020
multicellular organism reproductionGO:00325042330.020
Rat
cellular response to cytokine stimulusGO:00713451270.020
proteolysisGO:00065081750.020
positive regulation of cell morphogenesis involved in differentiationGO:0010770410.020
cellular response to hormone stimulusGO:00328702470.020
cation homeostasisGO:00550801950.020
sodium ion transportGO:0006814820.020
multicellular organism growthGO:003526410.020
positive regulation of mapk cascadeGO:0043410920.019
purine ribonucleotide metabolic processGO:00091502270.019
cellular ion homeostasisGO:00068731840.019
regulation of cellular amine metabolic processGO:003323880.019
cellular response to tumor necrosis factorGO:0071356460.019
regulation of cellular response to stressGO:0080135490.019
cytoskeleton organizationGO:00070101110.019
response to osmotic stressGO:0006970420.019
response to growth factorGO:00708481890.019
modification dependent macromolecule catabolic processGO:0043632140.019
nucleoside catabolic processGO:00091641260.019
maintenance of locationGO:0051235170.019
purine ribonucleoside metabolic processGO:00461281680.019
positive regulation of cell differentiationGO:00455972170.019
response to heatGO:0009408600.018
cytoplasmic transportGO:00164821150.018
cell motilityGO:00488702020.018
wound healing spreading of cellsGO:004431920.018
morphogenesis of embryonic epitheliumGO:001633130.018
wound healingGO:00420601220.018
response to carbohydrateGO:00097431830.018
positive regulation of reactive oxygen species biosynthetic processGO:190342820.018
chromosome organizationGO:0051276360.018
glycosyl compound metabolic processGO:19016571820.018
regulation of organelle organizationGO:0033043800.017
regulation of response to stressGO:00801341260.017
response to acid chemicalGO:00011012220.017
single organism reproductive processGO:00447022970.017
Rat
response to inorganic substanceGO:00100353770.017
regulation of apoptotic processGO:00429813350.017
cellular component assemblyGO:00226073600.017
organic hydroxy compound metabolic processGO:19016151150.017
microtubule polymerization or depolymerizationGO:0031109130.017
response to woundingGO:00096112540.017
protein transportGO:00150311320.017
protein modification by small protein conjugation or removalGO:0070647350.017
anterior posterior pattern specificationGO:000995210.017
negative regulation of catalytic activityGO:00430861030.017
immune responseGO:00069551040.017
negative regulation of stress activated protein kinase signaling cascadeGO:007030340.016
regulation of cellular catabolic processGO:00313291010.016
organelle localizationGO:0051640550.016
ribose phosphate metabolic processGO:00196932350.016
ion transmembrane transportGO:00342203650.016
cellular protein complex assemblyGO:0043623440.016
embryonic pattern specificationGO:000988010.016
negative regulation of protein phosphorylationGO:0001933440.016
cellular macromolecular complex assemblyGO:0034622580.016
ribonucleotide catabolic processGO:00092611360.016
regulation of metal ion transportGO:00109591180.016
reactive oxygen species biosynthetic processGO:190340980.016
positive regulation of fatty acid transportGO:200019390.016
Rat
reactive nitrogen species metabolic processGO:200105710.016
secretionGO:00469033070.016
Rat
regulation of fatty acid transportGO:2000191100.016
Rat
neurological system processGO:00508772190.016
axis specificationGO:000979840.016
aromatic compound catabolic processGO:00194391680.016
purine nucleoside metabolic processGO:00422781690.016
intracellular transportGO:00469071850.015
regulation of lipid metabolic processGO:0019216680.015
protein polymerizationGO:0051258220.015
metal ion homeostasisGO:00550651860.015
response to nutrientGO:00075842480.015
regulation of microtubule based processGO:0032886140.015
negative regulation of phosphate metabolic processGO:0045936800.015
collateral sproutingGO:004866820.015
synaptic transmissionGO:00072682350.015
Worm
regulation of cytoskeleton organizationGO:0051493490.015
regulation of anatomical structure sizeGO:00900661350.015
response to metal ionGO:00100382530.015
response to oxidative stressGO:00069791860.015
organophosphate catabolic processGO:00464341480.015
actin filament based movementGO:0030048160.015
organonitrogen compound biosynthetic processGO:19015661670.015
heterocycle catabolic processGO:00467001670.014
cellular cation homeostasisGO:00300031800.014
positive regulation of icosanoid secretionGO:003230570.014
Rat
protein homooligomerizationGO:0051260910.014
macromolecule localizationGO:00330362520.014
Rat
locomotionGO:00400112370.014
regulation of prostaglandin secretionGO:003230660.014
Rat
negative regulation of transportGO:00510511360.014
negative regulation of cell communicationGO:00106481580.014
cellular response to oxidative stressGO:0034599760.014
hormone mediated signaling pathwayGO:0009755230.014
purine ribonucleoside triphosphate metabolic processGO:00092051400.014
response to temperature stimulusGO:0009266940.014
response to light stimulusGO:0009416520.014
enzyme linked receptor protein signaling pathwayGO:00071671160.014
response to corticosteroidGO:00319602350.014
ribonucleoside catabolic processGO:00424541260.014
purine nucleoside catabolic processGO:00061521240.014
purine nucleotide catabolic processGO:00061951360.014
response to lipopolysaccharideGO:00324961910.014
Rat
response to peptide hormoneGO:00434342780.014
axonogenesisGO:0007409710.014
negative regulation of response to stimulusGO:00485851550.014
regulation of reactive oxygen species biosynthetic processGO:190342650.014
regulation of transcription from rna polymerase ii promoterGO:00063572340.013
gamete generationGO:00072761240.013
cell cycle dna replicationGO:004478610.013
cellular response to peptideGO:19016531330.013
anion transportGO:00068201780.013
Rat
nucleotide catabolic processGO:00091661390.013
regulation of growthGO:00400081050.013
microtubule based processGO:0007017360.013
carboxylic acid biosynthetic processGO:0046394830.013
regulation of nervous system developmentGO:00519602640.013
cellular response to peptide hormone stimulusGO:00713751200.013
nucleoside metabolic processGO:00091161790.013
cellular nitrogen compound catabolic processGO:00442701630.013
negative regulation of cellular protein metabolic processGO:00322691060.013
regulation of protein localizationGO:0032880810.013
negative regulation of stress activated mapk cascadeGO:003287340.013
response to peptideGO:19016522920.013
ribonucleoside metabolic processGO:00091191740.013
regulation of locomotionGO:00400121480.013
single organism cellular localizationGO:19025801020.013
peptidyl serine phosphorylationGO:0018105330.013
response to amineGO:0014075460.013
fatty acid derivative metabolic processGO:1901568380.013
negative regulation of protein metabolic processGO:00512481140.013
positive regulation of organic acid transportGO:0032892220.013
Rat
lipid storageGO:001991510.013
cell morphogenesis involved in neuron differentiationGO:00486671060.013
regulation of neuron projection developmentGO:00109751610.013
positive regulation of cytoskeleton organizationGO:0051495260.013
regulation of transferase activityGO:00513381230.013
response to insulinGO:00328681330.013
regulation of microtubule polymerization or depolymerizationGO:0031110120.013
regulation of cell motilityGO:20001451310.013
regulation of system processGO:00440572080.013
protein modification by small protein conjugationGO:0032446310.013
negative regulation of cell differentiationGO:0045596990.012
vesicle localizationGO:0051648330.012
response to tumor necrosis factorGO:0034612560.012
chromosome segregationGO:000705920.012
regulation of cell proliferationGO:00421273590.012
regulation of cellular localizationGO:00603412630.012
negative regulation of mitotic cell cycle phase transitionGO:190199130.012
reproductionGO:00000032450.012
Rat
negative regulation of apoptotic processGO:00430661810.012
divalent metal ion transportGO:00708381320.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
regulation of cell cycleGO:0051726730.012
chromatin modificationGO:0016568330.012
regulation of multicellular organismal developmentGO:20000263760.012
Fly
tissue developmentGO:00098882520.012
cellular sodium ion homeostasisGO:000688340.012
regulation of cell growthGO:0001558850.011
regulation of catabolic processGO:00098941130.011
stress activated mapk cascadeGO:0051403350.011
cell cell signalingGO:00072673350.011
Worm
negative regulation of molecular functionGO:00440921330.011
positive regulation of apoptotic processGO:00430651540.011
regulation of microtubule cytoskeleton organizationGO:0070507140.011
carbohydrate derivative catabolic processGO:19011361470.011
response to cytokineGO:00340972150.011
organic cyclic compound catabolic processGO:19013611750.011
cellular response to acid chemicalGO:0071229750.011
positive regulation of protein kinase activityGO:0045860730.011
nucleoside phosphate biosynthetic processGO:19012931020.011
fatty acid biosynthetic processGO:0006633330.011
regulation of dna metabolic processGO:0051052600.011
spermatogenesisGO:0007283990.011
purine containing compound catabolic processGO:00725231380.011
epithelium developmentGO:0060429960.011
response to glucocorticoidGO:00513842230.011
negative regulation of programmed cell deathGO:00430691830.011
cellular response to inorganic substanceGO:0071241650.011
central nervous system developmentGO:00074173110.011
regulation of neurogenesisGO:00507672470.011
cellular response to alcoholGO:0097306870.011
g protein coupled receptor signaling pathwayGO:00071862420.011
carbohydrate derivative biosynthetic processGO:19011371240.011
response to glucoseGO:00097491360.011
negative regulation of phosphorylationGO:0042326570.011
homeostatic processGO:00425923310.011
nucleoside triphosphate catabolic processGO:00091431230.011
acid secretionGO:0046717480.011
Rat
positive regulation of nitric oxide synthase biosynthetic processGO:005177080.011
protein ubiquitinationGO:0016567280.011
multicellular organismal signalingGO:0035637440.011
regenerationGO:00310991630.011
chromatin organizationGO:0006325340.010
positive regulation of organelle organizationGO:0010638480.010
positive regulation of neurogenesisGO:00507691650.010
positive regulation of nervous system developmentGO:00519621780.010
negative regulation of cell deathGO:00605482290.010
wound healing spreading of epidermal cellsGO:003531320.010
unsaturated fatty acid metabolic processGO:0033559390.010
cellular homeostasisGO:00197252520.010
regulation of neuron differentiationGO:00456642080.010
regulation of nucleotide metabolic processGO:00061401170.010
sexual reproductionGO:00199531480.010
inorganic ion transmembrane transportGO:00986602290.010
nucleobase containing compound catabolic processGO:00346551520.010
regulation of proteasomal protein catabolic processGO:006113640.010
purine nucleoside triphosphate catabolic processGO:00091461220.010
divalent inorganic cation homeostasisGO:00725071650.010
positive regulation of cellular amino acid metabolic processGO:004576410.010

Map2k4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.023
nervous system diseaseDOID:86300.023
disease of metabolismDOID:001466700.017
sensory system diseaseDOID:005015500.015
inherited metabolic disorderDOID:65500.013
musculoskeletal system diseaseDOID:1700.012